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Stem Cell

  1. Cat.No. Product Name Information
  2. GN10797 Tangeretin Tangeretin  Chemical Structure
  3. GN10017 Wogonin Wogonin  Chemical Structure
  4. GC14037 Triptonide A diterpenoid with diverse biological activities Triptonide  Chemical Structure
  5. GC18107 Salinomycin sodium salt A selective cancer stem cell inhibitor Salinomycin sodium salt  Chemical Structure
  6. GC14882 Salinomycin A selective cancer stem cell inhibitor Salinomycin  Chemical Structure
  7. GC10556 PF-670462 An inhibitor of the CK1 isoforms CK1ε and CK1δ PF-670462  Chemical Structure
  8. GC14169 LDE225 Diphosphate A Smo antagonist LDE225 Diphosphate  Chemical Structure
  9. GC16454 IWP-2 An inhibitor of Wnt production IWP-2  Chemical Structure
  10. GC12951 HhAntag A hedgehog pathway inhibitor HhAntag  Chemical Structure
  11. GC17534 GSK343 A selective, cell-permeable EZH2 inhibitor GSK343  Chemical Structure
  12. GC15783 GSK126

    A selective EZH2 inhibitor

    GSK126  Chemical Structure
  13. GC16789 GANT 58 An inhibitor of Gli transcription GANT 58  Chemical Structure
  14. GC12134 FH535 An inhibitor of β-catenin signaling FH535  Chemical Structure
  15. GC13202 D4476 Inhibitor of CK1 and ALK5 D4476  Chemical Structure
  16. GC13628 BMS-833923 An orally bioavailable Smo inhibitor BMS-833923  Chemical Structure
  17. GC17107 PluriSIn #1 (NSC 14613) A selective inhibitor of stearoyl-CoA desaturase PluriSIn #1 (NSC 14613)  Chemical Structure
  18. GC12653 LY3039478 A Notch inhibitor LY3039478  Chemical Structure
  19. GC15794 Valproic acid sodium salt (Sodium valproate) A class I HDAC inhibitor Valproic acid sodium salt (Sodium valproate)  Chemical Structure
  20. GC13878 EPZ005687 A potent, selective inhibitor of EZH2 EPZ005687  Chemical Structure
  21. GC13673 BMS-708163 (Avagacestat) A potent inhibitor of γ-secretase BMS-708163 (Avagacestat)  Chemical Structure
  22. GC12191 LY-411575 A γ-secretase inhibitor LY-411575  Chemical Structure
  23. GC17671 YO-01027 (Dibenzazepine, DBZ) An inhibitor of γ-secretase YO-01027 (Dibenzazepine, DBZ)  Chemical Structure
  24. GC16197 RO4929097

    An inhibitor of γ-secretase

    RO4929097  Chemical Structure
  25. GC10493 GDC-0449 (Vismodegib) GDC-0449 (Vismodegib)  Chemical Structure
  26. GC16702 CHIR-99021 (CT99021) A selective GSK3 inhibitor CHIR-99021 (CT99021)  Chemical Structure
  27. GC12096 Semagacestat (LY450139) A pan γ-secretase inhibitor Semagacestat (LY450139)  Chemical Structure
  28. GC17907 3-Deazaneplanocin A (DZNep) hydrochloride An inhibitor of the lysine methyltransferase EZH2 3-Deazaneplanocin A (DZNep) hydrochloride  Chemical Structure
  29. GC13145 3-Deazaneplanocin,DZNep

