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Home >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Targets for  Cell Cycle/Checkpoint

Products for  Cell Cycle/Checkpoint

  1. Cat.No. Product Name Information
  2. GC40702 α-D-Galactopyranosylphenyl isothiocyanate

    α-D-Galactopyranosylphenyl isothiocyanate is a chemically activated form of galactose that has been used to prepare various neoglycoproteins, which consist of a glycosylated serum albumin substituted with either fluorescein or methotrexate.

     α-D-Galactopyranosylphenyl isothiocyanate Chemical Structure
  3. GC41676 (±)-Nornicotine (±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. (±)-Nornicotine Chemical Structure
  4. GC49482 (±)-Nornicotine-d4 An internal standard for the quantification of (±)-nornicotine (±)-Nornicotine-d4 Chemical Structure
  5. GC41684 (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane (BMC) is a cyclohexane with two mercaptoacetamido groups. (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane Chemical Structure
  6. GC40802 (±)12(13)-DiHOME

    (±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.

     (±)12(13)-DiHOME Chemical Structure
  7. GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol 2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system. (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol Chemical Structure
  8. GC45890 (+)-Abscisic Acid-d6 (+)-Abscisic Acid-d6 Chemical Structure
  9. GC62728 (1E)-CFI-400437 dihydrochloride (1E)-CFI-400437 dihydrochloride Chemical Structure
  10. GC49690 (3R,5R)-Rosuvastatin (calcium salt) A potential impurity found in bulk preparations of rosuvastatin (3R,5R)-Rosuvastatin (calcium salt) Chemical Structure
  11. GC41268 (E)-2-Hexadecenal Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase. (E)-2-Hexadecenal Chemical Structure
  12. GC41701 (E)-2-Hexadecenal Alkyne (E)-2-Hexadecenal alkyne is an alkyne version of the sphingolipid degradation product (E)-2-hexadecenal that can be used as a click chemistry probe. (E)-2-Hexadecenal Alkyne Chemical Structure
  13. GC10419 (R)-CCG-1423 Rho inhibitor (R)-CCG-1423 Chemical Structure
  14. GC16429 (R)-DRF053 dihydrochloride cdk/CK1 inhibitor,potent and ATP-competitive (R)-DRF053 dihydrochloride Chemical Structure
  15. GC41719 (R)-nitro-Blebbistatin (R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin, which is the inactive form of (-)-blebbistatin. (R)-nitro-Blebbistatin Chemical Structure
  16. GC41557 (S)-3'-amino Blebbistatin (S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (S)-3'-amino Blebbistatin Chemical Structure
  17. GC41484 (S)-3'-hydroxy Blebbistatin (S)-3'-hydroxy Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (S)-3'-hydroxy Blebbistatin Chemical Structure
  18. GC14497 (S)-CCG-1423 Rho inhibitor (S)-CCG-1423 Chemical Structure
  19. GC34999 (S)-Ceralasertib (S)-Ceralasertib Chemical Structure
  20. GC41737 (S)-Glycyl-H-1152 (hydrochloride) Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. (S)-Glycyl-H-1152 (hydrochloride) Chemical Structure
  21. GC40145 (S)-Laudanosine (S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium. (S)-Laudanosine Chemical Structure
  22. GC41739 (S)-nitro-Blebbistatin (S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (S)-nitro-Blebbistatin Chemical Structure
  23. GC18275 1,2-Dihexadecyl-sn-glycero-3-PC 1,2-Dihexadecyl-sn-glycero-3-PC is a synthetic ether-linked phospholipid containing hexadecyl groups at the sn-1 and sn-2 positions. 1,2-Dihexadecyl-sn-glycero-3-PC Chemical Structure
  24. GC45783 1,2-Dioleoyl-rac-glycerol-13C3 1,2-Dioleoyl-rac-glycerol-13C3 Chemical Structure
  25. GC41823 1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt)

    1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid.

