GLPBio

PSB 1114

Catalog No.: GC15635Purity:>98%
COASDSData Sheet
P2Y2 receptor agonist

Products are for research use only. Not for human use. We do not sell to patients.

PSB 1114
Cas No.: 1657025-60-9
1mgIn Stock
$449.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    31, 1291–1307 (2021)

Description

PSB 1114 is a potent and selective agonist of P2Y2 receptor with EC50 value of 0.134 μM [1].

P2Y2 receptor is a purinergic G protein-coupled receptor and is activated by ATP and UTP. P2Y2 receptor is a potential target for treatment of cystic fibrosis.

PSB 1114 is a potent and selective P2Y2 receptor agonist. PSB 1114 activated P2Y2, P2Y4 and P2Y6 with EC50 values of 0.134, 9.3 and 7.0 μM respectively and exhibited >60-fold selectivity versus P2Y6 and P2Y4 receptors [1].

Reference:
[1].  El-Tayeb A, Qi A, Nicholas RA, et al. Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem, 2011, 54(8): 2878-2890.

Chemical Properties

CAS No.
1657025-60-9
SMILES
FC(P([O-])([O-])=O)(P([O-])(OP([O-])(OC[C@](O1)([H])[C@](O)([H])[C@](O)([H])C1([H])N2C=CC(S)=NC2=O)=O)=O)F.[Na+].[Na+].[Na+].[Na+]
Molecular Formula
C10H11F2N2Na4O13P3S
Molecular Weight
622.14
Solubility
<10mM in Water
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

Reviews

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