Cell Cycle/Checkpoint
Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.
Targets for Cell Cycle/Checkpoint
- ATM/ATR(23)
- Aurora Kinase(17)
- Cdc42(4)
- Cdc7(3)
- Chk(14)
- c-Myc(20)
- CRM1(8)
- Cyclin-Dependent Kinases(77)
- E1 enzyme(1)
- G-quadruplex(11)
- Haspin(6)
- HMTase(1)
- Kinesin(23)
- Ksp(4)
- Microtubule/Tubulin(227)
- Mps1(15)
- Mitotic(7)
- RAD51(16)
- ROCK(68)
- Rho(13)
- PERK(11)
- PLK(35)
- PTEN(6)
- Wee1(8)
- PAK(22)
- Arp2/3 Complex(8)
- Dynamin(11)
- ECM & Adhesion Molecules(51)
- Cholesterol Metabolism(12)
- Endomembrane System & Vesicular Trafficking(35)
- G1(50)
- G2/M(38)
- G2/S(15)
- Genotoxic Stress(23)
- Inositol Phosphates(64)
- Proteolysis(182)
- Cytoskeleton & Motor Proteins(64)
- Cellular Chaperones(13)
- Cyclin G-associated Kinase (GAK)(0)
- MARK(0)
- NEKs(0)
Products for Cell Cycle/Checkpoint
- Cat.No. Product Name Information
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GC40702
α-D-Galactopyranosylphenyl isothiocyanate
α-D-Galactopyranosylphenyl isothiocyanate is a chemically activated form of galactose that has been used to prepare various neoglycoproteins, which consist of a glycosylated serum albumin substituted with either fluorescein or methotrexate.
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GC45226
β-BHC
β-HCH, β-Hexachlorocyclohexane, β-Lindane
β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane. -
GC41676
(±)-Nornicotine
DL-Nornicotine, (R,S)-Nornicotine
(±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. -
GC49482
(±)-Nornicotine-d4
DL-Nornicotine-d4, (R,S)-Nornicotine-d4
An internal standard for the quantification of (±)-nornicotine - GC46308 (±)-Sitagliptin-d4 (hydrochloride) A neuropeptide with diverse biological activities
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GC41684
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane
BMC, Vectrase P
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane (BMC) is a cyclohexane with two mercaptoacetamido groups. -
GC40802
(±)12(13)-DiHOME
Isoleukotoxin diol
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.
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GC41656
(±)2-(14,15-Epoxyeicosatrienoyl) Glycerol
(±)214,15EG
2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system. -
GC45890
(+)-Abscisic Acid-d6
(S)-(+)-Abscisic acid-d6; ABA-d6
An internal standard for the quantification of (+)-abscisic acid
- GC70332 (+)-Erinacin A (+)-Erinacin A is an anticancer compound that can be isolated from the mushroom Hericium erinaceum.
- GC62728 (1E)-CFI-400437 dihydrochloride (1E)-CFI-400437 dihydrochloride is a potent PLK4 (IC50= 0.6 nM) inhibitor and selective against other members of the PLK family (>10 μM). (1E)-CFI-400437 dihydrochloride inhibits Aurora A, Aurora B, KDR and FLT-3 with IC50s of 0.37, 0.21, 0.48, and 0.18 μM, respectively. Antiproliferative activity.
- GC49690 (3R,5R)-Rosuvastatin (calcium salt) A potential impurity found in bulk preparations of rosuvastatin
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GC41698
(D)2-Rh 110 (trifluoroacetate salt)
D2R, (Asp)2-Rhodamine 110, Rhodamine 110 bis-(L-aspartic acid amide)
(D)2-Rh 110 is a fluorogenic caspase substrate. -
GC41268
(E)-2-Hexadecenal
trans-2-Hexadecenal
Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase. - GC41701 (E)-2-Hexadecenal Alkyne (E)-2-Hexadecenal alkyne is an alkyne version of the sphingolipid degradation product (E)-2-hexadecenal that can be used as a click chemistry probe.
