Home >> Signaling Pathways >> Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel

  1. Cat.No. Product Name Information
  2. GC68476 (S)-Nicardipine (S)-Nicardipine  Chemical Structure
  3. GC68475 (R)-Nicardipine (R)-Nicardipine  Chemical Structure
  4. GC68438 AMPA receptor modulator-3 AMPA receptor modulator-3  Chemical Structure
  5. GC68425 Ranolazine-d3 Ranolazine-d3  Chemical Structure
  6. GC68397 Galicaftor Galicaftor  Chemical Structure
  7. GC68282 CFTR corrector 8 CFTR corrector 8  Chemical Structure
  8. GC68080 4-(Phenyldiazenyl)benzoic acid 4-(Phenyldiazenyl)benzoic acid  Chemical Structure
  9. GC68015 NJH-2-057 NJH-2-057  Chemical Structure
  10. GC68011 PF-06761281 PF-06761281  Chemical Structure
  11. GC68002 TRPM4-IN-2 TRPM4-IN-2  Chemical Structure
  12. GC67996 TPA-023B TPA-023B  Chemical Structure
  13. GC67949 GNE-0439 GNE-0439  Chemical Structure
  14. GC67939 CFTR corrector 4 CFTR corrector 4  Chemical Structure
  15. GC67925 Crinecerfont hydrochloride Crinecerfont hydrochloride  Chemical Structure
  16. GC67924 Dihydrocapsiate Dihydrocapsiate  Chemical Structure
  17. GC67922 Zelquistinel Zelquistinel  Chemical Structure
  18. GC67920 WS-898 WS-898  Chemical Structure
  19. GC67895 EVT-401 EVT-401  Chemical Structure
  20. GC67871 SSR504734 SSR504734  Chemical Structure
  21. GC67799 PF-05198007 PF-05198007  Chemical Structure
  22. GC67789 SRI-37240 SRI-37240  Chemical Structure
  23. GC67784 ML-SI3 ML-SI3  Chemical Structure
  24. GC67767 (R)-Olacaftor (R)-Olacaftor  Chemical Structure
  25. GC67747 Dalazatide TFA Dalazatide TFA  Chemical Structure
  26. GC67739 D-erythro-Sphingosine hydrochloride D-erythro-Sphingosine hydrochloride  Chemical Structure
  27. GC52503 FTase Inhibitor II (trifluoroacetate salt) A potent, selective inhibitor of farnesyltransferase FTase Inhibitor II (trifluoroacetate salt)  Chemical Structure
  28. GC52466 ICR-1 (potassium salt) A cell-impermeable fluorescent calcium indicator ICR-1 (potassium salt)  Chemical Structure
  29. GC52465 ICR-1 AM A cell-permeable fluorescent calcium indicator ICR-1 AM  Chemical Structure
  30. GC52250 Mevalonate (lithium salt) An intermediate in the mevalonate pathway Mevalonate (lithium salt)  Chemical Structure
  31. GC66843 L-Homocysteic acid L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders. L-Homocysteic acid  Chemical Structure
  32. GC66836 Dimethyl L-glutamate Dimethyl L-glutamate (Dimethyl glutamate), a membrane-permeable analog of Glutamate, can stimulate insulin release induced by Glucose. Dimethyl L-glutamate suppresses the KATP channel activities. Dimethyl L-glutamate inhibits E. gracilis growth and causes abnormal cell division. Dimethyl L-glutamate can be used in the research of diabetes, glucose transport, phosphorylation, and further metabolism. Dimethyl L-glutamate  Chemical Structure
  33. GC66470 SW157765 SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs. SW157765  Chemical Structure
  34. GC66436 FEMA 4809 FEMA 4809 is a TRPM8 receptor agonist (EC50=0.2 nM) for use as a cooling agent. TRPM8 is the ion channel responsible for the cool perception. FEMA 4809  Chemical Structure
  35. GC66419 (R)-Lercanidipine-d3 hydrochloride (R)-lercanidipine D3 (hydrochloride) is a deuterium labeled (R)-Lercanidipine hydrochloride. (R)-Lercanidipine D3 (hydrochloride), the R-enantiomer of Lercanidipine, is a calcium channel blocker. (R)-Lercanidipine-d3 hydrochloride  Chemical Structure
  36. GC66255 (E)-3,4,5-Trimethoxycinnamic acid (E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy. (E)-3,4,5-Trimethoxycinnamic acid  Chemical Structure
  37. GC66240 Lei-Dab7 TFA Lei-Dab7 TFA is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro. Lei-Dab7 TFA  Chemical Structure
  38. GC66073 Flupyradifurone Flupyradifurone is a systemic nAChR agonist that interferes with signal transduction in the central nervous system of sucking pests. Flupyradifurone can be used as a butenolide insecticide. Flupyradifurone  Chemical Structure
  39. GC66038 PF-06649298 PF-06649298 is a sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor. PF-06649298 specifically interacts with NaCT with an IC50 value of 16.2 μM to inhibits the transport of citrate in human hepatocytes. PF-06649298 can be used for the research of regulating glucose metabolism and lipid metabolism. PF-06649298  Chemical Structure
  40. GC66016 Evifacotrep Evifacotrep, a short transient receptor potential channel 5 (TRPC5) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. Evifacotrep  Chemical Structure
