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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel

Products for  Membrane Transporter/Ion Channel

  1. Cat.No. Product Name Information
  2. GC72133 &#181-Conotoxin-CnIIIC acetate µ-Conotoxin-CnIIIC acetate, a 22-residue conopeptide, is a potent antagonist of the voltage-gated NaV1.4 sodium channel with an IC50 of 1.3 nM acting at the neuromuscular junction. µ-Conotoxin-CnIIIC acetate Chemical Structure
  3. GC49097 α-Conotoxin AuIB (trifluoroacetate salt)

    GCCSYPPCFATNPDC

     A conotoxin and an antagonist of α3β4 subunit-containing nAChRs α-Conotoxin AuIB (trifluoroacetate salt) Chemical Structure
  4. GC49140 α-Conotoxin ImI (trifluoroacetate salt)

    α-CTx ImI, GCCSDPRCAWRC

     A conotoxin and an antagonist of α7 nAChRs α-Conotoxin ImI (trifluoroacetate salt) Chemical Structure
  5. GC63269 α-Conotoxin PIA TFA α-Conotoxin PIA TFA Chemical Structure
  6. GC63723 α-Conotoxin PnIA TFA α-Conotoxin PnIA TFA Chemical Structure
  7. GC10873 α-Spinasterol

    Bessisterol, Hitodesterol

     TRPV1 antagonist α-Spinasterol Chemical Structure
  8. GC70179 α7 Nicotinic receptor agonist-1

    Alpha-7 Nicotinic receptor agonist-1 (Preparation 5) is an alpha-7 nAChR agonist. It can be used for research on psychiatric disorders such as schizophrenia, mania or bipolar disorder, and anxiety disorders, as well as intellectual disabilities such as Alzheimer's disease, learning deficits, cognitive impairments, attention deficits, memory loss, Lewy body dementia and attention deficit hyperactivity disorder.

     α7 Nicotinic receptor agonist-1 Chemical Structure
  9. GC72246 αC-Conotoxin PrXA αC-Conotoxin PrXA is a paralytic peptide neurotoxin and a competitive nAChR antagonist, with IC50s of 1.8 nM (α1β1εδ, adult) and 3.0 nM (α1β1γδ, fetal), respectively. αC-Conotoxin PrXA Chemical Structure
  10. GC48998 β-Defensin-1 (human) (trifluoroacetate salt)

    hBD-1

     An antimicrobial peptide β-Defensin-1 (human) (trifluoroacetate salt) Chemical Structure
  11. GC70650 γ-Acetylenic GABA hydrochloride γ-Acetylenic GABA (GAG) hydrochloride is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA hydrochloride Chemical Structure
  12. GC38010 γ-Aminobutyric acid γ-Aminobutyric acid Chemical Structure
  13. GC64508 γ-Aminobutyric acid-d6

    γ-Aminobutyric acid-d6 (4-Aminobutyric acid-d6) is the deuterium labeled γ-Aminobutyric acid.

     γ-Aminobutyric acid-d6 Chemical Structure
  14. GC48313 γ-Lindane An insecticide and GABAA receptor antagonist γ-Lindane Chemical Structure
  15. GC15513 ω-Agatoxin IVA ω-Agatoxin IVA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker with IC50s of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. ω-Agatoxin IVA Chemical Structure
  16. GC12608 ω-Agatoxin TK ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca2+ channel blocker. ω-Agatoxin TK Chemical Structure
  17. GC13886 ω-Conotoxin GVIA ω-Conotoxin GVIA is a cone snail toxin that selectively blocks N-type channels in neurons . ω-Conotoxin GVIA Chemical Structure
  18. GC18070 ω-Conotoxin MVIIC wide spectrum blocker of N, P and Q type calcium channels ω-Conotoxin MVIIC Chemical Structure
  19. GC31248 β-Amino Acid Imagabalin Hydrochloride (PD-0332334)

