GLPBio

ML-031

Catalog No.: GC11668Purity:>98%Synonyms: CID-2113511
COASDSData Sheet
ML-031 is a potent and selective agonist Sphingosine 1-phosphate receptor 2 (S1PR2) with an IC50 and EC50 of 1.0 and 1.03 μM. ML-031 has the potential for the research of cancer diseases.

Products are for research use only. Not for human use. We do not sell to patients.

ML-031
Cas No.: 852230-33-2
1mgIn Stock
$68.00
1
5mgIn Stock
$182.00
1
10mgIn Stock
$298.00
1
25mgIn Stock
$576.00
1
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Description

ML-031 is an agonist of S1P2 with EC50 value of 1 μM [1].

Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid mediator mainly released from activated platelets and implicated in many biological responses, such as cell proliferation, migration, survival, and differentiation [1]. Sphingolipids belong to a family of bioactive molecules with cell signaling properties. Sphingosine 1-phosphate (S1P) is widely expressed on various tissues and cell types. S1P is a pleiotropic lysophospholipid mediator exists in plasma and is released in large amounts from activated platelets [1]. Until now, five sphingosine-1-phosphate receptors (S1PR1-S1PR5) have been identified. S1PR4 and S1PR5 are prominently expressed in the immune and nervous systems, respectively. S1P functions by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8.

ML-031 activated S1P2 with an EC50 value of 1 μM in a S1P reporter assay [1].

Reference:
[1] Satsu H, Schaeffer M T, Guerrero M, et al.  A sphingosine 1-phosphate receptor 2 selective allosteric agonist[J]. Bioorganic & medicinal chemistry, 2013, 21(17): 5373-5382.

Chemical Properties

CAS No.
852230-33-2
Synonyms
CID-2113511
Chemical Name
1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-2,5-pyrrolidinedione
SMILES
CC1=CC(C(CN2C(CCC2=O)=O)=O)=C(C)N1CC3=CC=CC=C3
Molecular Formula
C19H20N2O3
Molecular Weight
324.4
Solubility
≤5mg/ml in ethanol;5mg/ml in DMSO
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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