PYD-106 |
| Catalog No.GC48013 |
A positive allosteric modulator of NR2C subunit-containing NMDARs
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1560894-05-4
Sample solution is provided at 25 µL, 10mM.
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PYD-106 is a positive allosteric modulator of NR2C subunit-containing NMDA receptors (NMDARs).1 It enhances glutamate-induced maximal current responses in HEK293 cells expressing NR1/NR2C NMDA receptors (EC50 = 13 µM). PYD-106 is selective for NR2C subunit-containing NMDA receptors over NRA-, NR2B-, and NR2D-subunit containing NMDA receptors in Xenopus oocytes expressing NR1/NR2 heteromeric NMDA receptors at 30 µM.
1.Khatri, A., Burger, P.B., Swanger, S.A., et al.Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulatorMol. Pharmacol.86(5)548-560(2014)
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