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Home >> Signaling Pathways >> MAPK Signaling

MAPK Signaling

Targets for  MAPK Signaling

Products for  MAPK Signaling

  1. Cat.No. Product Name Information
  2. GC48920 β-Carboline-1-carboxylic Acid

    1-Formic Acid-β-carboline

     An alkaloid with diverse biological activities β-Carboline-1-carboxylic Acid Chemical Structure
  3. GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol

    (±)214,15EG

     2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system. (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol Chemical Structure
  4. GC60393 (-)-Zuonin A (-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively. (-)-Zuonin A Chemical Structure
  5. GC13944 (5Z)-7-Oxozeaenol

    FR148083,L-783,279,LL-Z 1640-2

    TAK1 mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor

     (5Z)-7-Oxozeaenol Chemical Structure
  6. GC63903 (E)-Osmundacetone (E)-Osmundacetone is the isomer of Osmundacetone. (E)-Osmundacetone Chemical Structure
  7. GC62528 (Rac)-Hesperetin (Rac)-Hesperetin is the racemate of Hesperetin. (Rac)-Hesperetin Chemical Structure
  8. GC41740 (S)-p38 MAPK Inhibitor III

    (S)-p38 MAP Kinase Inhibitor III, (S)-p38 Mitogen-activated Protein Kinase Inhibitor III

     (S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro). (S)-p38 MAPK Inhibitor III Chemical Structure
  9. GC12851 10Z-Hymenialdisine Pan kinase inhibitor 10Z-Hymenialdisine Chemical Structure
  10. GC46554 2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate

    2’-O-Succinyl-cAMP, 2’-O-Succinyl-3’,5’-cyclic AMP

     2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate is a cAMP analog that can be covalently coupled to acetylcholinesterase. 2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate Chemical Structure
  11. GC39325 2,5-Dihydroxyacetophenone 2,5-Dihydroxyacetophenone, isolated from Rehmanniae Radix Preparata, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways. 2,5-Dihydroxyacetophenone Chemical Structure
  12. GC35132 4-Hydroxylonchocarpin 4-Hydroxylonchocarpin is a chalcone compound from an extract of Psoralea corylifolia. 4-Hydroxylonchocarpin Chemical Structure
  13. GC48381 5'-pApA (sodium salt)

    c-di-AMP Control, Cyclic di-AMP Negative Control

     A linearized form of cyclic di-AMP 5'-pApA (sodium salt) Chemical Structure
  14. GC63700 5,6,7-Trimethoxyflavone 5,6,7-Trimethoxyflavone is a novel p38-α MAPK inhibitor with an anti-inflammatory effect. 5,6,7-Trimethoxyflavone Chemical Structure
  15. GC41423 5-trans Prostaglandin E2

    transDinoprostone, 5,6trans PGE2

     5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1. 5-trans Prostaglandin E2 Chemical Structure
  16. GC12834 6-Bnz-cAMP sodium salt

    6-Bnz-cAMP

     cAMP analog,PKA activator 6-Bnz-cAMP sodium salt Chemical Structure
  17. GC42616 7-oxo Staurosporine

    BMY 41950, RK-1409

    7-oxo Staurosporine is an antibiotic originally isolated from S.

     7-oxo Staurosporine Chemical Structure
  18. GC16929 8-Bromo-cAMP, sodium salt

    8-Br-cAMP, 8-Bromoadenosine 3',5'-cyclic monophosphate, 8-bromo-cAMP

     8-Bromo-cAMP (8-Bromo-cAMP, sodium salt) is a cell-permeable cAMP analogue that acts as a CAMP-dependent protein kinase activator (PKA activator). 8-Bromo-cAMP, sodium salt Chemical Structure
  19. GC42622 8-bromo-Cyclic AMP

    8-Bromoadenosine 3',5'-cyclic monophosphate, 8-Br-cAMP, 8-bromo-cAMP, NSC 171719

     8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase. 8-bromo-Cyclic AMP Chemical Structure
  20. GC64460 8-Chloro-cAMP 8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity. 8-Chloro-cAMP Chemical Structure
  21. GC15352 8-CPT-Cyclic AMP (sodium salt)

