GLPBio

PGE synthase

Prostagladin E synthase catalzyes the oxidoreduction of PGHS (prostaglandin endoperoxde h2) into PGE2(prostaglandin E2). It is implicated in physiological conditions such as fever, pain and arthritis etc.

Products Related to PGE synthase(26)

  • GC14438 structure
    GC14438Suprofen
    CAS: 40828-46-4
    Purity: >99.50%

    dual COX-1/COX-2 inhibitor

  • GC16607 structure
    GC16607Mesalamine
    CAS: 89-57-6
    Purity: >98.00%

    5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

  • GC16880 structure
    GC16880Flurbiprofen
    CAS: 5104-49-4
    Purity: >99.50%

    Cyclooxygenase inhibitors

  • GC10564 structure
    GC10564HQL 79
    CAS: 162641-16-9
    Purity: >99.00%

    human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor

  • GC11670 structure
    GC11670Pranoprofen
    CAS: 52549-17-4
    Purity: >98.00%

    non-steroidal COX inhibitor

  • GC11743 structure
    GC11743MF63
    CAS: 892549-43-8
    Purity: >99.00%

    A potent, selective, and orally active mPGES-1 inhibitor

  • GC12330 structure
    GC12330SAR191801
    CAS: 1234708-04-3
    Purity: >99.50%

    SAR191801 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay.

  • GC14633 structure
    GC14633HPGDS inhibitor 1
    CAS: 1033836-12-2
    Purity: >99.00%

    HPGDS inhibitor

  • GC15058 structure
    GC15058Benzydamine HCl
    CAS: 132-69-4
    Purity: >98.00%

    Benzydamine HCl is a topical non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic, antipyretic, and local anesthetic activities.

  • GC17707 structure
    GC17707Bismuth Subsalicylate
    CAS: 14882-18-9
    Purity: >97.00%

    Prostaglandin G/H Synthase 1/2 inhibitor

  • GC18700 structure
    GC18700PF-4693627
    CAS: 1312815-93-2
    Purity: >98.50%

    PF-4693627 is an orally bioavailable inhibitor of microsomal prostaglandin E (PGE) synthase-1 (mPGES-1; IC50 = 3 nM).

  • GC18904 structure
    GC18904CAY10678
    CAS: 1268709-57-4
    Purity: >98.00%

    Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product PGH2 into the biologically active PGE2.

  • GC31687 structure
    GC31687Zomepirac sodium salt (McN-2783-21-98)
    CAS: 64092-48-4
    Purity: >99.00%

    Zomepirac sodium salt (McN-2783-21-98) (McN-2783-21-98) is a potent prostaglandin biosynthesis inhibitor.

  • GC32038 structure
    GC32038PGS-IN-1 (KME-4)
    CAS: 102271-49-8
    Purity: >99.50%

    PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM.

  • GC36254 structure
    GC36254HPGDS inhibitor 2
    CAS: 2101626-26-8
    Purity: >99.50%

    HPGDS inhibitor 2 is a highly potent and selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with an IC50 of 9.9 nM.

  • GC36463 structure
    GC36463Limaprost
    CAS: 74397-12-9
    Purity: >99.50%

    A stable, potent analog of PGE 1

  • GC36649 structure
    GC36649mPGES1-IN-3
    CAS: 1469976-70-2
    Purity: >98%

    mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC50: 8 nM), cell (A549 IC50: 16.24 nM) and human whole blood potency (IC50: 249.9 nM).

  • GC38431 structure
    GC38431Dehydroevodiamine
    CAS: 67909-49-3
    Purity: >98.00%

    Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes.

  • GC38678 structure
    GC38678Ethyl Caffeate
    CAS: 102-37-4
    Purity: >98.50%

    Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa.

  • GC40352 structure
    GC40352Cafestol
    CAS: 469-83-0
    Purity: >98.00%

    Cafestol, one of the major components of coffee, is a coffee-specific diterpene form and an inhibitor of ERK2.

  • GC50101 structure
    GC50101TFC 007
    CAS: 927878-49-7
    Purity: >98%

    Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor

  • GC63394 structure
    GC63394Zaloglanstat
    CAS: 1513852-12-4
    Purity: >98%

    Zaloglanstat (ISC-27864) is the inhibitor of the microsomal prostaglandin E synthase-1 (mPGES-1), and can be used to study asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases, etc.

  • GC70119 structure
    GC70119Vipoglanstat
    CAS: 1360622-01-0
    Purity: >99.00%

    Vipoglanstat (BI 1029539), also known as formylamide, is an effective, selective, non-peptide small molecule inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) with oral activity. Vipoglanstat also has anti-inflammatory activity.

  • GC80415 structure
    GC80415(S)-Flurbiprofen-d 3
    Purity: >98%

    (S)-Flurbiprofen-d3 (Esflurbiprofen-d3) is the deuterium labeled (S)-Flurbiprofen.