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Beta-secretase

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Beta-secretase (BACE) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer. Alzheimer's disease (AD) is caused by aggregates of the amyloid peptide (Abeta), which is generated by cleavage of the Abeta protein precursor (APP) by beta-secretase (BACE-1) followed by gamma-secretase. BACE-1 cleavage is limiting for the production of Abeta, Drugs to block this enzyme (BACE inhibitors) prevent the build up of beta-amyloid and may help slow or stop Alzheimers disease.

Products Related to Beta-secretase(27)

  • GC65970 structure
    GC65970NB-360
    CAS: 1262857-73-7
    Purity: >99.00%

    NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E.

  • GC73144 structure
    GC73144K284-6111
    CAS: 702668-62-0
    Purity: >98.00%

    K284-6111 is an orally active inhibitor for protein chitinase 3-like 1 (CHI3L1).

  • GN10716 structure
    GN10716Epiberberine
    CAS: 6873-09-2
    Purity: >98.00%