PI3K/Akt/mTOR Signaling
- Akt(107)
- AMPK(66)
- CK2(8)
- DNA-PK(20)
- GSK-3(65)
- MELK(6)
- mTOR(101)
- PI3K(196)
- PI4K(14)
- PDK-1(13)
- PIKfyve(3)
- PKB(1)
- S6 Kinase(9)
- Cat.No. Product Name Information
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GN10752
Pachymic acid
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GN10732
Oroxin B
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GN10709
Polyphyllin A
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GN10692
Oridonin
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GN10681
Sophocarpine
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GN10664
Honokiol
-
GN10647
Artemisinine
-
GN10624
Scutellarin
-
GN10592
Platycodin D
-
GN10584
Ginsenoside Rk1
-
GN10583
Dihydromyricetin
-
GN10473
Ginkgolide C
-
GN10312
Polygalasaponin F
-
GN10266
Quercetin
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GN10222
Cimigenol-3-O-α-L-arabinoside
-
GN10127
Salidroside
-
GN10093
6-gingerol
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GN10023
Isorhamnetin
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GA10282
H-Leu-OH
-
GC15484
Deguelin
A potent antiproliferative rotenoid compound
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GC12336
XL765
PI3K/mTOR inhibitor
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GC16481
XL388
An mTOR inhibitor
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GC17771
VS-5584 (SB2343)
A selective PI3K/mTOR kinase inhibitor
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GC10649
TTP 22
A CK2 inhibitor
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GC12181
TBB
An inhibitor of CK2
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GC18032
QL-IX-55
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GC16379
PI-103 Hydrochloride
A potent, cell-permeable PI3K inhibitor
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GC12866
PDK1 inhibitor
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GC14504
NVP-BKM120 Hydrochloride
An inhibitor of class I PI3K isoforms
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GC13725
NVP-BAG956
A dual PDK1 and class I PI3K inhibitor
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GC18089
Nordihydroguaiaretic acid
A non-selective LO inhibitor
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GC10900
GDC-mTOR inhibitor
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GC17187
LY2090314
A potent and selective inhibitor of GSK3
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GC12045
LY 303511
An inhibitor of cell proliferation
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GC13795
Isobavachalcone
A chalcone and flavonoid with diverse biological activities
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GC16154
GDC-0941 dimethanesulfonate
A pan inhibitor of class I PI3K isoforms
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GC14125
FMK
An inhibitor of RSK2
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GC17837
DMAT
A cell-permeable inhibitor of CK2
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GC14798
CZC24832
A PI3Kγ inhibitor
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GC14693
CMK
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GC11135
CAL-130 Hydrochloride
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GC13271
BEZ235 Tosylate
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GC10918
AT7867 dihydrochloride
A potent and orally bioavailable pan-Akt inhibitor
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GC15425
AR-A014418
A selective inhibitor of GSK3β
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GC16366
AKT Kinase Inhibitor
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GC11589
AKT inhibitor VIII
A potent inhibitor of Akt1 and Akt2
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GC12502
A-443654
A pan Akt inhibitor
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GC15508
PI4KIII beta inhibitor 3
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GC12115
CUDC-907
A dual inhibitor of HDACs and PI3Ks
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GC11931
BKM120
An inhibitor of class I PI3K isoforms
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GC16702
CHIR-99021 (CT99021)
A selective GSK3 inhibitor
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GC16304
MK-2206 dihydrochloride
An allosteric Akt inhibitor
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GC11214
GDC-0068 (RG7440)
A pan-Akt inhibitor
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GC13396
CAL-101 (Idelalisib, GS-1101)
A selective PI3K p110δ inhibitor
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GC10518
AICAR
An activator of AMPK
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GC13601
Everolimus (RAD001)
A rapamycin derivative
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GC15031
Rapamycin (Sirolimus)
An allosteric inhibitor of mTORC1
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GP10104
S6 Kinase Substrate Peptide 32
Measures the activity of kinases that phosphorylate ribosomal protein S6.
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GC26049
WAY-119064
WAY-119064 is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 value of 80.5 nM.
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GC26044
VPS34 inhibitor 1 (Compound 19)
VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM.
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GC25913
Selective PI3Kδ Inhibitor 1 (compound 7n)
Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM].
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GC25648
MOTS-c
MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway.
