GLPBio

(R)-Birabresib

Catalog No.: GC73749Purity:>99.00%Synonyms: (R)-OTX-015; (R)-MK-8628
COASDSData Sheet
(R)-Birabresib is the isomer of Birabresib , and can be used as an experimental control.

Products are for research use only. Not for human use. We do not sell to patients.

(R)-Birabresib
Cas No.: 1983196-25-3
1 mgIn Stock
$166.00
1
5 mgIn Stock
$366.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

(R)-Birabresib is the isomer of Birabresib , and can be used as an experimental control. Birabresib (OTX-015) is a potent bromodomain (BRD2/3/4) inhibitor with IC50s ranging from 92 to 112 nM.

References:
[1]. Marie-Magdelaine Coudé, et al. BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells. Oncotarget. 2015 Jul 10; 6(19): 17698–17712. [2]. Lu P, et al. The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb. Sci Rep. 2016 Apr 12;6:24100 [3]. Vázquez R, et al. The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with RAD001. Oncotarget. 2017 Jan 31;8(5):7598-7613.
[4]. J. Kay Noel, et al. Abstract C244: Development of the BET bromodomain inhibitor OTX015. Mol Cancer Ther November 2013 12; C244.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1983196-25-3
Synonyms
(R)-OTX-015; (R)-MK-8628
Molecular Formula
C25H22ClN5O2S
Molecular Weight
491.99
Solubility
DMSO : 200 mg/mL (406.51 mM; Need ultrasonic)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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