Chromatin/Epigenetics

Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Targets for Chromatin/Epigenetics
- Bromodomain(48)
- Aurora Kinase(60)
- DNA Methyltransferase(31)
- HDAC(167)
- Histone Acetyltransferases(64)
- Histone Demethylases(84)
- Histone Methyltransferase(178)
- HIF(83)
- JAK(135)
- MBT Domains(1)
- PARP(88)
- Pim(31)
- Protein Ser/Thr Phosphatases(34)
- RNA Polymerase(9)
- Sirtuin(66)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(18)
- Epigenetic Reader Domain(177)
- MicroRNA(9)
- Protein Arginine Deiminase(9)
- Chromodomain(1)
- Citrullination(9)
- DNA/RNA Demethylation(1)
- DNA/RNA Methylation(6)
- Histone Deacetylation(34)
- Histones/Histone Peptides(5)
- PHD Domains(0)
- Tandem Tudor & Tudor-like Domains(1)
Products for Chromatin/Epigenetics
- Cat.No. Product Name Information
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GC31365
γ-Oryzanol
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GC45258
(+)-Biotin 4-Amidobenzoic Acid (sodium salt)
(+)-Biotin 4-amidobenzoic acid is a substrate of biotinidase, which cleaves biotin amide to give biotin in vivo.
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GC61595
(+)-JQ-1-aldehyde
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GC34958
(+)-JQ1 PA
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GC13822
(-)-JQ1
BET bromodomain inhibitor
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GC34964
(1S,3R,5R)-PIM447 dihydrochloride
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GC62130
(2R,5S)-Ritlecitinib
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GC34971
(3R,4S)-Tofacitinib
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GC34972
(3S,4R)-Tofacitinib
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GC34973
(3S,4S)-Tofacitinib
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GC41695
(6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)
(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.
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GC41088
(6S)-Tetrahydrofolic Acid
(6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid, a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.
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GC61807
(E/Z)-AG490
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GC63864
(E/Z)-Zotiraciclib hydrochloride
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GC15104
(R)-(+)-Etomoxir sodium salt
carnitine palmitoyltransferase I (CPT1) inhibitor
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GC63791
(R)-(-)-JQ1 Enantiomer
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GC45908
(R)-BAY-598
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GC34443
(R)-BAY1238097
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GC64210
(R)-GSK-3685032
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GC11340
(R)-PFI 2 hydrochloride
SETD7 histone lysine methyltransferase inhibitor
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GC34446
(rac)-BAY1238097
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GC60004
(rel)-Tranylcypromine D5 hydrochloride
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GC33198
(S)-JQ-35 (TEN-010)
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GC13634
(S)-PFI-2 (hydrochloride)
Negative control of (R)-PFI 2 hydrochloride
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GC17055
1,2,3,4,5,6-Hexabromocyclohexane
JAK2 tyrosine kinase inhibitor
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GC61949
1,4-DPCA ethyl ester
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GC40468
1,5-Isoquinolinediol
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis.
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GC41984
1-Alaninechlamydocin
1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp.
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GC39214
1-Naphthohydroxamic acid
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GC12775
2',3',5'-triacetyl-5-Azacytidine
prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor
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GC16195
2,4-DPD
cell permeable, competitive inhibitor of HIF-PH
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GC11873
2,4-Pyridinedicarboxylic Acid
Histone LSD inhibitor
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GC42075
2,4-Pyridinedicarboxylic Acid (hydrate)
2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes.
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GC62233
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
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GC10408
2-D08
Sumoylation inhibitor
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GC11249
2-hexyl-4-Pentynoic Acid
Potent and robust HDACs inhibitor
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GC15084
2-Methoxyestradiol (2-MeOE2)
Apoptotic, antiproliferative and antiangiogenic agent
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GC62781
2-Methylquinazolin-4-ol
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GC14282
3-acetyl-11-keto-β-Boswellic Acid
A 5-lipoxygenase inhibitor
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GC17907
3-Deazaneplanocin A (DZNep) hydrochloride
A SAHH and ENZ2 inhibitor
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GC13145
3-Deazaneplanocin,DZNep
S-adenosylhomocysteine and EZH2 inhibitor
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GC18509
3-Methylcytidine (methosulfate)
3-Methylcytidine (methosulfate) is a cytidine derivative used as an internal standard for HPLC.
