Cell Cycle/Checkpoint

Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.
Products for Cell Cycle/Checkpoint
- ATM/ATR(23)
- Aurora Kinase(44)
- Cdc42(4)
- Cdc7(3)
- Chk(12)
- c-Myc(20)
- CRM1(8)
- Cyclin-Dependent Kinases(70)
- E1 enzyme(1)
- G-quadruplex(11)
- Haspin(5)
- HMTase(1)
- Kinesin(23)
- Ksp(4)
- Microtubule/Tubulin(209)
- Mps1(13)
- Mitotic(7)
- RAD51(13)
- ROCK(56)
- Rho(13)
- PERK(7)
- PLK(33)
- PTEN(6)
- Wee1(7)
- PAK(20)
- Arp2/3 Complex(8)
- Dynamin(9)
- ECM & Adhesion Molecules(40)
- Cholesterol Metabolism(3)
- Endomembrane System & Vesicular Trafficking(26)
- G1(38)
- G2/M(25)
- G2/S(9)
- Genotoxic Stress(17)
- Inositol Phosphates(18)
- Proteolysis(95)
- Cytoskeleton & Motor Proteins(50)
- Cellular Chaperones(8)
- Cat.No. Product Name Information
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GC68416
RAD51-IN-3
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GC68366
Thiocolchicine-d3
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GC68147
dAURK-4 hydrochloride
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GC68024
Antiproliferative agent-14
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GC68021
BMVC
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GC67900
AMXI-5001 hydrochloride
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GC67899
Aurora kinase inhibitor-8
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GC67888
RAD51-IN-5
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GC52513
Indolimine-214
A genotoxic gut microbiota metabolite
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GC52499
Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp (trifluoroacetate salt)
A sensitive substrate for neutrophil elastase
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GC52489
Ceramide (hydroxy) (bovine spinal cord)
A sphingolipid
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GC52486
Ceramide Phosphoethanolamine (bovine)
A sphingolipid
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GC52485
Ceramide (non-hydroxy) (bovine spinal cord)
A sphingolipid
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GC52484
Purified Ganglioside Mixture (bovine) (ammonium salt)
A mixture of purified bovine gangliosides
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GC52474
Arg-Gly-Asp (trifluoroacetate salt)
A synthetic peptide corresponding to an integrin cell adhesion sequence
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GC52472
Inostamycin A (sodium salt)
A bacterial metabolite with anticancer activity
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GC52447
Suc-Leu-Leu-Val-Tyr-AMC (trifluoroacetate salt)
A fluorogenic substrate for the 20S proteasome and calpains
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GC52389
Caveolin-1 (82-101) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
A synthetic peptide fragment of caveolin-1
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GC52372
Ac-VDVAD-AFC (trifluoroacetate salt)
A fluorogenic substrate for caspase-2
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GC52371
Vimentin (G146R) (139-159)-biotin Peptide
A biotinylated mutant vimentin peptide
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GC52370
Citrullinated Vimentin (R144) (139-159)-biotin Peptide
A biotinylated and citrullinated vimentin peptide
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GC52367
Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide
A biotinylated and citrullinated mutant vimentin peptide
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GC52365
4-tert-Octylphenol monoethoxylate
An alkylphenolethoxylate and a degradation product of non-ionic surfactants
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GC52364
Vimentin (139-159)-biotin Peptide
A biotinylated vimentin peptide
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GC52360
Chymotrypsin Substrate I, Colorimetric (trifluoroacetate salt)
A colorimetric chymotrypsin substrate
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GC52358
Malachite Green (chloride)
A triphenylmethane dye
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GC52332
Arimoclomol
A co-inducer of heat shock proteins
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GC52293
STAT3 Inhibitor 4m
A STAT3 inhibitor
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GC52288
Fumonisin B1-13C34
An internal standard for the quantification of fumonisin B1
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GC52245
CAY10792
An anticancer agent
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GC52227
5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone
An active metabolite of various polyphenols
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GC67333
Estramustine
Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts.
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GC66457
MY-875
MY-875 is a competitive microtubulin polymerization inhibitor with an IC50 value of 0.92 μM. MY-875 inhibits microtubulin polymerization by targeting colchicine binding sites and activates the Hippo pathway. MY-875 induces apoptosis and has anticancer activity.
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GC66437
SB-216
SB-216 is a potent tubulin polymerization inhibitor. SB-216 shows strong antiproliferative potency in a panel of human cancer cell lines, including melanoma, lung cancer, and breast cancer. SB-216 can be used for cancer research.
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GC66338
ROCK1-IN-1
ROCK1-IN-1 is a ROCK1 inhibitor with a Ki value of 540 nM. ROCK1-IN-1 can be used for the research of hypertension, glaucoma and erectile dysfunction.