     1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt) Chemical Structure
  26. GC19528 1,4-Benzoquinone 1,4-Benzoquinone Chemical Structure
  27. GC18726 1-Methyl-1,4-dihydronicotinamide 1-Methyl-1,4-dihydronicotinamide is a derivative of nicotinamide . 1-Methyl-1,4-dihydronicotinamide Chemical Structure
  28. GC49736 10-acetyl Docetaxel A derivative of paclitaxel and an inhibitor of microtubule depolymerization 10-acetyl Docetaxel Chemical Structure
  29. GC12954 10-DAB (10-Deacetylbaccatin)

    Precursor of antitumor compound Palitaxel and Docetaxel

     10-DAB (10-Deacetylbaccatin) Chemical Structure
  30. GC35044 10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyl paclitaxel Chemical Structure
  31. GC35045 10-Oxo Docetaxel 10-Oxo Docetaxel Chemical Structure
  32. GC17295 10058-F4 C-Myc-Max dimerization inhibitor 10058-F4 Chemical Structure
  33. GC63576 10074-A4 10074-A4 Chemical Structure
  34. GC14918 10074-G5 c-Myc inhibitor 10074-G5 Chemical Structure
  35. GC40448 12(S)-HETE

    12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.

     12(S)-HETE Chemical Structure
  36. GC41110 16-epi Latrunculin B 16-epi Latrunculin B, first isolated from the Red Sea sponge N. 16-epi Latrunculin B Chemical Structure
  37. GC42151 2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate) 2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. 2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate) Chemical Structure
  38. GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone 2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E. 2,3-Dimethoxy-5-methyl-p-benzoquinone Chemical Structure
  39. GC49671 2,3-Oxidosqualene An intermediate in the biosynthesis of sterols 2,3-Oxidosqualene Chemical Structure
  40. GC45324 2,5-dimethyl Celecoxib   2,5-dimethyl Celecoxib Chemical Structure
  41. GC40675 2-deoxy-Artemisinin 2-deoxy-Artemisinin is an inactive metabolite of the antimalarial agent artemisinin. 2-deoxy-Artemisinin Chemical Structure
  42. GC15084 2-Methoxyestradiol (2-MeOE2) Apoptotic, antiproliferative and antiangiogenic agent 2-Methoxyestradiol (2-MeOE2) Chemical Structure
  43. GC42161 2H-Cho-Arg (trifluoroacetate salt) 2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection. 2H-Cho-Arg (trifluoroacetate salt) Chemical Structure
  44. GC40618 3',4',7-Trihydroxyisoflavone 3',4',7-Trihydroxyisoflavone is a natural isoflavonoid that has antioxidant activity. 3',4',7-Trihydroxyisoflavone Chemical Structure
  45. GC45332 3'-Dephosphocoenzyme A 3'-Dephosphocoenzyme A Chemical Structure
  46. GC42239 3,6-diacetoxy Phthalonitrile 3,6-diacetoxy Phthalonitrile is a fluorescent probe for monitoring intracellular pH by flow cytometry in living cells. 3,6-diacetoxy Phthalonitrile Chemical Structure
  47. GC12314 3-(4-Pyridyl)indole ROCK-I inhibitor 3-(4-Pyridyl)indole Chemical Structure
  48. GC15389 360A

