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Home >> Signaling Pathways >> Chromatin/Epigenetics

Chromatin/Epigenetics

Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

  1. Cat.No. Product Name Information
  2. GN10669 Glucosamine sulfate Glucosamine sulfate Chemical Structure
  3. GN10629 5,7-dihydroxychromone 5,7-dihydroxychromone Chemical Structure
  4. GN10627 Atractylenolide I Atractylenolide I Chemical Structure
  5. GN10584 Ginsenoside Rk1 Ginsenoside Rk1 Chemical Structure
  6. GN10518 Chitosamine hydrochloride Chitosamine hydrochloride Chemical Structure
  7. GN10473 Ginkgolide C Ginkgolide C Chemical Structure
  8. GN10452 Paeoniflorin Paeoniflorin Chemical Structure
  9. GN10442 Curculigoside Curculigoside Chemical Structure
  10. GN10420 Ophiopogonin D' Ophiopogonin D' Chemical Structure
  11. GN10413 Agrimol B Agrimol B Chemical Structure
  12. GN10357 Parthenolide Parthenolide Chemical Structure
  13. GN10347 Nicotinamide (Vitamin B3) Nicotinamide (Vitamin B3) Chemical Structure
  14. GN10308 Chlorogenic acid Chlorogenic acid Chemical Structure
  15. GN10114 Oroxin A Oroxin A Chemical Structure
  16. GN10040 Dehydrocorydaline Dehydrocorydaline Chemical Structure
  17. GN10030 Fisetin Fisetin Chemical Structure
  18. GC12660 AZD1208 A pan-Pim kinase inhibitor AZD1208 Chemical Structure
  19. GC17783 Veliparib dihydrochloride An orally bioavailable inhibitor of PARP1 and PARP2 Veliparib dihydrochloride Chemical Structure
  20. GC13102 XL228 A tyrosine kinase inhibitor XL228 Chemical Structure
  21. GC14327 XL019 A potent, bioavailable JAK2 inhibitor XL019 Chemical Structure
  22. GC15956 WHI-P97 WHI-P97 Chemical Structure
  23. GC16794 UNC1215 Potent L3MBTL3 domain inhibitor UNC1215 Chemical Structure
  24. GC14340 Tasquinimod An orally-active anti-cancer compound Tasquinimod Chemical Structure
  25. GC15109 SRT2104 (GSK2245840)

    SRT2104 (GSK2245840) is a highly selective small-molecule activator of Sirtuin 1 (SIRT1).

     SRT2104 (GSK2245840) Chemical Structure
  26. GC16614 SCH-1473759 SCH-1473759 Chemical Structure
  27. GC12064 SB1317 A multi-kinase inhibitor SB1317 Chemical Structure
  28. GC16124 Ruxolitinib phosphate A potent and selective JAK1/JAK2 inhibitor Ruxolitinib phosphate Chemical Structure
  29. GC10423 RG2833 An HDAC inhibitor RG2833 Chemical Structure
  30. GC14651 Reversine A purine derivative Reversine Chemical Structure
  31. GC14243 Resminostat hydrochloride An orally bioavailable HDAC inhibitor Resminostat hydrochloride Chemical Structure
  32. GC11525 Pyridone 6 A pan-JAK inhibitor Pyridone 6 Chemical Structure
  33. GC10995 PJ34 An inhibitor of poly (ADP-ribose) polymerases PJ34 Chemical Structure
  34. GC17973 OTX-015 A BRD2, BRD3, and BRD4 inhibitor OTX-015 Chemical Structure
  35. GC13229 NVP-BSK805

