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Home >> Signaling Pathways >> Stem Cell

Stem Cell

  1. Cat.No. Product Name Information
  2. GC68028 Wnt/β-catenin agonist 4 Wnt/β-catenin agonist 4 Chemical Structure
  3. GC67775 Casein kinase 1δ-IN-3 Casein kinase 1δ-IN-3 Chemical Structure
  4. GC67737 NLS-StAx-h TFA NLS-StAx-h TFA Chemical Structure
  5. GC52376 BMP2-derived Peptide (trifluoroacetate salt) A synthetic peptide BMP2-derived Peptide (trifluoroacetate salt) Chemical Structure
  6. GC66390 3-epi-Vitamin D3 3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC50 of 39.2 μM measured in U87MG cells. 3-epi-Vitamin D3 Chemical Structure
  7. GC66371 (E)-Ferulic acid-d3 (E)-Ferulic acid-d3 ((E)-Coniferic acid-d3) is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. (E)-Ferulic acid-d3 Chemical Structure
  8. GC66039 Wnt/β-catenin agonist 3 Wnt/β-catenin agonist 3 (compound 98) is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis. Wnt/β-catenin agonist 3 Chemical Structure
  9. GC66035 GSK3-IN-1 GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes. GSK3-IN-1 Chemical Structure
  10. GC66033 Casein kinase 1δ-IN-1 Casein kinase 1δ-IN-1 (compound 822) is an inhibitor of casein kinase 1 delta (CK1δ), exhibits inhibition of greater than 5%. Casein kinase 1δ-IN-1 can be used for neurodegenerative disorders such as Alzheimer's disease research. Casein kinase 1δ-IN-1 Chemical Structure
  11. GC66032 GSK-3β inhibitor 11 GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research. GSK-3β inhibitor 11 Chemical Structure
  12. GC65993 MSC-4106 MSC-4106 is an orally active and potent inhibitor of YAP/TAZ-TEAD. MSC-4106 inhibits TEAD1 or TEAD3 auto-palmitoylation and shows inhibitory effect on NCI-H226 tumor xenograft model. MSC-4106 Chemical Structure
  13. GC65919 NRX-252114 NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation. NRX-252114 Chemical Structure
  14. GC65916 NRX-103095 NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM. NRX-103095 Chemical Structure
  15. GC65889 TDI-011536 TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration. TDI-011536 Chemical Structure
  16. GC65375 Phospho-Glycogen Synthase Peptide-2(substrate) TFA Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases. Phospho-Glycogen Synthase Peptide-2(substrate) TFA Chemical Structure
  17. GC65356 KY-02327 acetate KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 acetate Chemical Structure
  18. GC65336 NRX-252262 NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM. NRX-252262 Chemical Structure
  19. GC65185 TEAD-IN-2 TEAD-IN-2 is a novel, orally active inhibitor of transcriptional enhancer associate domain (TEAD) and modulates TEAD by ubiquitination and/or degradation by compounds. TEAD-IN-2 can be used for the research of a variety of diseases, disorders or conditions associated with TEAD. TEAD-IN-2 Chemical Structure
  20. GC65167 Carboxylesterase-IN-3 Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease. Carboxylesterase-IN-3 Chemical Structure
  21. GC65165 Carboxylesterase-IN-2 Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease. Carboxylesterase-IN-2 Chemical Structure
  22. GC65131 YAP/TAZ inhibitor-2 YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity. YAP/TAZ inhibitor-2 Chemical Structure
  23. GC65116 GA-017 GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids. GA-017 Chemical Structure
  24. GC65066 Prodigiosin hydrochloride Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride Chemical Structure
  25. GC64922 Rovalpituzumab Rovalpituzumab is a humanized monoclonal antibody against delta-like protein 3 (DLL3). Rovalpituzumab can be used in the synthesis of antibody-drug conjugate (ADC), Rovalpituzumab Tesirine. Rovalpituzumab has activity against small cell lung cancer (SCLC). Rovalpituzumab Chemical Structure
  26. GC64837 Nefopam D3 hydrochloride Nefopam D3 hydrochloride Chemical Structure
  27. GC64832 NRX-2663 NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 ?M and a Kd of 54.8 nM. NRX-2663 Chemical Structure
  28. GC64816 Coronaridine Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression. Coronaridine Chemical Structure
  29. GC64638 ALV1 ALV1 is a potent Ikaros and Helios degrader. ALV1 Chemical Structure
  30. GC64536 Notch 1 TFA Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Notch 1 TFA Chemical Structure
  31. GC64419 MRT-14 MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling. MRT-14 Chemical Structure
  32. GC64382 SGC-CK2-1 SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC50s of 36 and 16 nM for CK2α and CK2α′respectively in the nanoBRET assay. SGC-CK2-1 Chemical Structure
  33. GC64378 Valproic acid-d6 Valproic acid-d6 (VPA-d6) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid-d6 Chemical Structure
  34. GC64134 Hh-Ag1.5 Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM. Hh-Ag1.5 Chemical Structure
  35. GC64131 TMX-4116 TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma. TMX-4116 Chemical Structure
  36. GC64005 FPFT-2216 FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 Chemical Structure
  37. GC63863 MRT-83 hydrochloride MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease. MRT-83 hydrochloride Chemical Structure
  38. GC49687 Goralatide (acetate) A tetrapeptide regulator of hematopoiesis Goralatide (acetate) Chemical Structure
  39. GC49667 PD 168568 (hydrochloride) A dopamine D4 receptor antagonist PD 168568 (hydrochloride) Chemical Structure
  40. GC49651 19-alkyne Cholesterol An alkyne derivative of cholesterol for click chemistry 19-alkyne Cholesterol Chemical Structure
  41. GC63695 Wnt/β-catenin agonist 2 Wnt/β-catenin agonist 2 is a potent Wnt agonist. Wnt/β-catenin agonist 2 Chemical Structure
  42. GC63560 ZW4864 ZW4864 is an orally active and selective β catenin/B-Cell lymphoma 9 protein?protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM. ZW4864 Chemical Structure
  43. GC63559 ZW4864 free base ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein?protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 (free base) inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM. ZW4864 free base Chemical Structure
  44. GC63465 KY-02327 KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 Chemical Structure
  45. GC63336 MRT-81 MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer. MRT-81 Chemical Structure
  46. GC63303 YB-0158