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GC25638
Miransertib (ARQ 092) HCl
Miransertib (ARQ 092) HCl is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors.
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GC25626
MELK-8a Dihydrochloride
MELK-8a Dihydrochloride is a novel inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 of 2 nM.
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GC68429
GNE-490
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GC68413
CYH33
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GC68219
L-Leucine-13C
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GC68037
L-Leucine-1-13C,15N
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GC67961
AMPK-IN-3
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GC67954
PI3K-IN-36
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GC67772
BAY-3827
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GC67700
AKT Kinase Inhibitor hydrochloride
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GC52443
Akt Substrate (trifluoroacetate salt)
An Akt peptide substrate
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GC52387
Crosstide (trifluoroacetate salt)
A peptide substrate for Akt
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GC66474
PDK1-IN-RS2
PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1.
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GC66463
PI3K/Akt/mTOR-IN-2
PI3K/Akt/mTOR-IN-2 is a PI3K/AKT/mTOR pathway inhibitor. PI3K/Akt/mTOR-IN-2 possess anti-cancer effects and selectivity against MDA-MB-231 cells with IC50 value of 2.29 μM. PI3K/Akt/mTOR-IN-2 can induce cancer cell cycle arrest and apoptosis.
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GC66447
PI3K/mTOR Inhibitor-4
PI3K/mTOR Inhibitor-4 is an orally active pan-class I PI3K/mTOR inhibitor. PI3K/mTOR Inhibitor-4 has enzymatic inhibition activity for PI3Kα, PI3Kγ, PI3Kδ and mTOR with IC50 values of 0.63 nM, 22 nM, 9.2 nM and 13.85 nM, respectively. PI3K/mTOR Inhibitor-4 can be used for the research of cancer.
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GC66357
L-Leucine-d2
L-Leucine-d2 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
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GC66065
MELK-IN-1
MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 and a Ki of 3 nM and 0.39 nM, respectively.
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GC66035
GSK3-IN-1
GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes.
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GC66032
GSK-3β inhibitor 11
GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research.
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GC66024
Aldometanib
Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis.
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GC66013
MOMIPP
MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB).
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GC66002
PF-06685249
PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research.
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GC65969
CHMFL-PI3KD-317
CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC50, 62.6 nM), PI3Kβ (IC50, 284 nM), PI3Kγ (IC50, 202.7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882.3 nM), VPS34 (IC50, 1801.7 nM), PI4KIIIA (IC50, 574.1 nM) and PI4KIIIB (IC50, 300.2 nM). CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC50 of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells.
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GC65944
CC214-2
CC214-2 is a potent and dual inhibitor of mTORC1/mTORC2. Mycobacterium tuberculosis modulates mammalian target of rapamycin (mTOR) signaling to impede autophagy. CC214-2 has the potential to shorten the duration of TB.
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GC65559
INY-03-041
INY-03-041 is a potent, highly selective and PROTAC-based pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide (Cereblon ligand). INY-03-041 inhibits AKT1, AKT2 and AKT3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively.
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GC65534
Boc-L-cyclobutylglycine
Boc-L-cyclobutylglycine is a glycine derivative that can be used for PI3K inhibitor synthesis.
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GC65507
AZD8154
AZD8154 is a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease.
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GC65466
MS170
MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1.3 nM, 77 nM, and 6.5 nM, respectively.
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GC65460
HDACs/mTOR Inhibitor 1
HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo.
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GC65454
UCT943
UCT943 is a next-generation Plasmodium falciparum PI4K inhibitor.
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GC65442
Musk ketone
Musk ketone (MK) is a widely used artificial fragrance.
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GC65375
Phospho-Glycogen Synthase Peptide-2(substrate) TFA
Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases.
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GC65367
Borussertib
Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt.
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GC65309
GSK-F1
GSK-F1 (Compound F1) is an orally active PI4KA inhibitor with pIC50 values of 8.0, 5.9, 5.8, 5.9, 5.9 and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG and PI3KD, respectively.
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GC65249
STL127705
STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC50 of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis.
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GC65199
PI3Kδ-IN-1
PI3Kδ-IN-1 is a potent, selective, and efficacious PI3Kδ inhibitor with an IC50 of 1.7 nM.
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GC65149
AZD3458
AZD3458 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively.
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GC65143
MKC-1
MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family.