GLPBio

MCI-INI-3

Catalog No.: GC91980Purity:>95.00%
COASDSData Sheet
MCI-INI-3 is an inhibitor of aldehyde dehydrogenase 1A3 (ALDH1A3; Ki = 0.55 ?M).

Products are for research use only. Not for human use. We do not sell to patients.

MCI-INI-3
Cas No.: 1011366-31-6
1 mgIn Stock
$83.00
1
5 mgIn Stock
$330.00
1
10 mgIn Stock
$620.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

MCI-INI-3 is an inhibitor of aldehyde dehydrogenase 1A3 (ALDH1A3; Ki = 0.55 ?M).1 It is selective for ALDH1A3 over ALDH1A1 (Ki = 78.2 ?M). MCI-INI-3 (15 ?M) inhibits the conversion of retinol to retinaldehyde in U87MG glioblastoma cells. It reduces the viability of GSC-83 and GSC-326 glioblastoma cells when used at a concentration of 15 ?M.

References:
[1]. Li, J., Garavaglia, S., Ye, Z., et al.A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cellsCommun. Biol.4(1)1420(2021).

Product Documents

Purity:>95.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1011366-31-6
Chemical Name
5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylic acid, methyl ester
SMILES
O=C(C1=CC(C2=CC3=C(OCO3)C=C2)=NC4=CC(C5=CC=CC=C5)=NN41)OC
Molecular Formula
C21H15N3O4
Molecular Weight
373.4
Solubility
Acetonitrile: Slightly soluble: 0.1-1 mg/ml,DMSO: Sparingly soluble: 1-10 mg/ml
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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