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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

Products for  PI3K/Akt/mTOR Signaling

  1. Cat.No. Product Name Information
  2. GC10350 TIC10 isomer

    ONC201 isomer

    Potent Akt/ERK inhibitor

     TIC10 isomer Chemical Structure
  3. GC17330 (+)-Usniacin (+)-Usniacin is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usniacin inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity. (+)-Usniacin possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium. (+)-Usniacin Chemical Structure
  4. GC63524 (32-Carbonyl)-RMC-5552 (32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2). (32-Carbonyl)-RMC-5552 Chemical Structure
  5. GC62122 (E)-Akt inhibitor-IV

    (E)-AKTIV

     (E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic. (E)-Akt inhibitor-IV Chemical Structure
  6. GC62736 (E/Z)-GSK-3β inhibitor 1 (E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. (E/Z)-GSK-3β inhibitor 1 Chemical Structure
  7. GC74261 (R)-(+)-O-Demethylbuchenavianine (R)-(+)-O-Demetlbuchenavianine is an inhibitor for Cyclin-dependent kinases (CDK). (R)-(+)-O-Demethylbuchenavianine Chemical Structure
  8. GC72915 (R)-MRT199665 (R)-MRT199665 is an isomer of MRT199665. (R)-MRT199665 Chemical Structure
  9. GC63802 (R)-PS210 (R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of?PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment. (R)-PS210 Chemical Structure
  10. GC62450 (S)-PI3Kα-IN-4 (S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the research of cancer. (S)-PI3Kα-IN-4 Chemical Structure
  11. GC35037 1,3-Dicaffeoylquinic acid

    1,5-DCQA, 1,3-Dicaffeoylquinic Acid

     1,3-Dicaffeoylquinic acid is a caffeoylquinic acid derivative, and activates PI3K/Akt. 1,3-Dicaffeoylquinic acid Chemical Structure
  12. GC13907 1-Azakenpaullone GSK-3β inhibitor,potent and selective,cell-permeable 1-Azakenpaullone Chemical Structure
  13. GC41992 1-Deoxynojirimycin (hydrochloride)

    1-DNJ, 1-dNM, Moranoline

     1-Deoxynojirimycin (1-dNM) (hydrochloride), produced by Bacillus species, is a glucose analog that potently inhibits α-glucosidase I and II. 1-Deoxynojirimycin (hydrochloride) Chemical Structure
  14. GC42018 1-O-Octadecyl-2-O-methyl-sn-glycerol

    2Methyl1octadecylsnglycerol, PIA 7

     1-O-Octadecyl-2-O-methyl-sn-glycerol is a metabolite of a phosphotidylinositol ether lipid analog (PIA). 1-O-Octadecyl-2-O-methyl-sn-glycerol Chemical Structure
  15. GC13006 10-DEBC hydrochloride

    Akt Inhibitor X

     Akt inhibitor 10-DEBC hydrochloride Chemical Structure
  16. GC41979 17β-hydroxy Wortmannin 17β-hydroxy Wortmannin is an analog of wortmannin. 17β-hydroxy Wortmannin Chemical Structure
  17. GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone

    Coenzyme Q0, CoQ0

     2,3-Dimethoxy-5-methyl-p-benzoquinone (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. 2,3-Dimethoxy-5-methyl-p-benzoquinone Chemical Structure
  18. GC46531 2-Amino-5-bromo-6-chloropyrazine A heterocyclic building block 2-Amino-5-bromo-6-chloropyrazine Chemical Structure
  19. GC64670 24-Methylenecycloartanyl ferulate 24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. 24-Methylenecycloartanyl ferulate promotes parvin-beta expression in human breast cancer cells. 24-Methylenecycloartanyl ferulate is a potential ATP-competitive Akt1 inhibitor (EC50= 33.3μM). 24-Methylenecycloartanyl ferulate Chemical Structure
  20. GC35124 3α-Hydroxymogrol 3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acts as a potent AMPK activator, and enhances AMPK phosphorylation. 3α-Hydroxymogrol Chemical Structure
  21. GC42237 3,5-dimethyl PIT-1 PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. 3,5-dimethyl PIT-1 Chemical Structure
  22. GC13992 3-Guanidinopropionic Acid

    β-GPA,PNU 10483

     RGX-202 (3-Guanidinopropionic acid) is an oral small-molecule SLC6A8 transporter inhibitor. RGX-202 robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. RGX-202 can be used for the research of cancer and duchenne muscular dystrophy. 3-Guanidinopropionic Acid Chemical Structure
  23. GC10710 3-Methyladenine

    3-MA

    3-Methyladenine is a classic autophagy inhibitor.

     3-Methyladenine Chemical Structure
  24. GC68539 3-Methyladenine-d3

    3-Methyladenine-d3 is the deuterated form of 3-Methyladenine. 3-Methyladenine (3-MA) is an inhibitor of PI3K. It is widely used as an autophagy inhibitor by inhibiting class III PI3K.

     3-Methyladenine-d3 Chemical Structure
  25. GC32767 3BDO

    3-Benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one

     A butyrolactone derivative and autophagy inhibitor 3BDO Chemical Structure
  26. GC12078 3CAI

    3-chloroacetyl Indole

     AKT inhibitor 3CAI Chemical Structure
  27. GC14306 3F8 GSK-3β inhibitor 3F8 Chemical Structure
  28. GC16960 4,5,6,7-Tetrabromobenzimidazole

    Casein Kinase II Inhibitor XII,TBBz

     4,5,6,7-Tetrabromobenzimidazole is a selective and ATP competitive CK2 (casein kinase 2) inhibitor. 4,5,6,7-Tetrabromobenzimidazole Chemical Structure
  29. GC52091 5,7-Dichlorothiazolo[5,4-d]pyrimidine A building block 5,7-Dichlorothiazolo[5,4-d]pyrimidine Chemical Structure
  30. GC90376 5-Bromopentanoic Acid-d4

    An internal standard for the quantification of 5-bromopentanoic acid

     5-Bromopentanoic Acid-d4 Chemical Structure
  31. GC35162 5-Iodo-indirubin-3'-monoxime 5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively. 5-Iodo-indirubin-3'-monoxime Chemical Structure
  32. GN10093 6-gingerol 6-gingerol Chemical Structure
  33. GC46724 6-Hydroxypyridin-3-ylboronic Acid A heterocyclic building block 6-Hydroxypyridin-3-ylboronic Acid Chemical Structure
  34. GC70708 6-Me-ATP trisodium 6-Me-ATP (N6-Methyl-ATP) trisodium is a N6-modified ATP derivative. 6-Me-ATP trisodium Chemical Structure
  35. GC46738 7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine A building block 7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine Chemical Structure
  36. GC31348 7-Methoxyisoflavone

    5-methyl-7-Methoxyisoflavone

     A synthetic isoflavone 7-Methoxyisoflavone Chemical Structure
  37. GC16157 740 Y-P

    740YPDGFR; PDGFR 740Y-P

     740 Y-P is an activator of PI3K with concentration of 20 μM [1]. 740 Y-P Chemical Structure
  38. GC39152 9-ING-41

    Elraglusib

     9-ING-41 is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic drugs. 9-ING-41 Chemical Structure
  39. GC10336 A 1070722 GSK-3 inhibitor A 1070722 Chemical Structure
  40. GC12502 A-443654 A pan Akt inhibitor A-443654 Chemical Structure
  41. GC11875 A-674563

    Akt1/PKA/CDK2 inhibitor,potent and selective

     A-674563 Chemical Structure
  42. GC35212 A-674563 hydrochloride A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM. A-674563 hydrochloride Chemical Structure
  43. GC11234 A-769662

    A-769662;A769662

    A-769662 is an activator of AMP-activated protein kinase, which has an EC50 value of 0.8μM.

     A-769662 Chemical Structure
  44. GC17550 A66

    A 66; A-66

     A66 is a highly specific and selective p110α inhibitor with an IC50 value of 32nM. A66 Chemical Structure
  45. GC68592 ABC1183

    ABC1183 is a selective dual inhibitor of GSK3 and CDK9 with oral activity. Its IC50 values for GSK3β, GSK3α, and CDK9/cyclin T1 are 657 nM, 327 nM, and 321 nM respectively. ABC1183 has anti-inflammatory properties as well as anti-tumor activity.

