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PI3K/Akt/mTOR Signaling

Products for  PI3K/Akt/mTOR Signaling

  1. Cat.No. Product Name Information
  2. GC10350 TIC10 isomer

    Potent Akt/ERK inhibitor

     TIC10 isomer  Chemical Structure
  3. GC17330 (+)-Usniacin (+)-Usniacin is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usniacin inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity. (+)-Usniacin possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium. (+)-Usniacin  Chemical Structure
  4. GC63524 (32-Carbonyl)-RMC-5552 (32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2). (32-Carbonyl)-RMC-5552  Chemical Structure
  5. GC62122 (E)-Akt inhibitor-IV (E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic. (E)-Akt inhibitor-IV  Chemical Structure
  6. GC62736 (E/Z)-GSK-3β inhibitor 1 (E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. (E/Z)-GSK-3β inhibitor 1  Chemical Structure
  7. GC63802 (R)-PS210 (R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of?PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment. (R)-PS210  Chemical Structure
  8. GC62450 (S)-PI3Kα-IN-4 (S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the research of cancer. (S)-PI3Kα-IN-4  Chemical Structure
  9. GC35037 1,3-Dicaffeoylquinic acid 1,3-Dicaffeoylquinic acid is a caffeoylquinic acid derivative, and activates PI3K/Akt. 1,3-Dicaffeoylquinic acid  Chemical Structure
  10. GC13907 1-Azakenpaullone GSK-3β inhibitor,potent and selective,cell-permeable 1-Azakenpaullone  Chemical Structure
  11. GC41992 1-Deoxynojirimycin (hydrochloride) 1-Deoxynojirimycin (1-dNM) (hydrochloride), produced by Bacillus species, is a glucose analog that potently inhibits α-glucosidase I and II. 1-Deoxynojirimycin (hydrochloride)  Chemical Structure
  12. GC42018 1-O-Octadecyl-2-O-methyl-sn-glycerol 1-O-Octadecyl-2-O-methyl-sn-glycerol is a metabolite of a phosphotidylinositol ether lipid analog (PIA). 1-O-Octadecyl-2-O-methyl-sn-glycerol  Chemical Structure
  13. GC13006 10-DEBC hydrochloride Akt inhibitor 10-DEBC hydrochloride  Chemical Structure
  14. GC41979 17β-hydroxy Wortmannin 17β-hydroxy Wortmannin is an analog of wortmannin. 17β-hydroxy Wortmannin  Chemical Structure
  15. GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone 2,3-Dimethoxy-5-methyl-p-benzoquinone (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. 2,3-Dimethoxy-5-methyl-p-benzoquinone  Chemical Structure
  16. GC46531 2-Amino-5-bromo-6-chloropyrazine A heterocyclic building block 2-Amino-5-bromo-6-chloropyrazine  Chemical Structure
  17. GC64670 24-Methylenecycloartanyl ferulate 24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. 24-Methylenecycloartanyl ferulate promotes parvin-beta expression in human breast cancer cells. 24-Methylenecycloartanyl ferulate is a potential ATP-competitive Akt1 inhibitor (EC50= 33.3μM). 24-Methylenecycloartanyl ferulate  Chemical Structure
  18. GC35124 3α-Hydroxymogrol 3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acts as a potent AMPK activator, and enhances AMPK phosphorylation. 3α-Hydroxymogrol  Chemical Structure
  19. GC42237 3,5-dimethyl PIT-1 PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. 3,5-dimethyl PIT-1  Chemical Structure
  20. GC13992 3-Guanidinopropionic Acid RGX-202 (3-Guanidinopropionic acid) is an oral small-molecule SLC6A8 transporter inhibitor. RGX-202 robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. RGX-202 can be used for the research of cancer and duchenne muscular dystrophy. 3-Guanidinopropionic Acid  Chemical Structure
  21. GC10710 3-Methyladenine

    3-Methyladenine is a classic autophagy inhibitor.

    3-Methyladenine  Chemical Structure
  22. GC68539 3-Methyladenine-d3

    3-Methyladenine-d3 is the deuterated form of 3-Methyladenine. 3-Methyladenine (3-MA) is an inhibitor of PI3K. It is widely used as an autophagy inhibitor by inhibiting class III PI3K.

    3-Methyladenine-d3  Chemical Structure
  23. GC32767 3BDO A butyrolactone derivative and autophagy inhibitor 3BDO  Chemical Structure
  24. GC12078 3CAI AKT inhibitor 3CAI  Chemical Structure
  25. GC14306 3F8 GSK-3β inhibitor 3F8  Chemical Structure
  26. GC16960 4,5,6,7-Tetrabromobenzimidazole 4,5,6,7-Tetrabromobenzimidazole is a selective and ATP competitive CK2 (casein kinase 2) inhibitor. 4,5,6,7-Tetrabromobenzimidazole  Chemical Structure
  27. GC52091 5,7-Dichlorothiazolo[5,4-d]pyrimidine A building block 5,7-Dichlorothiazolo[5,4-d]pyrimidine  Chemical Structure
  28. GC35162 5-Iodo-indirubin-3'-monoxime 5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively. 5-Iodo-indirubin-3'-monoxime  Chemical Structure
  29. GN10093 6-gingerol 6-gingerol  Chemical Structure
  30. GC46724 6-Hydroxypyridin-3-ylboronic Acid A heterocyclic building block 6-Hydroxypyridin-3-ylboronic Acid  Chemical Structure
  31. GC46738 7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine A building block 7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine  Chemical Structure
  32. GC31348 7-Methoxyisoflavone A synthetic isoflavone 7-Methoxyisoflavone  Chemical Structure
  33. GC16157 740 Y-P