    An inhibitor of lysine methyltransferase EZH2

    3-Deazaneplanocin,DZNep  Chemical Structure
  30. GC26088 YAP-TEAD Inhibitor 1 (Peptide 17) YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM. YAP-TEAD Inhibitor 1 (Peptide 17)  Chemical Structure
  31. GC26049 WAY-119064 WAY-119064 is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 value of 80.5 nM. WAY-119064  Chemical Structure
  32. GC25838 RBPJ Inhibitor-1 (RIN1) RBPJ Inhibitor-1 (RIN1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ. RBPJ Inhibitor-1 (RIN1)  Chemical Structure
  33. GC25603 M2912 M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity. M2912  Chemical Structure
  34. GC68028 Wnt/β-catenin agonist 4 Wnt/β-catenin agonist 4  Chemical Structure
  35. GC67775 Casein kinase 1δ-IN-3 Casein kinase 1δ-IN-3  Chemical Structure
  36. GC67737 NLS-StAx-h TFA NLS-StAx-h TFA  Chemical Structure
  37. GC52376 BMP2-derived Peptide (trifluoroacetate salt) A synthetic peptide BMP2-derived Peptide (trifluoroacetate salt)  Chemical Structure
  38. GC66390 3-epi-Vitamin D3 3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC50 of 39.2 μM measured in U87MG cells. 3-epi-Vitamin D3  Chemical Structure
  39. GC66371 (E)-Ferulic acid-d3 (E)-Ferulic acid-d3 ((E)-Coniferic acid-d3) is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. (E)-Ferulic acid-d3  Chemical Structure
  40. GC66039 Wnt/β-catenin agonist 3 Wnt/β-catenin agonist 3 (compound 98) is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis. Wnt/β-catenin agonist 3  Chemical Structure
  41. GC66035 GSK3-IN-1 GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes. GSK3-IN-1  Chemical Structure
  42. GC66033 Casein kinase 1δ-IN-1 Casein kinase 1δ-IN-1 (compound 822) is an inhibitor of casein kinase 1 delta (CK1δ), exhibits inhibition of greater than 5%. Casein kinase 1δ-IN-1 can be used for neurodegenerative disorders such as Alzheimer's disease research. Casein kinase 1δ-IN-1  Chemical Structure
  43. GC66032 GSK-3β inhibitor 11 GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research. GSK-3β inhibitor 11  Chemical Structure
  44. GC65993 MSC-4106 MSC-4106 is an orally active and potent inhibitor of YAP/TAZ-TEAD. MSC-4106 inhibits TEAD1 or TEAD3 auto-palmitoylation and shows inhibitory effect on NCI-H226 tumor xenograft model. MSC-4106  Chemical Structure
  45. GC65919 NRX-252114 NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation. NRX-252114  Chemical Structure
  46. GC65916 NRX-103095 NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM. NRX-103095  Chemical Structure
  47. GC65889 TDI-011536 TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration. TDI-011536  Chemical Structure
  48. GC65375 Phospho-Glycogen Synthase Peptide-2(substrate) TFA Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases. Phospho-Glycogen Synthase Peptide-2(substrate) TFA  Chemical Structure
  49. GC65356 KY-02327 acetate KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 acetate  Chemical Structure
  50. GC65336 NRX-252262 NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM. NRX-252262  Chemical Structure
  51. GC65185 TEAD-IN-2 TEAD-IN-2 is a novel, orally active inhibitor of transcriptional enhancer associate domain (TEAD) and modulates TEAD by ubiquitination and/or degradation by compounds. TEAD-IN-2 can be used for the research of a variety of diseases, disorders or conditions associated with TEAD. TEAD-IN-2  Chemical Structure
  52. GC65167 Carboxylesterase-IN-3 Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease. Carboxylesterase-IN-3  Chemical Structure
  53. GC65165 Carboxylesterase-IN-2 Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease. Carboxylesterase-IN-2  Chemical Structure
  54. GC65131 YAP/TAZ inhibitor-2 YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity. YAP/TAZ inhibitor-2  Chemical Structure
  55. GC65116 GA-017 GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids. GA-017  Chemical Structure
  56. GC65066 Prodigiosin hydrochloride Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride  Chemical Structure
  57. GC64922 Rovalpituzumab Rovalpituzumab is a humanized monoclonal antibody against delta-like protein 3 (DLL3). Rovalpituzumab can be used in the synthesis of antibody-drug conjugate (ADC), Rovalpituzumab Tesirine. Rovalpituzumab has activity against small cell lung cancer (SCLC). Rovalpituzumab  Chemical Structure
  58. GC64837 Nefopam D3 hydrochloride Nefopam D3 hydrochloride  Chemical Structure
  59. GC64832 NRX-2663 NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 ?M and a Kd of 54.8 nM. NRX-2663  Chemical Structure
  60. GC64816 Coronaridine Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression. Coronaridine  Chemical Structure
  61. GC64638 ALV1 ALV1 is a potent Ikaros and Helios degrader. ALV1  Chemical Structure
  62. GC64536 Notch 1 TFA Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Notch 1 TFA  Chemical Structure
  63. GC64419 MRT-14 MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling. MRT-14  Chemical Structure
  64. GC64382 SGC-CK2-1 SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC50s of 36 and 16 nM for CK2α and CK2α′respectively in the nanoBRET assay. SGC-CK2-1  Chemical Structure
  65. GC49827 5-Androstenetriol An active metabolite of DHEA 5-Androstenetriol  Chemical Structure
  66. GC64378 Valproic acid-d6 Valproic acid-d6 (VPA-d6) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid-d6  Chemical Structure
  67. GC64134 Hh-Ag1.5 Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM. Hh-Ag1.5  Chemical Structure
  68. GC64131 TMX-4116 TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma. TMX-4116  Chemical Structure
  69. GC64005 FPFT-2216 FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216  Chemical Structure
  70. GC63863 MRT-83 hydrochloride MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease. MRT-83 hydrochloride  Chemical Structure
  71. GC49687 Goralatide (acetate) A tetrapeptide regulator of hematopoiesis Goralatide (acetate)  Chemical Structure
  72. GC49667 PD 168568 (hydrochloride) A dopamine D4 receptor antagonist PD 168568 (hydrochloride)  Chemical Structure
  73. GC49651 19-alkyne Cholesterol An alkyne derivative of cholesterol for click chemistry 19-alkyne Cholesterol  Chemical Structure
  74. GC63695 Wnt/β-catenin agonist 2 Wnt/β-catenin agonist 2 is a potent Wnt agonist. Wnt/β-catenin agonist 2  Chemical Structure
  75. GC63560 ZW4864 ZW4864 is an orally active and selective β catenin/B-Cell lymphoma 9 protein?protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM. ZW4864  Chemical Structure
  76. GC63559 ZW4864 free base ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein?protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 (free base) inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM. ZW4864 free base  Chemical Structure
  77. GC63465 KY-02327 KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327  Chemical Structure
  78. GC63336 MRT-81 MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer. MRT-81  Chemical Structure
  79. GC63303 YB-0158

