Apoptosis

(Gly14)-Humanin (human) is a potent analogue of Humanin, with highly neuroprotective activity.

Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and acts as a CXCR2 agonist.

Dexrazoxane is a hydrophilic ring-closed analog of iron chelator ethylenediaminetetraacetic acid and also a strong inhibitor of topoisomerase II with IC 50 value of 10μM.

Ademetionine (S-Adenosyl methionine; AdoMet; SAMe) is an endogenous molecule generated from methionine and ATP by the action of methionine adenosyltransferase and plays an important role in cellular metabolism as the main methyl donor .

Cl-Amidine (trifluoroacetate salt) is a multi-targeting peptidylarginine deminase (PAD) inhibitor with the functional group RC(NR)NR2 that inhibits PAD1 (IC 50 =0.8μM), PAD3 (IC 50 =6.2μM), and PAD4 (IC 50 =5.9μM) with 15min half-time.

Fumonisin B1 is a mycotoxin produced from F. moniliforme, a prevalent fungus of corn and other grains.

4-Nitroquinoline N-oxide is a potent mutagenic and carcinogenic compound that induces DNA damage and oxidative stress, making 4-Nitroquinoline N-oxide an important tool for cancer research and the study of DNA repair mechanisms.

4-ethylphenyl sulfate is an orally active and blood-brain barrier-penetrating intestinal microbial metabolite.

Calcium chelator

MTT (MTT) is a colorimetric agent widely used to measure cell proliferation.

Cetrimonium Bromide (CTAB), a common used surfactant, act as a drug solubilizer with intrinsic antibacterial properties.

Cytochrome c (from pig), a 'extreme multifunctional' protein that belongs to class 1 of the c-type cytochrome family, mediates electron-transfer in the respiratory chain and acts as a detoxifying agent to dispose of ROS and plays a role in cell apoptosis.

Cytochrome C (from horse) is an important mediator in the apoptotic pathway and has been used in various studies as an inducer of mitochondria-dependent apoptosis.

Denosumab is an IgG2 monoclonal antibody that targets the RANKL protein.

Poly-L-lysine (M.W 70000~150000) is a polymer consists of numerous L-lysine with great biocompatibility.

Poly-L-lysine hydrobromide (MW 150000-300000) is a high-molecular-weight, positively charged synthetic polypeptide widely used to enhance cell adhesion to culture surfaces. Poly-L-lysine hydrobromide exhibits excellent water solubility and biocompatibility and serves as an essential reagent for the culture of primary neurons, epithelial cells, and stem cells.

Poly-L-lysine (3~7W) is a positively charged synthetic polypeptide polymerized from L-lysine.

Ulinastatin is a broad‑spectrum protease inhibitor that suppresses the activity of various hydrolases, including trypsin, chymotrypsin, and elastase.

(±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line.

Nimbolide is a triterpene derived from the leaves and flowers of Azadirachta indica L. Nimbolide inhibits NF- κ B induces tumor cell apoptosis. Nimbolide inhibited CDK4 / Cdk6 kinase activity. Nimbolide inhibits NF- κ B. Wnt, PI3K Akt, MAPK and JAK-STAT signaling pathways.

A potent p300 histone acetyltransferase activator

Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity.