Mer-NF5003F (Synonyms: F 1839M, NF 5003F, Stachybotrydial) |
| Catalog No.GC46169 |
A sesquiterpene with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 149598-70-9
Sample solution is provided at 25 µL, 10mM.
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Mer-NF5003F is a sesquiterpene originally isolated from Stachybotrys with diverse biological activities.1,2,3 It inhibits avian myeloblastosis virus (AMV) protease (IC50 = 7.8 μM).1 Mer-NF5003F inhibits sialyltransferase 6N (ST6N), ST3O, and ST3N (IC50s = 0.61, 6.7, and 10 μg/ml, respectively), as well as fucosyltransferase (IC50 = 11.3 μg/ml).2 It is active against herpes simplex virus 1 (HSV-1) in vitro (IC50 = 4.32 μg/ml).3 Mer-NF5003F is also active against the multidrug-resistant P. falciparum strain K1 (IC50 = 0.85 μg/ml).
|1. Kaneto, R., Dobashi, K., Kojima, I., et al. Mer-NF5003B, E and F, novel sesquiterpenoids as avian myeloblastosis virus protease inhibitors produced by Stachybotrys sp. J. Antibiot. (Tokyo) 47(6), 727-730 (1994).|2. Lin, T.-W., Chang, W.-W., Chen, C.-C., et al. Stachybotrydial, a potent inhibitor of fucosyltransferase and sialyltransferase. Biochem. Biophys. Res. Commun. 331(4), 953-957 (2005).|3. Sawadjoon, S., Kittakoop, P., Isaka, M., et al. Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora. Planta Med. 70(11), 1085-1087 (2004).
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