Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. Product Name Information
GC31365 γ-Oryzanol
GC34958 (+)-JQ1 PA
GC13822 (-)-JQ1
BET bromodomain inhibitor
GC34964 (1S,3R,5R)-PIM447 dihydrochloride
GC34971 (3R,4S)-Tofacitinib
GC34972 (3S,4R)-Tofacitinib
GC34973 (3S,4S)-Tofacitinib
GC15104 (R)-(+)-Etomoxir sodium salt carnitine palmitoyltransferase I (CPT1) inhibitor
GC34443 (R)-BAY1238097
GC11340 (R)-PFI 2 hydrochloride SETD7 histone lysine methyltransferase inhibitor
GC34446 (rac)-BAY1238097
GC33198 (S)-JQ-35 (TEN-010)
GC13634 (S)-PFI-2 (hydrochloride) Negative control of (R)-PFI 2 hydrochloride
GC17055 1,2,3,4,5,6-Hexabromocyclohexane JAK2 tyrosine kinase inhibitor
GC12775 2',3',5'-triacetyl-5-Azacytidine prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor
GC11873 2,4-Pyridinedicarboxylic Acid Histone LSD inhibitor
GC10408 2-D08 Sumoylation inhibitor
GC11249 2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor
GC15084 2-Methoxyestradiol (2-MeOE2)
Apoptotic, antiproliferative and antiangiogenic agent
GC14282 3-acetyl-11-keto-β-Boswellic Acid 5-lipoxygenase inhibitor