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Home >> Signaling Pathways >> Stem Cell >> Wnt/β-catenin

Wnt/β-catenin

β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).

Products for  Wnt/β-catenin

  1. Cat.No. Product Name Information
  2. GC62432 β-catenin-IN-2 β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer. β-catenin-IN-2 Chemical Structure
  3. GC72805 β-catenin-IN-6 β-catenin-IN-6 is a β-catenin inhibitor, targeting to canonical Wingless-related integration site signaling pathway. β-catenin-IN-6 Chemical Structure
  4. GC34980 (E)-Ferulic acid (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. (E)-Ferulic acid Chemical Structure
  5. GC66371 (E)-Ferulic acid-d3

    (E)-Coniferic acid-d3

     (E)-Ferulic acid-d3 ((E)-Coniferic acid-d3) is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. (E)-Ferulic acid-d3 Chemical Structure
  6. GC45354 4β-Hydroxywithanolide E

    NSC 212509

     A withanolide with anti-inflammatory and anticancer activities 4β-Hydroxywithanolide E Chemical Structure
  7. GC42669 ABC99 ABC99 is an N-hydroxyhydantoin (NHH)-carbamate-based, irreversible and selective inhibitor of Wnt-deacylating enzyme NOTUM. ABC99 Chemical Structure
  8. GC31663 Adavivint (SM04690)

    SM04690; Lorecivivint

     Adavivint (SM04690) (SM04690; Lorecivivint) is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells. Adavivint (SM04690) Chemical Structure
  9. GC50323 AMBMP hydrochloride AMBMP hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50of 700 nM. AMBMP hydrochloride Chemical Structure
  10. GC68695 ARUK3001185

    ARUK3001185 (Compound 8l) is an effective, selective, orally active Notum inhibitor that can penetrate the blood-brain barrier with an IC50 value of 6.7 nM.

     ARUK3001185 Chemical Structure
  11. GC74321 aStAx-35R TFA

    aStAx-35R TFA, a stapled peptide, antagonizes nuclear form of β-catenin and inhibits Wnt signaling.

     aStAx-35R TFA Chemical Structure
  12. GC17764 BML-284 (Wnt agonist 1)

    BML-284

     BML-284 (Wnt agonist 1) is a potent agonist of Wnt signaling, with an EC50 value of 0.7μM for inducing β-catenin- and TCF-dependent transcriptional activity. BML-284 (Wnt agonist 1) Chemical Structure
  13. GC72937 Box5 Box5 is a potent Wnt5a antagonist. Box5 Chemical Structure
  14. GC68797 Box5 TFA

    Box5 TFA is an effective Wnt5a antagonist. It inhibits the Wnt5a signal and suppresses Wnt5a-mediated Ca2+ release. Box5 TFA also inhibits cell migration and has potential in melanoma research.

     Box5 TFA Chemical Structure
  15. GC65165 Carboxylesterase-IN-2 Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease. Carboxylesterase-IN-2 Chemical Structure
  16. GC65167 Carboxylesterase-IN-3 Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease. Carboxylesterase-IN-3 Chemical Structure
  17. GC17840 Cardiogenol C hydrochloride Induces differentiation of mouse embryonic stem cells (ESCs) into cardiomyocytes Cardiogenol C hydrochloride Chemical Structure
  18. GC17782 Cardionogen 1 Wnt signaling modulator Cardionogen 1 Chemical Structure
  19. GC10253 CCT 031374 hydrobromide inhibits TCF-dependent transcription, blocks BIO-induced β-catenin stabilization CCT 031374 hydrobromide Chemical Structure
  20. GC17606 CCT251545 Orally bioavailable and potent WNT signaling inhibitor CCT251545 Chemical Structure
  21. GC73345 CDK8-IN-11 CDK8-IN-11 is a potent and selective CDK8 inhibitor with an IC50 value of 46 nM. CDK8-IN-11 Chemical Structure
  22. GC16702 CHIR-99021 (CT99021)

