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Home >> Signaling Pathways >> Chromatin/Epigenetics

Chromatin/Epigenetics

Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Targets for  Chromatin/Epigenetics

Products for  Chromatin/Epigenetics

  1. Cat.No. Product Name Information
  2. GC31365 γ-Oryzanol γ-Oryzanol Chemical Structure
  3. GC45258 (+)-Biotin 4-Amidobenzoic Acid (sodium salt) (+)-Biotin 4-amidobenzoic acid is a substrate of biotinidase, which cleaves biotin amide to give biotin in vivo. (+)-Biotin 4-Amidobenzoic Acid (sodium salt) Chemical Structure
  4. GC61595 (+)-JQ-1-aldehyde (+)-JQ-1-aldehyde Chemical Structure
  5. GC34958 (+)-JQ1 PA (+)-JQ1 PA Chemical Structure
  6. GC13822 (-)-JQ1

    BET bromodomain inhibitor

     (-)-JQ1 Chemical Structure
  7. GC34964 (1S,3R,5R)-PIM447 dihydrochloride (1S,3R,5R)-PIM447 dihydrochloride Chemical Structure
  8. GC62130 (2R,5S)-Ritlecitinib (2R,5S)-Ritlecitinib Chemical Structure
  9. GC34971 (3R,4S)-Tofacitinib (3R,4S)-Tofacitinib Chemical Structure
  10. GC34972 (3S,4R)-Tofacitinib (3S,4R)-Tofacitinib Chemical Structure
  11. GC34973 (3S,4S)-Tofacitinib (3S,4S)-Tofacitinib Chemical Structure
  12. GC41695 (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride) (6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride) Chemical Structure
  13. GC41088 (6S)-Tetrahydrofolic Acid (6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid, a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. (6S)-Tetrahydrofolic Acid Chemical Structure
  14. GC61807 (E/Z)-AG490 (E/Z)-AG490 Chemical Structure
  15. GC63864 (E/Z)-Zotiraciclib hydrochloride (E/Z)-Zotiraciclib hydrochloride Chemical Structure
  16. GC15104 (R)-(+)-Etomoxir sodium salt carnitine palmitoyltransferase I (CPT1) inhibitor (R)-(+)-Etomoxir sodium salt Chemical Structure
  17. GC63791 (R)-(-)-JQ1 Enantiomer (R)-(-)-JQ1 Enantiomer Chemical Structure
  18. GC45908 (R)-BAY-598 (R)-BAY-598 Chemical Structure
  19. GC34443 (R)-BAY1238097 (R)-BAY1238097 Chemical Structure
  20. GC64210 (R)-GSK-3685032 (R)-GSK-3685032 Chemical Structure
  21. GC11340 (R)-PFI 2 hydrochloride SETD7 histone lysine methyltransferase inhibitor (R)-PFI 2 hydrochloride Chemical Structure
  22. GC34446 (rac)-BAY1238097 (rac)-BAY1238097 Chemical Structure
  23. GC60004 (rel)-Tranylcypromine D5 hydrochloride (rel)-Tranylcypromine D5 hydrochloride Chemical Structure
  24. GC33198 (S)-JQ-35 (TEN-010) (S)-JQ-35 (TEN-010) Chemical Structure
  25. GC65045 (S)-MRTX-1719 (S)-MRTX-1719 Chemical Structure
  26. GC13634 (S)-PFI-2 (hydrochloride) Negative control of (R)-PFI 2 hydrochloride (S)-PFI-2 (hydrochloride) Chemical Structure
  27. GC65133 (S,R,S)-AHPC-C5-COOH (S,R,S)-AHPC-C5-COOH Chemical Structure
  28. GC17055 1,2,3,4,5,6-Hexabromocyclohexane JAK2 tyrosine kinase inhibitor 1,2,3,4,5,6-Hexabromocyclohexane Chemical Structure
  29. GC61949 1,4-DPCA ethyl ester 1,4-DPCA ethyl ester Chemical Structure
  30. GC40468 1,5-Isoquinolinediol

    The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis.

     1,5-Isoquinolinediol Chemical Structure
  31. GC41984 1-Alaninechlamydocin 1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. 1-Alaninechlamydocin Chemical Structure
  32. GC39214 1-Naphthohydroxamic acid 1-Naphthohydroxamic acid Chemical Structure
  33. GC12775 2',3',5'-triacetyl-5-Azacytidine prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor 2',3',5'-triacetyl-5-Azacytidine Chemical Structure
  34. GC16195 2,4-DPD cell permeable, competitive inhibitor of HIF-PH 2,4-DPD Chemical Structure
  35. GC11873 2,4-Pyridinedicarboxylic Acid Histone LSD inhibitor 2,4-Pyridinedicarboxylic Acid Chemical Structure
  36. GC42075 2,4-Pyridinedicarboxylic Acid (hydrate) 2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. 2,4-Pyridinedicarboxylic Acid (hydrate) Chemical Structure
  37. GC62233 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Chemical Structure
  38. GC10408 2-D08 Sumoylation inhibitor 2-D08 Chemical Structure
  39. GC11249 2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor 2-hexyl-4-Pentynoic Acid Chemical Structure
  40. GC15084 2-Methoxyestradiol (2-MeOE2) Apoptotic, antiproliferative and antiangiogenic agent 2-Methoxyestradiol (2-MeOE2) Chemical Structure
  41. GC62781 2-Methylquinazolin-4-ol 2-Methylquinazolin-4-ol Chemical Structure
  42. GC14282 3-acetyl-11-keto-β-Boswellic Acid A 5-lipoxygenase inhibitor 3-acetyl-11-keto-β-Boswellic Acid Chemical Structure
  43. GC17907 3-Deazaneplanocin A (DZNep) hydrochloride A SAHH and ENZ2 inhibitor 3-Deazaneplanocin A (DZNep) hydrochloride Chemical Structure
  44. GC13145 3-Deazaneplanocin,DZNep

    S-adenosylhomocysteine and EZH2 inhibitor

     3-Deazaneplanocin,DZNep Chemical Structure
  45. GC18509 3-Methylcytidine (methosulfate)

    3-Methylcytidine (methosulfate) is a cytidine derivative used as an internal standard for HPLC.

     3-Methylcytidine (methosulfate) Chemical Structure
  46. GC19013 3-TYP

    3-TYP inhibit SIRT3 with an IC50 of 16 nM, and is more potent over SIRT1 and SIRT2 with IC50 of 88 nM and 92 nM, respectively.

     3-TYP Chemical Structure
  47. GC62805 4’-Methoxychalcone 4’-Methoxychalcone Chemical Structure
  48. GC17922 4'-bromo-Resveratrol Sirt1 and Sirt3 inhibitor 4'-bromo-Resveratrol Chemical Structure
  49. GC11761 4-amino-1,8-Naphthalimide PARP inhibitor 4-amino-1,8-Naphthalimide Chemical Structure
  50. GC16474 4-HQN PARP inhibitor 4-HQN Chemical Structure
  51. GC17005 4-iodo-SAHA class I and class II histone deacetylase (HDAC) inhibitor 4-iodo-SAHA Chemical Structure
  52. GC12667 4SC-202 Class I HDAC inhibitor 4SC-202 Chemical Structure
  53. GN10629 5,7-dihydroxychromone Nrf2/ARE signal activator and PPARγ agonist 5,7-dihydroxychromone Chemical Structure
  54. GC10898 5-(N,N-dimethyl)-Amiloride (hydrochloride) NHE1, NHE2, and NHE3 inhibitor 5-(N,N-dimethyl)-Amiloride (hydrochloride) Chemical Structure
  55. GC10946 5-Azacytidine A DNA methyltransferase inhibitor 5-Azacytidine Chemical Structure
  56. GC61662 5-Fluoro-2'-deoxycytidine 5-Fluoro-2'-deoxycytidine Chemical Structure
  57. GC42562 5-Methyl-2'-deoxycytidine 5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo DNA methylation. 5-Methyl-2'-deoxycytidine Chemical Structure
  58. GC45772 6(5H)-Phenanthridinone 6(5H)-Phenanthridinone Chemical Structure
  59. GC35180 6-Methyl-5-azacytidine 6-Methyl-5-azacytidine Chemical Structure
  60. GC62279 653-47 653-47 Chemical Structure
  61. GC62144 653-47 hydrochloride 653-47 hydrochloride Chemical Structure
  62. GC32689 666-15 666-15 Chemical Structure
  63. GC62651 7-Chloro-4-(piperazin-1-yl)quinoline 7-Chloro-4-(piperazin-1-yl)quinoline Chemical Structure
  64. GC16015 A 366 G9a/GLP histone lysine methyltransferase inhibitor A 366 Chemical Structure
  65. GC32861 A-196 A-196 Chemical Structure
  66. GC33187 A-395 (A395) A-395 (A395) Chemical Structure
  67. GC32677 A-485 A p300/CBP inhibitor A-485 Chemical Structure
  68. GC30503 A-893 A-893 Chemical Structure
  69. GC12390 A-966492 PARP-1/-2 inhibitor, highly potent A-966492 Chemical Structure
  70. GC33280 A1874 A1874 Chemical Structure
  71. GC19409 ABBV-744

