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Protein Arginine Deiminase

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Protein arginine deiminases (PADs) is a unique family of enzymes that catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline on histones, fibrinogen, and other biologically relevant proteins. In humans, the PAD family is composed of five, calcium dependent isozymes (PADs 1-4 and 6), which share roughly 50% sequence similarity. PADs are found in a myriad of cell and tissue types, including the epidermis and uterus (PAD1), skeletal muscle, brain, inflammatory cells, several cancer cell lines, and secretory glands (PAD2), hair follicles and keratinocytes (PAD3), granulocytes and several types of cancer (PAD4), and oocytes and embryos (PAD6). PAD4, the best characterized isozyme, has also been shown to citrullinate a number of other proteins, including p300, ING4, RPS2, lamin C, and nucleophosmin.

Products Related to Protein Arginine Deiminase(15)

  • GC11032 structure
    GC11032Cl-Amidine (trifluoroacetate salt)
    CAS: 1043444-18-3
    Purity: >97.00%

    Cl-Amidine (trifluoroacetate salt) is a multi-targeting peptidylarginine deminase (PAD) inhibitor with the functional group RC(NR)NR2 that inhibits PAD1 (IC 50 =0.8μM), PAD3 (IC 50 =6.2μM), and PAD4 (IC 50 =5.9μM) with 15min half-time.

  • GC18925 structure
    GC18925Cl-Amidine (hydrochloride)
    CAS: 1373232-26-8
    Purity: >98.50%

    Cl-amidine is an inhibitor of protein arginine deiminases (PAD; IC50s = 0.8, 6.2, and 5.9 uM for PAD1, PAD3, and PAD4 in vitro, respectively).

  • GC19184 structure
    GC19184GSK484 hydrochloride
    CAS: 1652591-81-5
    Purity: >98.00%

    GSK484 is a selective PAD4 inhibitor, has been used as an anti-ischemic compound and exerts inhibitory activity against PAD4.

  • GC32303 structure
    GC32303Streptonigrin (Bruneomycin)
    CAS: 3930-19-6
    Purity: >98%

    Streptonigrin (Bruneomycin) (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity.

  • GC33261 structure
    GC33261YW3-56
    CAS: 1374311-17-7
    Purity: >98%
  • GC35480 structure
    GC35480BB-Cl-Amidine hydrochloride
    CAS: 2436747-41-8
    Purity: >99.00%

    BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor.

  • GC35706 structure
    GC35706Cl-amidine
    CAS: 913723-61-2
    Purity: >97.00%

    Cl-amidine (N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine amide), is a PAD4 inactivator with enhanced potency.

  • GC63780 structure
    GC63780D-Cl-amidine hydrochloride
    CAS: 2985338-61-0
    Purity: >99.00%

    D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity.

  • GC64367 structure
    GC64367PAD2-IN-1
    CAS: 2095109-82-1
    Purity: >98%

    PAD2-IN-1, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor.

  • GC66335 structure
    GC66335PAD2-IN-1 hydrochloride
    Purity: >99.00%

    PAD2-IN-1 hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold).

  • GC66379 structure
    GC66379AFM-30a hydrochloride
    Purity: >99.00%

    AFM-30a hydrochloride is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a hydrochloride binds to PAD2 with an EC50 value of 9.5 μM. AFM-30a hydrochloride also inhibits H3 citrullination with an EC50 value of 0.4 μM. AFM-30a hydrochloride can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis.

  • GC67873 structure
    GC67873PAD-IN-2
    CAS: 2304852-21-7
    Purity: >98%
  • GC73447 structure
    GC73447JBI-589
    CAS: 2308504-22-3
    Purity: >98.00%

    JBI-589 is a non-covalent PAD4 isoform-selective inhibitor with oral bioavailability.

  • GC73542 structure
    GC73542PAD4-IN-2 TFA
    Purity: >95.00%

    PAD4-IN-2 (compound 5i) TFA is a PAD4 inhibitor (IC50=1.94 μM).

  • GC81837 structure
    GC81837Histone H4 peptide substrate (1-21) acetate
    Purity: >98.00%

    Histone H4 peptide substrate (1-21) acetate is a PAD4 peptide substrate.