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GC66242
Flutax-2 (5/6-mixture)
Flutax-2 (5/6-mixture) is an active fluorescent derivative of Taxol. Flutax-2 (5/6-mixture) binds to polymerized α,β-tubulin dimers. Flutax-2 (5/6-mixture) is able to stabilize microtubules of intact T. gallinae and T. foetus trophozoites.
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GC66198
Anti-α-Tubulin Antibody, AF555 conjugate
Anti-α-Tubulin Antibody, AF555 conjugate is a conjugate of mouse anti-α-tubulin monoclonal antibody and the red fluorescent dye Alexa Fluor 555. Anti-α-Tubulin Antibody, AF555 conjugate can be used for the detection of tubulin (Ex/Em: 554/567 nm).
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GC66056
Dynole 2-24
Dynole 2-24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2-24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2-24 also shows 4.4-fold selectivity for dynamin I. Dynole 2-24 is active in-cell inhibitor of clathrin-mediated endocytosis. CME: Clathrin mediated endocytosis
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GC66050
Rho-Kinase-IN-2
Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and central nervous system (CNS)-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC50=3 nM). Rho-Kinase-IN-2 can be used in Huntington's research.
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GC66036
AZ13705339 hemihydrate
AZ13705339 hemihydrate is a highly potent and selective PAK1 inhibitor with IC50s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities to PAK1 and PAK2, with Kds of 0.28 nM and 0.32 nM, respectively. AZ13705339 hemihydrate can be used in the research of cancers.
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GC65994
WEE1-IN-5
WEE1-IN-5 is a potent WEE1 inhibitor with an IC50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer.
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GC65935
CAM833
CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization.
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GC65897
OXi8007
OXi8007 is a water-soluble phosphate prodrug of OXi8006, a tubulin-binding compound.
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GC65887
SOP1812
SOP1812 is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer.
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GC52196
RGD Peptide
RGD Peptide acts as an inhibitor of integrin-ligand interactions and plays an important role in cell adhesion, migration, growth, and differentiation.
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GC52192
(S)-4'-nitro-Blebbistatin
(S)-4'-nitro-Blebbistatin is a non-cytotoxic, photostable, fluorescent and specific Myosin II inhibitor, usd in the study of the specific role of myosin II in physiological, developmental, and cell biological studies.
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GC52140
2-Methoxyhydroquinone
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GC52129
3-Amino-5-hydroxybenzoic Acid
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GC52126
8-chloro Caffeine
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GC65578
Aminobenzenesulfonic auristatin E TFA
Aminobenzenesulfonic auristatin E TFA is a drug-linker conjugate for ADC. Aminobenzenesulfonic auristatin E TFA has potent antitumor activity by using Auristatin E (a cytotoxic tubulin modifier), linked via the ADC linker Aminobenzenesulfonic.
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GC65575
Cabazitaxel-d6
Cabazitaxel-d6 (XRP6258-d6) is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.
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GC65514
ATR inhibitor 1
ATR inhibitor 1 is a ATR inhibitor extracted from patent WO2015187451A1, compound I-l, has a Ki value below 1 ?Μ.
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GC65383
RAD51-IN-2
RAD51-IN-2 (compound example 67A) is a RAD51 inhibitor extracted from patent WO2019/051465A1.
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GC65339
Mps1-IN-3 hydrochloride
Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model.
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GC65331
IZCZ-3
IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity.
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GC65327
ATM Inhibitor-5
ATM Inhibitor-5 [formula (1)] is a potent inhibitor of serine/threonine protein kinase ATM (extracted from patent WO2022058351A1).
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GC65189
PLK4-IN-1
PLK4-IN-1 (Example A6) is a PLK4 inhibitor, with an IC50 of ≤ 0.1 μM.
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GC65188
IRES-C11
IRES-C11 is a spectfic c-MYC internal ribosome entry site (IRES) translation inhibitor. IRES-C11 blocks the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleoprotein A1, with its IRES. IRES-C11 does not inhibits BAG-1, XIAP and p53 IRESes.
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GC65143
MKC-1
MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family.
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GC64938
AZD-7648
AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity.
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GC64927
Drp1-IN-1
Drp1-IN-1 (comp A-7) is a dynamin-1-like protein (Drp1) inhibitor, with an IC50 of 0.91 μM.
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GC64915
Vindesine sulfate
Vindesine sulfate is a potent tubulin inhibitor with an Ki of 0.110 ?M. Vindesine sulfate shows anti-proliferation effect in vitro. Vindesine sulfate shows antitumor effect in vivo.
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GC64866
PERK-IN-5
PERK-IN-5 is a highly potent, selectively and orally bioavailable PERK inhibitor (IC50s of 2 and 9 nM for PERK and p-eIF2α, respectively). PERK-IN-5 can significantly inhibit tumor growth in the 786-O renal cell carcinoma xenograft tumor model.
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GC64857
KIF18A-IN-3
KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer.
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GC64808
KIF18A-IN-2
KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer.