    ABBV-744 is a BDII-selective BET bromodomain inhibitor

     ABBV-744 Chemical Structure
  72. GC10154 ABC294640 Sphingosine kinase 2 inhibitor,selective and competitive ABC294640 Chemical Structure
  73. GC32023 Abrocitinib (PF-04965842) Abrocitinib (PF-04965842) Chemical Structure
  74. GC12422 ABT-888 (Veliparib) A potent PARP inhibitor ABT-888 (Veliparib) Chemical Structure
  75. GA20481 Ac-Arg-Gly-Lys(Ac)-AMC Ac-RGK(Ac)-AMC, fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluorescent group by trypsin. Ac-Arg-Gly-Lys(Ac)-AMC Chemical Structure
  76. GA20605 Ac-Lys-AMC Ac-Lys-AMC is cleaved by trypsin. Ac-Lys-AMC Chemical Structure
  77. GC12917 Acetaminophen

    A COX inhibitor

     Acetaminophen Chemical Structure
  78. GC64137 Acetaminophen-d3 Acetaminophen-d3 Chemical Structure
  79. GC32083 Acriflavine Acriflavine Chemical Structure
  80. GC62354 Acriflavine hydrochloride Acriflavine hydrochloride Chemical Structure
  81. GC34458 ACY-1083 ACY-1083 Chemical Structure
  82. GC10417 ACY-241 Selective and orally active HDAC6 inhibitor ACY-241 Chemical Structure
  83. GC19020 ACY-738 ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM; ACY-738 also inhibits HDAC1, HDAC2, and HDAC3, with IC50s of 94, 128, and 218 nM. ACY-738 Chemical Structure
  84. GC30782 ACY-775 ACY-775 Chemical Structure
  85. GC30526 ACY-957 ACY-957 Chemical Structure
  86. GC12487 Adaptaquin HIF-prolyl hydroxylase-2 (PHD2) inhibitor Adaptaquin Chemical Structure
  87. GC16509 Adox

    indirect methyltransferase inhibitor

     Adox Chemical Structure
  88. GC64527 ADTL-SA1215 ADTL-SA1215 Chemical Structure
  89. GC65330 AES-135 AES-135 Chemical Structure
  90. GC33416 AFP464 AFP464 Chemical Structure
  91. GC16318 AG-14361 Potent PARP1 inhibitor AG-14361 Chemical Structure
  92. GC17881 AGK 2 SIRT2 inhibitor, potent and selective AGK 2 Chemical Structure
  93. GC15931 AGK7 cell-permeable, selective inhibitor of SIRT2 AGK7 Chemical Structure
  94. GN10413 Agrimol B Extracted from hairyvein agrimony;Store the product in sealed, cool and dry condition Agrimol B Chemical Structure
  95. GC10676 AK-7

    selective and brain-permeable SIRT2 inhibitor

     AK-7 Chemical Structure
  96. GC62277 AKB-6899 AKB-6899 Chemical Structure
  97. GC62433 AKI603 AKI603 Chemical Structure
  98. GC17344 Alexidine dihydrochloride PTPMT1 inhibitor Alexidine dihydrochloride Chemical Structure
  99. GC35297 Alobresib Alobresib Chemical Structure
  100. GC13198 AMG-900 Aurora kinase inhibitor AMG-900 Chemical Structure
  101. GC17275 AMI-1 PRMT1 inhibitor AMI-1 Chemical Structure

Items 1 to 100 of 1118 total

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