NS19504 |
| Catalog No.GC38826 |
NS19504 is a Ca2+-activated K+ channel (BK channel, KCa1.1 channel) activator (EC50=11.0 ?M) with relaxing effect on bladder smooth muscle spontaneous phasic contractions.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 327062-46-4
Sample solution is provided at 25 µL, 10mM.
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NS19504 is a Ca2+-activated K+ channel (BK channel, KCa1.1 channel) activator (EC50=11.0 µM) with relaxing effect on bladder smooth muscle spontaneous phasic contractions[1].
NS19504 increases BK currents in freshly isolated guinea pig bladder smooth muscle cells and whole-cell. NS19504 increases the whole-cell currents response to 127 %, 194 %, 258 %, 561 % of control at a concentration of 0.32 µM, 1.0 µM, 3.2 µM and 10 µM, respectively[1].
[1]. Nausch B, et al. NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J Pharmacol Exp Ther. 2014 Sep;350(3):520-30.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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