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Neprilysin

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Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging.

Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.

Products Related to Neprilysin(12)

  • GC10146 structure
    GC10146AHU-377(Sacubitril)
    CAS: 149709-62-6
    Purity: >99.00%

    AHU-377(Sacubitril) (AHU-377) is a potent and orally active NEP (neprilysin) inhibitor with an IC50 of 5 nM.

  • GC11784 structure
    GC11784LCZ696
    CAS: 936623-90-4
    Purity: >99.50%

    LCZ696, a combination of prodrug sacubitril and valsartan at equal molar ratios, is an oral active angiotensin II receptor-neprilysin inhibitor.

  • GC16138 structure
    GC16138AHU-377 hemicalcium salt
    CAS: 1369773-39-6
    Purity: >99.50%

    AHU-377 hemicalcium salt (AHU-377 hemicalcium salt) is a potent NEP inhibitor with an IC50 of 5 nM.

  • GC16768 structure
    GC16768Phosphoramidon Disodium Salt
    CAS: 164204-38-0
    Purity: >98%

    Phosphoramidon Disodium Salt is a metalloprotease inhibitor.

  • GC17017 structure
    GC17017Racecadotril
    CAS: 81110-73-8
    Purity: >98.50%

    Potent enkephalinase inhibitor

  • GC30786 structure
    GC30786Sacubitrilat (LBQ-657)
    CAS: 149709-44-4
    Purity: >98.00%

    Sacubitrilat (LBQ-657) (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.

  • GC31267 structure
    GC31267NEP-In-1
    CAS: 465527-94-0
    Purity: >98%

    NEP-IN-1 is a neutral endopeptidase (NEP) inhibitor with IC50 of 2 nM for dNEP.

  • GC31583 structure
    GC31583SQ28603 (SQ28,603)
    CAS: 100845-83-8
    Purity: >98%

    SQ28603 (SQ28,603) is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP).

  • GC31608 structure
    GC31608Candoxatril (UK 79300)
    CAS: 123122-55-4
    Purity: >98%

    Candoxatril (UK 79300) is a neutral endopeptidase (NEP) inhibitor.

  • GC32671 structure
    GC32671NEP-IN-2
    CAS: 145775-14-0
    Purity: >98%

    NEP-IN-2 is an inhibitor of neutral endopeptidase, used in the research of proliferation in atherosclerosis, restenosis.

  • GC38856 structure
    GC38856TD-0212 TFA
    CAS: 1073549-11-7
    Purity: >98.00%

    TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP.

  • GC63732 structure
    GC63732Sacubitril-13C4 hemicalcium salt
    Purity: >98%