Casein Kinase

Orobol is a major soy isoflavone with various pharmacological activities, including anti-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K subtypes (for PI3K α/β/γ/K/δ, IC50=3.46-5.27 μM).

Casein kinase 1δ-IN-6 is a potent and selective protein kinase CK-1δ inhibitor with an IC50 of 23 nM.

Casein Kinase 2 Substrate Peptide is a common CK2 substrate peptide.

SRPIN803 is a potent CK2 and SRPK1 dual inhibitor, with IC50s of 203 nM and 2.4 μM, respectively.

CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor with an IC50 values of 123, 19.8, 26.8, 74.3 nM for CK1a, CK1d, CK1e, p38a, respectively.

ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively.

DEG-77, a PROTAC based IKZF2 and CK1α degrader, possesses suitable pharmacokinetic properties, solubility, and selectivity for in vivo studies (t1/2=8h).

SJ3149 is a selective and potent in vitro and in vivo degrader of CK1α protein with broad antiproliferative activity.

CK1-IN-5 (compound B-AZ) is an inhibitor of CK1.

CK2-TN03 is an ATP-competitive casein kinase 2 ( CK2 ) inhibitor, with an IC 50 of 165 nM and a K i of 20 nM.

PF-670462 is a selective CKI ε/δ inhibitor.

Casein Kinase II Substrate acetate is a casein kinase II ( CK2 ) peptide substrate that can be selectively phosphorylated by CK2 [1] .

CCK1-specific peptide substrate acetate is a biological active peptide.

Azocasein is a useful tracer molecule for characterizing the permeability of the top coat of the multilayer-coated polyester threads.