NAE

NAE (NEDD8-activating enzyme) catalyzes the initial step of the neddylation signaling that regulates CRLs (cullin-ring ubiquitin ligases) activities. Its downstream effect is linked to cancer cell growth and survival.

Products Related to NAE(2)

GC15086 MLN4924
CAS: 905579-51-3
Purity: >98.00%
MLN4924 is a potent and selective small-molecule inhibitor of NEDD8-activating enzyme (NAE) (IC50 = 4 nM), and is selective relative to the closely related enzymes UAE, SAE, UBA6 and ATG7 (IC50 = 1.5, 8.2, 1.8 and >10 µM, respectively).
GC12175 MLN4924 HCl salt
CAS: 1160295-21-5
Purity: >98.00%
A selective inhibitor of NEDD8-activating enzyme

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC15086	MLN4924	905579-51-3	>98.00%
GC15086	MLN4924 is a potent and selective small-molecule inhibitor of NEDD8-activating enzyme (NAE) (IC50 = 4 nM), and is selective relative to the closely related enzymes UAE, SAE, UBA6 and ATG7 (IC50 = 1.5, 8.2, 1.8 and >10 µM, respectively).
GC12175	MLN4924 HCl salt	1160295-21-5	>98.00%
GC12175	A selective inhibitor of NEDD8-activating enzyme