GLPBio

NT-0249 free base

Catalog No.: GC73942
COASDSData Sheet
NT-0249 free base is an orally active NLRP3 inhibitor.

Products are for research use only. Not for human use. We do not sell to patients.

NT-0249 free base
1 mgIn Stock
$117.00
1
5 mgIn Stock
$252.00
1
10 mgIn Stock
$405.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

NT-0249 free base is an orally active NLRP3 inhibitor. NT-0249 has anti-inflammatory activity.

NT-0249 (100 mg/kg, orally, 3 times a day for 28 days) reduces systemic inflammation and astrocyte formation in mice in a pre-established obesity state[1].

References:
[1]. Thornton P, et al. Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796. J Pharmacol Exp Ther. 2024;388(3):813-826. Published 2024 Feb 15.

Product Documents

Appearance:A solid
COASDSData Sheet

Chemical Properties

Molecular Formula
C22H29N5O4S
Molecular Weight
459.56
Solubility
DMSO : 100 mg/mL (217.60 mM; Need ultrasonic)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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