  41. GC65999 piCRAC-1 piCRAC-1 is a potent, photoinducible Ca2+ release-activated Ca2+ (CRAC) channel inhibitor. piCRAC-1 alleviates thrombocytopenia and hemorrhage. piCRAC-1  Chemical Structure
  42. GC65959 CaV1.3 antagonist-1 CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research. CaV1.3 antagonist-1  Chemical Structure
  43. GC65954 Plazinemdor Plazinemdor is a N-methyl-D-aspartate(NMDA) receptor positive allosteric modulator. Plazinemdor can be uses in the research of psychiatric, neurological, and neurodevelopmental disorders, as well as diseases of the nervous system.. Plazinemdor  Chemical Structure
  44. GC65940 Zandatrigine Zandatrigine (NBI-921352) is a sodium channel protein type 8 subunit alpha (Scn8α) blocker. Zandatrigine  Chemical Structure
  45. GC65611 AMG 333 AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM. AMG 333  Chemical Structure
  46. GC65593 6-Benzoylheteratisine 6-Benzoylheteratisine is a naturally occurring antagonist of the Na+ channel activator aconitine. 6-Benzoylheteratisine  Chemical Structure
  47. GC65536 TRPV4 agonist-1 TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay. TRPV4 agonist-1  Chemical Structure
  48. GC65531 Hardwickiic acid Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels. Hardwickiic acid  Chemical Structure
  49. GC65513 Radequinil Radequinil (AC-3933) is a benzodiazepine receptor (BzR) partial inverse agonist. Radequinil  Chemical Structure
  50. GC65416 Flecainide Flecainide is a potent and orally active antiarrhythmic agent. Flecainide  Chemical Structure
  51. GC65406 T16A(inh)-C01 T16A(inh)-C01 is an inhibitor of TMEM16A (ANO1). T16A(inh)-C01  Chemical Structure
  52. GC65385 Ganoderenic acid B Ganoderenic acid B is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderenic acid B exhibits potent reversal effect on ABCB1-mediated multidrug resistance of HepG2/ADM cells to Doxorubicin. Ganoderenic acid B  Chemical Structure
  53. GC65377 Abeprazan hydrochloride Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride  Chemical Structure
  54. GC65362 URAT1 inhibitor 1 URAT1 inhibitor 1 (1g) is a uric acid transporter 1 (URAT1) inhibitor, with an IC50 of 32 nM. URAT1 inhibitor 1  Chemical Structure
  55. GC65320 Nav1.7-IN-3 Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Nav1.7-IN-3  Chemical Structure
  56. GC65319 GlyT1 Inhibitor 1 GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC50 of 38 nM for rGlyT1. GlyT1 Inhibitor 1  Chemical Structure
  57. GC65292 Lotilaner Lotilaner is a parasiticide, acts as a potent non-competitive antagonist of insects GABACl receptors, with an IC50 of 23.84 nM for Drosophila melanogaster GABA receptor. Lotilaner  Chemical Structure
  58. GC65280 RU-TRAAK-2 RU-TRAAK-2 is a completely reversible TRAAK (TWIK-related arachidonic acid-stimulated K+ channel) inhibitor. RU-TRAAK-2  Chemical Structure
  59. GC65272 APETx2 TFA APETx2 TFA, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC50 of 63 nM. APETx2 TFA  Chemical Structure
  60. GC65248 Etripamil Etripamil (MSP-2017) is a short-acting L-type calcium-channel antagonist, can be used for the research of Paroxysmal Supraventricular Tachycardia (PSVT). Etripamil  Chemical Structure
  61. GC65231 N-Bromoacetamide N-Bromoacetamide can irreversibly remove sodium channel inactivation in the cytoplasmic face of the membrane, also decreasing K current rapid inactivation. N-Bromoacetamide  Chemical Structure
  62. GC65211 Umbellulone Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone  Chemical Structure
  63. GC65184 YS-370 YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity. YS-370  Chemical Structure
  64. GC65183 P-gp inhibitor 1 P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance. P-gp inhibitor 1  Chemical Structure
  65. GC65150 Flecainide hydrochloride Flecainide hydrochloride is a potent and orally active antiarrhythmic agent. Flecainide hydrochloride  Chemical Structure
  66. GC65125 VU0529331 VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 ?M and 5.2 ?M for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel. VU0529331  Chemical Structure
  67. GC65106 Pregnenolone-d4-1 Pregnenolone-d4-1  Chemical Structure
  68. GC65095 L-Glutamic acid-d5 L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid. L-Glutamic acid-d5  Chemical Structure
  69. GC65081 CALP1 TFA CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 ?M) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 TFA  Chemical Structure
  70. GC65078 YM-244769 dihydrochloride YM-244769 dihydrochloride is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 dihydrochloride  Chemical Structure
