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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Products for  Cell Cycle/Checkpoint

  1. Cat.No. Product Name Information
  2. GC68416 RAD51-IN-3 RAD51-IN-3  Chemical Structure
  3. GC68366 Thiocolchicine-d3 Thiocolchicine-d3  Chemical Structure
  4. GC68147 dAURK-4 hydrochloride dAURK-4 hydrochloride  Chemical Structure
  5. GC68024 Antiproliferative agent-14 Antiproliferative agent-14  Chemical Structure
  6. GC68021 BMVC BMVC  Chemical Structure
  7. GC67900 AMXI-5001 hydrochloride AMXI-5001 hydrochloride  Chemical Structure
  8. GC67899 Aurora kinase inhibitor-8 Aurora kinase inhibitor-8  Chemical Structure
  9. GC67888 RAD51-IN-5 RAD51-IN-5  Chemical Structure
  10. GC52513 Indolimine-214 A genotoxic gut microbiota metabolite Indolimine-214  Chemical Structure
  11. GC52499 Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp (trifluoroacetate salt) A sensitive substrate for neutrophil elastase Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp (trifluoroacetate salt)  Chemical Structure
  12. GC52489 Ceramide (hydroxy) (bovine spinal cord) A sphingolipid Ceramide (hydroxy) (bovine spinal cord)  Chemical Structure
  13. GC52486 Ceramide Phosphoethanolamine (bovine) A sphingolipid Ceramide Phosphoethanolamine (bovine)  Chemical Structure
  14. GC52485 Ceramide (non-hydroxy) (bovine spinal cord) A sphingolipid Ceramide (non-hydroxy) (bovine spinal cord)  Chemical Structure
  15. GC52484 Purified Ganglioside Mixture (bovine) (ammonium salt) A mixture of purified bovine gangliosides Purified Ganglioside Mixture (bovine) (ammonium salt)  Chemical Structure
  16. GC52474 Arg-Gly-Asp (trifluoroacetate salt) A synthetic peptide corresponding to an integrin cell adhesion sequence Arg-Gly-Asp (trifluoroacetate salt)  Chemical Structure
  17. GC52472 Inostamycin A (sodium salt) A bacterial metabolite with anticancer activity Inostamycin A (sodium salt)  Chemical Structure
  18. GC52447 Suc-Leu-Leu-Val-Tyr-AMC (trifluoroacetate salt) A fluorogenic substrate for the 20S proteasome and calpains Suc-Leu-Leu-Val-Tyr-AMC (trifluoroacetate salt)  Chemical Structure
  19. GC52389 Caveolin-1 (82-101) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) A synthetic peptide fragment of caveolin-1 Caveolin-1 (82-101) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)  Chemical Structure
  20. GC52372 Ac-VDVAD-AFC (trifluoroacetate salt) A fluorogenic substrate for caspase-2 Ac-VDVAD-AFC (trifluoroacetate salt)  Chemical Structure
  21. GC52371 Vimentin (G146R) (139-159)-biotin Peptide A biotinylated mutant vimentin peptide Vimentin (G146R) (139-159)-biotin Peptide  Chemical Structure
  22. GC52370 Citrullinated Vimentin (R144) (139-159)-biotin Peptide A biotinylated and citrullinated vimentin peptide Citrullinated Vimentin (R144) (139-159)-biotin Peptide  Chemical Structure
  23. GC52367 Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide A biotinylated and citrullinated mutant vimentin peptide Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide  Chemical Structure
  24. GC52365 4-tert-Octylphenol monoethoxylate An alkylphenolethoxylate and a degradation product of non-ionic surfactants 4-tert-Octylphenol monoethoxylate  Chemical Structure
  25. GC52364 Vimentin (139-159)-biotin Peptide A biotinylated vimentin peptide Vimentin (139-159)-biotin Peptide  Chemical Structure
  26. GC52360 Chymotrypsin Substrate I, Colorimetric (trifluoroacetate salt) A colorimetric chymotrypsin substrate Chymotrypsin Substrate I, Colorimetric (trifluoroacetate salt)  Chemical Structure
  27. GC52358 Malachite Green (chloride) A triphenylmethane dye Malachite Green (chloride)  Chemical Structure
  28. GC52332 Arimoclomol A co-inducer of heat shock proteins Arimoclomol  Chemical Structure
  29. GC52293 STAT3 Inhibitor 4m A STAT3 inhibitor STAT3 Inhibitor 4m  Chemical Structure
  30. GC52288 Fumonisin B1-13C34 An internal standard for the quantification of fumonisin B1 Fumonisin B1-13C34  Chemical Structure
  31. GC52245 CAY10792 An anticancer agent CAY10792  Chemical Structure