     ABC1183 Chemical Structure
  46. GC10860 Acalisib (GS-9820)

    GS-9820

     Acalisib (GS-9820) is a potent and selective PI3Kδ inhibitor with an IC50 of 12.7 nM. Acalisib (GS-9820) Chemical Structure
  47. GC35242 Actein Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo. Actein Chemical Structure
  48. GC16475 Afuresertib

    GSK2110183

     pan-AKT inhibitor Afuresertib Chemical Structure
  49. GC42747 Afuresertib (hydrochloride)

    GSK2110183B

     Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively. Afuresertib (hydrochloride) Chemical Structure
  50. GC10518 AICAR

    Acadesine, AICA-Riboside, NSC 105823

     AICAR (also called acadesine) is a purine nucleoside. AICAR Chemical Structure
  51. GC10580 AICAR phosphate AMPK activator AICAR phosphate Chemical Structure
  52. GC42759 Akt Inhibitor IV Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner. Akt Inhibitor IV Chemical Structure
  53. GC11589 AKT inhibitor VIII A potent inhibitor of Akt1 and Akt2 AKT inhibitor VIII Chemical Structure
  54. GC16366 AKT Kinase Inhibitor

    AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1].

     AKT Kinase Inhibitor Chemical Structure
  55. GC67700 AKT Kinase Inhibitor hydrochloride AKT Kinase Inhibitor hydrochloride Chemical Structure
  56. GC52443 Akt Substrate (trifluoroacetate salt)

    RPRAATF

     An Akt peptide substrate Akt Substrate (trifluoroacetate salt) Chemical Structure
  57. GC91648 Akt-I-1

    Akt-IN-1

     Akt-I-1 is an inhibitor of Akt1 (IC50 = 4.6 µM). Akt-I-1 Chemical Structure
  58. GC33308 AKT-IN-1 AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. AKT-IN-1 Chemical Structure
  59. GC35275 AKT-IN-3 AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells. AKT-IN-3 Chemical Structure
  60. GC62190 AKT-IN-6 AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1). AKT-IN-6 Chemical Structure
  61. GC32939 Akt1 and Akt2-IN-1 Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50=3.5 nM) and Akt2 (IC50=42 nM), with potent and balanced activity. Akt1 and Akt2-IN-1 Chemical Structure
  62. GC66024 Aldometanib

    LXY-05-029

     Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis. Aldometanib Chemical Structure
  63. GC73642 ALK-IN-26 ALK-IN-26 is an ALK inhibitor with IC50 value of 7.0 μM for ALK tyrosine kinase. ALK-IN-26 Chemical Structure
  64. GC68640 ALM301

    ALM301 is a highly specific AKT inhibitor with oral activity. Its IC50 values for AKT1, AKT2 and AKT3 are 0.13 μM, 0.09 μM and 2.75 μM, respectively. ALM301 inhibits the phosphorylation of AKT and regulates downstream signaling in vitro. It can inhibit cancer cell proliferation and tumor growth.

     ALM301 Chemical Structure
  65. GC15841 Alsterpaullone

    9-Nitropaullone,NSC 705701

     CDKs and GSK3β inhibitor Alsterpaullone Chemical Structure
  66. GC64818 AMA-37 AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively. AMA-37 Chemical Structure
  67. GC42776 Amarogentin

    A secoiridoid glycoside with diverse biological activities

     Amarogentin Chemical Structure
  68. GC72896 AMDE-1 AMDE-1 is a potent autophagy inducer. AMDE-1 Chemical Structure
  69. GC13913 AMG319 PI3Kδ inhibitor AMG319 Chemical Structure
  70. GC11190 AMPK activator

    D942

     AMPK activator is a cell penetrant AMPK activator and partially inhibits the mitochondrial complex I. In multiple myeloma cells, AMPK activator inhibits cell growth. AMPK activator Chemical Structure
  71. GC35327 AMPK activator 1 AMPK activator 1 is an AMPK activator extracted from patent WO2013116491A1, compound No.1-75, has an EC50 of <0.1μM. AMPK activator 1 Chemical Structure
  72. GC73233 AMPK activator 12 AMPK activator 12 (compound 21) is a potent AMPK activator and GDF15 inducer. AMPK activator 12 Chemical Structure
  73. GC71333 AMPK activator 13 AMPK activator 13 is a potent activator of AMPK. AMPK activator 13 Chemical Structure
  74. GC72998 AMPK activator 2 hydrochloride AMPK activator 2 (compound 7a) drochloride, a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 hydrochloride Chemical Structure
  75. GC62841 AMPK activator 4 AMPK activator 4 is a potent AMPK activator without inhibition of mitochondrial complex I. AMPK activator 4 Chemical Structure
  76. GC67961 AMPK-IN-3 AMPK-IN-3 Chemical Structure
  77. GC16534 Ampkinone AMPK activator Ampkinone Chemical Structure
  78. GC18374 API-1