    A potent, selective JAK2 inhibitor

     NVP-BSK805 Chemical Structure
  36. GC17802 MK-4827 An orally bioavailable PARP1/2 inhibitor MK-4827 Chemical Structure
  37. GC12199 MI-3 An inhibitor of menin-MLL fusion protein interactions MI-3 Chemical Structure
  38. GC11418 MI-2 An inhibitor of menin-MLL fusion protein interactions MI-2 Chemical Structure
  39. GC13154 LKB1(AAK1 dual inhibitor) LKB1(AAK1 dual inhibitor) Chemical Structure
  40. GC14671 JANEX-1 A selective JAK3 inhibitor JANEX-1 Chemical Structure
  41. GC13826 JAK2 Inhibitor V, Z3 A selective inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK JAK2 Inhibitor V, Z3 Chemical Structure
  42. GC17534 GSK343 A selective, cell-permeable EZH2 inhibitor GSK343 Chemical Structure
  43. GC15783 GSK126

    A selective EZH2 inhibitor

     GSK126 Chemical Structure
  44. GC10524 GSK 525768A GSK 525768A Chemical Structure
  45. GC15830 Daminozide Selective inhibitor of KDM2/7 histone demethylases Daminozide Chemical Structure
  46. GC16468 CYT387 sulfate salt A potent inhibitor of JAK1 and JAK2 CYT387 sulfate salt Chemical Structure
  47. GC13056 CX-6258 A pan-Pim kinase inhibitor CX-6258 Chemical Structure
  48. GC14787 Curcumin A yellow pigment with diverse biological activities Curcumin Chemical Structure
  49. GC11975 CHAPS CHAPS Chemical Structure
  50. GC10920 BMN-673 8R,9S BMN-673 8R,9S Chemical Structure
  51. GC13830 Baricitinib phosphate A JAK1 and JAK2 inhibitor Baricitinib phosphate Chemical Structure
  52. GC11572 Bardoxolone methyl A synthetic triterpenoid with potent anticancer and antidiabetic activity Bardoxolone methyl Chemical Structure
  53. GC14709 AZD1152 AZD1152 Chemical Structure
  54. GC12454 BMS-911543 A potent, selective JAK2 inhibitor BMS-911543 Chemical Structure
  55. GC10402 Bromosporine A non-specific bromodomain inhibitor Bromosporine Chemical Structure
  56. GC13383 EPZ004777 A potent inhibitor of DOT1L EPZ004777 Chemical Structure
  57. GC11491 SGC 0946 A potent inhibitor of DOT1L SGC 0946 Chemical Structure
  58. GC17428 SGI-110 SGI-110 Chemical Structure
  59. GC14165 Tenovin-1 A small molecule activator of p53 Tenovin-1 Chemical Structure
  60. GC11104 SMI-4a A Pim kinase inhibitor SMI-4a Chemical Structure
  61. GC18074 PF-03814735 An inhibitor of Aurora A and B kinases PF-03814735 Chemical Structure
  62. GC10008 GSK1070916 A potent inhibitor of Aurora B and C kinases GSK1070916 Chemical Structure
  63. GC13332 Aurora A Inhibitor I A potent and selective inhibitor of Aurora A kinase Aurora A Inhibitor I Chemical Structure
  64. GC15106 CYC116 A potent Aurora kinase inhibitor CYC116 Chemical Structure
  65. GC11085 TAK-901 A non-selective inhibitor of Aurora kinases TAK-901 Chemical Structure
  66. GC14592 KW 2449 A multi-kinase inhibitor KW 2449 Chemical Structure
  67. GC10479 PHA-680632 An Aurora kinase inhibitor PHA-680632 Chemical Structure
  68. GC13837 SNS-314 Mesylate A pan-Aurora kinase inhibitor SNS-314 Mesylate Chemical Structure
  69. GC17162 MK-5108 (VX-689) A potent inhibitor of Aurora kinases MK-5108 (VX-689) Chemical Structure
  70. GC13198 AMG-900 A selective pan-Aurora kinase inhibitor AMG-900 Chemical Structure
  71. GC17196 Hesperadin A multi-kinase inhibitor Hesperadin Chemical Structure
  72. GC10638 AT9283 A broad spectrum kinase inhibitor AT9283 Chemical Structure
  73. GC15217 Danusertib (PHA-739358) A pan-Aurora kinase and Abl inhibitor Danusertib (PHA-739358) Chemical Structure
  74. GC12612 JNJ-7706621 A dual inhibitor of CDKs and Aurora kinases JNJ-7706621 Chemical Structure
  75. GC12208 MLN8054 An inhibitor of Aurora A kinase MLN8054 Chemical Structure
  76. GC16456 M344 HDAC inhibitor M344 Chemical Structure
  77. GC14590 AR-42 (OSU-HDAC42)

