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Antifolate

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<div class="colum_1 clearer"><p>Antifolates are compounds that antagonise the actions of folic acid (vitamin B9). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as Proguanil, Pyrimethamine and Trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR). Many are primarily DHFR inhibitors, but Raltitrexed is an inhibitor of thymidylate synthase, and Pemetrexed inhibits both and a third enzyme. Antifolates act specifically during DNA and RNA synthesis, and thus are cytotoxic during the S-phase of the cell cycle. Thus, they have a greater toxic effect on rapidly dividing cells.</p></div>

Products Related to Antifolate(33)

  • GC61047 structure
    GC61047Methotrexate disodium
    CAS: 7413-34-5
    Purity: >98.00%

    Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.

  • GC61058 structure
    GC61058Metoprine
    CAS: 7761-45-7
    Purity: >99.00%

    Metoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor.

  • GC62968 structure
    GC62968Fanotaprim
    CAS: 2120282-75-7
    Purity: >98%

    Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor with IC50s of 1.57 and 308 nM for tgDHFR (Toxoplasma gondii DHFR) and hDHFR (human DHFR), respectively.

  • GC63612 structure
    GC63612Tetroxoprim
    CAS: 53808-87-0
    Purity: >98%

    Tetroxoprim is an antimicrobial DHFR inhibitor.

  • GC65617 structure
    GC65617DHFR-IN-3
    CAS: 137553-43-6
    Purity: >99.00%

    DHFR-IN-3 is a dihydrofolate reductase (DHFR) inhibitor with the IC50 values of 19 μM and 12 μM in rat liver and P. carinii DHFR, respectively.

  • GC66387 structure
    GC66387Lometrexol disodium
    CAS: 120408-07-3
    Purity: >98.00%

    Lometrexol (DDATHF) disodium, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol disodium can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol disodium has anticancer activity. Lometrexol disodium also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.

  • GC66422 structure
    GC66422Trimethoprim-d9
    CAS: 1189460-62-5
    Purity: >98%

    Trimethoprim-d9 is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment.

  • GC69466 structure
    GC69466Mirvetuximab
    CAS: 1453084-36-0
    Purity: >99.00%

    Mirvetuximab (M9346A) is a monoclonal antibody that targets anti-FOLR1 (folate receptor 1). Mirvetuximab is an antibody molecule for a novel folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian cancer and other FRα-positive cancer research.

  • GC73018 structure
    GC73018Mirvetuximab soravtansine (solution)
    CAS: 1453084-37-1
    Purity: >99.00%

    Mirvetuximab soravtansine (IMGN853) solution is an anti-folate receptor α (FRα) ADC consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A.