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Home >> Signaling Pathways >> Chromatin/Epigenetics

Chromatin/Epigenetics

Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Targets for  Chromatin/Epigenetics

Products for  Chromatin/Epigenetics

  1. Cat.No. Product Name Information
  2. GC31365 γ-Oryzanol γ-Oryzanol Chemical Structure
  3. GC45258 (+)-Biotin 4-Amidobenzoic Acid (sodium salt) (+)-Biotin 4-amidobenzoic acid is a substrate of biotinidase, which cleaves biotin amide to give biotin in vivo. (+)-Biotin 4-Amidobenzoic Acid (sodium salt) Chemical Structure
  4. GC61595 (+)-JQ-1-aldehyde (+)-JQ-1-aldehyde Chemical Structure
  5. GC34958 (+)-JQ1 PA (+)-JQ1 PA Chemical Structure
  6. GC13822 (-)-JQ1

    BET bromodomain inhibitor

     (-)-JQ1 Chemical Structure
  7. GC34964 (1S,3R,5R)-PIM447 dihydrochloride (1S,3R,5R)-PIM447 dihydrochloride Chemical Structure
  8. GC62130 (2R,5S)-Ritlecitinib (2R,5S)-Ritlecitinib Chemical Structure
  9. GC34971 (3R,4S)-Tofacitinib (3R,4S)-Tofacitinib Chemical Structure
  10. GC34972 (3S,4R)-Tofacitinib (3S,4R)-Tofacitinib Chemical Structure
  11. GC34973 (3S,4S)-Tofacitinib (3S,4S)-Tofacitinib Chemical Structure
  12. GC41695 (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride) (6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride) Chemical Structure
  13. GC41088 (6S)-Tetrahydrofolic Acid (6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid, a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. (6S)-Tetrahydrofolic Acid Chemical Structure
  14. GC61807 (E/Z)-AG490 (E/Z)-AG490 Chemical Structure
  15. GC63864 (E/Z)-Zotiraciclib hydrochloride (E/Z)-Zotiraciclib hydrochloride Chemical Structure
  16. GC15104 (R)-(+)-Etomoxir sodium salt carnitine palmitoyltransferase I (CPT1) inhibitor (R)-(+)-Etomoxir sodium salt Chemical Structure
  17. GC63791 (R)-(-)-JQ1 Enantiomer (R)-(-)-JQ1 Enantiomer Chemical Structure
  18. GC45908 (R)-BAY-598 (R)-BAY-598 Chemical Structure
  19. GC34443 (R)-BAY1238097 (R)-BAY1238097 Chemical Structure
  20. GC64210 (R)-GSK-3685032 (R)-GSK-3685032 Chemical Structure
  21. GC11340 (R)-PFI 2 hydrochloride SETD7 histone lysine methyltransferase inhibitor (R)-PFI 2 hydrochloride Chemical Structure
  22. GC34446 (rac)-BAY1238097 (rac)-BAY1238097 Chemical Structure
  23. GC60004 (rel)-Tranylcypromine D5 hydrochloride (rel)-Tranylcypromine D5 hydrochloride Chemical Structure
  24. GC33198 (S)-JQ-35 (TEN-010) (S)-JQ-35 (TEN-010) Chemical Structure
  25. GC13634 (S)-PFI-2 (hydrochloride) Negative control of (R)-PFI 2 hydrochloride (S)-PFI-2 (hydrochloride) Chemical Structure
  26. GC17055 1,2,3,4,5,6-Hexabromocyclohexane JAK2 tyrosine kinase inhibitor 1,2,3,4,5,6-Hexabromocyclohexane Chemical Structure
  27. GC61949 1,4-DPCA ethyl ester 1,4-DPCA ethyl ester Chemical Structure
  28. GC40468 1,5-Isoquinolinediol

    The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis.

     1,5-Isoquinolinediol Chemical Structure
  29. GC41984 1-Alaninechlamydocin 1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. 1-Alaninechlamydocin Chemical Structure
  30. GC39214 1-Naphthohydroxamic acid 1-Naphthohydroxamic acid Chemical Structure
  31. GC12775 2',3',5'-triacetyl-5-Azacytidine prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor 2',3',5'-triacetyl-5-Azacytidine Chemical Structure
  32. GC16195 2,4-DPD cell permeable, competitive inhibitor of HIF-PH 2,4-DPD Chemical Structure
  33. GC11873 2,4-Pyridinedicarboxylic Acid Histone LSD inhibitor 2,4-Pyridinedicarboxylic Acid Chemical Structure
  34. GC42075 2,4-Pyridinedicarboxylic Acid (hydrate) 2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. 2,4-Pyridinedicarboxylic Acid (hydrate) Chemical Structure
  35. GC62233 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Chemical Structure
  36. GC10408 2-D08 Sumoylation inhibitor 2-D08 Chemical Structure
  37. GC11249 2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor 2-hexyl-4-Pentynoic Acid Chemical Structure
  38. GC15084 2-Methoxyestradiol (2-MeOE2) Apoptotic, antiproliferative and antiangiogenic agent 2-Methoxyestradiol (2-MeOE2) Chemical Structure
  39. GC62781 2-Methylquinazolin-4-ol 2-Methylquinazolin-4-ol Chemical Structure
  40. GC14282 3-acetyl-11-keto-β-Boswellic Acid A 5-lipoxygenase inhibitor 3-acetyl-11-keto-β-Boswellic Acid Chemical Structure
  41. GC17907 3-Deazaneplanocin A (DZNep) hydrochloride A SAHH and ENZ2 inhibitor 3-Deazaneplanocin A (DZNep) hydrochloride Chemical Structure
  42. GC13145 3-Deazaneplanocin,DZNep

    S-adenosylhomocysteine and EZH2 inhibitor

     3-Deazaneplanocin,DZNep Chemical Structure
  43. GC18509 3-Methylcytidine (methosulfate)

    3-Methylcytidine (methosulfate) is a cytidine derivative used as an internal standard for HPLC.

     3-Methylcytidine (methosulfate) Chemical Structure
  44. GC19013 3-TYP A SIRT3 inhibitor 3-TYP Chemical Structure
  45. GC62805 4’-Methoxychalcone 4’-Methoxychalcone Chemical Structure
  46. GC17922 4'-bromo-Resveratrol Sirt1 and Sirt3 inhibitor 4'-bromo-Resveratrol Chemical Structure
  47. GC11761 4-amino-1,8-Naphthalimide PARP inhibitor 4-amino-1,8-Naphthalimide Chemical Structure
  48. GC16474 4-HQN PARP inhibitor 4-HQN Chemical Structure
  49. GC17005 4-iodo-SAHA class I and class II histone deacetylase (HDAC) inhibitor 4-iodo-SAHA Chemical Structure
  50. GC12667 4SC-202 Class I HDAC inhibitor 4SC-202 Chemical Structure
  51. GN10629 5,7-dihydroxychromone Nrf2/ARE signal activator and PPARγ agonist 5,7-dihydroxychromone Chemical Structure
  52. GC10898 5-(N,N-dimethyl)-Amiloride (hydrochloride) NHE1, NHE2, and NHE3 inhibitor 5-(N,N-dimethyl)-Amiloride (hydrochloride) Chemical Structure
  53. GC10946 5-Azacytidine A DNA methyltransferase inhibitor 5-Azacytidine Chemical Structure
  54. GC61662 5-Fluoro-2'-deoxycytidine 5-Fluoro-2'-deoxycytidine Chemical Structure
  55. GC42562 5-Methyl-2'-deoxycytidine 5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo DNA methylation. 5-Methyl-2'-deoxycytidine Chemical Structure
  56. GC45772 6(5H)-Phenanthridinone 6(5H)-Phenanthridinone Chemical Structure
  57. GC35180 6-Methyl-5-azacytidine 6-Methyl-5-azacytidine Chemical Structure
  58. GC62279 653-47 653-47 Chemical Structure
  59. GC62144 653-47 hydrochloride 653-47 hydrochloride Chemical Structure
  60. GC32689 666-15 666-15 Chemical Structure
  61. GC62651 7-Chloro-4-(piperazin-1-yl)quinoline 7-Chloro-4-(piperazin-1-yl)quinoline Chemical Structure
  62. GC16015 A 366 G9a/GLP histone lysine methyltransferase inhibitor A 366 Chemical Structure
  63. GC32861 A-196 A-196 Chemical Structure
  64. GC33187 A-395 (A395) A-395 (A395) Chemical Structure
  65. GC32677 A-485 A p300/CBP inhibitor A-485 Chemical Structure
  66. GC30503 A-893 A-893 Chemical Structure
  67. GC12390 A-966492 PARP-1/-2 inhibitor, highly potent A-966492 Chemical Structure
  68. GC33280 A1874 A1874 Chemical Structure
  69. GC19409 ABBV-744