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GC46335
(E)-Fenpyroximate
Fenpyroximate, NNI-850
A phenoxypyrazole acaricide - GC10419 (R)-CCG-1423 Rho inhibitor
- GC16429 (R)-DRF053 dihydrochloride cdk/CK1 inhibitor,potent and ATP-competitive
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GC41719
(R)-nitro-Blebbistatin
R(-)7Desmethyl8nitro Blebbistatin
(R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin, which is the inactive form of (-)-blebbistatin. -
GC46347
(S)-(+)-Methoprene
Altosid, d-Methoprene, ZR 2458
An insect growth regulator and Met agonist -
GC41557
(S)-3'-amino Blebbistatin
(-)-3'-amino Blebbistatin, m-amino Blebbistatin, meta-amino Blebbistatin
(S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. -
GC41484
(S)-3'-hydroxy Blebbistatin
(-)-3'-hydroxy Blebbistatin, meta-hydroxy-Blebbistatin, m-hydroxy-Blebbistatin
(S)-3'-hydroxy Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. -
GC52192
(S)-4'-nitro-Blebbistatin
(-)-4'-nitro-Blebbistatin, p-nitro-Blebbistatin, para-nitro-Blebbistatin
(S)-4'-nitro-Blebbistatin is a non-cytotoxic, photostable, fluorescent and specific Myosin II inhibitor, usd in the study of the specific role of myosin II in physiological, developmental, and cell biological studies. - GC14497 (S)-CCG-1423 Rho inhibitor
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GC34999
(S)-Ceralasertib
(S)-AZD6738
(S)-Ceralasertib ((S)-AZD6738) is extracted from patent WO2011154737A1, Compound II, exhibits an IC50 of 2.578 nM.(S)-Ceralasertib is a potent and selective sulfoximine morpholinopyrimidine ATR inhibitor with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics.(S)-Ceralasertib is developed improving aqueous solubility and eliminates CYP3A4 time-dependent inhibition. - GC46351 (S)-CR8 An inhibitor of cyclin-dependent kinases
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GC41737
(S)-Glycyl-H-1152 (hydrochloride)
Rho Kinase Inhibitor IV
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. -
GC40145
(S)-Laudanosine
(+)-Laudanosine, L-Laudanosine, L-(+)-Laudanosine, NSC 35045
(S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium. -
GC41739
(S)-nitro-Blebbistatin
S(-)7Desmethyl8nitro Blebbistatin
(S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. -
GC40121
(Z-DEVD)2-Rh 110 (trifluoroacetate salt)
(Z-Asp-Glu-Val-Asp)2-Rhodamine 110
(Z-DEVD)2-Rh 110 is a fluorogenic substrate for caspase-3. -
GC41742
(Z-IETD)2-Rh 110 (trifluoroacetate salt)
(Z-Ile-Glu-Thr-Asp)2-R110, Rhodamine 110 bis-(N-CBZ-IETD)2
(Z-IETD)2-Rh 110 is a fluorogenic substrate for caspase-8. -
GC18275
1,2-Dihexadecyl-sn-glycero-3-PC
1,2-Dihexadecyl-sn-glycero-3-Phosphocholine
1,2-Dihexadecyl-sn-glycero-3-PC is a synthetic ether-linked phospholipid containing hexadecyl groups at the sn-1 and sn-2 positions. - GC45783 1,2-Dioleoyl-rac-glycerol-13C3 An internal standard for the quantification of 1,2-dioleoyl-rac-glycerol
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GC46379
1,2-Dioleoyl-sn-glycero-3-PS (sodium salt)
1,2-DOPS, 18:1/18:1-PS; PS(18:1/18:1), 1,2-Dioctadecenoyl-sn-glycero-3-Phosphoserine, 1,2-Dioctadecenoyl-sn-glycero-3-Phosphatidylserine
1,2-Dioleoyl-sn-glycero-3-PS (sodium salt) is a ubstitute for Phosphoserine/phosphatidylserine. -
GC41823
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt)
biotin-cap-DPPE
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid.
- GC46385 1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-α-D-Mannopyranose A ManNAc analog and building block
-
GC19528
1,4-Benzoquinone
p-Benzoquinone, NSC 36324, p-Quinone
A toxic metabolite of benzene - GC18726 1-Methyl-1,4-dihydronicotinamide 1-Methyl-1,4-dihydronicotinamide is a derivative of nicotinamide .