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GC19013
3-TYP
A SIRT3 inhibitor
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GC62805
4’-Methoxychalcone
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GC17922
4'-bromo-Resveratrol
Sirt1 and Sirt3 inhibitor
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GC11761
4-amino-1,8-Naphthalimide
PARP inhibitor
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GC16474
4-HQN
PARP inhibitor
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GC17005
4-iodo-SAHA
class I and class II histone deacetylase (HDAC) inhibitor
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GC12667
4SC-202
Class I HDAC inhibitor
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GN10629
5,7-dihydroxychromone
Nrf2/ARE signal activator and PPARγ agonist
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GC10898
5-(N,N-dimethyl)-Amiloride (hydrochloride)
NHE1, NHE2, and NHE3 inhibitor
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GC10946
5-Azacytidine
A DNA methyltransferase inhibitor
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GC61662
5-Fluoro-2'-deoxycytidine
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GC42562
5-Methyl-2'-deoxycytidine
5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo DNA methylation.
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GC45772
6(5H)-Phenanthridinone
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GC35180
6-Methyl-5-azacytidine
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GC62279
653-47
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GC62144
653-47 hydrochloride
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GC32689
666-15
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GC62651
7-Chloro-4-(piperazin-1-yl)quinoline
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GC16015
A 366
G9a/GLP histone lysine methyltransferase inhibitor
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GC32861
A-196
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GC33187
A-395 (A395)
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GC32677
A-485
A p300/CBP inhibitor
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GC30503
A-893
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GC12390
A-966492
PARP-1/-2 inhibitor, highly potent
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GC33280
A1874
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GC19409
ABBV-744
ABBV-744 is a BDII-selective BET bromodomain inhibitor
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GC10154
ABC294640
Sphingosine kinase 2 inhibitor,selective and competitive
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GC32023
Abrocitinib (PF-04965842)
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GC12422
ABT-888 (Veliparib)
A potent PARP inhibitor
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GA20481
Ac-Arg-Gly-Lys(Ac)-AMC
Ac-RGK(Ac)-AMC, fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluorescent group by trypsin.
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GA20605
Ac-Lys-AMC
Ac-Lys-AMC is cleaved by trypsin.
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GC12917
Acetaminophen
A COX inhibitor
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GC64137
Acetaminophen-d3
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GC32083
Acriflavine
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GC62354
Acriflavine hydrochloride
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GC34458
ACY-1083
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GC10417
ACY-241
Selective and orally active HDAC6 inhibitor
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GC19020
ACY-738
ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM; ACY-738 also inhibits HDAC1, HDAC2, and HDAC3, with IC50s of 94, 128, and 218 nM.
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GC30782
ACY-775
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GC30526
ACY-957
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GC12487
Adaptaquin
HIF-prolyl hydroxylase-2 (PHD2) inhibitor
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GC16509
Adox
indirect methyltransferase inhibitor
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GC33416
AFP464
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GC16318
AG-14361
Potent PARP1 inhibitor
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GC17881
AGK 2
SIRT2 inhibitor, potent and selective
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GC15931
AGK7
cell-permeable, selective inhibitor of SIRT2
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GN10413
Agrimol B
Extracted from hairyvein agrimony;Store the product in sealed, cool and dry condition
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GC10676
AK-7
selective and brain-permeable SIRT2 inhibitor
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GC62277
AKB-6899
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GC62433
AKI603
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GC17344
Alexidine dihydrochloride
PTPMT1 inhibitor
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GC35297
Alobresib
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GC13198
AMG-900
Aurora kinase inhibitor
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GC17275
AMI-1
PRMT1 inhibitor
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GC39840
AMI-1 free acid
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GC17546
AMI5
protein methyltransferase inhibitor
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GC42785
Amifostine (hydrate)
Amifostine is a prodrug that through dephosphorylation by alkaline phosphatase is converted to an active thiol, WR 1065 that has free radical scavenging, DNA protective, and hypoxia inducing activities.
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GC42790
Amodiaquine
Amodiaquine is an aminoquinoline antimalarial compound.