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Progesterone Receptor

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Progesterone receptor (PR) is a protein found inside cells, which is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11q22, it has two main forms, A and B, that differ in their molecular weight. Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration. After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins. Progesterone receptor plays a central role in diverse reproductive events associated with establishment and maintenance of pregnancy, alveolar development in the breast and sexual behavior.

Products Related to Progesterone Receptor(37)

  • GC50394 structure
    GC50394AG 205
    CAS: 442656-02-2
    Purity: >98.00%

    Progesterone receptor membrane component 1 (Pgrmc1) ligand

  • GC60815 structure
    GC60815Estradiol dipropionate
    CAS: 113-38-2
    Purity: >98.00%

    Estradiol dipropionate is a combined estrogen-progesterone, acts as an estrogen and progesterone agonist.

  • GC61850 structure
    GC61850Medroxyprogesterone acetate D3
    Purity: >98.00%
  • GC63143 structure
    GC63143PF-02413873
    CAS: 936345-35-6
    Purity: >99.00%

    PF-02413873 (PF-2413873) is a potent selective, fully competitive and orally active nonsteroidal progesterone receptor (PR) antagonist, with a Ki of 2.6 nM.

  • GC63706 structure
    GC63706Dydrogesterone-D6
    Purity: >98%
  • GC63751 structure
    GC63751Levonorgestrel-D8
    Purity: >98%
  • GC63752 structure
    GC63752Norethindrone acetate-D8
    Purity: >98%
  • GC68493 structure
    GC6849317α-Hydroxyprogesterone-d8
    CAS: 850023-80-2
    Purity: >99.00%

    17α-Hydroxyprogesterone-d8 is the deuterated form of 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-OHP) is an endogenous progestogen that serves as a chemical intermediate in the biosynthesis of other steroid hormones, including glucocorticoids, androgens, and estrogens.

  • GC70472 structure
    GC70472Promegestone
    CAS: 34184-77-5
    Purity: >98.00%

    Promegestone (R-5020), a progestin, is a potent progesterone receptor (PR) agonist.

  • GC70603 structure
    GC70603PF-3882845
    CAS: 1023650-66-9
    Purity: >99.00%

    PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy.

  • GC71683 structure
    GC71683Chlormadinone acetate-d6-1
    Purity: >99.00%

    Chlormadinone acetate-d6-1 is deuterium labeled Chlormadinone acetate.

  • GC81361 structure
    GC81361Medrogestone
    CAS: 977-79-7
    Purity: >98%

    Medrogestone is an orally active Progestin.

  • GC81362 structure
    GC81362Melengesterol
    CAS: 5633-18-1
    Purity: >98%

    Melengestrol is a steroidal progestin of the 17α-hydroxyprogesterone group and an antineoplastic agent.