    PI 3-kinase activator,cell permeable

    740 Y-P  Chemical Structure
  34. GC39152 9-ING-41 9-ING-41 is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic drugs. 9-ING-41  Chemical Structure
  35. GC10336 A 1070722 GSK-3 inhibitor A 1070722  Chemical Structure
  36. GC12502 A-443654 A pan Akt inhibitor A-443654  Chemical Structure
  37. GC11875 A-674563

    Akt1/PKA/CDK2 inhibitor,potent and selective

    A-674563  Chemical Structure
  38. GC35212 A-674563 hydrochloride A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM. A-674563 hydrochloride  Chemical Structure
  39. GC11234 A-769662 A direct activator of AMPK A-769662  Chemical Structure
  40. GC17550 A66 P110α inhibitor A66  Chemical Structure
  41. GC10860 Acalisib (GS-9820) Acalisib (GS-9820) is a potent and selective PI3Kδ inhibitor with an IC50 of 12.7 nM. Acalisib (GS-9820)   Chemical Structure
  42. GC35242 Actein Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo. Actein  Chemical Structure
  43. GC16475 Afuresertib pan-AKT inhibitor Afuresertib  Chemical Structure
  44. GC42747 Afuresertib (hydrochloride) Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively. Afuresertib (hydrochloride)  Chemical Structure
  45. GC10518 AICAR

    An activator of AMPK

    AICAR  Chemical Structure
  46. GC10580 AICAR phosphate AMPK activator AICAR phosphate  Chemical Structure
  47. GC42759 Akt Inhibitor IV Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner. Akt Inhibitor IV  Chemical Structure
  48. GC11589 AKT inhibitor VIII A potent inhibitor of Akt1 and Akt2 AKT inhibitor VIII  Chemical Structure
  49. GC16366 AKT Kinase Inhibitor

    AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1].

    AKT Kinase Inhibitor  Chemical Structure
  50. GC67700 AKT Kinase Inhibitor hydrochloride AKT Kinase Inhibitor hydrochloride  Chemical Structure
  51. GC52443 Akt Substrate (trifluoroacetate salt) An Akt peptide substrate Akt Substrate (trifluoroacetate salt)  Chemical Structure
  52. GC33308 AKT-IN-1 AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. AKT-IN-1  Chemical Structure
  53. GC35275 AKT-IN-3 AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells. AKT-IN-3  Chemical Structure
  54. GC62190 AKT-IN-6 AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1). AKT-IN-6  Chemical Structure
  55. GC32939 Akt1 and Akt2-IN-1 Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50=3.5 nM) and Akt2 (IC50=42 nM), with potent and balanced activity. Akt1 and Akt2-IN-1  Chemical Structure
  56. GC66024 Aldometanib Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis. Aldometanib  Chemical Structure
  57. GC15841 Alsterpaullone CDKs and GSK3β inhibitor Alsterpaullone  Chemical Structure
  58. GC64818 AMA-37 AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively. AMA-37  Chemical Structure
  59. GC42776 Amarogentin

    A secoiridoid glycoside with diverse biological activities

    Amarogentin  Chemical Structure
  60. GC13913 AMG319 PI3Kδ inhibitor AMG319  Chemical Structure
  61. GC11190 AMPK activator AMPK activator is a cell penetrant AMPK activator and partially inhibits the mitochondrial complex I. In multiple myeloma cells, AMPK activator inhibits cell growth. AMPK activator  Chemical Structure
  62. GC35327 AMPK activator 1 AMPK activator 1 is an AMPK activator extracted from patent WO2013116491A1, compound No.1-75, has an EC50 of <0.1μM. AMPK activator 1  Chemical Structure
  63. GC62841 AMPK activator 4 AMPK activator 4 is a potent AMPK activator without inhibition of mitochondrial complex I. AMPK activator 4  Chemical Structure
  64. GC67961 AMPK-IN-3 AMPK-IN-3  Chemical Structure
  65. GC16534 Ampkinone AMPK activator Ampkinone  Chemical Structure
  66. GC18374 API-1 API-1 is an inhibitor of Akt that reduces the level of phosphorylated Akt (IC50 = ~0.8 uM in OVCAR3 cells) by binding to Akt and blocking its translocation to the cell membrane. API-1  Chemical Structure
  67. GC31661 APY0201 APY0201 is a potent PIKfyve inhibitor, which inhibits the conversion of PtdIns3P to PtdIns(3,5)P2 in the presence of in the presence of [33P]ATP with an IC50 of 5.2 nM. APY0201  Chemical Structure
  68. GC15425 AR-A014418 A selective inhibitor of GSK3β AR-A014418  Chemical Structure
  69. GC35395 Arnicolide D Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D  Chemical Structure
  70. GC19036 ARQ-092 ARQ-092 (ARQ-092) is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. ARQ-092  Chemical Structure
  71. GN10647 Artemisinine Artemisinine  Chemical Structure
  72. GC11910 AS-041164 PI3Kγ inhibitor AS-041164  Chemical Structure
  73. GC13901 AS-252424 PI3Kγ inhibitor,novel and potent AS-252424  Chemical Structure
  74. GC38061 AS-604850 A selective inhibitor of PI3Kγ AS-604850  Chemical Structure
  75. GC12080 AS-604850 PI3Kγ inhibitor,selective and ATP-competitve AS-604850  Chemical Structure
  76. GC12474 AS-605240 Potent and selective PI 3-Kγ inhibitor AS-605240  Chemical Structure
  77. GC17712 AT13148 Multi-AGC kinase inhibitor,ATP-competitive AT13148  Chemical Structure
  78. GC12297 AT7867

