Stem Cell
- CK1(5)
- EZH2(10)
- GSK-3(51)
- HSC(7)
- iPSC(6)
- Hedgehog(38)
- Notch(36)
- Smoothened(34)
- Wnt/β-catenin(117)
- Hippo Signaling(5)
- Cancer stem cell(23)
- MST1/2(1)
- ESC(1)
- Casein Kinase(27)
- Oct3/4(5)
- Porcupine(6)
- YAP(24)
Products for Stem Cell
- Cat.No. Product Name Information
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GC62432
β-catenin-IN-2
β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer.
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GC34980
(E)-Ferulic acid
(E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.
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GC66371
(E)-Ferulic acid-d3
(E)-Coniferic acid-d3
(E)-Ferulic acid-d3 ((E)-Coniferic acid-d3) is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. -
GC41719
(R)-nitro-Blebbistatin
R(-)7Desmethyl8nitro Blebbistatin
(R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin, which is the inactive form of (-)-blebbistatin. -
GC69847
(R)-VT104
(R)-VT104 is the R-enantiomer of VT104. The IC50 value of (R)-VT104 for firefly luciferase is 0.1-1 μμ. VT104 is an orally active pan-TEAD deacetylase inhibitor.
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GC13907
1-Azakenpaullone
GSK-3β inhibitor,potent and selective,cell-permeable
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GC49651
19-alkyne Cholesterol
19-ethynyl Cholesterol
An alkyne derivative of cholesterol for click chemistry -
GC15422
20(S)-Hydroxycholesterol
20α-hydroxy Cholesterol
An allosteric activator of the oncoprotein smoothened (Smo) -
GC40571
24(S),25-epoxy Cholesterol
24(S)-24,25-EC
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.
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GC17907
3-Deazaneplanocin A (DZNep) hydrochloride
2,3DMMC
3-Deazaneplanocin A (DZNep) hydrochloride is an adenosine analogue and is a competitive S-adenosylhomocysteine hydrolase inhibitor with a Ki of 50 pM in cell-free tests. -
GC13145
3-Deazaneplanocin,DZNep
DZNep, NSC 617989
An inhibitor of lysine methyltransferase EZH2
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GC66390
3-epi-Vitamin D3
Epicholecalciferol
3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC50 of 39.2 μM measured in U87MG cells. -
GC14306
3F8
GSK-3β inhibitor
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GC45354
4β-Hydroxywithanolide E
NSC 212509
A withanolide with anti-inflammatory and anticancer activities -
GC49827
5-Androstenetriol
Δ5-AT
An active metabolite of DHEA -
GC35162
5-Iodo-indirubin-3'-monoxime
5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively.
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GC39152
9-ING-41
Elraglusib
9-ING-41 is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic drugs. -
GC10336
A 1070722
GSK-3 inhibitor
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GC68592
ABC1183
ABC1183 is a selective dual inhibitor of GSK3 and CDK9 with oral activity. Its IC50 values for GSK3β, GSK3α, and CDK9/cyclin T1 are 657 nM, 327 nM, and 321 nM respectively. ABC1183 has anti-inflammatory properties as well as anti-tumor activity.
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GC42669
ABC99
An inhibitor of NOTUM
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GC31663
Adavivint (SM04690)
SM04690; Lorecivivint
Adavivint (SM04690) (SM04690; Lorecivivint) is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells. -
GC49110
AICA Ribonucleotide
AICA-Ribotide, AICA-Riboside-5'-phosphate, 5-Aminoimidazole-4-Carboxamide Ribonucelotide, NSC 283955, NSC 292227
An AMPK activator -
GC14749
ALLO-1
ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif.
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GC34463
ALLO-2
ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
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GC15841
Alsterpaullone
9-Nitropaullone,NSC 705701
CDKs and GSK3β inhibitor -
GC64638
ALV1
ALV1 is a potent Ikaros and Helios degrader.
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GC50323
AMBMP hydrochloride
AMBMP hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50of 700 nM.
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GC14899
AMG 548
P38α inhibitor,potent and selective
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GC38518
AMG-548 dihydrochloride
AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ.
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GC68695
ARUK3001185
ARUK3001185 (Compound 8l) is an effective, selective, orally active Notum inhibitor that can penetrate the blood-brain barrier with an IC50 value of 6.7 nM.
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GC68701
ASR-490
ASR-490 reduces the viability of HCT116 and SW620 cells by downregulating Notch1 signaling. ASR-490 overcomes the overexpression of Notch1 and inhibits the growth of HCT/Notch1 transfectants. In xenograft mice, ASR-490 suppresses tumor growth in control (pCMV/HCT116) and Notch1/HCT116 groups.