    G-quadruplex structures inhibitor

     360A Chemical Structure
  49. GC10115 360A iodide G-quadruplex structures inhibitor 360A iodide Chemical Structure
  50. GC14186 3MB-PP1 polo-like kinase 1 (Plk1) allele inhibitor,ATP-competitive 3MB-PP1 Chemical Structure
  51. GC45354 4β-Hydroxywithanolide E 4β-Hydroxywithanolide E Chemical Structure
  52. GC17271 4'-Demethylepipodophyllotoxin Anti-cancer drug 4'-Demethylepipodophyllotoxin Chemical Structure
  53. GC18359 4-Epianhydrochlortetracycline (hydrochloride) 4-Epianhydrochlortetracycline is a derivative of tetracycline . 4-Epianhydrochlortetracycline (hydrochloride) Chemical Structure
  54. GC42449 4-Methylumbelliferyl-α-L-Iduronide (free acid) 4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-Iduronide (free acid) Chemical Structure
  55. GC45357 5-Chlorouracil   5-Chlorouracil Chemical Structure
  56. GC41156 5-Octyl D-glutamate 5-Octyl D-glutamate, also known as 5-octyl ester D-glutamate, is a stable, cell-permeable molecule that generates free D-glutamate upon hydrolysis of the ester bond by cytoplasmic esterases. 5-Octyl D-glutamate Chemical Structure
  57. GC41423 5-trans Prostaglandin E2 5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1. 5-trans Prostaglandin E2 Chemical Structure
  58. GC42586 6α-hydroxy Paclitaxel 6α-hydroxy Paclitaxel is a primary metabolite of the anticancer compound paclitaxel, produced by the action of the cytochrome P450 isoform CYP2C8. 6α-hydroxy Paclitaxel Chemical Structure
  59. GC45969 6β-hydroxy Eplerenone 6β-hydroxy Eplerenone Chemical Structure
  60. GC15478 6H05 K-Ras inhibitor 6H05 Chemical Structure
  61. GC40202 7α-hydroxy Cholesterol-d7

    7α-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7α-hydroxy cholesterol by GC- or LC-MS.

     7α-hydroxy Cholesterol-d7 Chemical Structure
  62. GC46733 7,12-Dimethylbenz[a]anthracene 7,12-Dimethylbenz[a]anthracene Chemical Structure
  63. GC35188 7-Epi-10-oxo-docetaxel 7-Epi-10-oxo-docetaxel Chemical Structure
  64. GC35189 7-Epi-docetaxel 7-Epi-docetaxel Chemical Structure
  65. GN10625 7-Epitaxol Extracted from Taxus brevifolia;Store the product in sealed, cool and dry condition 7-Epitaxol Chemical Structure
  66. GC42610 7-hydroxy Pestalotin 7-hydroxy Pestalotin is a fungal metabolite originally isolated from Penicillium. 7-hydroxy Pestalotin Chemical Structure
  67. GC42616 7-oxo Staurosporine

    7-oxo Staurosporine is an antibiotic originally isolated from S.

     7-oxo Staurosporine Chemical Structure
  68. GC35197 7-xylosyltaxol 7-xylosyltaxol Chemical Structure
  69. GC40844 9-(2,2-Dicyanovinyl)julolidine 9-(2,2-Dicyanovinyl)julolidine (DCVJ) is a fluorogenic dye that is considered a fluorescent molecular rotor because its properties depend on the rotational relaxation of the molecule, which can be influenced by the viscosity of the solvent used. 9-(2,2-Dicyanovinyl)julolidine Chemical Structure
  70. GC42665 AAF-CMK (trifluoroacetate salt) Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK (trifluoroacetate salt) Chemical Structure
  71. GC15875 ABT-751 (E7010) Inhibitor of microtubule polymerization,antimitotic ABT-751 (E7010) Chemical Structure
  72. GC42683 Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human neutrophil elastase (kcat/Km = 531 mM-1s-1). Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp Chemical Structure
  73. GC42684 Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt) Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1). Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt) Chemical Structure
  74. GA20494 Ac-Asp-Glu-Val-Asp-pNA The cleavage of the chromogenic caspase-3 substrate Ac-DEVD-pNA can be monitored at 405 nm. Ac-Asp-Glu-Val-Asp-pNA Chemical Structure
  75. GC42689 Ac-DNLD-AMC Ac-DNLD-AMC is a fluorogenic caspase-3 substrate. Ac-DNLD-AMC Chemical Structure
  76. GC49704 Ac-FLTD-CMK (trifluoroacetate salt) An inhibitor of caspase-1, -4, -5, and -11 Ac-FLTD-CMK (trifluoroacetate salt) Chemical Structure
  77. GC18226 Ac-LEHD-AMC (trifluoroacetate salt)

    Ac-LEHD-AMC is a fluorogenic substrate for caspase-9.

