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Home >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Products for  Cell Cycle/Checkpoint

  1. Cat.No. Product Name Information
  2. GN10780 Cephalomannine Cephalomannine Chemical Structure
  3. GN10732 Oroxin B Oroxin B Chemical Structure
  4. GN10625 7-Epitaxol 7-Epitaxol Chemical Structure
  5. GN10426 Deacetyltaxol Deacetyltaxol Chemical Structure
  6. GN10299 Vinorelbine Vinorelbine Chemical Structure
  7. GN10091 Schaftoside Schaftoside Chemical Structure
  8. GC10200 Mdivi 1

    A mitochondrial division inhibitor

     Mdivi 1 Chemical Structure
  9. GC15571 SU 9516 A pro-apoptotic Cdk2/cyclin A inhibitor SU 9516 Chemical Structure
  10. GC11656 ARRY 520 trifluoroacetate A potent Eg5 inhibitor ARRY 520 trifluoroacetate Chemical Structure
  11. GC11007 VO-Ohpic trihydrate A specific inhibitor of PTEN VO-Ohpic trihydrate Chemical Structure
  12. GC14806 Vinorelbine ditartrate An inhibitor of microtubule polymerization Vinorelbine ditartrate Chemical Structure
  13. GC12286 Vinblastine sulfate An inhibitor of microtubule assembly Vinblastine sulfate Chemical Structure
  14. GC12827 SLx-2119 A ROCK2 inhibitor SLx-2119 Chemical Structure
  15. GC17792 SCH900776 S-isomer SCH900776 S-isomer Chemical Structure
  16. GC12064 SB1317 A multi-kinase inhibitor SB1317 Chemical Structure
  17. GC15437 RKI-1447 A ROCK1 and ROCK2 inhibitor RKI-1447 Chemical Structure
  18. GC18140 RI-1 A RAD51 inhibitor RI-1 Chemical Structure
  19. GC15162 Pyridostatin

    A stabilizer of G-quadruplexes

     Pyridostatin Chemical Structure
  20. GC13543 Poloxin An inhibitor of the Plk1 polo-box domain Poloxin Chemical Structure
  21. GC10521 Podophyllotoxin A lignan with diverse biological activities Podophyllotoxin Chemical Structure
  22. GC11324 PHA-767491 A potent Cdc7 kinase inhibitor PHA-767491 Chemical Structure
  23. GC17214 PF-3758309 An inhibitor of PAK4 PF-3758309 Chemical Structure
  24. GC16959 NVP-LCQ195 NVP-LCQ195 Chemical Structure
  25. GC12491 Narciclasine A plant growth regulator with anticancer activity Narciclasine Chemical Structure
  26. GC17276 Monomethyl auristatin E A potent antimitotic compound Monomethyl auristatin E Chemical Structure
  27. GC15798 MMAD MMAD Chemical Structure
  28. GC11823 LY2835219 free base A dual inhibitor of Cdk4 and Cdk6 LY2835219 free base Chemical Structure
  29. GC10222 KX2-391 dihydrochloride A Src kinase inhibitor KX2-391 dihydrochloride Chemical Structure
  30. GC16869 Ixabepilone A broad-spectrum anticancer agent Ixabepilone Chemical Structure
  31. GC10338 Hydroxyfasudil hydrochloride A ROCK inhibitor Hydroxyfasudil hydrochloride Chemical Structure
  32. GC10901 Hydroxyfasudil Hydroxyfasudil Chemical Structure
  33. GC11621 GW843682X A reversible polo-like kinase inhibitor GW843682X Chemical Structure
  34. GC15659 GSK-923295 An inhibitor of CENP-E GSK-923295 Chemical Structure
  35. GC17450 GSK2606414

    A selective PERK inhibitor

     GSK2606414 Chemical Structure
  36. GC16063 Flavopiridol An inhibitor of cyclin-dependent kinases Flavopiridol Chemical Structure
  37. GC17440 Epothilone D A microtubule-stabilizing agent Epothilone D Chemical Structure
  38. GC12550 Docetaxel Trihydrate Docetaxel Trihydrate Chemical Structure
  39. GC12384 D-64131 An inhibitor of tubulin polymerization D-64131 Chemical Structure
  40. GC18028 CVT-313 A Cdk2 inhibitor CVT-313 Chemical Structure
  41. GC13261 Colchicine