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GC12429
AY 9944 dihydrochloride
AY 9944 dihydrochloride is a specific cholesterol biosynthesis inhibitor.
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GC14715
AZ 12080282 dihydrochloride
Hedgehog inhibitor
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GC16568
AZD1080
GSK3βinhibitor
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GC14736
AZD2858
GSK-3 inhibitor,potent and selective
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GC10752
Bikinin
Abrasin
GSK3 inhibitor and Brassinosteroid activator
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GC14233
BIO-acetoxime
6-Bromoindirubin-3'-acetoxime, GSK3 Inhibitor X
GSK-3α/β inhibitor
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GC38892
BIP-135
BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively.
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GC42944
BIX01294 (hydrochloride hydrate)
The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression.
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GC52376
BMP2-derived Peptide (trifluoroacetate salt)
Bone Morphogenic Protein 2-derived Peptide, KIPKASSVPTELSAISTLYL-NH2
A synthetic peptide -
GC13673
BMS-708163 (Avagacestat)
BMS-708163
A potent inhibitor of γ-secretase -
GC13628
BMS-833923
BMS 833923;BMS833923;XL-139;XL139;XL 139
An orally bioavailable Smo inhibitor -
GC35535
BMS-906024
BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC50s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity.
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GC35537
BMS-983970
BMS-983970 is an oral pan-Notch inhibitor for the treatment of multiplecancers.
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GC46939
BODIPY-aminoacetaldehyde diethyl acetal
BAAA-DA
A stable precursor to the fluorescent ALDH substrate BAAA -
GC68797
Box5 TFA
Box5 TFA is an effective Wnt5a antagonist. It inhibits the Wnt5a signal and suppresses Wnt5a-mediated Ca2+ release. Box5 TFA also inhibits cell migration and has potential in melanoma research.
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GC46947
BRD-K4477
FH1, Methylenebis-4,4'-acetanilide, NSC 12407, Functional Hits 1
A small molecule promotor of hepatocyte differentiation -
GC68802
BRD0209
BRD0209 is an effective, selective, and dual inhibitor of GSK3α/β (GSK3α IC50 = 19 nM; GSK3β IC50 = 5 nM). It is also a reversible ATP-competitive inhibitor with fast kinetics (Ki values of 4.2 nM for both isoforms). BRD0209 is a tricyclic pyrazolone-fused tetrahydroquinoline compound. It has potential in researching mood disorders.
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GC39181
BRD0705
BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML) research.
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GC12811
BRD7116
inhibitor of leukemia stem cell activity
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GC68809
Brontictuzumab
OMP 52M51; Anti-Human NOTCH1 Recombinant Antibody
Brontictuzumab (OMP 52M51) is a monoclonal antibody (MAb) that can inhibit the Notch1 signal. Brontictuzumab selectively binds to the negative regulatory region of Notch1. Brontictuzumab can inhibit tumor cell proliferation and is used in research for leukemia and lymphoma.
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GC35559
Bruceine D
Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells.
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GC11275
C34
Toll-Like Receptor 4-C34
C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis. -
GC65165
Carboxylesterase-IN-2
Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease.
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GC65167
Carboxylesterase-IN-3
Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease.
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GC17840
Cardiogenol C hydrochloride
Induces differentiation of mouse embryonic stem cells (ESCs) into cardiomyocytes
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GC17782
Cardionogen 1
Wnt signaling modulator
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GC35612
Carvacrol
Cymophenol, Isopropyl o-cresol, NSC 6188, p-Cymen-2-ol
Carvacrol is a monoterpenoid phenol isolated from Thymus mongolicus Ronn. -
GC66033
Casein kinase 1δ-IN-1
Casein kinase 1δ-IN-1 (compound 822) is an inhibitor of casein kinase 1 delta (CK1δ), exhibits inhibition of greater than 5%. Casein kinase 1δ-IN-1 can be used for neurodegenerative disorders such as Alzheimer's disease research.
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GC67775
Casein kinase 1δ-IN-3
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GC71277
Casein kinase 1δ-IN-6
Casein kinase 1δ-IN-6 is a potent and selective protein kinase CK-1δ inhibitor with an IC50 of 23 nM.
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GC72207
Casein Kinase 2 Substrate Peptide
Casein Kinase 2 Substrate Peptide is a common CK2 substrate peptide.