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GC64705
Podophyllotoxone
Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the tubulin polymerization.
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GC64698
AM-5308
AM-5308 is a potent kinesin KIF18A inhibitor (WO2021211549A1, C13).
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GC64626
Oryzalin
Oryzalin is a dinitroaniline herbicide, binding to plant tubulin and inhibits microtubule (MT) polymerization in vitro.
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GC64591
MM41
MM41 is a potent stabilizer of human telomeric and gene promoter DNA quadruplexes. MM41 is potently against the MIA PaCa-2 pancreatic cancer cell line with IC50 value of <10 nM.
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GC64562
VPC-70619
VPC-70619 is a potent, orally active N-Myc inhibitor. VPC-70619 blocks the N-Myc-Max heterocomplex from binding to DNA E-boxes and demonstrated strong inhibition activity against N-Myc-dependent cell lines as well as high bioavailability in both oral and intraperitoneal administration.
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GC64539
SKLB-197
SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
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GC64451
Vincristine-d3-ester sulfate
Vincristine-d3-ester (Leurocristine-d3-ester) sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM.
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GC52095
Dodecyltrimethylammonium (bromide)
A cationic surfactant
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GC52061
Ethylene Glycol monododecyl ether
A nonionic surfactant
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GC52057
QN523
An anticancer agent
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GC52054
Ranitidine S-oxide
Ranitidine S-oxide is the metabolite of Ranitidine.
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GC52029
2-Aminoflubendazole
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GC52007
N-hydroxylamine Dapsone
An active metabolite of dapsone
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GC64278
RP-3500
RP-3500 (ATR inhibitor 4) is an orally active, selective ATR kinase inhibitor (ATRi) with an IC50 of 1.00 nM in biochemical assays. RP-3500 shows 30-fold selectivity for ATR over mTOR (IC50=120 nM) and >2,000-fold selectivity over ATM, DNA-PK, and PI3Kα kinases. RP-3500 has potent antitumor activity.
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GC64273
AMXI-5001
AMXI-5001 is a potent, orally active, and dual parp1/2 and microtubule polymerization inhibitor. MXI-5001 exhibits selective antitumor cytotoxicity across a wide variety of human cancer cells with much lower IC50s than existing clinical PARP1/2 inhibitors. AMXI-5001 induces complete regression of established tumors, including exceedingly large tumors.
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GC64085
KIF18A-IN-1
KIF18A-IN-1 is a mitotic kinesin KIF18A inhibitor extracted from patent WO2021026098A1 example 100-13.
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GC64019
Sovilnesib
Sovilnesib (AMG 650) is a kinesin-like protein KIF18A inhibitor (WO2020132648). Sovilnesib can be used for the research of cancer.
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GC63977
BMVC2
BMVC2 (o-BMVC) is a bisubstitute carbazole derivative of BMVC. BMVC2 is a G-quadruplex (G4) stabilizer.
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GC63845
Eribulin-d3 mesylate
Eribulin-d3 mesylate is a deuterium labeled Eribulin mesylate. Eribulin mesylate is a microtubule targeting agent that is used for the research of cancer.
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GC49744
GRP94 Monoclonal Antibody (Clone 9G10)
For immunochemical detection of GRP94
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GC49742
Hsf1 Monoclonal Antibody (Clone 10H8)
For immunochemical analysis of Hsf1
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GC49740
Brevetoxin 3
A neurotoxin
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GC49736
10-acetyl Docetaxel
10-acetyl Docetaxel (10-Acetyl docetaxel) is an analog of Docetaxel, with anticancer activity. Docetaxel is a microtubule disassembly inhibitor, with antimitotic activity.
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GC49735
Thallos AM
A cell-permeable fluorescent thallium indicator
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GC49724
BIO-1211 (trifluoroacetate salt)
A peptide inhibitor of α4β1 integrin
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GC49723
SenTraGor™ Cell Senescence Reagent
A cellular senescence detection reagent
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GC49716
Cyclo(RGDyK) (trifluoroacetate salt)
A cyclic peptide ligand of αVβ3 integrin
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GC49713
SIKVAV (acetate)
A laminin α1-derived peptide
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GC49709
cyclo(RGDyC) (trifluoroacetate salt)
A cyclic pentapeptide
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GC49704
Ac-FLTD-CMK (trifluoroacetate salt)
An inhibitor of caspase-1, -4, -5, and -11
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GC49702
Papain Inhibitor (trifluoroacetate salt)
A peptide inhibitor of papain
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GC49699
Acetyl Tetrapeptide-9 (acetate)
A synthetic signal peptide
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GC49695
FKBP52 Monoclonal Antibody (Clone Hi52C)
For immunochemical analysis of FKBP52
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GC49690
(3R,5R)-Rosuvastatin (calcium salt)
A potential impurity found in bulk preparations of rosuvastatin
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GC49687
Goralatide (acetate)
A tetrapeptide regulator of hematopoiesis