Mps1
MPS1 (monopolar spindle 1 kinase) is a crucial part of the spindle assembly checkpoint. It facilitates the formation of C-MAD2 (closed MAD2) conformer and the MCC (mitotic checkpoint complex) assembly, and involved in the tumor growth.
Products Related to Mps1(14)
- GC18491CFI-402257CAS: 1610759-22-2Purity: >99.50%
CFI-402257 is a potent, highly selective, and orally active small-molecule inhibitor of Threonine tyrosine kinase, with an IC 50 value of 1.7nM and a K i value of 0.1nM.
- GC19058BAY1217389CAS: 1554458-53-5Purity: >98.00%
BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM.
- GC32846BOS-172722CAS: 1578245-44-9Purity: >99.00%
BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer.
- GC34073Empesertib (BAY 1161909)CAS: 1443763-60-7Purity: >98.00%
Empesertib (BAY 1161909) (BAY 1161909) is a potent Mps1 inhibitor, with an IC50 of < 1 nM.
- GC65339Mps1-IN-3 hydrochloridePurity: >98.00%
Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC15283 | AZ3146 | 1124329-14-1 | >99.50% | |
Mps1 inhibitor,potent and selective | ||||
| GC10083 | MPI-0479605 | 1246529-32-7 | >99.00% | |
Mps1 inhibitor,selective and ATP competitive | ||||
| GC11292 | Mps1-IN-1 | 1125593-20-5 | >99.50% | |
Mps1 kinase inhibitor | ||||
| GC13727 | TC Mps1 12 | 1206170-62-8 | >99.00% | |
Mps1 inhibitor | ||||
| GC18491 | CFI-402257 | 1610759-22-2 | >99.50% | |
CFI-402257 is a potent, highly selective, and orally active small-molecule inhibitor of Threonine tyrosine kinase, with an IC 50 value of 1.7nM and a K i value of 0.1nM. | ||||
| GC19058 | BAY1217389 | 1554458-53-5 | >98.00% | |
BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM. | ||||
| GC32846 | BOS-172722 | 1578245-44-9 | >99.00% | |
BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer. | ||||
| GC33213 | CCT251455 | 1400284-80-1 | >98.00% | |
CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM. | ||||
| GC34073 | Empesertib (BAY 1161909) | 1443763-60-7 | >98.00% | |
Empesertib (BAY 1161909) (BAY 1161909) is a potent Mps1 inhibitor, with an IC50 of < 1 nM. | ||||
| GC36651 | Mps1-IN-3 | 1609584-72-6 | >99.00% | |
Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC50 of 50 nM. | ||||
| GC36752 | NMS-P715 | 1202055-32-0 | >99.50% | |
An Mps1/TTK inhibitor | ||||
| GC50110 | Mps1-IN-1 dihydrochloride | 1883548-93-3 | >98% | |
Selective Mps1 kinase inhibitor | ||||
| GC65339 | Mps1-IN-3 hydrochloride | - | >98.00% | |
Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model. | ||||
| GC15745 | Mps1-IN-2 | 1228817-38-6 | >98.00% | |
Mps1 kinase inhibitor | ||||