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GC90829
1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-PC
A phospholipid-porphyrin conjugate
-
GC49736
10-acetyl Docetaxel
PNU 101383, 10-acetyl Taxotere
10-acetyl Docetaxel (10-Acetyl docetaxel) is an analog of Docetaxel, with anticancer activity. Docetaxel is a microtubule disassembly inhibitor, with antimitotic activity. -
GC12954
10-DAB (10-Deacetylbaccatin)
NSC 251677
An inhibitor of microtubule assembly - GC35044 10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features.
- GC35045 10-Oxo Docetaxel A docetaxel degradation product
- GC17295 10058-F4 10058-F4 is a c-Myc inhibitor that inhibits c-Myc-Max dimerization and prevents transcriptional activation of c-Myc target gene expression.
- GC63576 10074-A4 10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects.
- GC14918 10074-G5 c-Myc inhibitor
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GC40448
12(S)-HETE
12(S)-Hydroxyeicosatetraenoic Acid
12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.
- GC40449 12(S)-HETE MaxSpec® Standard 12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.
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GC26213
13,14-Dihydro-13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine-14-carbonitrile
DIHYDROSANGUINARINE
- GC46434 13C15-Nivalenol An internal standard for the quantification of nivalenol
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GC49390
13C6-4-Nitroaniline
13C6-p-Nitroaniline
An internal standard for the quantification of 4-nitroaniline - GC40452 15(S)-HETE MaxSpec® Standard 15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway.
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GC46446
15-deoxy-δ12,14-Prostaglandin J2-biotin
15deoxyΔ12,14PGJ2biotin
A neuropeptide with diverse biological activities - GC41110 16-epi Latrunculin B 16-epi Latrunculin B, first isolated from the Red Sea sponge N.
-
GC48423
19-O-Acetylchaetoglobosin A
Chaetoglobosin A Acetate
A fungal metabolite with actin polymerization inhibitory and cytotoxic activities -
GC42151
2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
dGMP
2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. -
GC90819
2,3,7,8-Tetrachlorodibenzofuran
A polychlorinated dibenzofuran and dioxin
-
GC40947
2,3-Dimethoxy-5-methyl-p-benzoquinone
Coenzyme Q0, CoQ0
2,3-Dimethoxy-5-methyl-p-benzoquinone (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. -
GC49671
2,3-Oxidosqualene
(3R,S)-Oxidosqualene, Squalene 2,3-oxide
An intermediate in the biosynthesis of sterols -
GC45324
2,5-dimethyl Celecoxib
DMC
-
GC49362
2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline
MeIQx
A food-derived carcinogen -
GC52029
2-Aminoflubendazole
Hydrolyzed Flubendazole
-
GC90840
2-Chloroadenosine-5'-O-diphosphate (sodium salt)
A derivative of ADP
- GC40675 2-deoxy-Artemisinin 2-deoxy-Artemisinin is an inactive metabolite of the antimalarial agent artemisinin.
- GC62777 2-Methoxy-4-vinylphenol 2-Methoxy-4-vinylphenol (2M4VP), a naturally Germination inhibitor, exerts potent anti-inflammatory effects.
-
GC15084
2-Methoxyestradiol (2-MeOE2)
2Hydroxyestradiol 2methyl ether, 2ME2, NSC 659853, Panzem
2-Methoxyestradiol (2-MeOE2/2-Me) is an HIF-1α inhibitor. -
GC52140
2-Methoxyhydroquinone
o-Methoxyhydroquinone, MHQ, MOHQ
-
GC91133
2-n-Dodecylfuran
A synthetic intermediate
- GC48449 28-(Poc-amino)betulin
- GC42161 2H-Cho-Arg (trifluoroacetate salt) 2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.