    8-(p-Chlorophenylthio)-cAMP,8-CPT-cAMP

     8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). 8-CPT-Cyclic AMP (sodium salt) Chemical Structure
  22. GC60037 A-3 hydrochloride A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride Chemical Structure
  23. GA20623 Ac-muramyl-Ala-D-Glu-NH₂

    MDP, N-Acetylmuramoyl dipeptide

     Ac-muramyl-Ala-D-Glu-NH₂ (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Ac-muramyl-Ala-D-Glu-NH₂ Chemical Structure
  24. GC68597 ACA-28

    ACA-28 (compound 2a) is an effective ERK MAPK signaling regulator. ACA-28 induces apoptosis through excessive activation of ERK and selectively inhibits cancer cell growth. ACA-28 inhibits the growth of melanoma cells (SK-MEL-28) and normal melanocytes (NHEM), with IC50 values of 5.3 and 10.1 μM, respectively.

     ACA-28 Chemical Structure
  25. GC35242 Actein Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo. Actein Chemical Structure
  26. GC19019 Acumapimod

    BCT-197

     Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 uM for p38α. Acumapimod Chemical Structure
  27. GC32797 AD80 AD80, a multikinase inhibitor, inhibits RET, RAF,SRCand S6K, with greatly reduced mTOR activity. AD80 Chemical Structure
  28. GC49285 Adenosine 5’-methylenediphosphate (hydrate)

    Adenosine 5'-(α,β-methylene)diphosphate, AMP-CP, APCP, 5'-APCP

     An inhibitor of ecto-5’-nucleotidase Adenosine 5’-methylenediphosphate (hydrate) Chemical Structure
  29. GC46808 ADTL-EI1712 A dual ERK1 and ERK5 inhibitor ADTL-EI1712 Chemical Structure
  30. GC10204 AEG 3482 inhibitor of Jun kinase (JNK)-dependent apoptosis AEG 3482 Chemical Structure
  31. GC17265 AG-126

    Tyrphostin AG-126

     ERK1 (p44) and ERK2 (p42) inhibitor AG-126 Chemical Structure
  32. GC12646 AL 8697 p38α inhibitor,potent and selective AL 8697 Chemical Structure
  33. GC14899 AMG 548

    P38α inhibitor,potent and selective

     AMG 548 Chemical Structure
  34. GC38518 AMG-548 dihydrochloride AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride Chemical Structure
  35. GC65917 Andrograpanin Andrograpanin, a bioactive compound from Andrographis paniculata, exhibits anti-inflammatory and anti-infectious properties. Andrograpanin Chemical Structure
  36. GC11559 Anisomycin

    Flagecidin, NSC 76712, Wuningmeisu C

    JNK agonist, potent and specific

     Anisomycin Chemical Structure
  37. GC68671 Anti-inflammatory agent 35

    Anti-inflammatory agent 35 (compound 5a27) is an orally effective curcumin analogue with anti-inflammatory activity. It can block the signaling of mitogen-activated protein kinase (MAPK) and nuclear translocation of NF-kB. Anti-inflammatory agent 35 also inhibits neutrophil infiltration and proinflammatory cytokine production in vitro. In vivo studies have shown that Anti-inflammatory agent 35 significantly alleviates acute lung injury (ALI) induced by lipopolysaccharide (LPS).

     Anti-inflammatory agent 35 Chemical Structure
  38. GC15240 APS-2-79 APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling. APS-2-79 Chemical Structure
  39. GC32692 APTO-253 (LOR-253)

    APTO-253

     APTO-253 (LOR-253) (LOR-253) is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 (LOR-253) Chemical Structure
  40. GN10063 Arctigenin Arctigenin Chemical Structure
  41. GC12882 AS 602801

    AS-602801

     A selective, orally bioavailable JNK inhibitor AS 602801 Chemical Structure
  42. GC10010 AS601245

    AS-601245, c-Jun N-terminal Kinase Inhibitor V

     A c-Jun NH2-terminal protein kinase inhibitor AS601245 Chemical Structure
  43. GC19041 ASK1-IN-1 ASK1-IN-1 is a potent, orally available and selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87 nM. ASK1-IN-1 Chemical Structure
  44. GC62426 ASK1-IN-2 ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 Chemical Structure
  45. GC35412 Asperulosidic Acid Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid Chemical Structure
  46. GN10494 Astragaloside IV

