GLPBio

PKD

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Protein kinase D (PKD) are a family of serine/threonine kinases comprised of three different but closely related members of Calmodulin-dependent protein kinases, including PKD1, PKD2 and PKD3, that are involved in fission of vesicles at the Golgi compartment, coordination of cell migration and invasion, and regulation of gene transcription. All PKD protein kinases are diacylglycerol (DAG) receptors characterized by the presence of a highly conserved N-terminal regulatory domain, which consists of two zinc finger-like cysteine-rich domains, and an autoinhibitory pleckstrin homology (PH) domain. DAG is able to bind to the cysteine-rich domain of PKD enzymes, which is crucial for kinase activation.

Products Related to PKD(6)

  • GC13589 structure
    GC13589CID 755673
    CAS: 521937-07-5
    Purity: >99.50%

    PKD inhibitor

  • GC11319 structure
    GC11319kb NB 142-70
    CAS: 1233533-04-4
    Purity: >98.00%

    A selective PKD inhibitor

  • GC14355 structure
    GC14355CRT5
    CAS: 1034297-58-9
    Purity: >98%

    PKD1, PKD2, and PKD3 inhibitor

  • GC35750 structure
    GC35750CRT0066101 dihydrochloride
    CAS: 1883545-60-5
    Purity: >98.00%

    CRT0066101 dihydrochloride is a potent and specific PKD inhibitor with IC50 values of 1, 2.5 and 2 nM for PKD1, 2, and 3 respectively.

  • GC43326 structure
    GC43326CRT0066101 (hydrochloride)
    CAS: 1290629-45-6
    Purity: >95.00%

    Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.

  • GC68537 structure
    GC685373-IN-PP1
    CAS: 2227110-54-3
    Purity: >98%

    3-IN-PP1 is a protein kinase D (PKD) inhibitor. It has effective and broad PKD inhibitory activity against PKD1, PKD2, and PKD3 with IC50 values of 108, 94, and 108 nM respectively. Additionally, 3-IN-PP1 is a broad-spectrum anticancer agent that inhibits the growth of various tumor cells. It can be used in cancer research.