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Home >> Signaling Pathways >> Chromatin/Epigenetics

Chromatin/Epigenetics

Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Targets for  Chromatin/Epigenetics

Products for  Chromatin/Epigenetics

  1. Cat.No. Product Name Information
  2. GC72837 α-Hydroxyglutaric acid-d4 disodium

    2-Hydroxyglutarate-d4 disodium; 2-Hydroxyglutaric acid-d4 disodium; 2-Hydroxypentanedioic acid-d4 disodium

     α-droxyglutaric acid-d4 (disodium) is the deuterium labeled α-droxyglutaric acid disodium. α-Hydroxyglutaric acid-d4 disodium Chemical Structure
  3. GC31365 γ-Oryzanol γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol Chemical Structure
  4. GC45258 (+)-Biotin 4-Amidobenzoic Acid (sodium salt)

    (+)-Biotin PABA, N-Biotinyl-4-aminobenzoic Acid

     (+)-Biotin 4-amidobenzoic acid is a substrate of biotinidase, which cleaves biotin amide to give biotin in vivo. (+)-Biotin 4-Amidobenzoic Acid (sodium salt) Chemical Structure
  5. GC61595 (+)-JQ-1-aldehyde (+)-JQ-1-aldehyde is the aldehyde form of (+)-JQ1. (+)-JQ-1-aldehyde can be uesd as a precursor to synthesize PROTACs, which targets BET bromodomains. (+)-JQ-1-aldehyde Chemical Structure
  6. GC34958 (+)-JQ1 PA

    A clickable form of (+)-JQ1

     (+)-JQ1 PA Chemical Structure
  7. GC13822 (-)-JQ1 A selective inhibitor of BET bromodomains (-)-JQ1 Chemical Structure
  8. GC72769 (1R)-AZD-1480 (1R)-AZD-1480 is the (1R) chiral isomer of AZD-1480, an ATP competitive JAK1 and JAK2 inhibitor. (1R)-AZD-1480 Chemical Structure
  9. GC34964 (1S,3R,5R)-PIM447 dihydrochloride

    (1S,3R,5R)-LGH447 dihydrochloride

     (1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3. (1S,3R,5R)-PIM447 dihydrochloride Chemical Structure
  10. GC62130 (2R,5S)-Ritlecitinib

    (2R,5S)-PF-06651600

     (2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective JAK3 inhibitor (IC50=144.8 nM) extracted from patent US20150158864A1, example 68. (2R,5S)-Ritlecitinib Chemical Structure
  11. GC34971 (3R,4S)-Tofacitinib (3R,4S)-Tofacitinib is an less active enantiomer of Tofacitinib. (3R,4S)-Tofacitinib Chemical Structure
  12. GC34972 (3S,4R)-Tofacitinib (3S,4R)-Tofacitinib is an less active enantiomer of Tofacitinib. (3S,4R)-Tofacitinib Chemical Structure
  13. GC34973 (3S,4S)-Tofacitinib (3S,4S)-Tofacitinib is the less active S-enantiomer of Tofacitinib. (3S,4S)-Tofacitinib Chemical Structure
  14. GC41695 (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)

    Tetrahydrofolate, THFA

     (6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride) Chemical Structure
  15. GC41088 (6S)-Tetrahydrofolic Acid

    (6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid, a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.

     (6S)-Tetrahydrofolic Acid Chemical Structure
  16. GC72591 (E,E)-RGFP966 (E,E)-RGFP966 is a selective and CNS permeable HDAC3 inhibitor that can be used for the research of Huntington’s disease. (E,E)-RGFP966 Chemical Structure
  17. GC61807 (E/Z)-AG490 (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3. (E/Z)-AG490 Chemical Structure
  18. GC63864 (E/Z)-Zotiraciclib hydrochloride

    (E/Z)-TG02 hydrochloride; (E/Z)-SB1317 hydrochloride

     (E/Z)-Zotiraciclib ((E/Z)-TG02) hydrochloride is a potent CDK2, JAK2, and FLT3 inhibitor. (E/Z)-Zotiraciclib hydrochloride Chemical Structure
  19. GC15104 (R)-(+)-Etomoxir sodium salt