    CHIR99021, CHIR-99021, CHIR 99021, CT99021,GSK-3 Inhibitor XVI

     CHIR-99021 (CT99021) is a kind of highly selective inhibitor of GSK-3, the IC50 values for GSK-3α and GSK-3β are 10nM and 6.7nM respectively. CHIR-99021 (CT99021) Chemical Structure
  23. GC17153 CHIR-99021 (CT99021) HCl

    CHIR-99021 monohydrochloride; CT99021 monohydrochloride

     Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 (CT99021) HCl shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 (CT99021) HCl is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 (CT99021) HCl enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 (CT99021) HCl induces autophagy. CHIR-99021 (CT99021) HCl Chemical Structure
  24. GC64816 Coronaridine Coronaridine is an inhibitor of TCF/β-catenin, with an IC50 value of 5.8μM. Coronaridine Chemical Structure
  25. GC35873 DK419 DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK. DK419 Chemical Structure
  26. GC32914 EMT inhibitor-1 EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities. EMT inhibitor-1 Chemical Structure
  27. GC19144 ETC-159

    ETC-1922159

     ETC-159 is a potent, orally available PORCN inhibitor. ETC-159 Chemical Structure
  28. GC14299 exo-IWR 1 Negative control for endo-IWR 1 (Wnt signaling inhibitor) exo-IWR 1 Chemical Structure
  29. GC73610 F7H F7H is a Frizzled receptor FZD7 antagonist (IC50: 1.25 μM). F7H Chemical Structure
  30. GC12134 FH535 An inhibitor of β-catenin signaling FH535 Chemical Structure
  31. GC62214 FIDAS-3 FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. FIDAS-3 Chemical Structure
  32. GC36073 Foxy-5 Foxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. Foxy-5 Chemical Structure
  33. GC47372 Foxy-5 (trifluoroacetate salt)

    N-formyl-Met-Asp-Gly-Cys-Glu-Leu, N-formyl-MDGCEL

     A neuropeptide with diverse biological activities Foxy-5 (trifluoroacetate salt) Chemical Structure
  34. GC74320 fStAx-35R TFA fStAx-35R TFA is the drocarbon-stapled peptide. fStAx-35R TFA inhibits Wnt/β-catenin signaling pathway by disrupting the β-catenin-TCF interaction. fStAx-35R TFA can be used in cancer research. fStAx-35R TFA Chemical Structure
  35. GC74343 Fz7-21S Fz7-21S is a negative control of Fz7-21. Fz7-21S Chemical Structure
  36. GC41534 FzM1

    Frizzled M1

     Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. FzM1 Chemical Structure
  37. GC50624 FzM1.8 Frizzled 4 allosteric agonist; exhibits biased siginaling; preserves stemness FzM1.8 Chemical Structure
  38. GC18595 G244-LM An inhibitor of Wnt signaling G244-LM Chemical Structure
  39. GC43725 Gallocyanine

    IIIC3, Alizarine Navy Blue, Anthracene Blue SWGG, Brilliant Chrome Blue P, C.I. 51030, Fast Violet, Mordant Blue 10

     Gallocyanine, a synthetic blue dyestuff, blocks DKK1 inhibitory activity by disrupting DKK1/LRP6 interaction. Gallocyanine Chemical Structure
  40. GC33304 Gigantol Gigantol is a bibenzyl compound derived from several medicinal orchids. Giganto shows promising therapeutic potential against cancer cells. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. Gigantol Chemical Structure
  41. GC31717 Ginkgetin Ginkgetin is a natural biflavonoid compound extracted from Ginkgo biloba leaves, inhibits the Wnt signaling pathway (IC₅₀=5.92μM). Ginkgetin Chemical Structure
  42. GC18875 GSK3β Inhibitor XVIII An inhibitor of GSK3β GSK3β Inhibitor XVIII Chemical Structure
  43. GC73573 hCA/Wnt/β-catenin-IN-1

    hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor of hCA (Ki: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). hCA/Wnt/β-catenin-IN-1 reduces P-gp activity.

