Membrane Transporter/Ion Channel
- Piezo Channels(1)
- Aquaporins(1)
- AMPAR(54)
- ATPase(69)
- Calcium Channel(289)
- Cannabinoid Transporters(6)
- CFTR(36)
- Chloride Channels(12)
- GABA Receptor(174)
- Glucose Transporters(8)
- Glutamate (EAAT) Transporters(18)
- Glycine Receptors(2)
- GlyT(17)
- GTPase(21)
- ICB(1)
- MCT2(2)
- Monoamine transporter(11)
- Monocarboxylate Transporters(10)
- Multidrug Transporters(4)
- Na+/Ca2+ Exchanger(15)
- NKCC(7)
- NMDA Receptor(75)
- Nucleoside Transporters(4)
- Pannexin-1(2)
- P2X purinergic receptor(61)
- P-gp(9)
- Proton Pump(51)
- Potassium Channel(261)
- Sodium Channel(173)
- TRP Channel(140)
- TRPV1(10)
- URAT1(5)
- Other Channel Modulators(9)
- MCT(3)
- Kainate Receptors(11)
- Ionophore(3)
- sodium-hydrogen exchanger(3)
- Chloride Channel(23)
- CRAC Channel(13)
- EAAT2(6)
- HCN Channel(4)
- Na+/HCO3- Cotransporter(1)
- Na+/K+ ATPase(28)
- P-glycoprotein(47)
- iGluR(145)
- nAChR(85)
- VDAC(2)
- Cat.No. Product Name Information
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GC68476
(S)-Nicardipine
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GC68475
(R)-Nicardipine
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GC68438
AMPA receptor modulator-3
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GC68425
Ranolazine-d3
-
GC68397
Galicaftor
-
GC68282
CFTR corrector 8
-
GC68080
4-(Phenyldiazenyl)benzoic acid
-
GC68015
NJH-2-057
-
GC68011
PF-06761281
-
GC68002
TRPM4-IN-2
-
GC67996
TPA-023B
-
GC67949
GNE-0439
-
GC67939
CFTR corrector 4
-
GC67925
Crinecerfont hydrochloride
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GC67924
Dihydrocapsiate
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GC67922
Zelquistinel
-
GC67920
WS-898
-
GC67895
EVT-401
-
GC67871
SSR504734
-
GC67799
PF-05198007
-
GC67789
SRI-37240
-
GC67784
ML-SI3
-
GC67767
(R)-Olacaftor
-
GC67747
Dalazatide TFA
-
GC67739
D-erythro-Sphingosine hydrochloride
-
GC52503
FTase Inhibitor II (trifluoroacetate salt)
A potent, selective inhibitor of farnesyltransferase
-
GC52466
ICR-1 (potassium salt)
A cell-impermeable fluorescent calcium indicator
-
GC52465
ICR-1 AM
A cell-permeable fluorescent calcium indicator
-
GC52250
Mevalonate (lithium salt)
An intermediate in the mevalonate pathway
-
GC66843
L-Homocysteic acid
L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders.
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GC66836
Dimethyl L-glutamate
Dimethyl L-glutamate (Dimethyl glutamate), a membrane-permeable analog of Glutamate, can stimulate insulin release induced by Glucose. Dimethyl L-glutamate suppresses the KATP channel activities. Dimethyl L-glutamate inhibits E. gracilis growth and causes abnormal cell division. Dimethyl L-glutamate can be used in the research of diabetes, glucose transport, phosphorylation, and further metabolism.
-
GC66470
SW157765
SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs.
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GC66436
FEMA 4809
FEMA 4809 is a TRPM8 receptor agonist (EC50=0.2 nM) for use as a cooling agent. TRPM8 is the ion channel responsible for the cool perception.
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GC66419
(R)-Lercanidipine-d3 hydrochloride
(R)-lercanidipine D3 (hydrochloride) is a deuterium labeled (R)-Lercanidipine hydrochloride. (R)-Lercanidipine D3 (hydrochloride), the R-enantiomer of Lercanidipine, is a calcium channel blocker.
