GLPBio

HQL 79

Catalog No.: GC10564Purity:>99.00%
COASDSData Sheet
human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor

Products are for research use only. Not for human use. We do not sell to patients.

HQL 79
Cas No.: 162641-16-9
10mgIn Stock
$133.00
1
50mgIn Stock
$546.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

HQL-79 is a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS[1].

HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH[1].

References:
[1]. Aritake K, et al. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86. Epub 2006 Mar 17.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
162641-16-9
Chemical Name
1-(3-(2H-tetrazol-5-yl)propyl)-4-(benzhydryloxy)piperidine
SMILES
N1(CCCC2=NNN=N2)CCC(CC1)OC(C3=CC=CC=C3)C4=CC=CC=C4
Molecular Formula
C22H27N5O
Molecular Weight
377.48
Solubility
Methanol: 2.5 mg/ml
Storage
Store at RT
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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