     hCA/Wnt/β-catenin-IN-1 Chemical Structure
  44. GC39266 Hematein Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells. Hematein Chemical Structure
  45. GC30767 Heparan Sulfate Heparan Sulfate is a complex polyanionic polysaccharide, regulates important developmental processes in invertebrates and vertebrates. Heparan Sulfate Chemical Structure
  46. GC16963 HLY78 positive modulator of the Wnt/β-catenin pathway HLY78 Chemical Structure
  47. GC16893 ICG 001 ICG 001 is an inhibitor of the β-catenin pathway. ICG 001 functions by specifically binding to CBP (IC50=3μM). ICG 001 Chemical Structure
  48. GC16640 iCRT 14 CRT inhibitor iCRT 14 Chemical Structure
  49. GC19198 iCRT3 iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription. iCRT3 Chemical Structure
  50. GC15123 IDE 1 activate the TGF-β signaling pathway IDE 1 Chemical Structure
  51. GC10854 IDE 2 inducer of definitive endoderm formation IDE 2 Chemical Structure
  52. GC10910 IQ 1 IQ 1 is a Wnt/β-catenin/CBP signalling sustainer. IQ 1 Chemical Structure
  53. GC10472 ISX 9

    Isoxazole 9, Neuronal Differentiation Inducer III

     ISX 9 is a potent inducer of adult neural stem cell differentiation. ISX 9 Chemical Structure
  54. GC16013 IWP 4

    Inhibitor of Wnt Production4

     Potent inhibitor of Wnt/β-catenin signaling IWP 4 Chemical Structure
  55. GC16454 IWP-2

    IWP 2

     IWP-2 is a specific inhibitor of Porcupine enzyme in the Wnt signaling pathway, with an IC50 value of 27 nM. IWP-2 Chemical Structure
  56. GC14546 IWP-2-V2

    Inhibitor of Wnt Production-2-V2

     Wnt production inhibitor IWP-2-V2 Chemical Structure
  57. GC17071 IWP-3

    Inhibitor of Wnt Production-3

     inhibitor of Wnt production IWP-3 Chemical Structure
  58. GC17708 IWP-L6

    PORCN Inhibitor III, Wnt Pathway Inhibitor XIX

     Porcupine inhibitor,highy potent IWP-L6 Chemical Structure
  59. GC34628 IWP-O1 IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. IWP-O1 Chemical Structure
  60. GC10950 IWR-1-endo

    endo-IWR 1; IWR-1-endo

     IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. IWR-1-endo Chemical Structure
  61. GC18734 JS-K JS-K is a nitric oxide (NO) donor that reacts with glutathione to generate NO at physiological pH. JS-K Chemical Structure
  62. GC12869 JW 55

    Tankyrase 1/2 Inhibitor IV

     A TNKS1/2 inhibitor JW 55 Chemical Structure
  63. GC10138 JW 67 inhibitor of canonical Wnt pathway signaling JW 67 Chemical Structure
  64. GC13978 JW 74 inhibitor of the catalytic PARP domain of TNKS1/2 JW 74 Chemical Structure
  65. GC15057 Kartogenin Kartogenin is an inducer of cartilage-like tissue formation (EC50: 100nM) Kartogenin Chemical Structure
  66. GC13582 KHS 101 hydrochloride neuronal differentiation inducer KHS 101 hydrochloride Chemical Structure
  67. GC46015 KY 05009 A TNIK inhibitor KY 05009 Chemical Structure
  68. GC63465 KY-02327 KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 Chemical Structure
  69. GC65356 KY-02327 acetate KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 acetate Chemical Structure
  70. GC32923 KY1220 KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells. KY1220 Chemical Structure
  71. GC60970 KY19382

    A3051

     KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 Chemical Structure
  72. GC19216 KYA1797K A potent and selective Wnt/β-catenin inhibitor KYA1797K Chemical Structure
  73. GC36483 L-Quebrachitol L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway. L-Quebrachitol Chemical Structure
  74. GC32763 LF3 LF3 is an antagonist of the β-Catenin/TCF4 interaction with antitumor activity; has an IC50 of 1.65 μM. LF3 Chemical Structure
  75. GC12392 LGK-974

    PORCN Inhibitor IV

     LGK-974 is a potent and specific inhibitor of Porcupine (PORCN). LGK-974 Chemical Structure
  76. GC47570 Lipoxygenin An inhibitor of 5-LO Lipoxygenin Chemical Structure
  77. GC25603 M2912

    MSC2504877

     M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity. M2912 Chemical Structure
  78. GC31794 Methyl vanillate

    Methyl vanillate, one of the ingredients in Hovenia dulcis Thunb, is a Wnt/β-catenin pathway activator.

