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HQL 79 Catalog No.GC10564

human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor

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10mg
$131.00
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50mg
$536.00
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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 162641-16-9 SDF
Chemical Name 1-(3-(2H-tetrazol-5-yl)propyl)-4-(benzhydryloxy)piperidine
Canonical SMILES N1(CCCC2=NNN=N2)CCC(CC1)OC(C3=CC=CC=C3)C4=CC=CC=C4
Formula C22H27N5O M.Wt 377.48
Solubility Soluble in DMSO Storage Store at RT
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

HQL-79 is a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS[1].

HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH[1].

References:
[1]. Aritake K, et al. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86. Epub 2006 Mar 17.