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Home >> Signaling Pathways >> Stem Cell >> Wnt/β-catenin

Wnt/β-catenin

β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).

Products for  Wnt/β-catenin

  1. Cat.No. Product Name Information
  2. GC62432 β-catenin-IN-2 β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer. β-catenin-IN-2 Chemical Structure
  3. GC34980 (E)-Ferulic acid (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. (E)-Ferulic acid Chemical Structure
  4. GC66371 (E)-Ferulic acid-d3 (E)-Ferulic acid-d3 ((E)-Coniferic acid-d3) is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. (E)-Ferulic acid-d3 Chemical Structure
  5. GC45354 4β-Hydroxywithanolide E A withanolide with anti-inflammatory and anticancer activities 4β-Hydroxywithanolide E Chemical Structure
  6. GC42669 ABC99 An inhibitor of NOTUM ABC99 Chemical Structure
  7. GC31663 Adavivint (SM04690) Adavivint (SM04690) (SM04690; Lorecivivint) is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells. Adavivint (SM04690) Chemical Structure
  8. GC50323 AMBMP hydrochloride AMBMP hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50of 700 nM. AMBMP hydrochloride Chemical Structure
  9. GC65165 Carboxylesterase-IN-2 Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease. Carboxylesterase-IN-2 Chemical Structure
  10. GC65167 Carboxylesterase-IN-3 Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease. Carboxylesterase-IN-3 Chemical Structure
  11. GC17840 Cardiogenol C hydrochloride Induces differentiation of mouse embryonic stem cells (ESCs) into cardiomyocytes Cardiogenol C hydrochloride Chemical Structure
  12. GC17782 Cardionogen 1 Wnt signaling modulator Cardionogen 1 Chemical Structure
  13. GC10253 CCT 031374 hydrobromide inhibits TCF-dependent transcription, blocks BIO-induced β-catenin stabilization CCT 031374 hydrobromide Chemical Structure
  14. GC17606 CCT251545 Orally bioavailable and potent WNT signaling inhibitor CCT251545 Chemical Structure
  15. GC16702 CHIR-99021 (CT99021)

    A selective GSK3 inhibitor

     CHIR-99021 (CT99021) Chemical Structure
  16. GC17153 CHIR-99021 (CT99021) HCl Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 (CT99021) HCl shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 (CT99021) HCl is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 (CT99021) HCl enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 (CT99021) HCl induces autophagy. CHIR-99021 (CT99021) HCl Chemical Structure
  17. GC64816 Coronaridine Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression. Coronaridine Chemical Structure
  18. GC35873 DK419 DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK. DK419 Chemical Structure
  19. GC32914 EMT inhibitor-1 EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities. EMT inhibitor-1 Chemical Structure
  20. GC19144 ETC-159 ETC-159 is a potent, orally available PORCN inhibitor. ETC-159 Chemical Structure
  21. GC14299 exo-IWR 1 Negative control for endo-IWR 1 (Wnt signaling inhibitor) exo-IWR 1 Chemical Structure
  22. GC12134 FH535 An inhibitor of β-catenin signaling FH535 Chemical Structure
  23. GC62214 FIDAS-3 FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. FIDAS-3 Chemical Structure
  24. GC36073 Foxy-5 Foxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. Foxy-5 Chemical Structure
  25. GC41534 FzM1 Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. FzM1 Chemical Structure
  26. GC50624 FzM1.8 Frizzled 4 allosteric agonist; exhibits biased siginaling; preserves stemness FzM1.8 Chemical Structure
  27. GC18595 G244-LM An inhibitor of Wnt signaling G244-LM Chemical Structure
  28. GC43725 Gallocyanine Gallocyanine, a synthetic blue dyestuff, blocks DKK1 inhibitory activity by disrupting DKK1/LRP6 interaction. Gallocyanine Chemical Structure
  29. GC33304 Gigantol Gigantol is a bibenzyl compound derived from several medicinal orchids. Giganto shows promising therapeutic potential against cancer cells. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. Gigantol Chemical Structure
  30. GC31717 Ginkgetin A biflavonoid with diverse biological activities Ginkgetin Chemical Structure
  31. GC18875 GSK3β Inhibitor XVIII An inhibitor of GSK3β GSK3β Inhibitor XVIII Chemical Structure
  32. GC39266 Hematein Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells. Hematein Chemical Structure
  33. GC30767 Heparan Sulfate

    Heparan sulfate (HS) is a complex, polyanionic polysaccharide ubiquitously expressed on cell surfaces and in the extracellular matrix.

