GLPBio

NKCC

NKCC (Na-K-Cl cotransporter) is an electrically silent membrane-bound channels that mediates Na and Cl reabsorption. It functions in regulating cell volume and ionic balance.

Products Related to NKCC(8)

  • GC12970 structure
    GC12970Furosemide
    CAS: 54-31-9
    Purity: >98.00%

    GABAA receptors antagonist

  • GC15524 structure
    GC15524Bumetanide
    CAS: 28395-03-1
    Purity: >99.50%

    NKCC cotransporter inhibitor

  • GC14041 structure
    GC14041Ethacrynic Acid
    CAS: 58-54-8
    Purity: >98.00%

    Ethacrynic Acid is a potent, orally effective loop diuretic.

  • GC16795 structure
    GC16795DCA
    CAS: 2156-56-1
    Purity: >98.00%

    DCA is a metabolic regulator in cancer cells' mitochondria with anticancer activity. DCA inhibits PDHK, resulting in decreased lactic acid in the tumor microenvironment. DCA increases reactive oxygen species (ROS) generation and promotes cancer cell apoptosis. DCA also works as NKCC inhibitor.

  • GC36091 structure
    GC36091Furosemide sodium
    CAS: 41733-55-5
    Purity: >99.50%

    A loop diuretic inhibitor of Na+/2Cl-/K+ (NKCC) cotransporter

  • GC38738 structure
    GC38738Azosemide
    CAS: 27589-33-9
    Purity: >97.00%

    Azosemide, a sulfonamide loop diuretic, is a potent NKCC1 inhibitor with IC50s of 0.246??M and 0.197??M for hNKCC1A and NKCC1B, respectively.

  • GC46957 structure
    GC46957Bumetanide-d5
    CAS: 1216739-35-3
    Purity: >99.00%

    An internal standard for the quantification of bumetanide

  • GC79492 structure
    GC79492ML077
    CAS: 1135304-61-8
    Purity: >98%

    ML007 is a selective antagonist targeting the neuron-specific potassium-chloride co-transporter 2 ( KCC2 ) with an IC 50 for KCC2 is 537 nM, while its inhibitory activity on KCC1 is extremely weak ( IC 50 > 50 μM).