Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

  1. Cat.No. Product Name Information
  2. GN10752 Pachymic acid Pachymic acid  Chemical Structure
  3. GN10732 Oroxin B Oroxin B  Chemical Structure
  4. GN10709 Polyphyllin A Polyphyllin A  Chemical Structure
  5. GN10692 Oridonin Oridonin  Chemical Structure
  6. GN10681 Sophocarpine Sophocarpine  Chemical Structure
  7. GN10664 Honokiol Honokiol  Chemical Structure
  8. GN10647 Artemisinine Artemisinine  Chemical Structure
  9. GN10624 Scutellarin Scutellarin  Chemical Structure
  10. GN10592 Platycodin D Platycodin D  Chemical Structure
  11. GN10584 Ginsenoside Rk1 Ginsenoside Rk1  Chemical Structure
  12. GN10583 Dihydromyricetin Dihydromyricetin  Chemical Structure
  13. GN10473 Ginkgolide C Ginkgolide C  Chemical Structure
  14. GN10312 Polygalasaponin F Polygalasaponin F  Chemical Structure
  15. GN10266 Quercetin Quercetin  Chemical Structure
  16. GN10222 Cimigenol-3-O-α-L-arabinoside Cimigenol-3-O-α-L-arabinoside  Chemical Structure
  17. GN10127 Salidroside Salidroside  Chemical Structure
  18. GN10093 6-gingerol 6-gingerol  Chemical Structure
  19. GN10023 Isorhamnetin Isorhamnetin  Chemical Structure
  20. GA10282 H-Leu-OH H-Leu-OH  Chemical Structure
  21. GC15484 Deguelin A potent antiproliferative rotenoid compound Deguelin  Chemical Structure
  22. GC12336 XL765 PI3K/mTOR inhibitor XL765  Chemical Structure
  23. GC16481 XL388 An mTOR inhibitor XL388  Chemical Structure
  24. GC17771 VS-5584 (SB2343) A selective PI3K/mTOR kinase inhibitor VS-5584 (SB2343)  Chemical Structure
  25. GC10649 TTP 22 A CK2 inhibitor TTP 22  Chemical Structure
  26. GC12181 TBB An inhibitor of CK2 TBB  Chemical Structure
  27. GC18032 QL-IX-55 QL-IX-55  Chemical Structure
  28. GC16379 PI-103 Hydrochloride A potent, cell-permeable PI3K inhibitor PI-103 Hydrochloride  Chemical Structure
  29. GC12866 PDK1 inhibitor PDK1 inhibitor  Chemical Structure
  30. GC14504 NVP-BKM120 Hydrochloride An inhibitor of class I PI3K isoforms NVP-BKM120 Hydrochloride  Chemical Structure
  31. GC13725 NVP-BAG956 A dual PDK1 and class I PI3K inhibitor NVP-BAG956  Chemical Structure
  32. GC18089 Nordihydroguaiaretic acid A non-selective LO inhibitor Nordihydroguaiaretic acid  Chemical Structure
  33. GC10900 GDC-mTOR inhibitor GDC-mTOR inhibitor  Chemical Structure
  34. GC17187 LY2090314 A potent and selective inhibitor of GSK3 LY2090314  Chemical Structure
  35. GC12045 LY 303511 An inhibitor of cell proliferation LY 303511  Chemical Structure
  36. GC13795 Isobavachalcone A chalcone and flavonoid with diverse biological activities Isobavachalcone  Chemical Structure
  37. GC16154 GDC-0941 dimethanesulfonate A pan inhibitor of class I PI3K isoforms GDC-0941 dimethanesulfonate  Chemical Structure
  38. GC14125 FMK An inhibitor of RSK2 FMK  Chemical Structure
  39. GC17837 DMAT A cell-permeable inhibitor of CK2 DMAT  Chemical Structure
  40. GC14798 CZC24832 A PI3Kγ inhibitor CZC24832  Chemical Structure
  41. GC14693 CMK CMK  Chemical Structure
  42. GC11135 CAL-130 Hydrochloride CAL-130 Hydrochloride  Chemical Structure
  43. GC13271 BEZ235 Tosylate BEZ235 Tosylate  Chemical Structure
  44. GC10918 AT7867 dihydrochloride A potent and orally bioavailable pan-Akt inhibitor AT7867 dihydrochloride  Chemical Structure
  45. GC15425 AR-A014418 A selective inhibitor of GSK3β AR-A014418  Chemical Structure
  46. GC16366 AKT Kinase Inhibitor AKT Kinase Inhibitor  Chemical Structure
  47. GC11589 AKT inhibitor VIII A potent inhibitor of Akt1 and Akt2 AKT inhibitor VIII  Chemical Structure
  48. GC12502 A-443654 A pan Akt inhibitor A-443654  Chemical Structure
  49. GC15508 PI4KIII beta inhibitor 3 PI4KIII beta inhibitor 3  Chemical Structure
  50. GC12115 CUDC-907 A dual inhibitor of HDACs and PI3Ks CUDC-907  Chemical Structure
  51. GC11931 BKM120 An inhibitor of class I PI3K isoforms BKM120  Chemical Structure
  52. GC16702 CHIR-99021 (CT99021) A selective GSK3 inhibitor CHIR-99021 (CT99021)  Chemical Structure
  53. GC16304 MK-2206 dihydrochloride