    (R)(+)Etomoxir

     (R)-(+)-Etomoxir sodium salt(Etomoxir) is a small molecule developed for metabolic and cardiovascular disease that exhibits nanomolar potency toward CPT-1a and CPT-1b upon enzymatic conversion to the active inhibitor etomoxiryl CoA (IC50 = 0.01-0.70 µM). (R)-(+)-Etomoxir sodium salt Chemical Structure
  20. GC45908 (R)-BAY-598 An inhibitor of SMYD2 (R)-BAY-598 Chemical Structure
  21. GC34443 (R)-BAY1238097 (R)-BAY1238097 is the R-isomer with lower activity of BAY1238097. BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome. (R)-BAY1238097 Chemical Structure
  22. GC64210 (R)-GSK-3685032 (R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition. (R)-GSK-3685032 Chemical Structure
  23. GC70906 (R)-HH2853 (R)-HH2853 is a mutant EZH2 inhibitor with an IC50 of <100 nM for EZH2-Y641F. (R)-HH2853 Chemical Structure
  24. GC11340 (R)-PFI 2 hydrochloride

    (-)PFI2

     PFI-2 ((R)-(R)-PFI 2 hydrochloride) hydrochloride is a potent and selective SET domain containing lysine methyltransferase 7 (SETD7) inhibitor. (R)-PFI 2 hydrochloride Chemical Structure
  25. GC69794 (Rac)-Arnebin 1

    (Rac)-β,β-Dimethylacrylalkannin; (Rac)-β,β-?Dimethylacrylshikonin

    (Rac)-Arnebin 1 is the racemic form of β,β-Dimethylacrylalkannin and/or β,β-Dimethylacrylshikonin. These compounds are naphthoquinones isolated from plants in the Lithospermum genus, with β,β-Dimethylacrylshikonin exhibiting anti-tumor activity.

     (Rac)-Arnebin 1 Chemical Structure
  26. GC34446 (rac)-BAY1238097 (Rac)-BAY1238097 is a BET inhibitor, with an IC50 of 1.02 μM for BRD4. Used in cancer research. (rac)-BAY1238097 Chemical Structure
  27. GC60004 (rel)-Tranylcypromine D5 hydrochloride Tranylcypromine-d5 (SKF 385-d5) hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride. (rel)-Tranylcypromine D5 hydrochloride Chemical Structure
  28. GC72866 (S)-GSK852 (S)-GSK852 is a diastereomer of GSK852. (S)-GSK852 Chemical Structure
  29. GC33198 (S)-JQ-35 (TEN-010)

    TEN-010

     (S)-JQ-35 (TEN-010) (TEN-010) is an inhibitor of the Bromodomain and Extra-Terminal (BET) family bromodomain-containing proteins with potential antineoplastic activity. (S)-JQ-35 (TEN-010) Chemical Structure
  30. GC65045 (S)-MRTX-1719 (S)-MRTX-1719 (example 16-7) is the S-enantiomer of MRTX-1719. (S)-MRTX-1719 is a PRMT5/MTA complex inhibitor, with an IC50 of 7070 nM. (S)-MRTX-1719 Chemical Structure
  31. GC13634 (S)-PFI-2 (hydrochloride)

    (+)-PFI-2

     Negative control of (R)-PFI 2 hydrochloride (S)-PFI-2 (hydrochloride) Chemical Structure
  32. GC73435 (S)-TNG260 (S)-TNG260 is an isomer of TNG260. (S)-TNG260 Chemical Structure
  33. GC65133 (S,R,S)-AHPC-C5-COOH

    VH032-C5-COOH

     (S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized?E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases. (S,R,S)-AHPC-C5-COOH Chemical Structure
  34. GC73208 (Z)-JQ1-TCO JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 , an inhibitor of BET. (Z)-JQ1-TCO Chemical Structure
  35. GC17055 1,2,3,4,5,6-Hexabromocyclohexane

    Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation.

     1,2,3,4,5,6-Hexabromocyclohexane Chemical Structure
  36. GC61949 1,4-DPCA ethyl ester 1,4-DPCA ethyl ester is the ethyl ester of 1,4-DPCA and can inhibit factor inhibiting HIF (FIH). 1,4-DPCA ethyl ester Chemical Structure
  37. GC40468 1,5-Isoquinolinediol

    NSC 65585

    The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis.

