Ophthalmology

Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.

Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.

Fluprostenol is a well-studied, potent analog of PGF2α acting primarily through the FP receptor.

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma.

AL 8810 is an 11β-fluoro analog of prostaglandin F2α (PGF2α) which acts as a potent and selective antagonist at the FP receptor.

BMS 470539 (hydrochloride) is a highly selective and potent melanocortin-1 receptor (MC-1R) agonist. In cAMP accumulation assays, its EC 50 values for human and mouse MC1R are 16.8 and 11.6nM, respectively.

Brain-derived basic fibroblast growth factor (1-24) (brain-derived bFGF) is a peptide fragment of brain-derived bFGF.

C16 Phytoceramide (t18:0/16:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis.

Cholesteryl arachidate is a cholesterol ester that has been found in human meibum.

2-arachidonyl glycerol (2-AG) exhibits cannabinoid (CB) agonist activity at the CB1 receptor, is an important endogenous monoglyceride species, and is thus considered to be the natural ligand for the CB1 receptor.

GAT229 is a positive allosteric modulator of cannabinoid receptor 1 (CB1) and the S-(-) enantiomer of the CB1 modulator GAT211.

Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide.

There are currently four prostaglandin (PG) derivatives which have been approved for human clinical use for the treatment of glaucoma.

Lutein is a naturally occurring carotenoid with multiple biological activities and is widely found in green leafy vegetables, corn, and egg yolks.

LX7101 is a potent inhibitor of LIM kinase (LIMK) 1 and 2 and Rho-associated kinase 1 (ROCK-1) and ROCK-2 with IC50 values of 32, 4.3, 69, and 32 nM, respectively.

Prostaglandin F2α ethyl amide (PGF2α-NEt) is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-ethyl amide.

PGF2α isopropyl ester is an ester prodrug of PGF2α with enhanced lipid solubility.

Sphinganine-1-phosphate (d17:0) is a sphingolipid analog of sphinganine-1-phosphate (d18:0) and sphingosine-1-phosphate (d18:1) that has a 17-carbon base.

C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO cells.

Sterculic acid is a cyclopropene fatty acid that has been found in S.

12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway.

Unoprostone isopropyl ester (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca2+-activated K+ (BK) channels activator.

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma.