GLPBio

p38

p38 (p38 mitogen-activated protein kinases) are serine/threonine kinases that activated by environmental stress and proinflammatory cydtokines. They mediates cell growth, differentiation, transcrption and development.

Products Related to p38(129)

  • GC70928 structure
    GC70928Emprumapimod hydrochloride
    Purity: >98.00%

    Emprumapimod (PF-07265803) hydrochloride is an orally active and selective inhibitor of p38α MAPK.

  • GC73312 structure
    GC73312(R)-STU104
    CAS: 2767124-77-4
    Purity: >99.00%

    (R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC50s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation.

  • GC73590 structure
    GC73590MAPK-IN-2
    Purity: >98.00%

    MAPK-IN-2 (compound 3h) is a potent MAPK inhibitor with antineoplastic activity.

  • GC79195 structure
    GC79195Semaglutide-FITC
    Purity: >96.50%

    Semaglutide -FITC (Semaglutide-Lys(FITC)) is a fluorescent tracer probe (Ex/Em = 495/520 nm) obtained by covalently coupling the green fluorescent dye fluorescein isothiocyanate (FITC) to the long-acting analogue of GLP-1, Semaglutide.

  • GC79196 structure
    GC79196Semaglutide, Cy5 labeled
    Purity: >98%

    Semaglutide, Cy5-labeled (Semaglutide-Cys(Cy5)) is a CY5 -labeled version of Semaglutide (Ex/Em = 633/670 nm).

  • GC79232 structure
    GC79232PAR2 modulator-1
    CAS: 2378159-28-3
    Purity: >98.50%

    PAR2 modulator-1 is a biased protease-activated receptor 2 ( PAR2 ) inhibitor.

  • GC79245 structure
    GC79245KRAS G12D-IN-30
    CAS: 3022287-75-5
    Purity: >99.00%

    KRAS G12D-IN-30 (Compound 4) is a KRAS inhibitor.

  • GC79389 structure
    GC79389ETI41
    CAS: 2773474-99-8
    Purity: >98%

    ETI41 is an orally active, selective TLR inhibitor that targets the nucleoside-binding Site I on TLR7 ( IC 50 = 0.63 μM) and TLR9 ( IC 50 = 0.16 μM), sparing surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4 and TLR5).

  • GC79390 structure
    GC79390ETI60
    CAS: 2773475-11-7
    Purity: >99.50%

    ETI60 is an orally active, selective TLR inhibitor that targets the nucleoside-binding Site I on TLR7 ( IC 50 = 0.68 μM) and TLR9 ( IC 50 = 0.12 μM), sparing surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4 and TLR5).

  • GC79391 structure
    GC79391MyD88-IN-3
    Purity: >99.00%

    MyD88-IN-3 is an orally active, selective MyD88 Inhibitor.

  • GC79462 structure
    GC79462AZ14289671
    CAS: 3101563-22-5
    Purity: >98.50%

    AZ14289671 is an orally active, blood-brain barrier-penetrant tyrosine kinase ( tyrosine kinase ) inhibitor (TKI) that specifically targets non-small cell lung cancer (NSCLC) harboring EGFR exon 20 insertion mutations ( EGFR Exon20Ins ), while largely sparing wild-type EGFR to reduce off-target toxicities such as rash and diarrhea.

  • GC79475 structure
    GC79475MKK7-JNK activator 1
    CAS: 3100092-62-1
    Purity: >99.50%

    MKK7-JNK activator 1 (Compound 10) is a MKK7-JNK pathway activator.

  • GC79815 structure
    GC79815(E/Z)-Sinigrin free base
    CAS: 534-69-0
    Purity: >98%

    (E/Z)-Sinigrin ((E/Z)-Allyl-glucosinolate; (E/Z)-2-Propenyl-glucosinolate) free base is an orally active aliphatic thioglucoside anti-leukemia compound.

  • GC79816 structure
    GC79816Cryptolepine
    CAS: 480-26-2
    Purity: >98%

    Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties.

  • GC80407 structure
    GC80407Semaglutide-d 8 tetraTFA
    Purity: >99.50%

    Semaglutide -d 8 tetraTFA is the deuterium labeled Semaglutide.

  • GC80868 structure
    GC80868Antcin K
    CAS: 741268-13-3
    Purity: >98%

    Antcin K is a selective inhibitor targeting the PI3K/Akt, NF-κB, MEK1/2-ERK, p38 and AP-1 pathways.

  • GC80869 structure
    GC80869Calebin A
    CAS: 336784-82-8
    Purity: >98.00%

    Calebin A is a PI3K/Akt/mTOR, MAPK, and NF-κB inhibitor with oral effectiveness.

  • GC81021 structure
    GC81021p38α ligand-1
    CAS: 586379-64-8
    Purity: >98.50%

    P38α ligand-1 is a p38α ligand that can be used for the synthesis of PROTACs, such as NR-7h [1] .

  • GC81027 structure
    GC81027PROTAC HIF-1α degrader-2
    CAS: 3095636-64-6
    Purity: >98%

    PROTAC HIF-1α degrader-2 is a highly efficient and selective PROTAC degrader targeting HIF-1α. PROTAC HIF-1α degrader-2 promotes HIF-1α degradation via the ubiquitin-proteasome pathway by facilitating the formation of a HIF-1α/VHL ternary complex.

  • GC81460 structure
    GC81460BTX-6654 formate
    Purity: >98.50%

    BTX-6654 formate is a SOS1 PROTAC degrader.

  • GC81684 structure
    GC81684CK37
    CAS: 1001478-90-5
    Purity: >98%

    CK37 is a competitive choline kinase-α inhibitor.

  • GC81757 structure
    GC817573-Ethoxy-5,6-dibromosalicylaldehyde
    CAS: 20041-64-9
    Purity: >99.50%

    3-Ethoxy-5,6-dibromosalicylaldehyde is an IRE1/ERN1 inhibitor, with an IC 50 of 0.12 μM, a K i of 71-88 nM, and a K d of 100 nM against the ribonuclease activity of hIRE1α, as well as an IC 50 of 4.8 μM against yeast Ire1.

  • GC81771 structure
    GC81771RANKL-IN-1 formate
    Purity: >99.50%

    RANKL-IN-1 formate is a selective receptor activator of nuclear factor-κB ligand inhibitor ligand ( RANKL ) inhibitor with a K D value of 7.6 μM.

  • GC81827 structure
    GC81827Buforin IIb TFA
    Purity: >98.00%

    Buforin IIb TFA (BF2-B TFA) is an anticancer peptide, as well as an Antibacterial and Antifungal agent.