  32. GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone An active metabolite of various polyphenols 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone  Chemical Structure
  33. GC67333 Estramustine Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts. Estramustine  Chemical Structure
  34. GC66457 MY-875 MY-875 is a competitive microtubulin polymerization inhibitor with an IC50 value of 0.92 μM. MY-875 inhibits microtubulin polymerization by targeting colchicine binding sites and activates the Hippo pathway. MY-875 induces apoptosis and has anticancer activity. MY-875  Chemical Structure
  35. GC66437 SB-216 SB-216 is a potent tubulin polymerization inhibitor. SB-216 shows strong antiproliferative potency in a panel of human cancer cell lines, including melanoma, lung cancer, and breast cancer. SB-216 can be used for cancer research. SB-216  Chemical Structure
  36. GC66338 ROCK1-IN-1 ROCK1-IN-1 is a ROCK1 inhibitor with a Ki value of 540 nM. ROCK1-IN-1 can be used for the research of hypertension, glaucoma and erectile dysfunction. ROCK1-IN-1  Chemical Structure
  37. GC66242 Flutax-2 (5/6-mixture) Flutax-2 (5/6-mixture) is an active fluorescent derivative of Taxol. Flutax-2 (5/6-mixture) binds to polymerized α,β-tubulin dimers. Flutax-2 (5/6-mixture) is able to stabilize microtubules of intact T. gallinae and T. foetus trophozoites. Flutax-2 (5/6-mixture)  Chemical Structure
  38. GC66198 Anti-α-Tubulin Antibody, AF555 conjugate Anti-α-Tubulin Antibody, AF555 conjugate is a conjugate of mouse anti-α-tubulin monoclonal antibody and the red fluorescent dye Alexa Fluor 555. Anti-α-Tubulin Antibody, AF555 conjugate can be used for the detection of tubulin (Ex/Em: 554/567 nm). Anti-α-Tubulin Antibody, AF555 conjugate  Chemical Structure
  39. GC66056 Dynole 2-24 Dynole 2-24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2-24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2-24 also shows 4.4-fold selectivity for dynamin I. Dynole 2-24 is active in-cell inhibitor of clathrin-mediated endocytosis. CME: Clathrin mediated endocytosis Dynole 2-24  Chemical Structure
  40. GC66050 Rho-Kinase-IN-2 Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and central nervous system (CNS)-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC50=3 nM). Rho-Kinase-IN-2 can be used in Huntington's research. Rho-Kinase-IN-2  Chemical Structure
  41. GC66036 AZ13705339 hemihydrate AZ13705339 hemihydrate is a highly potent and selective PAK1 inhibitor with IC50s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities to PAK1 and PAK2, with Kds of 0.28 nM and 0.32 nM, respectively. AZ13705339 hemihydrate can be used in the research of cancers. AZ13705339 hemihydrate  Chemical Structure
  42. GC65994 WEE1-IN-5 WEE1-IN-5 is a potent WEE1 inhibitor with an IC50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer. WEE1-IN-5  Chemical Structure
  43. GC65935 CAM833 CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization. CAM833  Chemical Structure
  44. GC65897 OXi8007 OXi8007 is a water-soluble phosphate prodrug of OXi8006, a tubulin-binding compound. OXi8007  Chemical Structure
  45. GC65887 SOP1812 SOP1812 is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer. SOP1812  Chemical Structure
  46. GC52196 RGD Peptide RGD Peptide acts as an inhibitor of integrin-ligand interactions and plays an important role in cell adhesion, migration, growth, and differentiation. RGD Peptide  Chemical Structure
  47. GC52192 (S)-4'-nitro-Blebbistatin (S)-4'-nitro-Blebbistatin is a non-cytotoxic, photostable, fluorescent and specific Myosin II inhibitor, usd in the study of the specific role of myosin II in physiological, developmental, and cell biological studies. (S)-4'-nitro-Blebbistatin  Chemical Structure
  48. GC52140 2-Methoxyhydroquinone 2-Methoxyhydroquinone  Chemical Structure
  49. GC52129 3-Amino-5-hydroxybenzoic Acid 3-Amino-5-hydroxybenzoic Acid  Chemical Structure
  50. GC52126 8-chloro Caffeine 8-chloro Caffeine  Chemical Structure
  51. GC65578 Aminobenzenesulfonic auristatin E TFA Aminobenzenesulfonic auristatin E TFA is a drug-linker conjugate for ADC. Aminobenzenesulfonic auristatin E TFA has potent antitumor activity by using Auristatin E (a cytotoxic tubulin modifier), linked via the ADC linker Aminobenzenesulfonic. Aminobenzenesulfonic auristatin E TFA  Chemical Structure
  52. GC65575 Cabazitaxel-d6 Cabazitaxel-d6 (XRP6258-d6) is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel-d6  Chemical Structure
  53. GC65514 ATR inhibitor 1 ATR inhibitor 1 is a ATR inhibitor extracted from patent WO2015187451A1, compound I-l, has a Ki value below 1 ?Μ. ATR inhibitor 1  Chemical Structure
  54. GC65383 RAD51-IN-2 RAD51-IN-2 (compound example 67A) is a RAD51 inhibitor extracted from patent WO2019/051465A1. RAD51-IN-2  Chemical Structure
  55. GC65339 Mps1-IN-3 hydrochloride Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model. Mps1-IN-3 hydrochloride  Chemical Structure
  56. GC65331 IZCZ-3 IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity. IZCZ-3  Chemical Structure
  57. GC65327 ATM Inhibitor-5 ATM Inhibitor-5 [formula (1)] is a potent inhibitor of serine/threonine protein kinase ATM (extracted from patent WO2022058351A1). ATM Inhibitor-5  Chemical Structure
  58. GC65189 PLK4-IN-1 PLK4-IN-1 (Example A6) is a PLK4 inhibitor, with an IC50 of ≤ 0.1 μM. PLK4-IN-1  Chemical Structure
  59. GC65188 IRES-C11 IRES-C11 is a spectfic c-MYC internal ribosome entry site (IRES) translation inhibitor. IRES-C11 blocks the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleoprotein A1, with its IRES. IRES-C11 does not inhibits BAG-1, XIAP and p53 IRESes. IRES-C11  Chemical Structure
  60. GC65143 MKC-1 MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family. MKC-1  Chemical Structure
  61. GC64938 AZD-7648 AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity. AZD-7648  Chemical Structure
  62. GC64927 Drp1-IN-1 Drp1-IN-1 (comp A-7) is a dynamin-1-like protein (Drp1) inhibitor, with an IC50 of 0.91 μM. Drp1-IN-1  Chemical Structure
  63. GC64915 Vindesine sulfate Vindesine sulfate is a potent tubulin inhibitor with an Ki of 0.110 ?M. Vindesine sulfate shows anti-proliferation effect in vitro. Vindesine sulfate shows antitumor effect in vivo. Vindesine sulfate  Chemical Structure
  64. GC64866 PERK-IN-5 PERK-IN-5 is a highly potent, selectively and orally bioavailable PERK inhibitor (IC50s of 2 and 9 nM for PERK and p-eIF2α, respectively). PERK-IN-5 can significantly inhibit tumor growth in the 786-O renal cell carcinoma xenograft tumor model. PERK-IN-5  Chemical Structure
  65. GC64857 KIF18A-IN-3 KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer. KIF18A-IN-3  Chemical Structure
  66. GC64808 KIF18A-IN-2 KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer. KIF18A-IN-2  Chemical Structure
  67. GC64705 Podophyllotoxone Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the tubulin polymerization. Podophyllotoxone  Chemical Structure
  68. GC64698 AM-5308 AM-5308 is a potent kinesin KIF18A inhibitor (WO2021211549A1, C13). AM-5308  Chemical Structure
  69. GC64626 Oryzalin Oryzalin is a dinitroaniline herbicide, binding to plant tubulin and inhibits microtubule (MT) polymerization in vitro. Oryzalin  Chemical Structure
  70. GC64591 MM41 MM41 is a potent stabilizer of human telomeric and gene promoter DNA quadruplexes. MM41 is potently against the MIA PaCa-2 pancreatic cancer cell line with IC50 value of <10 nM. MM41  Chemical Structure
  71. GC64562 VPC-70619 VPC-70619 is a potent, orally active N-Myc inhibitor. VPC-70619 blocks the N-Myc-Max heterocomplex from binding to DNA E-boxes and demonstrated strong inhibition activity against N-Myc-dependent cell lines as well as high bioavailability in both oral and intraperitoneal administration. VPC-70619  Chemical Structure
  72. GC64539 SKLB-197 SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo. SKLB-197  Chemical Structure
  73. GC64451 Vincristine-d3-ester sulfate Vincristine-d3-ester (Leurocristine-d3-ester) sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM. Vincristine-d3-ester sulfate  Chemical Structure
  74. GC52095 Dodecyltrimethylammonium (bromide) A cationic surfactant Dodecyltrimethylammonium (bromide)  Chemical Structure
  75. GC52061 Ethylene Glycol monododecyl ether A nonionic surfactant Ethylene Glycol monododecyl ether  Chemical Structure
  76. GC52057 QN523 An anticancer agent QN523  Chemical Structure
  77. GC52054 Ranitidine S-oxide Ranitidine S-oxide is the metabolite of Ranitidine. Ranitidine S-oxide  Chemical Structure
  78. GC52029 2-Aminoflubendazole 2-Aminoflubendazole  Chemical Structure
  79. GC52007 N-hydroxylamine Dapsone An active metabolite of dapsone N-hydroxylamine Dapsone  Chemical Structure
  80. GC64278 RP-3500 RP-3500 (ATR inhibitor 4) is an orally active, selective ATR kinase inhibitor (ATRi) with an IC50 of 1.00 nM in biochemical assays. RP-3500 shows 30-fold selectivity for ATR over mTOR (IC50=120 nM) and >2,000-fold selectivity over ATM, DNA-PK, and PI3Kα kinases. RP-3500 has potent antitumor activity. RP-3500  Chemical Structure
  81. GC64273 AMXI-5001 AMXI-5001 is a potent, orally active, and dual parp1/2 and microtubule polymerization inhibitor. MXI-5001 exhibits selective antitumor cytotoxicity across a wide variety of human cancer cells with much lower IC50s than existing clinical PARP1/2 inhibitors. AMXI-5001 induces complete regression of established tumors, including exceedingly large tumors. AMXI-5001  Chemical Structure
  82. GC64085 KIF18A-IN-1 KIF18A-IN-1 is a mitotic kinesin KIF18A inhibitor extracted from patent WO2021026098A1 example 100-13. KIF18A-IN-1  Chemical Structure
  83. GC64019 Sovilnesib Sovilnesib (AMG 650) is a kinesin-like protein KIF18A inhibitor (WO2020132648). Sovilnesib can be used for the research of cancer. Sovilnesib  Chemical Structure
  84. GC63977 BMVC2 BMVC2 (o-BMVC) is a bisubstitute carbazole derivative of BMVC. BMVC2 is a G-quadruplex (G4) stabilizer. BMVC2  Chemical Structure
  85. GC63845 Eribulin-d3 mesylate Eribulin-d3 mesylate is a deuterium labeled Eribulin mesylate. Eribulin mesylate is a microtubule targeting agent that is used for the research of cancer. Eribulin-d3 mesylate  Chemical Structure
  86. GC49744 GRP94 Monoclonal Antibody (Clone 9G10) For immunochemical detection of GRP94 GRP94 Monoclonal Antibody (Clone 9G10)  Chemical Structure
  87. GC49742 Hsf1 Monoclonal Antibody (Clone 10H8) For immunochemical analysis of Hsf1 Hsf1 Monoclonal Antibody (Clone 10H8)  Chemical Structure
  88. GC49740 Brevetoxin 3 A neurotoxin Brevetoxin 3  Chemical Structure
  89. GC49736 10-acetyl Docetaxel 10-acetyl Docetaxel (10-Acetyl docetaxel) is an analog of Docetaxel, with anticancer activity. Docetaxel is a microtubule disassembly inhibitor, with antimitotic activity. 10-acetyl Docetaxel  Chemical Structure
  90. GC49735 Thallos AM A cell-permeable fluorescent thallium indicator Thallos AM  Chemical Structure
  91. GC49724 BIO-1211 (trifluoroacetate salt) A peptide inhibitor of α4β1 integrin BIO-1211 (trifluoroacetate salt)  Chemical Structure
  92. GC49723 SenTraGor™ Cell Senescence Reagent A cellular senescence detection reagent SenTraGor™ Cell Senescence Reagent  Chemical Structure
  93. GC49716 Cyclo(RGDyK) (trifluoroacetate salt) A cyclic peptide ligand of αVβ3 integrin Cyclo(RGDyK) (trifluoroacetate salt)  Chemical Structure
  94. GC49713 SIKVAV (acetate) A laminin α1-derived peptide SIKVAV (acetate)  Chemical Structure
  95. GC49709 cyclo(RGDyC) (trifluoroacetate salt) A cyclic pentapeptide cyclo(RGDyC) (trifluoroacetate salt)  Chemical Structure
  96. GC49704 Ac-FLTD-CMK (trifluoroacetate salt) An inhibitor of caspase-1, -4, -5, and -11 Ac-FLTD-CMK (trifluoroacetate salt)  Chemical Structure
  97. GC49702 Papain Inhibitor (trifluoroacetate salt) A peptide inhibitor of papain Papain Inhibitor (trifluoroacetate salt)  Chemical Structure
  98. GC49699 Acetyl Tetrapeptide-9 (acetate) A synthetic signal peptide Acetyl Tetrapeptide-9 (acetate)  Chemical Structure
  99. GC49695 FKBP52 Monoclonal Antibody (Clone Hi52C) For immunochemical analysis of FKBP52 FKBP52 Monoclonal Antibody (Clone Hi52C)  Chemical Structure
  100. GC49690 (3R,5R)-Rosuvastatin (calcium salt) A potential impurity found in bulk preparations of rosuvastatin (3R,5R)-Rosuvastatin (calcium salt)  Chemical Structure
  101. GC49687 Goralatide (acetate) A tetrapeptide regulator of hematopoiesis Goralatide (acetate)  Chemical Structure

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