    YB-0158 is known as Wnt pathway inhibitor 2.

     YB-0158 Chemical Structure
  47. GC63257 VT103 VT103, an analog of VT101, is an orally active and selective TEAD1 protein palmitoylation inhibitor. VT103 inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation, and disrupts interaction between YAP/TAZ and TEAD. VT103 can be used for the research of cancer. VT103 Chemical Structure
  48. GC63100 N-Desmethylnefopam D5 hydrochloride N-Desmethylnefopam D5 hydrochloride is a deuterium labeled N-Desmethylnefopam hydrochloride. N-Desmethylnefopam D5 hydrochloride Chemical Structure
  49. GC63088 MYF-01-37 MYF-01-37 is a covalent TEAD inhibitor targeting Cys380. MYF-01-37 has a reversible inhibition on YAP/TEAD interaction. MYF-01-37 Chemical Structure
  50. GC49241 Methyl Diethyldithiocarbamate An active metabolite of disulfiram Methyl Diethyldithiocarbamate Chemical Structure
  51. GC49110 AICA Ribonucleotide An AMPK activator AICA Ribonucleotide Chemical Structure
  52. GC49027 Hexamethylene bisacetamide Hexamethylene bisacetamide is a tumor cell-differentiating agent. Hexamethylene bisacetamide Chemical Structure
  53. GC48992 CGP 77675 (hydrate) An inhibitor of Src family kinases CGP 77675 (hydrate) Chemical Structure
  54. GC48980 EPZ004777 (formate) A potent inhibitor of DOT1L EPZ004777 (formate) Chemical Structure
  55. GC62524 VT107 VT-107, as an analogous to VT104, is an orally active and potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer. VT107 Chemical Structure
  56. GC62432 β-catenin-IN-2 β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer. β-catenin-IN-2 Chemical Structure
  57. GC62424 PY-60 PY-60 is a robust and specific activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a Kd of 1.4 ?M. PY-60 Chemical Structure
  58. GC62394 Teplinovivint Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. Teplinovivint Chemical Structure
  59. GC62258 SAG-d3 SAG-d3 is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG-d3 Chemical Structure
  60. GC62214 FIDAS-3 FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. FIDAS-3 Chemical Structure
  61. GC62132 K-975 K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma. K-975 Chemical Structure
  62. GC61861 Oct3/4-inducer-1 Oct3/4-inducer-1 (compound 2) is a potent Oct3/4 inducer. Oct3/4-inducer-1 Chemical Structure
  63. GC61781 Super-TDU Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model. Super-TDU Chemical Structure
  64. GC61527 Lats-IN-1 Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 Chemical Structure
  65. GC61410 I3MT-3 I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM). I3MT-3 Chemical Structure
  66. GC48434 Elsinochrome A A fungal metabolite Elsinochrome A Chemical Structure
  67. GC50703 Yhhu 3792 Yhhu 3792 Chemical Structure
  68. GC50685 Dynapyrazole A Dynapyrazole A Chemical Structure
  69. GC48070 SB-431542 (hydrate) Inhibitor of receptors ALK4, ALK5, and ALK7 SB-431542 (hydrate) Chemical Structure
  70. GC47570 Lipoxygenin An inhibitor of 5-LO Lipoxygenin Chemical Structure
  71. GC47538 L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) magnesium hydrate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) Chemical Structure
  72. GC47474 Itraconazole-d5 An internal standard for the quantification of itraconazole Itraconazole-d5 Chemical Structure
  73. GC47435 HPI-1 (hydrate) A Hedgehog pathway inhibitor HPI-1 (hydrate) Chemical Structure
  74. GC46947 BRD-K4477 A small molecule promotor of hepatocyte differentiation BRD-K4477 Chemical Structure
  75. GC46939 BODIPY-aminoacetaldehyde diethyl acetal A stable precursor to the fluorescent ALDH substrate BAAA BODIPY-aminoacetaldehyde diethyl acetal Chemical Structure
  76. GC61233 RBPJ Inhibitor-1 RBPJ Inhibitor-1 (RIN1), the first RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation. RBPJ Inhibitor-1 Chemical Structure
  77. GC18533 ZLDI-8