    HDAC inhibitor,novel and potent

     AR-42 (OSU-HDAC42) Chemical Structure
  78. GC15114 LAQ824 (NVP-LAQ824,Dacinostat) A hydroxamate-based HDAC inhibitor LAQ824 (NVP-LAQ824,Dacinostat) Chemical Structure
  79. GC13408 CI994 (Tacedinaline) An inhibitor of HDAC1, -2, and -3 CI994 (Tacedinaline) Chemical Structure
  80. GC10839 Tubastatin A A potent HDAC6 inhibitor Tubastatin A Chemical Structure
  81. GC13706 Droxinostat An inhibitor of HDAC3, HDAC6, and HDAC8 Droxinostat Chemical Structure
  82. GC15794 Valproic acid sodium salt (Sodium valproate) A class I HDAC inhibitor Valproic acid sodium salt (Sodium valproate) Chemical Structure
  83. GC14682 PCI-24781 (CRA-024781) An HDAC inhibitor PCI-24781 (CRA-024781) Chemical Structure
  84. GC12115 CUDC-907 A dual inhibitor of HDACs and PI3Ks CUDC-907 Chemical Structure
  85. GC15962 Belinostat (PXD101) A class I and II HDAC inhibitor Belinostat (PXD101) Chemical Structure
  86. GC16734 Pracinostat (SB939)

    A pan-HDAC inhibitor

     Pracinostat (SB939) Chemical Structure
  87. GC15965 MC1568 A selective class IIa HDAC inhibitor MC1568 Chemical Structure
  88. GC14566 CCT137690 An inhibitor of Aurora kinases and FLT3 CCT137690 Chemical Structure
  89. GC11310 CCT129202 An Aurora kinase inhibitor CCT129202 Chemical Structure
  90. GC16519 ENMD-2076 A multi-kinase inhibitor ENMD-2076 Chemical Structure
  91. GC12145 ENMD-2076 L-(+)-Tartaric acid ENMD-2076 L-(+)-Tartaric acid Chemical Structure
  92. GC14409 ZM 447439 Selective inhibitor of Aurora B kinase ZM 447439 Chemical Structure
  93. GC14955 Barasertib (AZD1152-HQPA) A selective Aurora kinase B inhibitor Barasertib (AZD1152-HQPA) Chemical Structure
  94. GC11549 VX-680 (MK-0457,Tozasertib) An Aurora kinase inhibitor that regulates mitosis VX-680 (MK-0457,Tozasertib) Chemical Structure
  95. GC12690 MLN8237 (Alisertib)

    An Aurora A kinase inhibitor

     MLN8237 (Alisertib) Chemical Structure
  96. GC15879 Resminostat (RAS2410) Resminostat (RAS2410) Chemical Structure
  97. GC15002 Sodium Phenylbutyrate A chemical chaperone Sodium Phenylbutyrate Chemical Structure
  98. GC15315 Scriptaid HDAC inhibitor Scriptaid Chemical Structure
  99. GC16497 SGI-1776 free base A potent inhibitor of Pim kinases SGI-1776 free base Chemical Structure
  100. GC10617 GSK J1 A dual inhibitor of JMJD3 and UTX GSK J1 Chemical Structure
  101. GC15497 GSK J4 HCl Prodrug of a selective H3K27 histone demethylase inhibitor GSK J4 HCl Chemical Structure

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