MAPK Signaling

Targets for MAPK Signaling
- ERK(72)
- MEK1/2(64)
- NKCC(5)
- MNK(5)
- PKA(49)
- p38(95)
- Rac(2)
- Raf(63)
- RasGAP (Ras- P21)(1)
- JNK(56)
- cAMP(32)
- Protein Kinase G(3)
- RSK(28)
- Other(759)
- MAPKAPK(1)
- MKK(2)
- KLF(3)
- MAP3K(19)
- MAP4K(15)
- MAPKAPK2 (MK2)(8)
- Mixed Lineage Kinase(6)
Products for MAPK Signaling
- Cat.No. Product Name Information
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GC41656
(±)2-(14,15-Epoxyeicosatrienoyl) Glycerol
2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system.
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GC60393
(-)-Zuonin A
-
GC13944
(5Z)-7-Oxozeaenol
TAK1 mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor
-
GC34983
(E)-Necrosulfonamide
-
GC63903
(E)-Osmundacetone
-
GC62528
(Rac)-Hesperetin
-
GC41740
(S)-p38 MAPK Inhibitor III
(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro).
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GC12851
10Z-Hymenialdisine
Pan kinase inhibitor
-
GC39325
2,5-Dihydroxyacetophenone
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GC63700
5,6,7-Trimethoxyflavone
-
GC41423
5-trans Prostaglandin E2
5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1.
-
GC12834
6-Bnz-cAMP sodium salt
cAMP analog,PKA activator
-
GC42616
7-oxo Staurosporine
7-oxo Staurosporine is an antibiotic originally isolated from S.
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GC16929
8-Bromo-cAMP, sodium salt
Cell-permeable cAMP analog that activates PKA
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GC42622
8-bromo-Cyclic AMP
8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase.
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GC15352
8-CPT-Cyclic AMP (sodium salt)
lipophilic activator of the cyclic-AMP- and cyclic-GMP-dependent protein kinases, PKA and PKG
-
GC60037
A-3 hydrochloride
-
GA20623
Ac-muramyl-Ala-D-Glu-NH₂
Muramyl dipeptide (MDP) inhibits HIV replication in CD4? H9 lymphocytes..
-
GC35242
Actein
-
GC19019
Acumapimod
Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 uM for p38α.
-
GC32797
AD80
-
GC10204
AEG 3482
inhibitor of Jun kinase (JNK)-dependent apoptosis
-
GC17265
AG-126
ERK1 (p44) and ERK2 (p42) inhibitor
-
GC12646
AL 8697
p38α inhibitor,potent and selective
-
GC14899
AMG 548
P38α inhibitor,potent and selective
-
GC38518
AMG-548 dihydrochloride
-
GC11559
Anisomycin
JNK agonist, potent and specific
-
GC15240
APS-2-79
KSR-dependent MAPK modulator
-
GC32692
APTO-253 (LOR-253)
-
GN10063
Arctigenin
Anti-inflammatory, antiproliferative
-
GC12882
AS 602801
Jun Kinase Inhibitor
-
GC10010
AS601245
A c-Jun NH2-terminal protein kinase inhibitor
-
GC19041
ASK1-IN-1
ASK1-IN-1 is an apoptosis signal regulating kinase 1 (ASK1) inhibitor extracted from patent WO2016025474A1, Compound 4.
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GC62426
ASK1-IN-2
-
GN10494
Astragaloside IV
Anti-inflammatory;extract of Astragali radix
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GC17712
AT13148
Multi-AGC kinase inhibitor,ATP-competitive
-
GC12297
AT7867
Akt1/2/3 and p70S6K/PKA inhibitor
-
GC10918
AT7867 dihydrochloride
Akt1 and p70S6K/PKA inhibitor
-
GC31667
AX-15836
-
GC15055
AZ 628
Raf kinases,potent and ATP-competitive
-
GC19479
AZ304
A dual inhibitor
-
GC19048
AZD-0364
AZD-0364 is a potent and selective ERK2 inhibitor extracted from patent WO2017080979A1, compound example 18, has an IC50 of 0.6 nM.
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GC17030
AZD6244(Selumetinib)
A MEK inhibitor
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GC31924
AZD7624
-
GC14643
AZD8330
MEK 1/2 inhibitor
-
GC38738
Azosemide
-
GC10534
B-Raf IN 1
B-Raf inhibitor
-
GC12151
B-Raf inhibitor
A B-Raf inhibitor
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GC11599
B-Raf inhibitor 1
Potent and selective B-Raf inhibitor
-
GC14907
B-Raf inhibitor 1 dihydrochloride
B-Raf inhibitor,potent and selective
-
GN10590
Bakuchiol
Extracted from Psoralea corylifolia L. fruit;Store the product in sealed, cool and dry condition
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GC33305
Balamapimod (MKI 833)
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GC34342
BAY885
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GC32950
Belvarafenib
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GC35488
Belvarafenib TFA
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GC19066
BGB-283
BGB-283 is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively.
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GC12904
BI 78D3
Competitive JNK inhibitor
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GC17828
BI-847325
dual inhibitor of MEK and Aurora kinases
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GC18178
BI-882370
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GC13468
BI-D1870
P90 RSK inhibitor,ATP-competitive and cell-permeable
-
GC11497
BIRB 796 (Doramapimod)
P38 MAPK inhibitor,cell permeable and highly selective
-
GC35525
Bisabolangelone
-
GC15693
BIX 02188
MEK5 inhibitor,potent and selective
-
GC12220
BIX 02189
Selective MEK5 inhibitor
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GC12982
BIX 02565
RSK2 inhibitor
-
GC16997
BMS-582949
p38 MAPK inhibitor
-
GC10593
BMS-582949 hydrochloride
p38 MAPK inhibitor
-
GC42968
BPIQ-II (hydrochloride)
BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM).
-
GC12482
BRAF inhibitor
Potent B-raf inhibitor
-
GC16779
BRD 7389
P90 RSK inhibitor
-
GC35565
Bucladesine calcium salt
A membrane permeable selective activator of PKA
-
GC15524
Bumetanide
NKCC cotransporter inhibitor
-
GC11605
C-1
protein kinase C inhibitor
-
GC10693
c-JUN peptide
JNK/c-Jun interaction inhibitor
-
GC43065
C2 Phytoceramide (t18:0/2:0)
C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 μM) in suspended polymorphonuclear cells.
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GC40352
Cafestol
Cafestol is a natural diterpene which is abundant in unfiltered coffee.
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GC10941
cAMPS-Rp, triethylammonium salt
Cell-permeable cAMP analog, competitive antagonist of cAMP-induced activation of PKA
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GC12706
cAMPS-Sp, triethylammonium salt
Cell-permeable cAMP analog that activates cAMP receptor protein PKA
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GN10016
Carnosol
Extracted from Labiatae rosemary;Store the product in sealed, cool and dry condition
-
GC43167
CAY10561
The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes.
-
GC40650
CAY10706
CAY10706 is a ligustrazine-curcumin hybrid that promotes intracellular reactive oxygen species accumulation preferentially in lung cancer cells.
-
GC43198
CAY10717
CAY10717 is a multi-targeted kinase inhibitor that exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM.
-
GC50400
CC 401 dihydrochloride
High affinity JNK inhibitor; also inhibits HCMV replication
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GC13529
CC-401
JNK inhibitor,ATP-competitive
-
GC14197
CC-401 hydrochloride
A JNK inhibitor
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GC62492
CC-90001
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GC32900
CC-90003
-
GC10446
CC-930
JNK inhibitor,potent and selective
-
GC63441
CC-99677
-
GC19090
CCG215022
CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 uM, 0.38±0.06 uM and 3.9±1 uM for GRK2, GRK5 and GRK1, respectively.
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GC19091
CCT196969
CCT196969, a pan-Raf inhibitor, inhibits B-Raf with an IC50 of 0.1 uM.
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GC40054
CCT241161
CCT241161 is a multi-kinase inhibitor that inhibits B-RAF, B-RAFV600E, C-RAF, Src, and LCK (IC50s = 252, 15, 6, 15, and 3 nM, respectively).
-
GC61865
Cearoin
-
GC12841
CEP 1347
JNK inhibitor
-
GC16845
CEP-32496
BRAF(V600E)inhibitor,highly potent
-
GC17860
CEP-32496 hydrochloride
B-Raf/C-Raf inhibitor,highly potent
-
GC15391
Cercosporamide
Mnk2 and JAK3 inhibitor
-
GC15525
cGMP Dependent Kinase Inhibitor Peptide
cGMP-dependent protein kinase (PKG) inhibitor
-
GC10666
CGP 57380
MNK1 inhibitor, specific and selective
-
GC12532
CHPG
mGlu5 metabotropic glutamate receptor agonist