    Temiverine hydrochloride is a synthesized drug that is expected to have anticholinergic action.

    ZLDI-8 Chemical Structure
  78. GC39461 YAP-TEAD-IN-1 TFA YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of?YAP-TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd= 40 nM). YAP-TEAD-IN-1 TFA Chemical Structure
  79. GC39359 Ciliobrevin D Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro. Ciliobrevin D Chemical Structure
  80. GC50624 FzM1.8 Frizzled 4 allosteric agonist; exhibits biased siginaling; preserves stemness FzM1.8 Chemical Structure
  81. GC50489 NLS-StAx-h Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions NLS-StAx-h Chemical Structure
  82. GC50486 Dynarrestin Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein Dynarrestin Chemical Structure
  83. GC50470 SAHM1 Notch pathway inhibitor; prevents Notch complex assembly SAHM1 Chemical Structure
  84. GC50323 AMBMP hydrochloride AMBMP hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50of 700 nM. AMBMP hydrochloride Chemical Structure
  85. GC50203 IHR-Cy3 Potent fluorescent Smo antagonist IHR-Cy3 Chemical Structure
  86. GC50135 SAG 21k Hedgehog signaling activator; brain penetrant and orally bioavailable SAG 21k Chemical Structure
  87. GC50077 WAY 316606 hydrochloride Secreted Frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling WAY 316606 hydrochloride Chemical Structure
  88. GC39266 Hematein Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells. Hematein Chemical Structure
  89. GC39181 BRD0705 BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML) research. BRD0705 Chemical Structure
  90. GC39159 Tegatrabetan Tegatrabetan (BC2059) is a β-Catenin antagonist. Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1). Tegatrabetan Chemical Structure
  91. GC39152 9-ING-41 9-ING-41 is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic drugs. 9-ING-41 Chemical Structure
  92. GC38892 BIP-135 BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP-135 Chemical Structure
  93. GC46015 KY 05009 A TNIK inhibitor KY 05009 Chemical Structure
  94. GC38787 GNF4877 GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6?nM and 16?nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66?μM for mouse β (R7T1) cells). GNF4877 Chemical Structure
  95. GC38755 CKI-7 CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases. CKI-7 Chemical Structure
  96. GC38745 CB-103 CB-103 is a first-in-class, orally active protein-protein interaction (PPI) inhibitor of the NOTCH transcriptional activation complex. CB-103 has anti-tumor activity. CB-103 Chemical Structure
  97. GC38578 PI-828 A PI3K inhibitor PI-828 Chemical Structure
  98. GC38522 Neurodazine Small molecule inducer of neuronal differentiation Neurodazine Chemical Structure
  99. GC38518 AMG-548 dihydrochloride AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride Chemical Structure
  100. GC38330 EHT 5372 EHT 5372 Chemical Structure
  101. GC45596 YW1128   YW1128 Chemical Structure

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