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GC30276
Casein Kinase II Inhibitor IV
Casein Kinase II Inhibitor IV is a potent, ATP-competitive of casein kinase II inhibitor with an IC50 of 9 nM.
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GC34356
Casein Kinase II Inhibitor IV Hydrochloride
Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocytedifferentiation.
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GC38745
CB-103
CB-103 is a first-in-class, orally active protein-protein interaction (PPI) inhibitor of the NOTCH transcriptional activation complex. CB-103 has anti-tumor activity.
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GC10253
CCT 031374 hydrobromide
inhibits TCF-dependent transcription, blocks BIO-induced β-catenin stabilization
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GC17606
CCT251545
Orally bioavailable and potent WNT signaling inhibitor
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GC48992
CGP 77675 (hydrate)
An inhibitor of Src family kinases
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GC15642
CHIR 99021 trihydrochloride
CHIR-99021 trihydrochloride; CT99021 trihydrochloride
Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR 99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR 99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR 99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR 99021 trihydrochloride induces autophagy. -
GC12176
CHIR-98014
GSK-3β inhibitor,selective and ATP-competitive
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GC16702
CHIR-99021 (CT99021)
CHIR99021, CHIR-99021, CHIR 99021, CT99021,GSK-3 Inhibitor XVI
CHIR-99021 is the most commonly used GSK-3β inhibitor and is considered the standard small-molecule Wnt agonist. -
GC17153
CHIR-99021 (CT99021) HCl
CHIR-99021 monohydrochloride; CT99021 monohydrochloride
Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 (CT99021) HCl shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 (CT99021) HCl is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 (CT99021) HCl enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 (CT99021) HCl induces autophagy. -
GC32942
CHIR-99021 monohydrochloride (CT99021 monohydrochloride)
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GC11476
Ciliobrevin A
HPI-4
Hh pathway antagonist
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GC39359
Ciliobrevin D
Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro.
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GC41587
cis-Vaccenic Acid
C18:1 n-7, C18:1(11Z), cis-11-Octadecenoic Acid
An ω-7 fatty acid -
GC34536
CK1-IN-1
CK1-IN-1 is a casein kinase 1 (CK1) inhibitor extracted from patent WO2015119579A1, compound 1c, has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively.
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GC16325
CKI 7 dihydrochloride
Casein kinase 1 (CK1) inhibitor
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GC38755
CKI-7
CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases.
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GC64816
Coronaridine
Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression.
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GC13176
CP21R7
GSK3β inhibitor
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GC16599
CPI-169
EZH2 inhibitor
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GC12146
CPI-169 R-enantiomer
EZH2 inhibitor
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GC11484
CPI-169 S-enantiomer
EZH2 inhibitor
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GC17690
Cromolyn sodium
Mast cell membrane stabilizer
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GC11217
CUR 61414
G-856
potent inhibitor of hedgehog-induced cellular activity -
GC13037
CX-4945 (Silmitasertib)
CX 4945;CX4945
CX-4945 (Silmitasertib) (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. -
GC11325
CX-4945 sodium salt
CX-4945 sodium salt
CX-4945 sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. -
GC13441
Cyclopamine
11-Deoxojervine
Cyclopamine is a naturally occurring Hedgehog (Hh)?specific small?molecule signaling steroidal alkaloid inhibitor, causes a profound inhibition of tumor growth, has significant anti?invasive, anti?proliferative and anti?estrogenic potency in human breast cancer cells [2] [1]. -
GC43346
Cyclopamine-KAAD
Cyclopamine-KAAD, a hedgehog signaling inhibitor, is a smoothened antagonist.
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GC13202
D4476
Casein Kinase I Inhibitor
Inhibitor of CK1 and ALK5 -
GC68951
DC-TEADin02
DC-TEADin02 is an effective inhibitor of TEAD palmitylation. It inhibits TEAD palmitylation with an IC50 value of 197 nM. DC-TEADin02 can be used for developmental, regenerative, and tissue homeostasis studies.
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GC43462
Dihydrolipoic Acid
DHLA
Dihydrolipoic acid (DHLA) is a dithiol-containing carboxylic acid that is the reduced form of α-lipoic acid. -
GC35873
DK419
DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK.
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GC50685
Dynapyrazole A
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GC50486
Dynarrestin
Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
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GC38330
EHT 5372
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GC14756
EI1
EZH2 inhibitor
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GC15548
Ellagic acid
Gallogen, Lagistase, TBBD
Casein kinase 2 (CK2) inhibitor -
GC48434
Elsinochrome A
NSC 623609
A fungal metabolite