    AS-IV, AST-IV

     Astragaloside IV Chemical Structure
  47. GC17712 AT13148 Multi-AGC kinase inhibitor,ATP-competitive AT13148 Chemical Structure
  48. GC12297 AT7867

    Akt1/2/3 and p70S6K/PKA inhibitor

     AT7867 Chemical Structure
  49. GC10918 AT7867 dihydrochloride A potent and orally bioavailable pan-Akt inhibitor AT7867 dihydrochloride Chemical Structure
  50. GC31667 AX-15836 AX-15836 is a potent and selective ERK5 inhibitor with an IC50 of 8 nM. AX-15836 Chemical Structure
  51. GC15055 AZ 628

    AZ-628; AZ628

    Raf kinases,potent and ATP-competitive

     AZ 628 Chemical Structure
  52. GC19479 AZ304

    A dual inhibitor

     AZ304 Chemical Structure
  53. GC19048 AZD-0364

    AZD0364

     AZD-0364 (AZD0364) is a potent and selective ERK2 inhibitor extracted from patent WO2017080979A1, compound example 18, has an IC50 of 0.6 nM. AZD-0364 Chemical Structure
  54. GC17030 AZD6244(Selumetinib)

    AZD6244; ARRY-142886

     A highly selective inhibitor of MEK1/2 AZD6244(Selumetinib) Chemical Structure
  55. GC31924 AZD7624 AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624 Chemical Structure
  56. GC14643 AZD8330

    ARRY-424704; ARRY-704; AZD-8330; ARRY424704; ARRY704; AZD8330

     MEK 1/2 inhibitor AZD8330 Chemical Structure
  57. GC38738 Azosemide Azosemide, a sulfonamide loop diuretic, is a potent NKCC1 inhibitor with IC50s of 0.246??M and 0.197??M for hNKCC1A and NKCC1B, respectively. Azosemide Chemical Structure
  58. GC10534 B-Raf IN 1

    B-RAF Inhibitor 1

     B-Raf inhibitor B-Raf IN 1 Chemical Structure
  59. GC65978 B-Raf IN 10 B-Raf IN 10 (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. B-Raf IN 10 shows antitumor activity. B-Raf IN 10 Chemical Structure
  60. GC67800 B-Raf IN 11 B-Raf IN 11 Chemical Structure
  61. GC64550 B-Raf IN 2 B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound Ia. B-Raf IN 2 can be used for the research of cancer. B-Raf IN 2 Chemical Structure
  62. GC12151 B-Raf inhibitor B-Raf inhibitor Chemical Structure
  63. GC11599 B-Raf inhibitor 1 B-Raf inhibitor 1 is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively. B-Raf inhibitor 1 Chemical Structure
  64. GC14907 B-Raf inhibitor 1 dihydrochloride B-B-Raf inhibitor 1 dihydrochloride is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively. B-Raf inhibitor 1 dihydrochloride Chemical Structure
  65. GN10590 Bakuchiol

    (S)-(+)-Bakuchiol

     Bakuchiol Chemical Structure
  66. GC33305 Balamapimod (MKI 833)

    MKI 833

     Balamapimod (MKI 833) (MKI 833) is a reversible Ras/Raf/MEK inhibitor with potential anti-tumor activity. Balamapimod (MKI 833) Chemical Structure
  67. GC34342 BAY885 An ERK5 inhibitor BAY885 Chemical Structure
  68. GC32950 Belvarafenib

    GDC-5573, HM95573

     An inhibitor of B-RAF and C-RAF Belvarafenib Chemical Structure
  69. GC35488 Belvarafenib TFA

    HM95573 TFA; GDC-5573 TFA; RG6185 TFA

     Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. Belvarafenib TFA Chemical Structure
  70. GC19066 BGB-283 BGB-283 is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively. BGB-283 Chemical Structure
  71. GC12904 BI 78D3