    ABBV-744 is a BDII-selective BET bromodomain inhibitor

     ABBV-744 Chemical Structure
  70. GC10154 ABC294640 Sphingosine kinase 2 inhibitor,selective and competitive ABC294640 Chemical Structure
  71. GC32023 Abrocitinib (PF-04965842) Abrocitinib (PF-04965842) Chemical Structure
  72. GC12422 ABT-888 (Veliparib) A potent PARP inhibitor ABT-888 (Veliparib) Chemical Structure
  73. GA20481 Ac-Arg-Gly-Lys(Ac)-AMC Ac-RGK(Ac)-AMC, fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluorescent group by trypsin. Ac-Arg-Gly-Lys(Ac)-AMC Chemical Structure
  74. GA20605 Ac-Lys-AMC Ac-Lys-AMC is cleaved by trypsin. Ac-Lys-AMC Chemical Structure
  75. GC12917 Acetaminophen

    A COX inhibitor

     Acetaminophen Chemical Structure
  76. GC64137 Acetaminophen-d3 Acetaminophen-d3 Chemical Structure
  77. GC32083 Acriflavine Acriflavine Chemical Structure
  78. GC62354 Acriflavine hydrochloride Acriflavine hydrochloride Chemical Structure
  79. GC34458 ACY-1083 ACY-1083 Chemical Structure
  80. GC10417 ACY-241 Selective and orally active HDAC6 inhibitor ACY-241 Chemical Structure
  81. GC19020 ACY-738 ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM; ACY-738 also inhibits HDAC1, HDAC2, and HDAC3, with IC50s of 94, 128, and 218 nM. ACY-738 Chemical Structure
  82. GC30782 ACY-775 ACY-775 Chemical Structure
  83. GC30526 ACY-957 ACY-957 Chemical Structure
  84. GC12487 Adaptaquin HIF-prolyl hydroxylase-2 (PHD2) inhibitor Adaptaquin Chemical Structure
  85. GC16509 Adox

    indirect methyltransferase inhibitor

     Adox Chemical Structure
  86. GC33416 AFP464 AFP464 Chemical Structure
  87. GC16318 AG-14361 Potent PARP1 inhibitor AG-14361 Chemical Structure
  88. GC17881 AGK 2 SIRT2 inhibitor, potent and selective AGK 2 Chemical Structure
  89. GC15931 AGK7 cell-permeable, selective inhibitor of SIRT2 AGK7 Chemical Structure
  90. GN10413 Agrimol B Extracted from hairyvein agrimony;Store the product in sealed, cool and dry condition Agrimol B Chemical Structure
  91. GC10676 AK-7

    selective and brain-permeable SIRT2 inhibitor

     AK-7 Chemical Structure
  92. GC62277 AKB-6899 AKB-6899 Chemical Structure
  93. GC62433 AKI603 AKI603 Chemical Structure
  94. GC17344 Alexidine dihydrochloride PTPMT1 inhibitor Alexidine dihydrochloride Chemical Structure
  95. GC35297 Alobresib Alobresib Chemical Structure
  96. GC13198 AMG-900 Aurora kinase inhibitor AMG-900 Chemical Structure
  97. GC17275 AMI-1 PRMT1 inhibitor AMI-1 Chemical Structure
  98. GC39840 AMI-1 free acid AMI-1 free acid Chemical Structure
  99. GC17546 AMI5 protein methyltransferase inhibitor AMI5 Chemical Structure
  100. GC42785 Amifostine (hydrate) Amifostine is a prodrug that through dephosphorylation by alkaline phosphatase is converted to an active thiol, WR 1065 that has free radical scavenging, DNA protective, and hypoxia inducing activities. Amifostine (hydrate) Chemical Structure
  101. GC42790 Amodiaquine Amodiaquine is an aminoquinoline antimalarial compound. Amodiaquine Chemical Structure

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