     1,5-Isoquinolinediol Chemical Structure
  38. GC41984 1-Alaninechlamydocin 1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. 1-Alaninechlamydocin Chemical Structure
  39. GC39214 1-Naphthohydroxamic acid 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity.1-Naphthohydroxamic acid can induce tubulin acetylation. 1-Naphthohydroxamic acid Chemical Structure
  40. GC46508 2',2'-Difluoro-2'-deoxyuridine

    dFdU

     An active metabolite of gemcitabine 2',2'-Difluoro-2'-deoxyuridine Chemical Structure
  41. GC12775 2',3',5'-triacetyl-5-Azacytidine prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor 2',3',5'-triacetyl-5-Azacytidine Chemical Structure
  42. GC16195 2,4-DPD

    2,4-Diethylpyridine dicarboxylate

     Diethyl pyridine-2,4-dicarb is a potent prolyl 4-hydroxylase-directed proinhibitor. 2,4-DPD Chemical Structure
  43. GC11873 2,4-Pyridinedicarboxylic Acid 2,4-Pyridinedicarboxylic Acid (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase, including JmjC domain-containing family of histone demethylases (JHDMs). 2,4-Pyridinedicarboxylic Acid is a target chemical in the field of bio-based plastics. 2,4-Pyridinedicarboxylic Acid Chemical Structure
  44. GC42075 2,4-Pyridinedicarboxylic Acid (hydrate)

    2,4-Dicarboxylpyridine, 2,4-PDCA

     2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. 2,4-Pyridinedicarboxylic Acid (hydrate) Chemical Structure
  45. GC62233 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide GDC-046 is a potent, selective, and orally bioavailable TYK2 inhibitor with Kis of 4.8, 0.7, 0.7, and 0.4 nM for TYK2, JAK1, JAK2, and JAK3, respectively. 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Chemical Structure
  46. GC46503 2-(1,8-Naphthyridin-2-yl)phenol

    2-NP

     2-(1,8-Naphthyridin-2-yl)phenol is a selective enhancer of STAT1 transcription. 2-(1,8-Naphthyridin-2-yl)phenol can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells. 2-(1,8-Naphthyridin-2-yl)phenol Chemical Structure
  47. GC73817 2-APQC 2-APQC is a SIRT3 activator with the Kd value of 2.756 μM. 2-APQC Chemical Structure
  48. GC10408 2-D08 Sumoylation inhibitor 2-D08 Chemical Structure
  49. GC11249 2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor 2-hexyl-4-Pentynoic Acid Chemical Structure
  50. GC15084 2-Methoxyestradiol (2-MeOE2)

    2Hydroxyestradiol 2methyl ether, 2ME2, NSC 659853, Panzem

     2-Methoxyestradiol (2-MeOE2/2-Me) is an HIF-1α inhibitor. 2-Methoxyestradiol (2-MeOE2) Chemical Structure
  51. GC62781 2-Methylquinazolin-4-ol 2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol Chemical Structure
  52. GC14282 3-acetyl-11-keto-β-Boswellic Acid

    3-O-acetyl-11-keto-β-Boswellic acid,AKBA

     3-acetyl-11-keto-β-Boswellic Acid (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator. 3-acetyl-11-keto-β-Boswellic Acid Chemical Structure
  53. GC17907 3-Deazaneplanocin A (DZNep) hydrochloride

    2,3DMMC

     3-Deazaneplanocin A (DZNep) hydrochloride is an adenosine analogue and is a competitive S-adenosylhomocysteine hydrolase inhibitor with a Ki of 50 pM in cell-free tests. 3-Deazaneplanocin A (DZNep) hydrochloride Chemical Structure
  54. GC13145 3-Deazaneplanocin,DZNep

    DZNep, NSC 617989

    An inhibitor of lysine methyltransferase EZH2

     3-Deazaneplanocin,DZNep Chemical Structure
  55. GC18509 3-Methylcytidine (methosulfate)

    3-Methylcytidine (methosulfate) is a cytidine derivative used as an internal standard for HPLC.