    Akt1/2/3 and p70S6K/PKA inhibitor

    AT7867  Chemical Structure
  79. GC10918 AT7867 dihydrochloride A potent and orally bioavailable pan-Akt inhibitor AT7867 dihydrochloride  Chemical Structure
  80. GC62335 AZ2 AZ2 is a highly selective PI3Kγ inhibitor (The pIC50 value for PI3Kγ is 9.3). AZ2  Chemical Structure
  81. GC64938 AZD-7648 AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity. AZD-7648  Chemical Structure
  82. GC16568 AZD1080 GSK3βinhibitor AZD1080  Chemical Structure
  83. GC13029 AZD2014 AZD2014 (AZD2014) is an ATP competitive mTOR inhibitor with an IC50 of 2.81 nM. AZD2014 inhibits both mTORC1 and mTORC2 complexes. AZD2014  Chemical Structure
  84. GC14736 AZD2858 GSK-3 inhibitor,potent and selective AZD2858  Chemical Structure
  85. GC65149 AZD3458 AZD3458 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively. AZD3458  Chemical Structure
  86. GC11752 AZD5363 AZD5363 (AZD5363) is an orally active and potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively. AZD5363  Chemical Structure
  87. GC16851 AZD6482

    PI3Kβ inhibitor,potent and selective

    AZD6482  Chemical Structure
  88. GC16380 AZD8055

    AZD8055 is a new ATP-competitive mTOR inhibitor with an IC50 of 0.8 nmol/L and a Ki of 1.3 nmol/L.

    AZD8055  Chemical Structure
  89. GC65507 AZD8154 AZD8154 is a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease. AZD8154  Chemical Structure
  90. GC12576 AZD8186 Potent and selective inhibitor of PI3Kβ and PI3Kδ AZD8186  Chemical Structure
  91. GC11248 AZD8835 PI3Kα and PI3Kδ inhibitor AZD8835  Chemical Structure
  92. GC64377 Batatasin III Batatasin III, a stilbenoid, inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition (EMT) and FAK-AKT signals. Batatasin III has anti-cancer activities. Batatasin III  Chemical Structure
  93. GC17766 BAY 80-6946 (Copanlisib) BAY 80-6946 (Copanlisib) (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. BAY 80-6946 (Copanlisib) has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. BAY 80-6946 (Copanlisib) has superior antitumor activity. BAY 80-6946 (Copanlisib)  Chemical Structure
  94. GC67772 BAY-3827 BAY-3827  Chemical Structure
  95. GC62164 BAY1082439 BAY1082439 is an orally bioavailable, selective PI3Kα/β/δ inhibitor. BAY1082439 also inhibits mutated forms of PIK3CA. BAY1082439 is highly effective in inhibiting Pten-null prostate cancer growth. BAY1082439  Chemical Structure
  96. GC19484 BAY1125976

    A selective allosteric Akt1/Akt2 inhibitor

    BAY1125976   Chemical Structure
  97. GC62135 BC1618 BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation). BC1618  Chemical Structure
  98. GC33145 BEBT-908 (PI3Kα inhibitor 1) BEBT-908 (PI3Kα inhibitor 1) (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor extracted from patent US/20120088764A1, Compound 243, has an IC50<0.1 μM, PI3Kα inhibitor 1 also inhibits HDAC (0.1 μM≤IC50≤1 μM) . BEBT-908 (PI3Kα inhibitor 1)  Chemical Structure
  99. GC13271 BEZ235 Tosylate BEZ235 Tosylate  Chemical Structure
  100. GC32381 BF738735 BF738735 is a phosphatidylinositol 4-kinase III beta (PI4KIIIβ) inhibitor with an IC50 of 5.7 nM. BF738735  Chemical Structure
  101. GC35509 BGT226 BGT226 (NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ)/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells. BGT226  Chemical Structure

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