GLPBio

PTK7/β-catenin-IN-6

Catalog No.: GC73876
COASDSData Sheet
PTK7/β-catenin-IN-6 (Compound 03653) is an inhibitor for PTK7/β-catenin interaction, which inhibits the Wnt signaling pathway, and exhibits an anticancer activity against colorectal cancer (CRC).

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PTK7/β-catenin-IN-6
Cas No.: 1219439-82-3
1 mgIn Stock
$335.00
1
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Description

PTK7/β-catenin-IN-6 (Compound 03653) is an inhibitor for PTK7/β-catenin interaction, which inhibits the Wnt signaling pathway, and exhibits an anticancer activity against colorectal cancer (CRC).

PTK7/β-catenin-IN-6 (25 μM) misregulates the β-catenin responsive transcription and inihibits the Wnt signaling pathway through regulating the mRNA expressions of Wnt signaling related genes, which are associated with cell proliferation and migration[1].PTK7/β-catenin-IN-6 (0-100 μM) arrests the cell cycle in G0/G1 phase through block of CyclinA2, CyclinE2 and CDK production, inhibits proliferations of HCT116, SW480 and MEF with IC50s of 20.1, 19.6 and 46.3 μM, respectively[1].

References:
[1]. Ganier L, et al., Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer. ACS Chem Biol. 2022 May 20;17(5):1061-1072.

Product Documents

Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1219439-82-3
Molecular Formula
C25H19Cl2N3O3
Molecular Weight
480.34
Solubility
DMSO : 73.33 mg/mL (152.66 mM; Need ultrasonic)
Storage
4°C, protect from light
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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