  71. GC65057 Propofol-d18 Propofol-d18 is the deuterium labeled Propofol. Propofol-d18  Chemical Structure
  72. GC65050 L-Phenylalanine-d2 L-Phenylalanine-d2  Chemical Structure
  73. GC65029 CFTR corrector 9 CFTR corrector 9 (compound 42) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator. CFTR corrector 9  Chemical Structure
  74. GC65006 JNc-440 JNc-440 is a potent antihypertensive agent. JNc-440  Chemical Structure
  75. GC64965 ICA-105665 ICA-105665 (PF-04895162) is a potent and orally active neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels opener. ICA-105665  Chemical Structure
  76. GC64929 Pesampator Pesampator (PF-04958242) is a potent and highly selective positive allosteric modulator of AMPA receptor (an AMPA potentiator) with an EC50 of 310 nM and a Ki of 170 nM. Pesampator  Chemical Structure
  77. GC64925 Cibenzoline Cibenzoline is a potent inhibitor of KATP channel with directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline  Chemical Structure
  78. GC64899 ω-Conotoxin MVIIC TFA ω-Conotoxin MVIIC TFA  Chemical Structure
  79. GC64887 Gitoxin Gitoxin, a Na+/K+-ATPase inhibitor, usually appears as a result of metabolic degradation of Digitoxin, is just the hydroxyl (ZOH) group close to the C-17β position, which changes the pharmacokinetics and pharmacodynamics of these substances considerably. Gitoxin  Chemical Structure
  80. GC64876 GLUT inhibitor-1 GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1  Chemical Structure
  81. GC64870 Nicardipine-d3 hydrochloride Nicardipine D3 hydrochloride (YC-93 D3) is the deuterium labeled Nicardipine hydrochloride. Nicardipine-d3 hydrochloride  Chemical Structure
  82. GC64863 Dendrotoxin K Dendrotoxin K is a Kv1.1 channel blocker. Dendrotoxin K  Chemical Structure
  83. GC64852 Tivanisiran Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran  Chemical Structure
  84. GC64822 JNJ-42253432 JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9.1 and 7.9 for rat and human P2X7 channels, respectively. JNJ-42253432  Chemical Structure
  85. GC64806 HN37 HN37 as a potent and chemically stable antiepileptic drug candidate, with an EC50 of 37 nM for KCNQ2. HN37  Chemical Structure
  86. GC64735 (S)-(-)-Levamisole (S)-(-)-Levamisole (Levamisole), an anthelmintic agent with immunomodulatory properties. (S)-(-)-Levamisole  Chemical Structure
  87. GC64719 KCNQ1 activator-1 KCNQ1 activator-1 (compound 3) is a potent activator of KCNQ1 channel. KCNQ1 activator-1  Chemical Structure
  88. GC64691 RY796 RY796 is a potent and selective voltage-gated potassium (KV2) channel inhibitor with IC50s of 0.25 μM and 0.09 μM for KV2.1 and KV2.2. RY796  Chemical Structure
  89. GC64690 Opiranserin hydrochloride Opiranserin (VVZ-149) hydrochloride, a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin hydrochloride  Chemical Structure
  90. GC64678 K41498 TFA K41498 TFA is a potent and highly selective CRF2?receptor antagonist with Ki?values of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β?and CRF1 receptors respectively. K41498 TFA  Chemical Structure
  91. GC64673 Etbicyphat Etbicyphat (Trimethylopropane phosphate) is a potent GABA(A) receptors competitive antagonist. Etbicyphat  Chemical Structure
  92. GC64658 Bliretrigine Bliretrigine is a sodium channel blocker. Bliretrigine  Chemical Structure
  93. GC64650 TAK-653 TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats. TAK-653  Chemical Structure
  94. GC64574 BZAD-01 BZAD-01 is a potent, selective and orally active inhibitor of NMDA NR2B subunit, with a Ki of 72 nM. BZAD-01  Chemical Structure
  95. GC64573 PF-04745637 PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1. PF-04745637  Chemical Structure
  96. GC64568 DRB18 DRB18 is a potent pan-class GLUT inhibitor. DRB18 alters energy-related metabolism in A549 cells by changing the abundance of metabolites in glucose-related pathways. DRB18 can eventually lead to G1/S phase arrest and increase oxidative stress and necrotic cell death. DRB18 has anti-tumor activity. DRB18  Chemical Structure
  97. GC64521 NMDAR/TRPM4-IN-2 free base NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base  Chemical Structure
  98. GC64508 γ-Aminobutyric acid-d6 γ-Aminobutyric acid-d6  Chemical Structure
  99. GC64459 Englerin A Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload. Englerin A  Chemical Structure
  100. GC64448 Guanfu base A Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A  Chemical Structure
  101. GC64418 GAL-021 sulfate GAL-021 sulfate is a potent BKCa-channel blocker. GAL-021 sulfate  Chemical Structure

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