     3-Methylcytidine (methosulfate) Chemical Structure
  56. GC19013 3-TYP 3-TYP inhibit SIRT3 with an IC50 of 16 nM, and is more potent over SIRT1 and SIRT2 with IC50 of 88 nM and 92 nM, respectively. 3-TYP Chemical Structure
  57. GC62805 4’-Methoxychalcone 4’-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. 4’-Methoxychalcone Chemical Structure
  58. GC17922 4'-bromo-Resveratrol Sirt1 and Sirt3 inhibitor 4'-bromo-Resveratrol Chemical Structure
  59. GC46607 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone

    NNK

     4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone is a potent tobacco-specific carcinogen primarily found in tobacco products. It has a high affinity for α7 nicotinic acetylcholine receptors (α7 nAChR), with EC50 values of 0.03μM in small cell lung carcinoma (SCLCs) and 0.005μM in pulmonary neuroendocrine cells (PNECs). 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Chemical Structure
  60. GC11761 4-amino-1,8-Naphthalimide

    4-Aminonaphthalimide,4-ANI

     4-amino-1,8-Naphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells. 4-amino-1,8-Naphthalimide Chemical Structure
  61. GC46628 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline A building block and synthetic intermediate 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Chemical Structure
  62. GC17005 4-iodo-SAHA

    ISAHA

     class I and class II histone deacetylase (HDAC) inhibitor 4-iodo-SAHA Chemical Structure
  63. GC42466 4-pentynoyl-Coenzyme A (trifluoroacetate salt)

    Click Tag 4pentynoylCoA

     Protein acetylation is a reversible, post-translational modification regulated by lysine acetyltransferases and deacetylases and plays a key role in regulating gene expression. 4-pentynoyl-Coenzyme A (trifluoroacetate salt) Chemical Structure
  64. GC46675 4-Phenyl-2-pyrrolidinone A precursor and synthetic intermediate 4-Phenyl-2-pyrrolidinone Chemical Structure
  65. GC12667 4SC-202 4SC-202 (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). 4SC-202 Chemical Structure
  66. GC35150 5,7,4'-Trimethoxyflavone 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner. 5,7,4'-Trimethoxyflavone Chemical Structure
  67. GN10629 5,7-dihydroxychromone 5,7-dihydroxychromone Chemical Structure
  68. GC10898 5-(N,N-dimethyl)-Amiloride (hydrochloride)

    DMA,L-591,605,MK-685

     NHE1, NHE2, and NHE3 inhibitor 5-(N,N-dimethyl)-Amiloride (hydrochloride) Chemical Structure
  69. GC68161 5-AIQ

    5-Aminoisoquinolin-1-one

     5-AIQ Chemical Structure
  70. GC73073 5-Aza-4'-thio-2'-deoxycytidine

    5-Aza-T-dCyd; NTX-301

     5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA metltransferase I (DNMT1) inhibitor. 5-Aza-4'-thio-2'-deoxycytidine Chemical Structure
  71. GC10946 5-Azacytidine

    Antibiotic U 18496, 5AzaC, Ladakamycin, Mylosar, NSC 102816, NSC 103627, U 18496, WR 183027

     5-Azacytidine (also known as 5-AzaC), a compound belonging to a class of cytosine analogues, is a DNA methyl transferase (DNMT) inhibitor that exerts potent cytotoxicity against multiple myeloma (MM) cells, including MM.1S, MM.1R, RPMI-8266, RPMI-LR5, RPMI-Dox40 and Patient-derived MM, with the half maximal inhibition concentration IC50 values of 1.5 μmol/L, 0.7 μmol/L, 1.1 μmol/L, 2.5 μmol/L, 3.2 μmol/L and 1.5 μmol/L respectively. 5-Azacytidine Chemical Structure
  72. GC61662 5-Fluoro-2'-deoxycytidine 5-Fluoro-2'-deoxycytidine, a fluoropyrimidine nucleoside analogue, is a DNA methyltransferase (DNMT) inhibitor. 5-Fluoro-2'-deoxycytidine is a tumor-selective prodrug of the potent thymidylate synthase inhibitor 5-fluoro-2′-dUMP. 5-Fluoro-2'-deoxycytidine Chemical Structure
  73. GC71995 5-Heptadecylresorcinol 5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol Chemical Structure
  74. GC42562 5-Methyl-2'-deoxycytidine

    5Methyldeoxycytidine

     5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo DNA methylation. 5-Methyl-2'-deoxycytidine Chemical Structure
  75. GC66055 5-Phenylpentan-2-one 5-Phenylpentan-2-one is a potent histone deacetylases (HDACs) inhibitor. 5-Phenylpentan-2-one can be used for urea cycle disorder research. 5-Phenylpentan-2-one Chemical Structure
  76. GC45772 6(5H)-Phenanthridinone