     Ac-LEHD-AMC (trifluoroacetate salt) Chemical Structure
  78. GC40556 Ac-LETD-AFC Ac-LETD-AFC is a fluorogenic substrate that can be cleaved specifically by caspase-8. Ac-LETD-AFC Chemical Structure
  79. GC15171 Ac-LEVD-AFC Ac-LEVD-AFC Chemical Structure
  80. GC13400 Ac-VDVAD-AFC Ac-VDVAD-AFC Chemical Structure
  81. GC18021 Ac-YVAD-CHO Selective inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1) Ac-YVAD-CHO Chemical Structure
  82. GC42721 Ac-YVAD-CMK A selective caspase 1/ICE inhibitor Ac-YVAD-CMK Chemical Structure
  83. GC10244 Ac2-12 inhibitor of leukocyte extravasation Ac2-12 Chemical Structure
  84. GC15598 Ac2-26 inhibitor of leukocyte extravasation Ac2-26 Chemical Structure
  85. GC42701 Acetyl Tetrapeptide-3 Acetyl tetrapeptide-3 is a biomimetic peptide. Acetyl Tetrapeptide-3 Chemical Structure
  86. GC49699 Acetyl Tetrapeptide-9 (acetate) A synthetic signal peptide Acetyl Tetrapeptide-9 (acetate) Chemical Structure
  87. GC41242 Acridine Orange A fluorescent cationic dye useful for cell cycle determination Acridine Orange Chemical Structure
  88. GC16475 Afuresertib pan-AKT inhibitor Afuresertib Chemical Structure
  89. GC42747 Afuresertib (hydrochloride) Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively. Afuresertib (hydrochloride) Chemical Structure
  90. GC18539 all-trans-4-hydroxy Retinoic Acid all-trans-4-hydroxy Retinoic acid is a metabolite of all-trans retinoic acid formed by the cytochrome P450 (CYP) isoforms CYP26A1, B1, and C1. all-trans-4-hydroxy Retinoic Acid Chemical Structure
  91. GC40476 Allethrin Allethrin is a pyrethroid insecticide and modulator of voltage-gated sodium channels (NaV). Allethrin Chemical Structure
  92. GC45379 Alloxan (hydrate)   Alloxan (hydrate) Chemical Structure
  93. GC18386 Aloisine RP106 Aloisine is an inhibitor of Cdk1/cyclin B, Cdk5/p25, and GSK3 (IC50s = 0.70, 1.5, and 0.92 uM, respectively). Aloisine RP106 Chemical Structure
  94. GC15841 Alsterpaullone CDKs and GSK3β inhibitor Alsterpaullone Chemical Structure
  95. GC18437 Alternariol monomethyl ether Alternariol monomethyl ether (AME) is a mycotoxin originally isolated from A. Alternariol monomethyl ether Chemical Structure
  96. GC14974 AMG 925 FLT3/CDK4 inhibitor,potent and selective AMG 925 Chemical Structure
  97. GC39156 AMG PERK 44 AMG PERK 44 Chemical Structure
  98. GC13198 AMG-900 Aurora kinase inhibitor AMG-900 Chemical Structure
  99. GC45809 AMG-Tie2-1 AMG-Tie2-1 Chemical Structure
  100. GC42788 Aminopeptidase N Inhibitor Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). Aminopeptidase N Inhibitor Chemical Structure
  101. GC11410 Aminopurvalanol A cyclin-dependent kinase inhibitor Aminopurvalanol A Chemical Structure

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