GLPBio

PKG Inhibitor (trifluoroacetate salt)

Catalog No.: GC92078Purity:>95.00%Synonyms: Arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid; Protein Kinase G Inhibitor
COASDSData Sheet

PKG inhibitor is a specific cGMP-dependent PKG inhibitor (Ki = 86 μM).

Products are for research use only. Not for human use. We do not sell to patients.

PKG Inhibitor (trifluoroacetate salt)
1 mgIn Stock
$80.00
1
5 mgIn Stock
$367.00
1
10 mgIn Stock
$654.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

PKG inhibitor is a specific cGMP-dependent PKG inhibitor (Ki = 86 μM).1 This synthetic peptide is a nonphosphorylatable analog of a substrate corresponding to the serine-32 phosphorylation site in histone H2B.1 PKG inhibitor has been reported to block cGMP-dependent NMDA potentiation and nitric oxide-induced depression of GABA currents in cultured retinal amacrine cells.2

References:
[1]. Glass, D.B.Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitorsBiochem. J.213(1)159-164(1983).
[2]. Wexler, E.M., Stanton, P.K., and Nawy, S.Nitric oxide depresses GABAA receptor function via coactivation of cGMP-dependent kinase and phosphodiesteraseJ. Neurosci.18(7)2342-2349(1998).

Product Documents

Purity:>95.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Synonyms
Arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid; Protein Kinase G Inhibitor
Chemical Name
L-arginyl-L-lysyl-L-arginyl-L-alanyl-L-arginyl-L-lysyl-L-glutamic acid, trifluoroacetate salt
SMILES
O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)N)=O)CCCCN)=O)CCCNC(N)=N)=O)C)=O)CCCNC(N)=N)=O)CCCCN)N[C@@H](CCC(O)=O)C(O)=O.FC(F)(F)C(O)=O
Molecular Formula
C38H74N18O10 ? XCF3COOH
Molecular Weight
943.1
Solubility
DMF: 5 mg/ml,DMSO: 15 mg/ml,PBS (pH 7.2): 10 mg/ml
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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