    NSC 11021, NSC 40943, NSC 61083

     An inhibitor of PARP1 and 2 6(5H)-Phenanthridinone Chemical Structure
  77. GC35175 6-Demethoxytangeretin 6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. 6-Demethoxytangeretin Chemical Structure
  78. GC35180 6-Methyl-5-azacytidine 6-Methyl-5-azacytidine is a potent DNMT inhibitor. 6-Methyl-5-azacytidine Chemical Structure
  79. GC62279 653-47 653-47, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 is also a very weak CREB inhibitor with IC50 of 26.3 μM. 653-47 Chemical Structure
  80. GC62144 653-47 hydrochloride 653-47 hydrochloride, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC50 of 26.3 μM. 653-47 hydrochloride Chemical Structure
  81. GC32689 666-15

    Compound 3i

     666-15 is a selective cyclic AMP response element binding protein (CREB) inhibitor with an IC50 value of 0.081±0.04μM. 666-15 Chemical Structure
  82. GC46736 7-Bromoheptanoic Acid A building block 7-Bromoheptanoic Acid Chemical Structure
  83. GC62651 7-Chloro-4-(piperazin-1-yl)quinoline 7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinoline Chemical Structure
  84. GC48986 9-hydroxy Stearic Acid

    9-HSA, 9-hydroxy Octadecanoic Acid

     A hydroxy fatty acid 9-hydroxy Stearic Acid Chemical Structure
  85. GC16015 A 366 G9a/GLP histone lysine methyltransferase inhibitor A 366 Chemical Structure
  86. GC32861 A-196 A selective inhibitor of SUV420H1 and SUV420H2 A-196 Chemical Structure
  87. GC33187 A-395 (A395) A-395 (A395) is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 of 18 nM. A-395 (A395) Chemical Structure
  88. GC46081 A-395 (hydrochloride) A neuropeptide with diverse biological activities A-395 (hydrochloride) Chemical Structure
  89. GC32677 A-485 A-485 is a potent and selective p300/CBP (histone acetyltransferase paralog/CREB binding protein) catalytic inhibitor with IC50 of 60nM for p300 HAT. A-485 inhibits the activity of p300-BHC (bromodomain HAT-C/H3) and CBP-BHC domains with IC50 of 9.8nM and 2.6nM, respectively. A-485 Chemical Structure
  90. GC30503 A-893 A-893 is a cell-active inhibitor of Methyltransferase SMYD2, with an IC50 of 2.8 nM. A-893 Chemical Structure
  91. GC12390 A-966492 A PARP1 and PARP2 inhibitor A-966492 Chemical Structure
  92. GC33280 A1874 A1874 is a nutlin-based (MDM2 ligand) and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation. A1874 Chemical Structure
  93. GC35216 AAPK-25 AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM. AAPK-25 Chemical Structure
  94. GC19409 ABBV-744

    ABBV-744 is a BDII-selective BET bromodomain inhibitor

     ABBV-744 Chemical Structure
  95. GC10154 ABC294640 ABC294640 (ABC294640) is a selective, competitive sphingosine kinase 2 (SK2) inhibitor with Ki of 9.8 μM. ABC294640 Chemical Structure
  96. GC32023 Abrocitinib (PF-04965842)

    PF-04965842

     Abrocitinib (PF-04965842) (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) Chemical Structure
  97. GC12422 ABT-888 (Veliparib) ABT-888 (Veliparib) Chemical Structure
  98. GA20481 Ac-Arg-Gly-Lys(Ac)-AMC Ac-RGK(Ac)-AMC, fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluorescent group by trypsin. Ac-Arg-Gly-Lys(Ac)-AMC Chemical Structure
  99. GA20605 Ac-Lys-AMC Ac-Lys-AMC is cleaved by trypsin. Ac-Lys-AMC Chemical Structure
  100. GC48382 Ac-QPKK(Ac)-AMC

    Ac-Gln-Pro-Lys-Lys-(Ac)-AMC, Ac-Gln-Pro-Lys-Lys-(Ac)-7-amino-4-methylcoumarin, p53317-320 Substrate (Ac-QPKK(Ac)-AMC)

     A fluorogenic substrate for SIRT1, SIRT2, and SIRT3 Ac-QPKK(Ac)-AMC Chemical Structure
  101. GC73923 AC1Q3QWB

    AQB

     AC1Q3QWB upregulates CDKN1A and SOX17 by interrupting the HOTAIR-EZH2 interaction and enhances the efficacy of Tazemetostat in endometrial cancer. AC1Q3QWB Chemical Structure

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