    JNK Inhibitor X, c-Jun N-terminal Kinase Inhibitor X

     Competitive JNK inhibitor BI 78D3 Chemical Structure
  72. GC17828 BI-847325 dual inhibitor of MEK and Aurora kinases BI-847325 Chemical Structure
  73. GC18178 BI-882370 A RAF inhibitor BI-882370 Chemical Structure
  74. GC13468 BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable BI-D1870 Chemical Structure
  75. GC35518 Bilobetin A biflavonoid with diverse biological activities Bilobetin Chemical Structure
  76. GC11497 BIRB 796 (Doramapimod)

    BIRB796

     BIRB 796 (Doramapimod) (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. BIRB 796 (Doramapimod) Chemical Structure
  77. GC35525 Bisabolangelone Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone Chemical Structure
  78. GC15693 BIX 02188 MEK5 inhibitor,potent and selective BIX 02188 Chemical Structure
  79. GC12220 BIX 02189 Selective MEK5 inhibitor BIX 02189 Chemical Structure
  80. GC12982 BIX 02565 RSK2 inhibitor BIX 02565 Chemical Structure
  81. GC16997 BMS-582949 p38 MAPK inhibitor BMS-582949 Chemical Structure
  82. GC10593 BMS-582949 hydrochloride p38 MAPK inhibitor BMS-582949 hydrochloride Chemical Structure
  83. GC42968 BPIQ-II (hydrochloride)

    PD 158294

     BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM). BPIQ-II (hydrochloride) Chemical Structure
  84. GC12482 BRAF inhibitor BRAF inhibitor Chemical Structure
  85. GC16779 BRD 7389 P90 RSK inhibitor BRD 7389 Chemical Structure
  86. GC68811 BSJ-04-122

    BSJ-04-122 is a covalent dual inhibitor of MKK4/7. It inhibits both MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively. BSJ-04-122 can be used in cancer research.

     BSJ-04-122 Chemical Structure
  87. GC35565 Bucladesine calcium salt Bucladesine calcium salt salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine calcium salt Chemical Structure
  88. GC15524 Bumetanide

    PF-1593, Ro 10-6338

     NKCC cotransporter inhibitor Bumetanide Chemical Structure
  89. GC11605 C-1 C-1 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. C-1 also used as a ROCK inhibitor. C-1 Chemical Structure
  90. GC10693 c-JUN peptide JNK/c-Jun interaction inhibitor c-JUN peptide Chemical Structure
  91. GC43065 C2 Phytoceramide (t18:0/2:0)

    N-Acetyl Phytosphingosine, C2:0 Phytoceramide, Cer(t18:0/2:0), Ceramide (t18:0/2:0), NAPS

     C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 μM) in suspended polymorphonuclear cells. C2 Phytoceramide (t18:0/2:0) Chemical Structure
  92. GC40352 Cafestol Cafestol is a natural diterpene which is abundant in unfiltered coffee. Cafestol Chemical Structure
  93. GC10941 cAMPS-Rp, triethylammonium salt

    Rp-cAMPS

     cAMPS-Rp, triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. cAMPS-Rp, triethylammonium salt Chemical Structure
  94. GC12706 cAMPS-Sp, triethylammonium salt cAMPS-Sp, triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. cAMPS-Sp, triethylammonium salt Chemical Structure
  95. GN10016 Carnosol

    NSC 39143

     Carnosol Chemical Structure
  96. GC47045 Carvedilol-d5 An internal standard for the quantification of carvedilol Carvedilol-d5 Chemical Structure
  97. GC43167 CAY10561

    Pyrazolylpyrrole ERK Inhibitor

     The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. CAY10561 Chemical Structure
  98. GC40650 CAY10706 CAY10706 is a ligustrazine-curcumin hybrid that promotes intracellular reactive oxygen species accumulation preferentially in lung cancer cells. CAY10706 Chemical Structure
  99. GC43198 CAY10717 CAY10717 is a multi-targeted kinase inhibitor that exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM. CAY10717 Chemical Structure
  100. GC50400 CC 401 dihydrochloride High affinity JNK inhibitor; also inhibits HCMV replication CC 401 dihydrochloride Chemical Structure
  101. GC13529 CC-401 JNK inhibitor,ATP-competitive CC-401 Chemical Structure

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