     Methyl vanillate Chemical Structure
  79. GC69457 Miclxin

    DS37262926

    Miclxin (DS37262926) is an effective inhibitor of mutant β-catenin, involved in the Wnt signaling pathway. Miclxin can induce β-catenin-dependent apoptosis, leading to mitochondrial damage and loss of mitochondrial membrane. Miclxin targets MIC60 to kill tumors, which is a major component of the mitochondrial contact site and cristae organizing system (MICOS) complex.

     Miclxin Chemical Structure
  80. GC61093 MSAB MSAB (methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate) is a selective Wnt/β-catenin signaling inhibitor binding to β-catenin and promoting its degradation with an EC50 of 0.583μM. MSAB Chemical Structure
  81. GC63100 N-Desmethylnefopam D5 hydrochloride N-Desmethylnefopam D5 hydrochloride is a deuterium labeled N-Desmethylnefopam hydrochloride. N-Desmethylnefopam D5 hydrochloride Chemical Structure
  82. GC19260 NCB-0846 NCB-0846 is an orally available TNIK inhibitor with an IC50 of 21 nM. NCB-0846 Chemical Structure
  83. GC64837 Nefopam D3 hydrochloride

    Fenazoxine-d3 hydrochloride

     Nefopam D3 hydrochloride Chemical Structure
  84. GC11775 Nefopam HCl Nefopam HCl (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam HCl Chemical Structure
  85. GC38522 Neurodazine Small molecule inducer of neuronal differentiation Neurodazine Chemical Structure
  86. GC11454 Neurodazine Neurodazine functions as a neurogenic inducer, capable of promoting neurogenesis in pluripotent stem cells. Neurodazine Chemical Structure
  87. GC73959 NF764 NF764 is a potent β-catenin (CTNNB1) degrader. NF764 Chemical Structure
  88. GC50489 NLS-StAx-h Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions NLS-StAx-h Chemical Structure
  89. GC67737 NLS-StAx-h TFA NLS-StAx-h TFA Chemical Structure
  90. GC65916 NRX-103095 NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM. NRX-103095 Chemical Structure
  91. GC65919 NRX-252114 NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation. NRX-252114 Chemical Structure
  92. GC65336 NRX-252262 NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM. NRX-252262 Chemical Structure
  93. GC64832 NRX-2663 NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 ?M and a Kd of 54.8 nM. NRX-2663 Chemical Structure
  94. GC44467 NSC 668036 NSC 668036 is an inhibitor of the Dishevelled (Dvl) protein PDZ domain (Kd = 240 μM for mouse Dvl1 PDZ domain). NSC 668036 Chemical Structure
  95. GC72835 NSC260594 NSC260594 induces Apoptosis. NSC260594 Chemical Structure
  96. GC11115 Pamidronate Pamidronate is a drug used to treat a broad spectrum of bone absorption diseases. Pamidronate Chemical Structure
  97. GC18291 PKF118-310

    NSC 67078, Toxoflavin

     PKF118-310 (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity. PKF118-310 Chemical Structure
  98. GC16711 PNU 74654 Wnt signaling pathway inhibitor PNU 74654 Chemical Structure
  99. GC61205 PRI-724

    Foscenvivint

     PRI-724 (C-82 prodrug, ICG-001 analog) is a first-in-class Wnt signaling modulator that inhibits the interaction between cAMP response element (CREB) binding protein and β-catenin. PRI-724 Chemical Structure
  100. GC65066 Prodigiosin hydrochloride Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride Chemical Structure
  101. GC73874 PTK7/β-catenin-IN-1 PTK7/β-catenin-IN-1 (compound 01065) is a potent PTK7/β-catenin inhibitor with an IC50 of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 Chemical Structure

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