    NSC 177223

     API-1 is an inhibitor of Akt that reduces the level of phosphorylated Akt (IC50 = ~0.8 uM in OVCAR3 cells) by binding to Akt and blocking its translocation to the cell membrane. API-1 Chemical Structure
  79. GC31661 APY0201 APY0201 is a potent PIKfyve inhibitor, which inhibits the conversion of PtdIns3P to PtdIns(3,5)P2 in the presence of in the presence of [33P]ATP with an IC50 of 5.2 nM. APY0201 Chemical Structure
  80. GC15425 AR-A014418

    AR-AO 14418;AR 0133418;AR 014418;GSK 3β inhibitor

     A selective inhibitor of GSK3β AR-A014418 Chemical Structure
  81. GC74044 ARM165 ARM165 is a heterobifunctional molecule. ARM165 Chemical Structure
  82. GC35395 Arnicolide D

    ARD

     Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D Chemical Structure
  83. GC19036 ARQ-092

    Miransertib

     ARQ-092 (ARQ-092) is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. ARQ-092 Chemical Structure
  84. GN10647 Artemisinine

    NSC 369397

     Artemisinine Chemical Structure
  85. GC11910 AS-041164 PI3Kγ inhibitor AS-041164 Chemical Structure
  86. GC13901 AS-252424 PI3Kγ inhibitor,novel and potent AS-252424 Chemical Structure
  87. GC38061 AS-604850 A selective inhibitor of PI3Kγ AS-604850 Chemical Structure
  88. GC12080 AS-604850 PI3Kγ inhibitor,selective and ATP-competitve AS-604850 Chemical Structure
  89. GC12474 AS-605240 Potent and selective PI 3-Kγ inhibitor AS-605240 Chemical Structure
  90. GC42856 AS-605240 (potassium salt) Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of PI at the three position to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. AS-605240 (potassium salt) Chemical Structure
  91. GC74029 ASCT2-IN-1 ASCT2-IN-1 (compound 20k) is an ASCT2 inhibitor with IC50 values of 5.6 μM and 3.5 μM in cells A549 and HEK293, respectively. ASCT2-IN-1 Chemical Structure
  92. GC74030 ASCT2-IN-2 ASCT2-IN-2 (compound 25e) is an ASCT2 inhibitor with IC50 of 5.14 μM. ASCT2-IN-2 Chemical Structure
  93. GC17712 AT13148 Multi-AGC kinase inhibitor,ATP-competitive AT13148 Chemical Structure
  94. GC12297 AT7867

    Akt1/2/3 and p70S6K/PKA inhibitor

     AT7867 Chemical Structure
  95. GC10918 AT7867 dihydrochloride A potent and orally bioavailable pan-Akt inhibitor AT7867 dihydrochloride Chemical Structure
  96. GC62335 AZ2 AZ2 is a highly selective PI3Kγ inhibitor (The pIC50 value for PI3Kγ is 9.3). AZ2 Chemical Structure
  97. GC64938 AZD-7648 AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity. AZD-7648 Chemical Structure
  98. GC16568 AZD1080 GSK3βinhibitor AZD1080 Chemical Structure
  99. GC13029 AZD2014

    AZD 2014; AZD-2014

     AZD2014 (AZD2014) is an ATP competitive mTOR inhibitor with an IC50 of 2.81 nM. AZD2014 inhibits both mTORC1 and mTORC2 complexes. AZD2014 Chemical Structure
  100. GC14736 AZD2858 GSK-3 inhibitor,potent and selective AZD2858 Chemical Structure
  101. GC65149 AZD3458 AZD3458 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively. AZD3458 Chemical Structure

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