Cell Cycle/Checkpoint

Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.
Products for Cell Cycle/Checkpoint
- ATM/ATR(22)
- Aurora Kinase(19)
- Cdc42(4)
- Cdc7(3)
- Chk(13)
- c-Myc(20)
- CRM1(8)
- Cyclin-Dependent Kinases(70)
- E1 enzyme(1)
- G-quadruplex(11)
- Haspin(5)
- HMTase(1)
- Kinesin(23)
- Ksp(4)
- Microtubule/Tubulin(211)
- Mps1(13)
- Mitotic(7)
- RAD51(13)
- ROCK(59)
- Rho(13)
- PERK(9)
- PLK(34)
- PTEN(6)
- Wee1(7)
- PAK(20)
- Arp2/3 Complex(8)
- Dynamin(9)
- ECM & Adhesion Molecules(40)
- Cholesterol Metabolism(3)
- Endomembrane System & Vesicular Trafficking(26)
- G1(38)
- G2/M(26)
- G2/S(10)
- Genotoxic Stress(18)
- Inositol Phosphates(18)
- Proteolysis(98)
- Cytoskeleton & Motor Proteins(53)
- Cellular Chaperones(8)
- Cat.No. Product Name Information
-
GC70163
Zagotenemab
-
GC70076
Tubulin inhibitor 11
-
GC70030
Tinengotinib
-
GC69776
PT-262
-
GC69718
Plogosertib
-
GC69688
PERK-IN-6
-
GC69687
PERK-IN-2
-
GC69516
MY-943
-
GN10780
Cephalomannine
-
GN10732
Oroxin B
-
GN10625
7-Epitaxol
-
GN10426
Deacetyltaxol
-
GN10299
Vinorelbine
-
GN10091
Schaftoside
-
GC10200
Mdivi 1
A mitochondrial division inhibitor
-
GC15571
SU 9516
A pro-apoptotic Cdk2/cyclin A inhibitor
-
GC11656
ARRY 520 trifluoroacetate
A potent Eg5 inhibitor
-
GC11007
VO-Ohpic trihydrate
A specific inhibitor of PTEN
-
GC14806
Vinorelbine ditartrate
An inhibitor of microtubule polymerization
-
GC12286
Vinblastine sulfate
An inhibitor of microtubule assembly
-
GC12827
SLx-2119
A ROCK2 inhibitor
-
GC17792
SCH900776 S-isomer
-
GC12064
SB1317
A multi-kinase inhibitor
-
GC15437
RKI-1447
A ROCK1 and ROCK2 inhibitor
-
GC18140
RI-1
A RAD51 inhibitor
-
GC15162
Pyridostatin
A stabilizer of G-quadruplexes
-
GC13543
Poloxin
An inhibitor of the Plk1 polo-box domain
-
GC10521
Podophyllotoxin
A lignan with diverse biological activities
-
GC11324
PHA-767491
A potent Cdc7 kinase inhibitor
-
GC17214
PF-3758309
An inhibitor of PAK4
-
GC16959
NVP-LCQ195
-
GC12491
Narciclasine
A plant growth regulator with anticancer activity
-
GC17276
Monomethyl auristatin E
A potent antimitotic compound
-
GC15798
MMAD
-
GC11823
LY2835219 free base
A dual inhibitor of Cdk4 and Cdk6
-
GC10222
KX2-391 dihydrochloride
A Src kinase inhibitor
-
GC16869
Ixabepilone
A broad-spectrum anticancer agent
-
GC10338
Hydroxyfasudil hydrochloride
A ROCK inhibitor
-
GC10901
Hydroxyfasudil
-
GC11621
GW843682X
A reversible polo-like kinase inhibitor
-
GC15659
GSK-923295
An inhibitor of CENP-E
-
GC17450
GSK2606414
A selective PERK inhibitor
-
GC16063
Flavopiridol
An inhibitor of cyclin-dependent kinases
-
GC17440
Epothilone D
A microtubule-stabilizing agent
-
GC12550
Docetaxel Trihydrate
-
GC12384
D-64131
An inhibitor of tubulin polymerization
-
GC18028
CVT-313
A Cdk2 inhibitor
-
GC13261
Colchicine
An inhibitor of microtubule polymerization
-
GC16097
Chroman 1
A ROCK2 inhibitor
-
GC17254
CHR-6494
A selective Haspin protein kinase inhibitor
-
GC14650
CGP60474
A CDK inhibitor
-
GC17359
CDK9 inhibitor 2
-
GC12871
CDK9 inhibitor
-
GC12425
CDK inhibitor II
-
GC17105
CCT241533 hydrochloride
A selective Chk2 inhibitor
-
GC18053
CCT241533
A selective Chk2 inhibitor
-
GC12001
BS-181
A selective Cdk7 inhibitor
-
GC15597
AT7519 trifluoroacetate
-
GC13998
AT7519 Hydrochloride
A Cdk inhibitor
-
GC13282
ARRY-520 R enantiomer
-
GC11947
Ansamitocin P-3
A microtubule depolymerizing agent
-
GC17271
4'-Demethylepipodophyllotoxin
An inhibitor of tubulin polymerization
-
GC10115
360A iodide
-
GC15389
360A
-
GC12954
10-DAB (10-Deacetylbaccatin)
An inhibitor of microtubule assembly
-
GC16684
Docetaxel
Docetaxel is an antineoplastic drug by inhibiting microtubule depolymerization, and attenuating of the effects of bcl-2 and bcl-xL gene expression.