     Heparan Sulfate Chemical Structure
  34. GC16963 HLY78 positive modulator of the Wnt/β-catenin pathway HLY78 Chemical Structure
  35. GC16893 ICG 001 An inhibitor of β-catenin/CBP interactions ICG 001 Chemical Structure
  36. GC16640 iCRT 14 CRT inhibitor iCRT 14 Chemical Structure
  37. GC19198 iCRT3 iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription. iCRT3 Chemical Structure
  38. GC15123 IDE 1 activate the TGF-β signaling pathway IDE 1 Chemical Structure
  39. GC10854 IDE 2 inducer of definitive endoderm formation IDE 2 Chemical Structure
  40. GC10910 IQ 1 IQ 1 is a Wnt/β-catenin/CBP signalling sustainer. IQ 1 Chemical Structure
  41. GC10472 ISX 9 Neurogenic agent ISX 9 Chemical Structure
  42. GC16013 IWP 4 Potent inhibitor of Wnt/β-catenin signaling IWP 4 Chemical Structure
  43. GC16454 IWP-2 IWP-2 is a inhibitor of the Wnt signaling pathway, with an IC50 value of 27 nM. IWP-2 is also an ATP-competitive inhibitor of CK1δ, with an IC50 value of 40 nM. IWP-2 Chemical Structure
  44. GC14546 IWP-2-V2 Wnt production inhibitor IWP-2-V2 Chemical Structure
  45. GC17071 IWP-3 inhibitor of Wnt production IWP-3 Chemical Structure
  46. GC17708 IWP-L6 Porcupine inhibitor,highy potent IWP-L6 Chemical Structure
  47. GC34628 IWP-O1 IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. IWP-O1 Chemical Structure
  48. GC10950 IWR-1-endo IWR-1-endo is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway. IWR-1-endo Chemical Structure
  49. GC18734 JS-K JS-K is a nitric oxide (NO) donor that reacts with glutathione to generate NO at physiological pH. JS-K Chemical Structure
  50. GC12869 JW 55 A TNKS1/2 inhibitor JW 55 Chemical Structure
  51. GC10138 JW 67 inhibitor of canonical Wnt pathway signaling JW 67 Chemical Structure
  52. GC13978 JW 74 inhibitor of the catalytic PARP domain of TNKS1/2 JW 74 Chemical Structure
  53. GC15057 Kartogenin Promote differentiation of multipotent MSCs into chondrocytes Kartogenin Chemical Structure
  54. GC13582 KHS 101 hydrochloride neuronal differentiation inducer KHS 101 hydrochloride Chemical Structure
  55. GC46015 KY 05009 A TNIK inhibitor KY 05009 Chemical Structure
  56. GC63465 KY-02327 KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 Chemical Structure
  57. GC65356 KY-02327 acetate KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 acetate Chemical Structure
  58. GC32923 KY1220 KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells. KY1220 Chemical Structure
  59. GC19216 KYA1797K A potent and selective Wnt/β-catenin inhibitor KYA1797K Chemical Structure
  60. GC36483 L-Quebrachitol L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway. L-Quebrachitol Chemical Structure
  61. GC32763 LF3 LF3 is an antagonist of the β-Catenin/TCF4 interaction with antitumor activity; has an IC50 of 1.65 μM. LF3 Chemical Structure
  62. GC12392 LGK-974 PORCN inhibitor,potent and specific LGK-974 Chemical Structure
  63. GC47570 Lipoxygenin An inhibitor of 5-LO Lipoxygenin Chemical Structure
  64. GC25603 M2912 M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity. M2912 Chemical Structure
  65. GC31794 Methyl vanillate

    Methyl vanillate, one of the ingredients in Hovenia dulcis Thunb, is a Wnt/β-catenin pathway activator.

