GLPBio

PF-07284892

Catalog No.: GC73482Purity:>99.00%Synonyms: ARRY-558
COASDSData Sheet
PF-07284892 (ARRY-558) is a potent and orally active SHP2 inhibitor with an IC50 value of 21 nM.

Products are for research use only. Not for human use. We do not sell to patients.

PF-07284892
Cas No.: 2498597-94-5
10mM (in 1mL DMSO)In Stock
$178.00
1
5 mgIn Stock
$162.00
1
10 mgIn Stock
$225.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    641, 529–536 (2025)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    35, 97–116 (2025)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

PF-07284892 (ARRY-558) is a potent and orally active SHP2 inhibitor with an IC50 value of 21 nM. PF-07284892 decreases the expression of pERK.

PF-07284892 (100 nM; 4, 18 h) combines with lorlatinib (0-450 nM), binimetinib (0-160 nM) decreases the expression of pERK in H3122 lorR-06, VACO-432 cells[2].

PF-07284892 (10 mg/kg; p.o.) shows good oral bioavailability with F% of 85%, 94%, 102%, 64% for mouse, rat, dog, monkey, respectively[2].

References:
[1]. Abdayem P, et al. Ongoing progress in BRAF-mutated non-small cell lung cancer. Clin Adv Hematol Oncol. 2022 Nov;20(11):662-672.
[2]. Drilon A, et al. SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy. Cancer Discov. 2023 Jun 3:OF1-OF13.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2498597-94-5
Synonyms
ARRY-558
Molecular Formula
C21H22ClN7S
Molecular Weight
439.96
Solubility
DMSO : 100 mg/mL (227.29 mM; Need ultrasonic)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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