Apoptosis

Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid?hormone.

κ-Carrageenan is the sulfated form of D-galactan obtained from the red algae, which is commonly used to prepare edible films.

Ginsenoside CK, a secondary ginsenoside biotransformed from major ginsenosides, is more bioavailable and soluble than its parent ginsenosides and holds great significance.

4-Vinylcyclohexene dioxide (VCD), a metabolite of 4-vinylcyclohexene (VCH), is synthesized in industries as an intermediate diluent for epoxy resins and other epoxides.

Cardiolipin (Heart, Bovine) (sodium salt) is a phospholipid specific to mitochondria that can be extracted from bovine hearts. Cardiolipin is a tetra-acylated phospholipid in which the fatty acid side chains consist primarily of linoleic acid (18:2), with minor amounts of oleic acid. Cardiolipin is a potential target for research into neurodegenerative diseases.

Gypsogenin is a well-known natural saponin which has marked anticancer effects towards various types of cancer cell lines.

Hematoporphyrin (Hematoporphyrin IX) is a type of photosensitizer that possesses the porphyrin macrocycle structure.

Rehmannioside A is an inhibitor of cytochrome P450 enzymes (CYP3A4, 2C9, and 2D6), with IC 50 values of 10.08, 12.62, and 16.43μM, respectively.

DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist, with a K i value of 0.25μM.

FB23-2 is a selective inhibitor of mRNA N 6 -methyladenine (M 6 A) demethylase FTO (IC 50 = 2.6μM). It is can be used in research related to acute myeloid leukemia (AML).

Mycophenolic acid D3 is a deuterium-labeled Mycophenolic acid, which is an immunosuppressant drug inhibiting the inosine-monophosphate dehydrogenase.

Phosphocreatine is a high-energy phosphate compound that is abundant in muscle and brain.

5-Fluorouridine is a ribonucleotide metabolite of 5-Fluorouracil with anticancer activity. 5-Fluorouridine can mark active transcription sites of cells in vivo and in vitro for immunodetection of nascent RNA.

Desoxyrhaponticin, a stilbene glycoside from rhubarb, is a potent BACE1 inhibitor with an IC 50 value of 1.213μM.

Barbadin is a selective inhibitor of the β-arrestin/β2-adaptin interaction, with IC 50 values of 19.1μM and 15.6μM for β-arrestin1 and β-arrestin2, respectively.

Naringenin chalcone functions as an anti-allergic compound that can be taken orally and has shown effectiveness in reducing human placental CYP19A1 activity with an IC 50 value of 2.6μmol/L.

BTSA1 is a potent, high affinity and orally active BAX activator with an IC50 of 250 nM and an EC50 of 144 nM. BTSA1 binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.

BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity.

BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM.

DB1976 hydrochloride is a efficacious transcription factor PU.1 inhibitor. DB1976 dihydrochloride potently inhibits PU.1 binding (IC 50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, KD of 12 nM) in vitro. DB1976 dihydrochloride has apoptosis-inducing effect.

DT2216 is a proteolysis targeting chimera (PROTAC), and targets Bcl-xL for degradation in T-cell lymphomas that depend on the overexpressed proteins of the Bcl-2 family, such as Bcl-2, Bcl-xL, and Mcl-1.

all-trans Retinoic acid-d5 is intended for use as an internal standard for the quantification of all-trans retinoic acid by GC- or LC-MS.

Ac-AAVALLPAVLLALLAP-IETD-CHO is a composite of Ac-IETD-CHO, a peptide inhibitor of caspase-8, and a cell-permeable hydrophobic sequence derived from K-FGF.