GLPBio

HIV Protease

Read More about this category

Human immunodeficiency virus (HIV) protease, belonging to the aspartic proteinase family, is an enzyme encoded by the pol open reading frame (ORF) of HIV genome that catalyze the posttranslational processing of the HIV polyproteins to yield structural proteins of the viral core and enzymes. The chemical structure of a HIV protease molecule is a symmetrical homodimer in which the interface is formed primarily by a four-stranded antiparallel β-sheet. A conserved D25-T26-G27 triad has been identified in each HIV protease monomer, which is positioned in a loop forming part of the catalytic site. HIV protease has been found to cleave peptide bonds in the p55 gag and p160 gag-pol polyproteins as well as in various cellular proteins in vitro, including calmodulin, pro-interleukin 1β and NF-KB.

Products Related to HIV Protease(35)

  • GC36872 structure
    GC36872Pepstatin Trifluoroacetate
    Purity: >99.00%

    Pepstatin Trifluoroacetate (Pepstatin A Trifluoroacetate) is a specific aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively.

  • GC39068 structure
    GC39068Rosamultin
    CAS: 88515-58-6
    Purity: >98.00%

    Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina?L.

  • GC43358 structure
    GC43358Cytochalasin A
    CAS: 14110-64-6
    Purity: >98.00%

    The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization.

  • GC64331 structure
    GC64331Ritonavir-13C,d3
    CAS: 155213-67-5
    Purity: >98%
  • GC65440 structure
    GC65440ddCTP trisodium
    Purity: >99.00%

    ddCTP trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.

  • GC65584 structure
    GC65584TMC310911
    CAS: 1000287-05-7
    Purity: >99.00%

    TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1.

  • GC66400 structure
    GC66400Hinokinin
    CAS: 26543-89-5
    Purity: >99.00%

    Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme.

  • GC71023 structure
    GC71023CL-197
    CAS: 1030595-07-3
    Purity: >99.00%

    CL-197 is an orally active and long-acting purine anti-HIV nucleoside reverse transcriptase inhibitor (NRTI).

  • GC71947 structure
    GC71947Acetyl-binankadsurin A
    CAS: 77174-33-5

    Acetyl-binankadsurin A (compound 5) is a lignan isolated from Kadsura longipedunculata.

  • GC81868 structure
    GC81868Acetyl-pepstatin ammonium
    Purity: >98.00%

    Acetyl-pepstatin ammonium is an aspartic protease ( PRs ) inhibitor that targets HIV-1 protease and XMRV protease with K i values of 13 nM and 712 nM, respectively.

  • GN10545 structure
    GN10545Escin IA
    CAS: 123748-68-5
    Purity: >98.00%