    An inhibitor of microtubule polymerization

     Colchicine Chemical Structure
  42. GC16097 Chroman 1 A ROCK2 inhibitor Chroman 1 Chemical Structure
  43. GC17254 CHR-6494 A selective Haspin protein kinase inhibitor CHR-6494 Chemical Structure
  44. GC14650 CGP60474 A CDK inhibitor CGP60474 Chemical Structure
  45. GC17359 CDK9 inhibitor 2 CDK9 inhibitor 2 Chemical Structure
  46. GC12871 CDK9 inhibitor CDK9 inhibitor Chemical Structure
  47. GC12425 CDK inhibitor II CDK inhibitor II Chemical Structure
  48. GC17105 CCT241533 hydrochloride A selective Chk2 inhibitor CCT241533 hydrochloride Chemical Structure
  49. GC18053 CCT241533 A selective Chk2 inhibitor CCT241533 Chemical Structure
  50. GC12001 BS-181 A selective Cdk7 inhibitor BS-181 Chemical Structure
  51. GC15597 AT7519 trifluoroacetate AT7519 trifluoroacetate Chemical Structure
  52. GC13998 AT7519 Hydrochloride A Cdk inhibitor AT7519 Hydrochloride Chemical Structure
  53. GC13282 ARRY-520 R enantiomer ARRY-520 R enantiomer Chemical Structure
  54. GC11947 Ansamitocin P-3 A microtubule depolymerizing agent Ansamitocin P-3 Chemical Structure
  55. GC17271 4'-Demethylepipodophyllotoxin An inhibitor of tubulin polymerization 4'-Demethylepipodophyllotoxin Chemical Structure
  56. GC10115 360A iodide 360A iodide Chemical Structure
  57. GC15389 360A 360A Chemical Structure
  58. GC12954 10-DAB (10-Deacetylbaccatin) An inhibitor of microtubule assembly 10-DAB (10-Deacetylbaccatin) Chemical Structure
  59. GC16684 Docetaxel Docetaxel Chemical Structure
  60. GC12511 Paclitaxel (Taxol)

    A potent mitotic inhibitor

     Paclitaxel (Taxol) Chemical Structure
  61. GC16391 Amuvatinib (MP-470, HPK 56) A multi-targeted RTK inhibitor Amuvatinib (MP-470, HPK 56) Chemical Structure
  62. GC15084 2-Methoxyestradiol (2-MeOE2) A natural metabolite of estradiol 2-Methoxyestradiol (2-MeOE2) Chemical Structure
  63. GC10512 Y-27632 dihydrochloride