    PD-0332334

     β-Amino Acid Imagabalin Hydrochloride (PD-0332334) (PD-0332334) is a ligand for the α2δ subunit of the voltage-dependent calcium channel. β-Amino Acid Imagabalin Hydrochloride (PD-0332334) Chemical Structure
  20. GC11449 β-CCB

    benzodiazepine receptor ligand

     β-CCB Chemical Structure
  21. GC18033 γDGG γDGG is a competitive AMPA receptor blocker. γDGG Chemical Structure
  22. GC70188 ω-Agatoxin IVA TFA

    ω-Agatoxin IVA TFA is an effective selective blocker of P/Q-type Ca2+ (Cav2.1) channels, with IC50 values of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. ω-Agatoxin IVA TFA (IC50, 30-225 nM) inhibits high potassium-induced glutamate release and calcium influx. It also blocks the release of serotonin and adrenaline induced by high potassium, without affecting L-type or N-type calcium channels.

     ω-Agatoxin IVA TFA Chemical Structure
  23. GC62067 ω-Conotoxin GVIA TFA ω-Conotoxin GVIA TFA Chemical Structure
  24. GA24016 ω-Conotoxin MVIIA ω-Conotoxin MVIIA (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. ω-Conotoxin MVIIA Chemical Structure
  25. GC64899 ω-Conotoxin MVIIC TFA ω-Conotoxin MVIIC TFA Chemical Structure
  26. GC49296 τ-Fluvalinate

    tau-Fluvalinate

     A pyrethroid acaricide τ-Fluvalinate Chemical Structure
  27. GC10237 (±)-1-(1,2-Diphenylethyl)piperidine maleate NMDA receptor antagonist (±)-1-(1,2-Diphenylethyl)piperidine maleate Chemical Structure
  28. GC72625 (±)-Coniine hydrochloride (±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride Chemical Structure
  29. GC14410 (±)-Epibatidine

    CMI 545

     nicotinic agonist (±)-Epibatidine Chemical Structure
  30. GC11138 (±)-HIP-A excitatory amino acid transporter (EAAT) blocker (±)-HIP-A Chemical Structure
  31. GC13735 (±)-HIP-B

    excitatory amino acid transporter (EAAT) blocker

     (±)-HIP-B Chemical Structure
  32. GC45985 (±)-Indoxacarb

    DPX-JW062, DPX-MP062

     A broad-spectrum insecticide (±)-Indoxacarb Chemical Structure
  33. GC14834 (±)-Nipecotic acid

    (±)-Nipecotic Acid, (R,S)-Nipecotic Acid, 3-Piperidine Carboxylic Acid, DL-Piperidine 3-Carboxylic Acid

     GABA uptake inhibitor (±)-Nipecotic acid Chemical Structure
  34. GC41676 (±)-Nornicotine

    DL-Nornicotine, (R,S)-Nornicotine

     (±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. (±)-Nornicotine Chemical Structure
  35. GC49482 (±)-Nornicotine-d4

    DL-Nornicotine-d4, (R,S)-Nornicotine-d4

     An internal standard for the quantification of (±)-nornicotine (±)-Nornicotine-d4 Chemical Structure
  36. GC41677 (±)-SDZ-201 106

    DPI 201-106

     (±)-SDZ-201 106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. (±)-SDZ-201 106 Chemical Structure
  37. GC11982 (±)-threo-3-Methylglutamic acid glutamate transport blocker (±)-threo-3-Methylglutamic acid Chemical Structure
  38. GC40466 (±)11(12)-EET

    (±)11,12-EpETrE

    (±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.

     (±)11(12)-EET Chemical Structure
  39. GC40434 (±)16-HETE

    (±)16-Hydroxyeicosatetraenoic Acid

     Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE Chemical Structure
  40. GC40270 (±)5(6)-DiHET

    (±)5,6-DiHETrE

    5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases.