     Methyl vanillate Chemical Structure
  66. GC63100 N-Desmethylnefopam D5 hydrochloride N-Desmethylnefopam D5 hydrochloride is a deuterium labeled N-Desmethylnefopam hydrochloride. N-Desmethylnefopam D5 hydrochloride Chemical Structure
  67. GC19260 NCB-0846 NCB-0846 is an orally available TNIK inhibitor with an IC50 of 21 nM. NCB-0846 Chemical Structure
  68. GC64837 Nefopam D3 hydrochloride Nefopam D3 hydrochloride Chemical Structure
  69. GC11775 Nefopam HCl Nefopam HCl (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam HCl Chemical Structure
  70. GC38522 Neurodazine Small molecule inducer of neuronal differentiation Neurodazine Chemical Structure
  71. GC11454 Neurodazine Induces neurogenesis of non-pluripotent C2C12 myoblasts Neurodazine Chemical Structure
  72. GC50489 NLS-StAx-h Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions NLS-StAx-h Chemical Structure
  73. GC67737 NLS-StAx-h TFA NLS-StAx-h TFA Chemical Structure
  74. GC65916 NRX-103095 NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM. NRX-103095 Chemical Structure
  75. GC65919 NRX-252114 NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation. NRX-252114 Chemical Structure
  76. GC65336 NRX-252262 NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM. NRX-252262 Chemical Structure
  77. GC64832 NRX-2663 NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 ?M and a Kd of 54.8 nM. NRX-2663 Chemical Structure
  78. GC44467 NSC 668036 NSC 668036 is an inhibitor of the Dishevelled (Dvl) protein PDZ domain (Kd = 240 μM for mouse Dvl1 PDZ domain). NSC 668036 Chemical Structure
  79. GC11115 Pamidronate Pamidronate is a drug used to treat a broad spectrum of bone absorption diseases. Pamidronate Chemical Structure
  80. GC18291 PKF118-310 PKF118-310 (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity. PKF118-310 Chemical Structure
  81. GC16711 PNU 74654 Wnt signaling pathway inhibitor PNU 74654 Chemical Structure
  82. GC65066 Prodigiosin hydrochloride Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride Chemical Structure
  83. GC32698 Pyrvinium pamoate (Pyrvinium embonate) Pyrvinium pamoate (Pyrvinium embonate) is an FDA-approved antihelmintic drug that inhibits WNT pathway signaling. Pyrvinium pamoate (Pyrvinium embonate) Chemical Structure
  84. GC17251 QS 11 ARFGAP1 inhibitor,Wnt/beta-catenin pathway modulator QS 11 Chemical Structure
  85. GC69802 RA-V

    RA-V is a cyclic hexapeptide. RA-V has activity against Wnt, Myc and Notch with IC50 values of 50, 75 and 93 ng/mL respectively. RA-V can be used for research on cancer-related signaling pathways.

     RA-V Chemical Structure
  86. GC14882 Salinomycin A selective cancer stem cell inhibitor Salinomycin Chemical Structure
  87. GC18107 Salinomycin sodium salt A selective cancer stem cell inhibitor Salinomycin sodium salt Chemical Structure
  88. GC16320 Shz 1 induces phenotypic differentiation Shz 1 Chemical Structure
  89. GC16701 SKI II Sphingosine kinase(SK) inhibitor SKI II Chemical Structure
  90. GC16382 SKL2001 An activator of Wnt/β-catenin signaling SKL2001 Chemical Structure
  91. GC15041 Tankyrase Inhibitors (TNKS) 22 Tankyrase inhibitor Tankyrase Inhibitors (TNKS) 22 Chemical Structure
  92. GC11548 Tankyrase Inhibitors (TNKS) 49 Tankyrase inhibitor Tankyrase Inhibitors (TNKS) 49 Chemical Structure
  93. GC13301 TCS 2210 Inducer of neuronal differentiation in mesenchymal stem cells (MSCs) TCS 2210 Chemical Structure
  94. GC39159 Tegatrabetan Tegatrabetan (BC2059) is a β-Catenin antagonist. Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1). Tegatrabetan Chemical Structure
  95. GC62394 Teplinovivint Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. Teplinovivint Chemical Structure
  96. GC14037 Triptonide A diterpenoid with diverse biological activities Triptonide Chemical Structure
  97. GC50077 WAY 316606 hydrochloride

    Secreted Frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling

     WAY 316606 hydrochloride Chemical Structure
  98. GC15753 WAY-262611 β-Catenin agonist WAY-262611 Chemical Structure
  99. GC70143 WIC1

    WIC1 is an effective Wnt inhibitor that can be used in cancer research.

     WIC1 Chemical Structure
  100. GC11674 WIKI4 A potent TNKS1/2 inhibitor WIKI4 Chemical Structure
  101. GC12133 Windorphen Wnt inhibitor Windorphen Chemical Structure

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