-
GC12511
Paclitaxel (Taxol)
A potent mitotic inhibitor
-
GC16391
Amuvatinib (MP-470, HPK 56)
A multi-targeted RTK inhibitor
-
GC15084
2-Methoxyestradiol (2-MeOE2)
A natural metabolite of estradiol
-
GC10512
Y-27632 dihydrochloride
A ROCK inhibitor
-
GC25940
SNS-314
SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.
-
GC25482
GSK269962A HCl
GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
-
GC25372
Elimusertib (BAY-1895344) hydrochloride
Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.
-
GC25075
Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222)
Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM.
-
GC25025
Abraxane
Abraxane (Nab-Paclitaxel), a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system.
-
GC68416
RAD51-IN-3
-
GC68366
Thiocolchicine-d3
-
GC68147
dAURK-4 hydrochloride
-
GC68024
Antiproliferative agent-14
-
GC68021
BMVC
-
GC67900
AMXI-5001 hydrochloride
-
GC67899
Aurora kinase inhibitor-8
-
GC67888
RAD51-IN-5
-
GC52513
Indolimine-214
A genotoxic gut microbiota metabolite
-
GC52499
Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp (trifluoroacetate salt)
A sensitive substrate for neutrophil elastase
-
GC52489
Ceramide (hydroxy) (bovine spinal cord)
A sphingolipid
-
GC52486
Ceramide Phosphoethanolamine (bovine)
A sphingolipid
-
GC52485
Ceramide (non-hydroxy) (bovine spinal cord)
A sphingolipid
-
GC52484
Purified Ganglioside Mixture (bovine) (ammonium salt)
A mixture of purified bovine gangliosides
-
GC52474
Arg-Gly-Asp (trifluoroacetate salt)
A synthetic peptide corresponding to an integrin cell adhesion sequence
-
GC52472
Inostamycin A (sodium salt)
A bacterial metabolite with anticancer activity
-
GC52447
Suc-Leu-Leu-Val-Tyr-AMC (trifluoroacetate salt)
A fluorogenic substrate for the 20S proteasome and calpains
-
GC52389
Caveolin-1 (82-101) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
A synthetic peptide fragment of caveolin-1
-
GC52372
Ac-VDVAD-AFC (trifluoroacetate salt)
A fluorogenic substrate for caspase-2
-
GC52371
Vimentin (G146R) (139-159)-biotin Peptide
A biotinylated mutant vimentin peptide
-
GC52370
Citrullinated Vimentin (R144) (139-159)-biotin Peptide
A biotinylated and citrullinated vimentin peptide
-
GC52367
Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide
A biotinylated and citrullinated mutant vimentin peptide
-
GC52365
4-tert-Octylphenol monoethoxylate
An alkylphenolethoxylate and a degradation product of non-ionic surfactants
-
GC52364
Vimentin (139-159)-biotin Peptide
A biotinylated vimentin peptide
-
GC52360
Chymotrypsin Substrate I, Colorimetric (trifluoroacetate salt)
A colorimetric chymotrypsin substrate