     (±)5(6)-DiHET Chemical Structure
  41. GC40438 (±)5(6)-EET

    (±)5,6EpETrE

     5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. (±)5(6)-EET Chemical Structure
  42. GN10612 (+)- Praeruptorin C (+)- Praeruptorin C Chemical Structure
  43. GC34954 (+)-Borneol

    D-Borneol, (1R)-(+)-Borneol, (+)-endo-Borneol

     (+)-Borneol Chemical Structure
  44. GC30933 (+)-Kavain

    Kawain, NSC 112162

    An Analytical Reference Standard

     (+)-Kavain Chemical Structure
  45. GC40808 (+)-Menthol

    D-Menthol

     (+)-Menthol is a monoterpene alcohol that has been found in Cannabis and has antifungal activity. (+)-Menthol Chemical Structure
  46. GC16616 (+)-MK 801

    Dizocilpine maleate;Dizocilpine hydrogen maleate;(+)-MK 801;MK 801

     (+)-MK 801 Chemical Structure
  47. GC11025 (+)-MK 801 Maleate

    Dizocilpine Maleate

     (+)-MK 801 Maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes. (+)-MK 801 Maleate Chemical Structure
  48. GC32130 (+)-SJ733 (SJ000557733)

    SJ000557733

     (+)-SJ733 (SJ000557733) is an anti-malaria agent which can also inhibit Na+-ATPase PfATP4. (+)-SJ733 (SJ000557733) Chemical Structure
  49. GC34959 (+)-Sparteine

    Pachycarpin, Pachycarpine

     (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine Chemical Structure
  50. GC38677 (-)-α-Pinene

    NSC 7727

     (-)-α-Pinene is a monoterpene and shows sleep enhancing property through a direct binding to GABAA-benzodiazepine (BZD) receptors by acting as a partial modulator at the BZD binding site. (-)-α-Pinene Chemical Structure
  51. GC31084 (-)-(S)-B-973B (-)-(S)-B-973B Chemical Structure
  52. GC10065 (-)-Bicuculline methiodide GABAA receptor antagonist (-)-Bicuculline methiodide Chemical Structure
  53. GC16857 (-)-Bicuculline methobromide (-)-Bicuculline methobromide Chemical Structure
  54. GC15636 (-)-Bicuculline methochloride (-)-Bicuculline methochloride Chemical Structure
  55. GC13430 (-)-Blebbistatin

    (S)Blebbistatin

     (-)-Blebbistatin is one of the configurations of the racemic mixture (±)-Blebbistatin (Cat. No. GC12341) and is the active form. (-)-Blebbistatin is a cell-permeable inhibitor of non-muscle myosin II ATPase, which effectively inhibits multiple striated muscle myosins as well as vertebrate non-muscle myosins with IC50 values ranging from 0.5-5μM, and only slightly inhibits smooth muscle myosin (IC50=80μM) . (-)-Blebbistatin Chemical Structure
  56. GC63940 (-)-Denudatin B (-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B Chemical Structure
  57. GC14157 (-)-Lobeline hydrochloride

    (–)-α-Lobeline, VUF 10751

     nicotinic receptor partial agonist (-)-Lobeline hydrochloride Chemical Structure
  58. GC34951 (-)-Menthol

    L-Menthol, (1R,2S,5R)-(-)-Menthol, NSC 62788

     A monoterpene with diverse biological activities (-)-Menthol Chemical Structure
  59. GC15270 (-)-MK 801

    (-)-Dizocilpine Maleate

     (-)-MK 801 ((-)-MK-801 maleate) is a less active (-)-enantiomer of Dizocilpine. (-)-MK 801 Chemical Structure
  60. GN10445 (-)-pareruptorin A (-)-pareruptorin A Chemical Structure
  61. GC30889 (-)-Securinine

    NSC 107413, L-Securinine

     An alkaloid (-)-Securinine Chemical Structure
  62. GC34952 (-)-Sparteine sulfate pentahydrate (-)-Sparteine sulfate pentahydrate Chemical Structure
  63. GC14484 (-)-Xestospongin C

