GLPBio

Mineralocorticoid Receptor

The mineralocorticoid receptor is a nuclear hormone receptor for aldosterone and glucocorticoids. It acts as a transcription factor to regulate the water-salt homeostasis and blood pressure in the target cell. It also plays physiological roles in kidney, brain and cardiovascular system.

Products Related to Mineralocorticoid Receptor(23)

  • GC15831 structure
    GC15831Eplerenone
    CAS: 107724-20-9
    Purity: >98.00%

    Eplerenone is an orally active mineralocorticoid receptor (MR) antagonist that blocks the effects of aldosterone, with an IC 50 value of 0.081μM.

  • GC12349 structure
    GC12349Deoxycorticosterone acetate
    CAS: 56-47-3
    Purity: >98.00%

    Steroid hormone

  • GC17090 structure
    GC17090RU 28318, potassium salt
    CAS: 76676-34-1
    Purity: >98.00%

    RU 28318, potassium salt is a potent mineralocorticoid (MR) antagonist.

  • GC17537 structure
    GC17537Canrenone
    CAS: 976-71-6
    Purity: >98.00%

    Mineralocorticoid receptor antagonist

  • GC19143 structure
    GC19143Esaxerenone
    CAS: 1632006-28-0
    Purity: >99.50%

    Esaxerenone (CS-3150), a selective nonsteroidal mineralocorticoid receptor antagonist, has been shown to bind to mineralocorticoid receptors, thereby inhibiting aldosterone binding and activation of the receptor.

  • GC19273 structure
    GC19273Osilodrostat
    CAS: 928134-65-0
    Purity: >99.50%

    Osilodrostat (LCI699) is a potent inhibitor of human 11β-hydroxylase and aldosterone synthase with IC50 values of 2.5 and 0.7 nM, respectively.

  • GC31448 structure
    GC31448Apararenone (MT-3995)
    CAS: 945966-46-1
    Purity: >98.50%

    Apararenone (MT-3995) (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.

  • GC31789 structure
    GC31789Fludrocortisone (9α-Fludrocortisone)
    CAS: 127-31-1
    Purity: >95.00%

    Fludrocortisone (9α-Fludrocortisone), a synthetic mineralocorticoid with anti-inflammatory activity.

  • GC33848 structure
    GC33848Fludrocortisone acetate (9α-Fludrocortisone acetate)
    CAS: 514-36-3
    Purity: >99.50%

    Fludrocortisone acetate (9α-Fludrocortisone acetate) (9α-Fludrocortisone acetate (9α-Fludrocortisone acetate)) is a synthetic mineralocorticoid, used to control the amount of sodium and fluids in your body.

  • GC35862 structure
    GC35862Dicirenone
    CAS: 41020-79-5
    Purity: >98%

    Dicirenone (SC26304) inhibits the effects of Aldosterone on urinary K+:Na+ ratios and the binding of [3H]Aldosterone to renal cytoplasmic and nuclear receptors.

  • GC39564 structure
    GC39564Vamorolone
    CAS: 13209-41-1
    Purity: >99.00%

    Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer.

  • GC62332 structure
    GC62332(Rac)-Finerenone
    CAS: 1050477-27-4
    Purity: >98%

    (Rac)-Finerenone ((Rac)-BAY 94-8862) is the racemate of Finerenone.

  • GC62386 structure
    GC62386AZD9977
    CAS: 1850385-64-6
    Purity: >99.50%

    AZD9977 is a potent, selective, and orally active mineralocorticoid receptor (MR) modulator.

  • GC62759 structure
    GC6275918-Oxocortisol
    CAS: 2410-60-8
    Purity: >98.00%

    18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2).

  • GC64593 structure
    GC64593Baxdrostat
    CAS: 1428652-17-8
    Purity: >98.00%

    Baxdrostat is a novel, orally active aldosterone synthase (CYP11B2) inhibitor.

  • GC64594 structure
    GC64594(S)-Baxdrostat
    CAS: 1428652-16-7
    Purity: >98.00%

    (S)-Baxdrostat is the S-enantiomer of Baxdrostat.

  • GC65465 structure
    GC65465Ocedurenone
    CAS: 1359969-24-6
    Purity: >98%

    Ocedurenone is a corticosteroid receptor antagonist.

  • GC66454 structure
    GC66454Osilodrostat phosphate
    CAS: 1315449-72-9
    Purity: >99.00%

    Osilodrostat (LCI699) phosphate is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat phosphate is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat phosphate inhibits aldosterone and corticosterone synthesis. Osilodrostat phosphate has blood pressure lowering ability. Osilodrostat phosphate can be used for research of Cushing syndrome (CS).

  • GC69397 structure
    GC69397Lorundrostat
    CAS: 1820940-17-7
    Purity: >99.00%

    Lorundrostat is an aldosterone synthase inhibitor.

  • GC80845 structure
    GC80845Spironolactone-d 6 -1
    Purity: >99.00%

    Spironolactone -d 6 -1 is the deuterium labeled Spironolactone.

  • GC80862 structure
    GC80862(R)-Finerenone
    CAS: 1050477-30-9
    Purity: >99.50%

    (R)-Finerenone ((R)-BAY 94-8862) is the R-isomer of Finerenone.

  • GC80863 structure
    GC80863(R)-Balcinrenone
    CAS: 1850385-65-7
    Purity: >99.50%

    (R)-Balcinrenone ((R)-AZD9977) is an isomer of Balcinrenone.

  • GC80864 structure
    GC80864Esaxerenone-d 4
    Purity: >98%

    Esaxerenone -d 4 (CS-3150-d 4 ) is the deuterium labeled Esaxerenone.