JAK
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Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.
Products Related to JAK(169)
- GC71475JAK1-IN-13CAS: 2778330-90-6Purity: >98.00%
JAK1-IN-13 (compound 36b) is an orally active, potent and highly selective inhibitor of JAK1 with an IC50 of 0.044 nM.
- GC71575DeuruxolitinibCAS: 1513883-39-0Purity: >99.00%
Deuruxolitinib, a deuterated Ruxolitinib , modulates the activity of JAK1/JAK2.
- GC72769(1R)-AZD-1480CAS: 935666-99-2Purity: >97.00%
(1R)-AZD-1480 is the (1R) chiral isomer of AZD-1480, an ATP competitive JAK1 and JAK2 inhibitor.
- GC72815Itacnosertib (hydrocholide)CAS: 2409543-84-4Purity: >99.00%
Itacnosertib drocholide is an inhibitor of JAK2, ACVR1 (ALK2) and ALK5.
- GC73139SJ1008030 formicPurity: >97.00%
SJ1008030 (compound 8) formic is a JAK2 PROTAC which selectively degrades JAK2.
- GC73456JAK1-IN-11CAS: 2427608-43-1Purity: >98.00%
JAK1-IN-11 (compound 11) is a potent inhibitor of JAK，with IC50s of 0.02 nM (JAK1)，and 0.44 nM (JAK2)，respectively.
- GC73600JAK3-IN-14CAS: 454234-24-3Purity: >99.00%
JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively.
- GC73627HDAC/JAK/BRD4-IN-1CAS: 2755325-84-7Purity: >95.00%
HDAC/JAK/BRD4-IN-1(compound 25ap) is a potent HDAC/JAK/BRD4 triple inhibitor.
- GC79003WCY-8-67 TFAPurity: >99.00%
WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC 50 value of 1.33 μM.
- GC79070WWQ-03-012CAS: 3076807-15-0Purity: >98.00%
WWQ-03-012 is a selective DESI2 inhibitor with an IC 50 of 47.3 nM.
- GC80468Peficitinib-d 3Purity: >98%
Peficitinib -d 3 (ASP015K-d 3 ) is the deuterium labeled Peficitinib.
- GC80946PROTAC JAK1/2 degrader-1Purity: >99.00%
PROTAC JAK1/2 degrader-1 is an orally active JAK1 / JAK2 PROTAC degrader, with DC 50 values of 1.4 μM and 0.92 μM against JAK1 and JAK2, respectively.
- GC80947JAK1/2 ligand 1CAS: 1026028-96-5Purity: >99.50%
JAK1/2 ligand 1 is a ligand for the PROTAC target protein of JAK1/2, which can be used to synthesize PROTAC JAK1/2 degrader-1.
- GC81026PROTAC SKP2 Degrader-1CAS: 3120650-15-6Purity: >99.50%
PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K d value of 6.28 μM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC71475 | JAK1-IN-13 | 2778330-90-6 | >98.00% | |
JAK1-IN-13 (compound 36b) is an orally active, potent and highly selective inhibitor of JAK1 with an IC50 of 0.044 nM. | ||||
| GC71575 | Deuruxolitinib | 1513883-39-0 | >99.00% | |
Deuruxolitinib, a deuterated Ruxolitinib , modulates the activity of JAK1/JAK2. | ||||
| GC72769 | (1R)-AZD-1480 | 935666-99-2 | >97.00% | |
(1R)-AZD-1480 is the (1R) chiral isomer of AZD-1480, an ATP competitive JAK1 and JAK2 inhibitor. | ||||
| GC72815 | Itacnosertib (hydrocholide) | 2409543-84-4 | >99.00% | |
Itacnosertib drocholide is an inhibitor of JAK2, ACVR1 (ALK2) and ALK5. | ||||
| GC73139 | SJ1008030 formic | - | >97.00% | |
SJ1008030 (compound 8) formic is a JAK2 PROTAC which selectively degrades JAK2. | ||||
| GC73148 | JAK-IN-21 | 2445499-20-5 | >99.00% | |
JAK-IN-21 (Example 4) is a selective and potent JAK inhibitor with IC50s of 1.73, 2.04, 109 and 62.9 nM against JAK1, JAK2, J2V617F and TYK2, respectively. | ||||
| GC73369 | SJ988497 | 2595365-41-4 | >98.00% | |
SJ988497 is a PROTAC JAK2 degrader. | ||||
| GC73456 | JAK1-IN-11 | 2427608-43-1 | >98.00% | |
JAK1-IN-11 (compound 11) is a potent inhibitor of JAK，with IC50s of 0.02 nM (JAK1)，and 0.44 nM (JAK2)，respectively. | ||||
| GC73475 | JAK-IN-26 | 2417134-93-9 | >98.00% | |
JAK-IN-26 (compound 2) is an orally active JAK inhibitor with good pharmacokinetic characteristics. | ||||
| GC73600 | JAK3-IN-14 | 454234-24-3 | >99.00% | |
JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. | ||||
| GC73627 | HDAC/JAK/BRD4-IN-1 | 2755325-84-7 | >95.00% | |
HDAC/JAK/BRD4-IN-1(compound 25ap) is a potent HDAC/JAK/BRD4 triple inhibitor. | ||||
| GC79003 | WCY-8-67 TFA | - | >99.00% | |
WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC 50 value of 1.33 μM. | ||||
| GC79070 | WWQ-03-012 | 3076807-15-0 | >98.00% | |
WWQ-03-012 is a selective DESI2 inhibitor with an IC 50 of 47.3 nM. | ||||
| GC79181 | RAI-20 | 2549180-90-5 | >98.50% | |
RAI-20 (H018) is an orally active JAK1/JAK2 dual inhibitor ( IC 50 =15.1 and 22.7 nM). | ||||
| GC80468 | Peficitinib-d 3 | - | >98% | |
Peficitinib -d 3 (ASP015K-d 3 ) is the deuterium labeled Peficitinib. | ||||
| GC80946 | PROTAC JAK1/2 degrader-1 | - | >99.00% | |
PROTAC JAK1/2 degrader-1 is an orally active JAK1 / JAK2 PROTAC degrader, with DC 50 values of 1.4 μM and 0.92 μM against JAK1 and JAK2, respectively. | ||||
| GC80947 | JAK1/2 ligand 1 | 1026028-96-5 | >99.50% | |
JAK1/2 ligand 1 is a ligand for the PROTAC target protein of JAK1/2, which can be used to synthesize PROTAC JAK1/2 degrader-1. | ||||
| GC81026 | PROTAC SKP2 Degrader-1 | 3120650-15-6 | >99.50% | |
PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K d value of 6.28 μM. | ||||
| GC91059 | LCC-12 (formate) | - | >98.00% | |
A copper (II) chelator and derivative of metformin | ||||
| GC91148 | JAK Inhibitor 31 | 2891469-99-9 | >98.00% | |
A JAK2 inhibitor | ||||
| GC91506 | Bayer 18 | 1251752-12-1 | >98.00% | |
Bayer 18 is a tyrosine kinase 2 (TYK2) inhibitor (IC50 = 18.7 nM). | ||||
| GC91689 | TG46 | 936091-15-5 | >98.00% | |
TG46 is an inhibitor of JAK2 (IC50 = 12.5 µM). | ||||
| GN10442 | Curculigoside | 85643-19-2 | >99.50% | |
| GN10584 | Ginsenoside Rk1 | 494753-69-4 | >98.00% | |