    XeC, Araguspongine E

    IP3-dependent Ca2+ release inhibitor

     (-)-Xestospongin C Chemical Structure
  64. GC14044 (-)-[3R,4S]-Chromanol 293B (-)-[3R,4S]-Chromanol 293B is a potent and selective inhibitor of the slow component of delayed rectifier K+ current (IKs). (-)-[3R,4S]-Chromanol 293B Chemical Structure
  65. GC64062 (1R,2R)-ML-SI3

    (1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 (IC50 values of 1.6 and 2.3 μM) and a weak inhibitor (IC50 12.5 μM) of TRPML3.

     (1R,2R)-ML-SI3 Chemical Structure
  66. GC16915 (2R,3S)-Chlorpheg NMDA receptor antagonist (2R,3S)-Chlorpheg Chemical Structure
  67. GC50536 (2R/S)-6-PNG

    (±)-6-PN

     CaV3.2 blocker; active in vivo (2R/S)-6-PNG Chemical Structure
  68. GC66255 (E)-3,4,5-Trimethoxycinnamic acid

    TMCA

     (E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy. (E)-3,4,5-Trimethoxycinnamic acid Chemical Structure
  69. GC62560 (E/Z)-Sivopixant

    (E/Z)-S-600918

     (E/Z)-Sivopixant ((E/Z)-S-600918) is a potent P2X3 receptor antagonist with an IC50 of 4 nM. (E/Z)-Sivopixant Chemical Structure
  70. GC13895 (R)-(+)-Bay K 8644

    NI 105, R 4407

     L-type Ca2+-channel blocker (R)-(+)-Bay K 8644 Chemical Structure
  71. GC14085 (R)-(+)-HA-966 NMDA receptor antagonist/partial agonist (R)-(+)-HA-966 Chemical Structure
  72. GC40696 (R)-(+)-Pulegone

    NSC 15334, D-Pulegone

     (R)-(+)-Pulegone, the major chemical constituent of Calamintha nepeta (L. (R)-(+)-Pulegone Chemical Structure
  73. GC10168 (R)-4-Carboxyphenylglycine NMDA receptor antagonist (R)-4-Carboxyphenylglycine Chemical Structure
  74. GC11071 (R)-AMPA inactive enantiomer of AMPA (R)-AMPA Chemical Structure
  75. GC14111 (R)-baclofen GABA receptor agonist (R)-baclofen Chemical Structure
  76. GC34986 (R)-Baclofen hydrochloride

    (R)-Baclofen

     (R)-Baclofen hydrochloride (Arbaclofen hydrochloride) is a selective GABAB receptor agonist. (R)-Baclofen hydrochloride Chemical Structure
  77. GC31665 (R)-BPO-27 (R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR?inhibitor with an?IC50 of 4 nM. (R)-BPO-27 Chemical Structure
  78. GC14236 (R)-CPP NMDA antagonist (R)-CPP Chemical Structure
  79. GC69812 (R)-Elexacaftor

    (R)-VX-445

    (R)-Elexacaftor is the enantiomer of Elexacaftor (Compound 1) and comes from Compound 37 in patent WO2018107100A1. It is a corrector of cystic fibrosis transmembrane conductance regulator (CFTR), with an EC50 value of 0.29 uM for CFTR dF508.

     (R)-Elexacaftor Chemical Structure
  80. GC62739 (R)-Funapide

    (R)-TV 45070; (R)-XEN402

     (R)-Funapide ((R)-TV 45070) is the less active R-enantiomer of Funapide. (R)-Funapide Chemical Structure
  81. GC61847 (R)-Lanicemine (R)-Lanicemine ((R)-AZD6765) is the less active R-enantiomer of Lanicemine. (R)-Lanicemine Chemical Structure
  82. GC66419 (R)-Lercanidipine-d3 hydrochloride (R)-lercanidipine D3 (hydrochloride) is a deuterium labeled (R)-Lercanidipine hydrochloride. (R)-Lercanidipine D3 (hydrochloride), the R-enantiomer of Lercanidipine, is a calcium channel blocker. (R)-Lercanidipine-d3 hydrochloride Chemical Structure
  83. GC68475 (R)-Nicardipine

    (R)-YC-93 free base

     (R)-Nicardipine Chemical Structure
  84. GC41719 (R)-nitro-Blebbistatin

    R(-)7Desmethyl8nitro Blebbistatin

     (R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin, which is the inactive form of (-)-blebbistatin. (R)-nitro-Blebbistatin Chemical Structure
  85. GC67767 (R)-Olacaftor

    (R)-VX-440

     (R)-Olacaftor Chemical Structure
  86. GC62513 (R)-Posenacaftor sodium

    (R)-PTI-801 sodium

     (R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. (R)-Posenacaftor sodium Chemical Structure
  87. GC69839 (R)-Tegoprazan

    (R)-CJ-12420; (R)-RQ-00000004

    (R)-Tegoprazan ((R)-CJ-12420; example 3) is a benzimidazole derivative and an effective inhibitor of gastric H+/K+-ATPase. Its IC50 for canine kidney Na+/K+-ATPase is 98 nM. (R)-Tegoprazan has potential in the research of gastrointestinal diseases.

     (R)-Tegoprazan Chemical Structure
  88. GC70934 (R)-Vanzacaftor (R)-Vanzacaftor ((R)-VX-121) is a regulator of cystic fibrosis transmembrane conduction regulator (CFTR). (R)-Vanzacaftor Chemical Structure
  89. GC60407 (R)-Verapamil D7 hydrochloride

    (R)-(+)-Verapamil D7 hydrochloride

     (R)-Verapamil D7 hydrochloride ((R)-(+)-Verapamil D7 hydrochloride) is a deuterium labeled (R)-Verapamil hydrochloride. (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer drugs. (R)-Verapamil D7 hydrochloride Chemical Structure
  90. GC60408 (R)-Verapamil hydrochloride (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer drugs. (R)-Verapamil hydrochloride Chemical Structure
  91. GC70292 (Rac)-AMG8379 (Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. (Rac)-AMG8379 Chemical Structure
  92. GC63511 (Rac)-CP-601927 hydrochloride (Rac)-CP-601927 hydrochloride is the racemate of CP-601927. (Rac)-CP-601927 hydrochloride Chemical Structure
  93. GC61446 (Rac)-Lanicemine (Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. (Rac)-Lanicemine Chemical Structure
  94. GC61873 (Rac)-MEM 1003 (Rac)-MEM 1003 is the racemate of MEM 1003. (Rac)-MEM 1003 Chemical Structure
  95. GC60413 (Rac)-NMDAR antagonist 1 (Rac)-NMDAR antagonist 1 is the racemate of NMDAR antagonist 1. (Rac)-NMDAR antagonist 1 Chemical Structure
  96. GC12488 (RS)-(Tetrazol-5-yl)glycine

    Tet-Glycine, LY285265, DL-(Tetrazol-5-yl)glycine

     NMDA receptor agonist (RS)-(Tetrazol-5-yl)glycine Chemical Structure
  97. GC13631 (RS)-AMPA AMPA agonist (RS)-AMPA Chemical Structure
  98. GC13032 (RS)-AMPA hydrobromide AMPAR agonist (RS)-AMPA hydrobromide Chemical Structure
  99. GC62746 (RS)-AMPA monohydrate

    (±)-AMPA monohydrate

     (RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA monohydrate Chemical Structure
  100. GC10476 (RS)-CPP NMDA antagonist (RS)-CPP Chemical Structure
  101. GC11889 (S)-(-)-5-Fluorowillardiine AMPA receptor agonist (S)-(-)-5-Fluorowillardiine Chemical Structure

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