GLPBio

PIKfyve

PIKfyve (1-phosphatidylinositol 3-phosphate 5-kinase) catalyzes the production of PtdIns5P and PtdIns(3,5)biphosphate from the phosphorylation o f D-5 position in PtdIns and phosphatidylinositol-3-phosphate. It is involved in endosome carrier vesicle biogenesis in early endosomes and endomembrane homeostasis.

Products Related to PIKfyve(6)

  • GC10982 structure
    GC10982YM201636
    CAS: 371942-69-7
    Purity: >98.00%

    PIKfyve inhibitor,potent and selective

  • GC31661 structure
    GC31661APY0201
    CAS: 1232221-74-7
    Purity: >98.00%

    APY0201 is a potent PIKfyve inhibitor, which inhibits the conversion of PtdIns3P to PtdIns(3,5)P2 in the presence of in the presence of [33P]ATP with an IC50 of 5.2 nM.

  • GC66013 structure
    GC66013MOMIPP
    CAS: 1363421-46-8
    Purity: >98.00%

    MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB).

  • GC69711 structure
    GC69711PIKfyve-IN-1
    CAS: 2857982-26-2
    Purity: >98%

    PIKfyve-IN-1 is an efficient and cell-active chemical probe that can inhibit phosphoinositide 3-phosphate 5-kinase (PIKfyve) with an IC50 value of 6.9 nM. PIKfyve-IN-1 can be used for the study of PIKfyve in virology.

  • GC73606 structure
    GC73606PIK5-12d
    Purity: >99.00%

    PIK5-12d is a PROTAC PIKfyve degrader (DC50: 1.48 nM).

  • GC74025 structure
    GC74025PIKfyve-IN-3
    Purity: >99.00%

    PIKfyve-IN-3 (compound L22) has a remarkable interaction with PIKfyve kinase with a Kd value of 0.47 nM.