    A ROCK inhibitor

     Y-27632 dihydrochloride Chemical Structure
  64. GC25940 SNS-314 SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1. SNS-314 Chemical Structure
  65. GC25482 GSK269962A HCl GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. GSK269962A HCl Chemical Structure
  66. GC25372 Elimusertib (BAY-1895344) hydrochloride Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM. Elimusertib (BAY-1895344) hydrochloride Chemical Structure
  67. GC25075 Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM. Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) Chemical Structure
  68. GC25025 Abraxane Abraxane (Nab-Paclitaxel), a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system. Abraxane Chemical Structure
  69. GC68416 RAD51-IN-3 RAD51-IN-3 Chemical Structure
  70. GC68366 Thiocolchicine-d3 Thiocolchicine-d3 Chemical Structure
  71. GC68147 dAURK-4 hydrochloride dAURK-4 hydrochloride Chemical Structure
  72. GC68024 Antiproliferative agent-14 Antiproliferative agent-14 Chemical Structure
  73. GC68021 BMVC BMVC Chemical Structure
  74. GC67900 AMXI-5001 hydrochloride AMXI-5001 hydrochloride Chemical Structure
  75. GC67899 Aurora kinase inhibitor-8 Aurora kinase inhibitor-8 Chemical Structure
  76. GC67888 RAD51-IN-5 RAD51-IN-5 Chemical Structure
  77. GC52513 Indolimine-214 A genotoxic gut microbiota metabolite Indolimine-214 Chemical Structure
  78. GC52499 Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp (trifluoroacetate salt) A sensitive substrate for neutrophil elastase Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp (trifluoroacetate salt) Chemical Structure
  79. GC52489 Ceramide (hydroxy) (bovine spinal cord) A sphingolipid Ceramide (hydroxy) (bovine spinal cord) Chemical Structure
  80. GC52486 Ceramide Phosphoethanolamine (bovine) A sphingolipid Ceramide Phosphoethanolamine (bovine) Chemical Structure
  81. GC52485 Ceramide (non-hydroxy) (bovine spinal cord) A sphingolipid Ceramide (non-hydroxy) (bovine spinal cord) Chemical Structure
  82. GC52484 Purified Ganglioside Mixture (bovine) (ammonium salt) A mixture of purified bovine gangliosides Purified Ganglioside Mixture (bovine) (ammonium salt) Chemical Structure
  83. GC52474 Arg-Gly-Asp (trifluoroacetate salt) A synthetic peptide corresponding to an integrin cell adhesion sequence Arg-Gly-Asp (trifluoroacetate salt) Chemical Structure
  84. GC52472 Inostamycin A (sodium salt) A bacterial metabolite with anticancer activity Inostamycin A (sodium salt) Chemical Structure
  85. GC52447 Suc-Leu-Leu-Val-Tyr-AMC (trifluoroacetate salt) A fluorogenic substrate for the 20S proteasome and calpains Suc-Leu-Leu-Val-Tyr-AMC (trifluoroacetate salt) Chemical Structure
  86. GC52389 Caveolin-1 (82-101) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) A synthetic peptide fragment of caveolin-1 Caveolin-1 (82-101) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) Chemical Structure
  87. GC52372 Ac-VDVAD-AFC (trifluoroacetate salt) A fluorogenic substrate for caspase-2 Ac-VDVAD-AFC (trifluoroacetate salt) Chemical Structure
  88. GC52371 Vimentin (G146R) (139-159)-biotin Peptide A biotinylated mutant vimentin peptide Vimentin (G146R) (139-159)-biotin Peptide Chemical Structure
  89. GC52370 Citrullinated Vimentin (R144) (139-159)-biotin Peptide A biotinylated and citrullinated vimentin peptide Citrullinated Vimentin (R144) (139-159)-biotin Peptide Chemical Structure
  90. GC52367 Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide A biotinylated and citrullinated mutant vimentin peptide Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide Chemical Structure
  91. GC52365 4-tert-Octylphenol monoethoxylate An alkylphenolethoxylate and a degradation product of non-ionic surfactants 4-tert-Octylphenol monoethoxylate Chemical Structure
  92. GC52364 Vimentin (139-159)-biotin Peptide A biotinylated vimentin peptide Vimentin (139-159)-biotin Peptide Chemical Structure
  93. GC52360 Chymotrypsin Substrate I, Colorimetric (trifluoroacetate salt) A colorimetric chymotrypsin substrate Chymotrypsin Substrate I, Colorimetric (trifluoroacetate salt) Chemical Structure
  94. GC52358 Malachite Green (chloride) A triphenylmethane dye Malachite Green (chloride) Chemical Structure
  95. GC52332 Arimoclomol A co-inducer of heat shock proteins Arimoclomol Chemical Structure
  96. GC52293 STAT3 Inhibitor 4m A STAT3 inhibitor STAT3 Inhibitor 4m Chemical Structure
  97. GC52288 Fumonisin B1-13C34 An internal standard for the quantification of fumonisin B1 Fumonisin B1-13C34 Chemical Structure
  98. GC52245 CAY10792 An anticancer agent CAY10792 Chemical Structure
  99. GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone An active metabolite of various polyphenols 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone Chemical Structure
  100. GC67333 Estramustine Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts. Estramustine Chemical Structure
  101. GC66457 MY-875 MY-875 is a competitive microtubulin polymerization inhibitor with an IC50 value of 0.92 μM. MY-875 inhibits microtubulin polymerization by targeting colchicine binding sites and activates the Hippo pathway. MY-875 induces apoptosis and has anticancer activity. MY-875 Chemical Structure

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