Proteins

Disitamab vedotin is an antibody-drug conjugate (ADC) targeting HER2 protein that is comprised of hertuzumab coupling monomethyl auristatin E (MMAE) via a cleavable linker.

Saponarin is a natural flavonoid isolated from Gypsophila trichotoma, with antioxidant, anti-inflammatory and hepatoprotective activities.

Calcium glycerophosphate is an inhibitor of intestinal alkaline phosphatase F3.

LYP-IN-1 is a potent, selective and specific LYP inhibitor with a Ki and an IC50 of 110 nM and 0.259 μM, respectively.

GDC-1971 (compound 199) is a SHP2 inhibitor.

PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM.

Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity.

TD52 dihydrochloride, an Erlotinib derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity.

CD38 inhibitor 1 is a potent CD38 inhibitor with an IC 50 value of 1.9nM for mouse CD38.

BCI ((E)-BCI) hydrochloride is a DUSP6 (dual specificity phosphatase 6) inhibitor.

ARL67156 (FPL 67156) trisodium hydrate is a selective ecto-ATPase inhibitor.

ARL67156 (FPL 67156) triethylamine is a selective ecto-ATPase inhibitor.

Naphthol AS-BR is a substrate for the histochemical demonstration of acid and alkaline phosphatase.

EDP-305 is an orally active, potent and selective farnesoid X receptor (FXR) agonist, with EC50 values of 34 nM (chimeric FXR in CHO cells) and 8 nM (full-length FXR in HEK cells).

INX-SM-6 can be used for targeted delivery of anti-inflammatory agent.

INX-SM-56 is an anti-VISTA antibody drug conjugate and can be used for targeted delivery of anti-inflammatory agents.

SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 ?M.

7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM.

SHP394 is an orally active, selective and allosteric inhibitor of SHP2, with an IC50 of 23 nM.

NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26).