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GC66255
(E)-3,4,5-Trimethoxycinnamic acid
(E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy.
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GC66240
Lei-Dab7 TFA
Lei-Dab7 TFA is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.
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GC66073
Flupyradifurone
Flupyradifurone is a systemic nAChR agonist that interferes with signal transduction in the central nervous system of sucking pests. Flupyradifurone can be used as a butenolide insecticide.
-
GC66038
PF-06649298
PF-06649298 is a sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor. PF-06649298 specifically interacts with NaCT with an IC50 value of 16.2 μM to inhibits the transport of citrate in human hepatocytes. PF-06649298 can be used for the research of regulating glucose metabolism and lipid metabolism.
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GC66016
Evifacotrep
Evifacotrep, a short transient receptor potential channel 5 (TRPC5) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases.
-
GC65999
piCRAC-1
piCRAC-1 is a potent, photoinducible Ca2+ release-activated Ca2+ (CRAC) channel inhibitor. piCRAC-1 alleviates thrombocytopenia and hemorrhage.
-
GC65959
CaV1.3 antagonist-1
CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research.
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GC65954
Plazinemdor
Plazinemdor is a N-methyl-D-aspartate(NMDA) receptor positive allosteric modulator. Plazinemdor can be uses in the research of psychiatric, neurological, and neurodevelopmental disorders, as well as diseases of the nervous system..
-
GC65940
Zandatrigine
Zandatrigine (NBI-921352) is a sodium channel protein type 8 subunit alpha (Scn8α) blocker.
-
GC65611
AMG 333
AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM.
-
GC65593
6-Benzoylheteratisine
6-Benzoylheteratisine is a naturally occurring antagonist of the Na+ channel activator aconitine.
-
GC65536
TRPV4 agonist-1
TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay.
-
GC65531
Hardwickiic acid
Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels.
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GC65513
Radequinil
Radequinil (AC-3933) is a benzodiazepine receptor (BzR) partial inverse agonist.
-
GC65416
Flecainide
Flecainide is a potent and orally active antiarrhythmic agent.
-
GC65406
T16A(inh)-C01
T16A(inh)-C01 is an inhibitor of TMEM16A (ANO1).
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GC65385
Ganoderenic acid B
Ganoderenic acid B is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderenic acid B exhibits potent reversal effect on ABCB1-mediated multidrug resistance of HepG2/ADM cells to Doxorubicin.
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GC65377
Abeprazan hydrochloride
Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker.
-
GC65362
URAT1 inhibitor 1
URAT1 inhibitor 1 (1g) is a uric acid transporter 1 (URAT1) inhibitor, with an IC50 of 32 nM.
-
GC65320
Nav1.7-IN-3
Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM.
-
GC65319
GlyT1 Inhibitor 1
GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC50 of 38 nM for rGlyT1.
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GC65292
Lotilaner
Lotilaner is a parasiticide, acts as a potent non-competitive antagonist of insects GABACl receptors, with an IC50 of 23.84 nM for Drosophila melanogaster GABA receptor.
-
GC65280
RU-TRAAK-2
RU-TRAAK-2 is a completely reversible TRAAK (TWIK-related arachidonic acid-stimulated K+ channel) inhibitor.
-
GC65272
APETx2 TFA
APETx2 TFA, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC50 of 63 nM.
-
GC65248
Etripamil
Etripamil (MSP-2017) is a short-acting L-type calcium-channel antagonist, can be used for the research of Paroxysmal Supraventricular Tachycardia (PSVT).
-
GC65231
N-Bromoacetamide
N-Bromoacetamide can irreversibly remove sodium channel inactivation in the cytoplasmic face of the membrane, also decreasing K current rapid inactivation.
-
GC65211
Umbellulone
Umbellulone is an active constituent of the leaves of Umbellularia californica.
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GC65184
YS-370
YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity.
-
GC65183
P-gp inhibitor 1
P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance.
-
GC65150
Flecainide hydrochloride
Flecainide hydrochloride is a potent and orally active antiarrhythmic agent.
-
GC65125
VU0529331
VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 ?M and 5.2 ?M for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel.