-
GC62033
3α-Hydroxy pravastatin sodium
3α-Isopravastatin, R-416
3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. -
GC40618
3',4',7-Trihydroxyisoflavone
3'-hydroxy Daidzein, 3’,4’,7-THIF
3',4',7-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 3',4',7-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities. -
GC45332
3'-Dephosphocoenzyme A
depCoA, Dephospho-CoA
An intermediate in the biosynthesis of CoA -
GC18452
3,4-Dichloroisocoumarin
3,4-DCI
A serine protease inhibitor -
GC42239
3,6-diacetoxy Phthalonitrile
ADB, 1,4-Diacetoxy-2,3-dicyanobenzene, 2,3-Dicyano-1,4-hydroquinone diacetate
3,6-diacetoxy Phthalonitrile is a cell-permeable fluorescent probe. -
GC12314
3-(4-Pyridyl)indole
Rho Kinase Inhibitor III,ROCK Inhibitor III,Rockout
ROCK-I inhibitor -
GC46582
3-Acetyldeoxy Nivalenol-13C17
3-AcDON-13C17, DON 3-acetate-13C17, Deoxy Nivalenol-3-acetate-13C17
An internal standard for the quantification of 3-acetyldeoxy nivalenol -
GC52129
3-Amino-5-hydroxybenzoic Acid
AHBA
- GC15389 360A
- GC10115 360A iodide
- GC14186 3MB-PP1 polo-like kinase 1 (Plk1) allele inhibitor,ATP-competitive
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GC45354
4β-Hydroxywithanolide E
NSC 212509
A withanolide with anti-inflammatory and anticancer activities -
GC17271
4'-Demethylepipodophyllotoxin
(-)-4′-Demethylepipodophyllotoxin
An inhibitor of tubulin polymerization -
GC46606
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline
4-Aminophenylboronic Acid pinacol ester
A heterocyclic building block -
GC46635
4-deoxy Nivalenol-13C15
Vomitoxin-13C15, Deoxynivalenol-13C15, DON-13C15
An internal standard for the quantification of 4-deoxy nivalenol - GC18359 4-Epianhydrochlortetracycline (hydrochloride) 4-Epianhydrochlortetracycline is a derivative of tetracycline .
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GC42449
4-Methylumbelliferyl-α-L-Iduronide (free acid)
4-Methylumbelliferyl-α-L-Idopyranosiduronic Acid, 4-MU-α-IdoA, MU-α-IdoA
4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. -
GC49244
4-oxo Isotretinoin
Ro 22-6595
An active metabolite of isotretinoin -
GC52365
4-tert-Octylphenol monoethoxylate
NSC 5259, OP1EO
An alkylphenolethoxylate and a degradation product of non-ionic surfactants -
GC46687
5'-Deoxy-5'-methylthioadenosine-d3
5'-S-Methylthioadenosine-d3, MTA-d3, Vitamin L2-d3
A neuropeptide with diverse biological activities -
GC52227
5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone
(±)-δ-(3,4-Dihydroxyphenyl)-γ-Valerolactone, 5-(3',4'-Dihydroxyphenyl)-γ-VL
An active metabolite of various polyphenols -
GC46681
5-Bromouridine
(–)-5-Bromouridine, BrU, BrUrd, NSC 38296
A brominated uridine analog - GC45357 5-Chlorouracil
- GC42548 5-hydroxy Saxagliptin (hydrochloride) 5-hydroxy Saxagliptin is a major active metabolite of saxagliptin.
-
GC41156
5-Octyl D-glutamate
5-Octyl ester D-glutamatic acid
5-Octyl D-glutamate, also known as 5-octyl ester D-glutamate, is a stable, cell-permeable molecule that generates free D-glutamate upon hydrolysis of the ester bond by cytoplasmic esterases. -
GC41423
5-trans Prostaglandin E2
transDinoprostone, 5,6trans PGE2
5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1. -
GC42586
6α-hydroxy Paclitaxel
6α-hydroxy Taxol
6α-hydroxy Paclitaxel is a primary metabolite of the anticancer compound paclitaxel, produced by the action of the cytochrome P450 isoform CYP2C8. - GC63958 6α-Hydroxy Paclitaxel-d5 6α-Hydroxy Paclitaxel-d5 is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion-transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer.
- GC45969 6β-hydroxy Eplerenone A major metabolite of eplerenone
-
GC46721
6-Chloro-2-fluoropurine
NSC 37363
A heterocyclic building block