    An allosteric Akt inhibitor

    MK-2206 dihydrochloride  Chemical Structure
  54. GC11214 GDC-0068 (RG7440) A pan-Akt inhibitor GDC-0068 (RG7440)  Chemical Structure
  55. GC13396 CAL-101 (Idelalisib, GS-1101) A selective PI3K p110δ inhibitor CAL-101 (Idelalisib, GS-1101)  Chemical Structure
  56. GC10518 AICAR An activator of AMPK AICAR  Chemical Structure
  57. GC13601 Everolimus (RAD001) A rapamycin derivative Everolimus (RAD001)  Chemical Structure
  58. GC15031 Rapamycin (Sirolimus)

    An allosteric inhibitor of mTORC1

    Rapamycin (Sirolimus)  Chemical Structure
  59. GP10104 S6 Kinase Substrate Peptide 32 Measures the activity of kinases that phosphorylate ribosomal protein S6. S6 Kinase Substrate Peptide 32  Chemical Structure
  60. GC26049 WAY-119064 WAY-119064 is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 value of 80.5 nM. WAY-119064  Chemical Structure
  61. GC26044 VPS34 inhibitor 1 (Compound 19) VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM. VPS34 inhibitor 1 (Compound 19)  Chemical Structure
  62. GC25913 Selective PI3Kδ Inhibitor 1 (compound 7n) Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM]. Selective PI3Kδ Inhibitor 1 (compound 7n)  Chemical Structure
  63. GC25648 MOTS-c MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway. MOTS-c  Chemical Structure
  64. GC25638 Miransertib (ARQ 092) HCl Miransertib (ARQ 092) HCl is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors. Miransertib (ARQ 092) HCl  Chemical Structure
  65. GC25626 MELK-8a Dihydrochloride MELK-8a Dihydrochloride is a novel inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 of 2 nM. MELK-8a Dihydrochloride  Chemical Structure
  66. GC68429 GNE-490 GNE-490  Chemical Structure
  67. GC68413 CYH33 CYH33  Chemical Structure
  68. GC68219 L-Leucine-13C L-Leucine-13C  Chemical Structure
  69. GC68037 L-Leucine-1-13C,15N L-Leucine-1-13C,15N  Chemical Structure
  70. GC67961 AMPK-IN-3 AMPK-IN-3  Chemical Structure
  71. GC67954 PI3K-IN-36 PI3K-IN-36  Chemical Structure
  72. GC67772 BAY-3827 BAY-3827  Chemical Structure
  73. GC67700 AKT Kinase Inhibitor hydrochloride AKT Kinase Inhibitor hydrochloride  Chemical Structure
  74. GC52443 Akt Substrate (trifluoroacetate salt) An Akt peptide substrate Akt Substrate (trifluoroacetate salt)  Chemical Structure
  75. GC52387 Crosstide (trifluoroacetate salt) A peptide substrate for Akt Crosstide (trifluoroacetate salt)  Chemical Structure
  76. GC66474 PDK1-IN-RS2 PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1. PDK1-IN-RS2  Chemical Structure
  77. GC66463 PI3K/Akt/mTOR-IN-2 PI3K/Akt/mTOR-IN-2 is a PI3K/AKT/mTOR pathway inhibitor. PI3K/Akt/mTOR-IN-2 possess anti-cancer effects and selectivity against MDA-MB-231 cells with IC50 value of 2.29 μM. PI3K/Akt/mTOR-IN-2 can induce cancer cell cycle arrest and apoptosis. PI3K/Akt/mTOR-IN-2  Chemical Structure
  78. GC66447 PI3K/mTOR Inhibitor-4 PI3K/mTOR Inhibitor-4 is an orally active pan-class I PI3K/mTOR inhibitor. PI3K/mTOR Inhibitor-4 has enzymatic inhibition activity for PI3Kα, PI3Kγ, PI3Kδ and mTOR with IC50 values of 0.63 nM, 22 nM, 9.2 nM and 13.85 nM, respectively. PI3K/mTOR Inhibitor-4 can be used for the research of cancer. PI3K/mTOR Inhibitor-4  Chemical Structure
  79. GC66357 L-Leucine-d2 L-Leucine-d2 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway. L-Leucine-d2  Chemical Structure
  80. GC66065 MELK-IN-1 MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 and a Ki of 3 nM and 0.39 nM, respectively. MELK-IN-1  Chemical Structure