-
GC65106
Pregnenolone-d4-1
-
GC65095
L-Glutamic acid-d5
L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid.
-
GC65081
CALP1 TFA
CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 ?M) with binding to the CaM EF-hand/Ca2+-binding site.
-
GC65078
YM-244769 dihydrochloride
YM-244769 dihydrochloride is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor.
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GC65057
Propofol-d18
Propofol-d18 is the deuterium labeled Propofol.
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GC65050
L-Phenylalanine-d2
-
GC65029
CFTR corrector 9
CFTR corrector 9 (compound 42) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator.
-
GC65006
JNc-440
JNc-440 is a potent antihypertensive agent.
-
GC64965
ICA-105665
ICA-105665 (PF-04895162) is a potent and orally active neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels opener.
-
GC64929
Pesampator
Pesampator (PF-04958242) is a potent and highly selective positive allosteric modulator of AMPA receptor (an AMPA potentiator) with an EC50 of 310 nM and a Ki of 170 nM.
-
GC64925
Cibenzoline
Cibenzoline is a potent inhibitor of KATP channel with directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit.
-
GC64899
ω-Conotoxin MVIIC TFA
-
GC64887
Gitoxin
Gitoxin, a Na+/K+-ATPase inhibitor, usually appears as a result of metabolic degradation of Digitoxin, is just the hydroxyl (ZOH) group close to the C-17β position, which changes the pharmacokinetics and pharmacodynamics of these substances considerably.
-
GC64876
GLUT inhibitor-1
GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively.
-
GC64870
Nicardipine-d3 hydrochloride
Nicardipine D3 hydrochloride (YC-93 D3) is the deuterium labeled Nicardipine hydrochloride.
-
GC64863
Dendrotoxin K
Dendrotoxin K is a Kv1.1 channel blocker.
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GC64852
Tivanisiran
Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease.
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GC64822
JNJ-42253432
JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9.1 and 7.9 for rat and human P2X7 channels, respectively.
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GC64806
HN37
HN37 as a potent and chemically stable antiepileptic drug candidate, with an EC50 of 37 nM for KCNQ2.
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GC64735
(S)-(-)-Levamisole
(S)-(-)-Levamisole (Levamisole), an anthelmintic agent with immunomodulatory properties.
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GC64719
KCNQ1 activator-1
KCNQ1 activator-1 (compound 3) is a potent activator of KCNQ1 channel.
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GC64691
RY796
RY796 is a potent and selective voltage-gated potassium (KV2) channel inhibitor with IC50s of 0.25 μM and 0.09 μM for KV2.1 and KV2.2.
-
GC64690
Opiranserin hydrochloride
Opiranserin (VVZ-149) hydrochloride, a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively.
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GC64678
K41498 TFA
K41498 TFA is a potent and highly selective CRF2?receptor antagonist with Ki?values of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β?and CRF1 receptors respectively.
-
GC64673
Etbicyphat
Etbicyphat (Trimethylopropane phosphate) is a potent GABA(A) receptors competitive antagonist.
-
GC64658
Bliretrigine
Bliretrigine is a sodium channel blocker.
-
GC64650
TAK-653
TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats.
-
GC64574
BZAD-01
BZAD-01 is a potent, selective and orally active inhibitor of NMDA NR2B subunit, with a Ki of 72 nM.
-
GC64573
PF-04745637
PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1.
-
GC64568
DRB18
DRB18 is a potent pan-class GLUT inhibitor. DRB18 alters energy-related metabolism in A549 cells by changing the abundance of metabolites in glucose-related pathways. DRB18 can eventually lead to G1/S phase arrest and increase oxidative stress and necrotic cell death. DRB18 has anti-tumor activity.
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GC64521
NMDAR/TRPM4-IN-2 free base
NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor.
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GC64508
γ-Aminobutyric acid-d6
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GC64459
Englerin A
Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload.
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GC64448
Guanfu base A
Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6).
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GC64418
GAL-021 sulfate
GAL-021 sulfate is a potent BKCa-channel blocker.