GLPBio

PtdIns-(4,5)-P2 (1,2-dipalmitoyl)-d62 (sodium salt)

Catalog No.: GC92090Purity:>99.00%Synonyms: DPPI-4,5-P2-d62; Phosphatidylinositol-4,5-diphosphate C16-d62; PI(4,5)P2 (16:0/16:0)-d62; PIP2[4',5'](16:0/16:0)-d62
COASDSData Sheet
PtdIns-(4,5)-P2 (1,2-dipalmitoyl)-d62 (sodium salt) is intended for use as an internal standard for the quantification of PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (sodium salt) by GC- or LC-mass spectrometry.

Products are for research use only. Not for human use. We do not sell to patients.

PtdIns-(4,5)-P2 (1,2-dipalmitoyl)-d62 (sodium salt)
25 µgIn Stock
$130.00
1
50 µgIn Stock
$246.00
1
100 µgIn Stock
$462.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

PtdIns-(4,5)-P2 (1,2-dipalmitoyl)-d62 (sodium salt) is intended for use as an internal standard for the quantification of PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (sodium salt) by GC- or LC-mass spectrometry. The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns-4,5-P2-(1,2-dipalmitoyl)-d62 is a synthetic analog of natural PtdIns containing deuterated C16:0 fatty acids at the sn-1 and sn-2 positions. This synthetic standard features the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound. The natural compound is the product of phosphatidylinositol 4-phosphate 5-kinase acting on PtdIns-(4)-P1. Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.

References:
[1]. Exton, J.H.Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteinsAnnu. Rev. Pharmacol. Toxicol.36481-509(1996).
[2]. Majerus, P.W.Inositol phosphate biochemistryAnnu. Rev. Biochem.61225-250(1992).

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Synonyms
DPPI-4,5-P2-d62; Phosphatidylinositol-4,5-diphosphate C16-d62; PI(4,5)P2 (16:0/16:0)-d62; PIP2[4',5'](16:0/16:0)-d62
Chemical Name
1-(1,2-dihexadecanoyl(2,2’,3,3’,4,4’,5,5’,6,6’,7,7’,8,8’,9,9’,10,10’,11,11’,12,12’,13,13’,14,14’,15,16,16,16-d31)phosphatidyl)inositol-4,5-bisphosphate, trisodium salt
SMILES
O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@@H](O)[C@H]1OP([O-])(OCC(COC(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)OC(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)=O.[Na+].[Na+].[Na+]
Molecular Formula
C41H16D62O19P3 ? 3Na
Molecular Weight
1099.3
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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