  81. GC66035 GSK3-IN-1 GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes. GSK3-IN-1  Chemical Structure
  82. GC66032 GSK-3β inhibitor 11 GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research. GSK-3β inhibitor 11  Chemical Structure
  83. GC66024 Aldometanib Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis. Aldometanib  Chemical Structure
  84. GC66013 MOMIPP MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB). MOMIPP  Chemical Structure
  85. GC66002 PF-06685249 PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research. PF-06685249  Chemical Structure
  86. GC65969 CHMFL-PI3KD-317 CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC50, 62.6 nM), PI3Kβ (IC50, 284 nM), PI3Kγ (IC50, 202.7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882.3 nM), VPS34 (IC50, 1801.7 nM), PI4KIIIA (IC50, 574.1 nM) and PI4KIIIB (IC50, 300.2 nM). CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC50 of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells. CHMFL-PI3KD-317  Chemical Structure
  87. GC65944 CC214-2 CC214-2 is a potent and dual inhibitor of mTORC1/mTORC2. Mycobacterium tuberculosis modulates mammalian target of rapamycin (mTOR) signaling to impede autophagy. CC214-2 has the potential to shorten the duration of TB. CC214-2  Chemical Structure
  88. GC65559 INY-03-041 INY-03-041 is a potent, highly selective and PROTAC-based pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide (Cereblon ligand). INY-03-041 inhibits AKT1, AKT2 and AKT3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively. INY-03-041  Chemical Structure
  89. GC65534 Boc-L-cyclobutylglycine Boc-L-cyclobutylglycine is a glycine derivative that can be used for PI3K inhibitor synthesis. Boc-L-cyclobutylglycine  Chemical Structure
  90. GC65507 AZD8154 AZD8154 is a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease. AZD8154  Chemical Structure
  91. GC65466 MS170 MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1.3 nM, 77 nM, and 6.5 nM, respectively. MS170  Chemical Structure
  92. GC65460 HDACs/mTOR Inhibitor 1 HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo. HDACs/mTOR Inhibitor 1  Chemical Structure
  93. GC65454 UCT943 UCT943 is a next-generation Plasmodium falciparum PI4K inhibitor. UCT943  Chemical Structure
  94. GC65442 Musk ketone Musk ketone (MK) is a widely used artificial fragrance. Musk ketone  Chemical Structure
  95. GC65375 Phospho-Glycogen Synthase Peptide-2(substrate) TFA Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases. Phospho-Glycogen Synthase Peptide-2(substrate) TFA  Chemical Structure
  96. GC65367 Borussertib Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt. Borussertib  Chemical Structure
  97. GC65309 GSK-F1 GSK-F1 (Compound F1) is an orally active PI4KA inhibitor with pIC50 values of 8.0, 5.9, 5.8, 5.9, 5.9 and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG and PI3KD, respectively. GSK-F1  Chemical Structure
  98. GC65249 STL127705 STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC50 of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis. STL127705  Chemical Structure
  99. GC65199 PI3Kδ-IN-1 PI3Kδ-IN-1 is a potent, selective, and efficacious PI3Kδ inhibitor with an IC50 of 1.7 nM. PI3Kδ-IN-1  Chemical Structure
  100. GC65149 AZD3458 AZD3458 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively. AZD3458  Chemical Structure
  101. GC65143 MKC-1 MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family. MKC-1  Chemical Structure

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