    YB-0158 is known as Wnt pathway inhibitor 2.

    YB-0158  Chemical Structure
  80. GC63257 VT103 VT103, an analog of VT101, is an orally active and selective TEAD1 protein palmitoylation inhibitor. VT103 inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation, and disrupts interaction between YAP/TAZ and TEAD. VT103 can be used for the research of cancer. VT103  Chemical Structure
  81. GC63100 N-Desmethylnefopam D5 hydrochloride N-Desmethylnefopam D5 hydrochloride is a deuterium labeled N-Desmethylnefopam hydrochloride. N-Desmethylnefopam D5 hydrochloride  Chemical Structure
  82. GC63088 MYF-01-37 MYF-01-37 is a covalent TEAD inhibitor targeting Cys380. MYF-01-37 has a reversible inhibition on YAP/TEAD interaction. MYF-01-37  Chemical Structure
  83. GC49241 Methyl Diethyldithiocarbamate An active metabolite of disulfiram Methyl Diethyldithiocarbamate  Chemical Structure
  84. GC49110 AICA Ribonucleotide An AMPK activator AICA Ribonucleotide  Chemical Structure
  85. GC49027 Hexamethylene bisacetamide Hexamethylene bisacetamide is a tumor cell-differentiating agent. Hexamethylene bisacetamide  Chemical Structure
  86. GC48992 CGP 77675 (hydrate) An inhibitor of Src family kinases CGP 77675 (hydrate)  Chemical Structure
  87. GC48980 EPZ004777 (formate) A potent inhibitor of DOT1L EPZ004777 (formate)  Chemical Structure
  88. GC62524 VT107 VT-107, as an analogous to VT104, is an orally active and potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer. VT107  Chemical Structure
  89. GC62432 β-catenin-IN-2 β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer. β-catenin-IN-2  Chemical Structure
  90. GC62424 PY-60 PY-60 is a robust and specific activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a Kd of 1.4 ?M. PY-60  Chemical Structure
  91. GC62394 Teplinovivint Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. Teplinovivint  Chemical Structure
  92. GC62258 SAG-d3 SAG-d3 is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG-d3  Chemical Structure
  93. GC62214 FIDAS-3 FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. FIDAS-3  Chemical Structure
  94. GC62132 K-975 K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma. K-975  Chemical Structure
  95. GC61861 Oct3/4-inducer-1 Oct3/4-inducer-1 (compound 2) is a potent Oct3/4 inducer. Oct3/4-inducer-1  Chemical Structure
  96. GC61781 Super-TDU Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model. Super-TDU  Chemical Structure
  97. GC61527 Lats-IN-1 Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1  Chemical Structure
  98. GC61410 I3MT-3 I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM). I3MT-3  Chemical Structure
  99. GC48434 Elsinochrome A A fungal metabolite Elsinochrome A  Chemical Structure
  100. GC50703 Yhhu 3792 Yhhu 3792  Chemical Structure
  101. GC50685 Dynapyrazole A Dynapyrazole A  Chemical Structure

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