GLPBio

(R)-eIF4A3-IN-2

Catalog No.: GC62738Purity:>95.00%
COASDSData Sheet
(R)-eIF4A3-IN-2 is a less active enantiomer of eIF4A3-IN-2.

Products are for research use only. Not for human use. We do not sell to patients.

(R)-eIF4A3-IN-2
Cas No.: 2095484-82-3
5 mgIn Stock
$432.00
1
10 mgIn Stock
$720.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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    183(7):1867-1883 (2020)
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Description

(R)-eIF4A3-IN-2 is a less active enantiomer of eIF4A3-IN-2. eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM[1].

Eukaryotic initiation factor 4A-3 (eIF4A3) is an Asp-Glu-Ala-Asp (DEAD) box-family adenosine triphosphate (ATP)-dependent RNA helicase[1].

[1]. Iwatani-Yoshihara M, et al. Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. ACS Chem Biol. 2017;12(7):1760-1768.

Product Documents

Purity:>95.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2095484-82-3
Molecular Formula
C25H19Br2ClN4O2
Molecular Weight
602.7
Solubility
DMSO : 50 mg/mL (82.96 mM; Need ultrasonic)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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