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Home >> Signaling Pathways >> Stem Cell

Stem Cell

Products for  Stem Cell

  1. Cat.No. Product Name Information
  2. GC62432 β-catenin-IN-2 β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer. β-catenin-IN-2 Chemical Structure
  3. GC34980 (E)-Ferulic acid (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. (E)-Ferulic acid Chemical Structure
  4. GC66371 (E)-Ferulic acid-d3 (E)-Ferulic acid-d3 ((E)-Coniferic acid-d3) is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. (E)-Ferulic acid-d3 Chemical Structure
  5. GC41719 (R)-nitro-Blebbistatin (R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin, which is the inactive form of (-)-blebbistatin. (R)-nitro-Blebbistatin Chemical Structure
  6. GC69847 (R)-VT104

    (R)-VT104 is the R-enantiomer of VT104. The IC50 value of (R)-VT104 for firefly luciferase is 0.1-1 μμ. VT104 is an orally active pan-TEAD deacetylase inhibitor.

     (R)-VT104 Chemical Structure
  7. GC13907 1-Azakenpaullone GSK-3β inhibitor,potent and selective,cell-permeable 1-Azakenpaullone Chemical Structure
  8. GC49651 19-alkyne Cholesterol An alkyne derivative of cholesterol for click chemistry 19-alkyne Cholesterol Chemical Structure
  9. GC15422 20(S)-Hydroxycholesterol An allosteric activator of the oncoprotein smoothened (Smo) 20(S)-Hydroxycholesterol Chemical Structure
  10. GC40571 24(S),25-epoxy Cholesterol

    24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.

     24(S),25-epoxy Cholesterol Chemical Structure
  11. GC17907 3-Deazaneplanocin A (DZNep) hydrochloride An inhibitor of the lysine methyltransferase EZH2 3-Deazaneplanocin A (DZNep) hydrochloride Chemical Structure
  12. GC13145 3-Deazaneplanocin,DZNep

    An inhibitor of lysine methyltransferase EZH2

     3-Deazaneplanocin,DZNep Chemical Structure
  13. GC66390 3-epi-Vitamin D3 3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC50 of 39.2 μM measured in U87MG cells. 3-epi-Vitamin D3 Chemical Structure
  14. GC14306 3F8 GSK-3β inhibitor 3F8 Chemical Structure
  15. GC45354 4β-Hydroxywithanolide E A withanolide with anti-inflammatory and anticancer activities 4β-Hydroxywithanolide E Chemical Structure
  16. GC49827 5-Androstenetriol An active metabolite of DHEA 5-Androstenetriol Chemical Structure
  17. GC35162 5-Iodo-indirubin-3'-monoxime 5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively. 5-Iodo-indirubin-3'-monoxime Chemical Structure
  18. GC39152 9-ING-41 9-ING-41 is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic drugs. 9-ING-41 Chemical Structure
  19. GC10336 A 1070722 GSK-3 inhibitor A 1070722 Chemical Structure
  20. GC42669 ABC99 An inhibitor of NOTUM ABC99 Chemical Structure
  21. GC31663 Adavivint (SM04690) Adavivint (SM04690) (SM04690; Lorecivivint) is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells. Adavivint (SM04690) Chemical Structure
  22. GC49110 AICA Ribonucleotide An AMPK activator AICA Ribonucleotide Chemical Structure
  23. GC14749 ALLO-1 ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif. ALLO-1 Chemical Structure
  24. GC34463 ALLO-2 ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM. ALLO-2 Chemical Structure
  25. GC15841 Alsterpaullone CDKs and GSK3β inhibitor Alsterpaullone Chemical Structure
  26. GC64638 ALV1 ALV1 is a potent Ikaros and Helios degrader. ALV1 Chemical Structure
  27. GC50323 AMBMP hydrochloride AMBMP hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50of 700 nM. AMBMP hydrochloride Chemical Structure
  28. GC14899 AMG 548

    P38α inhibitor,potent and selective

     AMG 548 Chemical Structure
  29. GC38518 AMG-548 dihydrochloride AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride Chemical Structure
  30. GC12429 AY 9944 dihydrochloride AY 9944 dihydrochloride is a specific cholesterol biosynthesis inhibitor. AY 9944 dihydrochloride Chemical Structure
  31. GC14715 AZ 12080282 dihydrochloride Hedgehog inhibitor AZ 12080282 dihydrochloride Chemical Structure
  32. GC16568 AZD1080 GSK3βinhibitor AZD1080 Chemical Structure
  33. GC14736 AZD2858 GSK-3 inhibitor,potent and selective AZD2858 Chemical Structure
  34. GC10752 Bikinin

    GSK3 inhibitor and Brassinosteroid activator

     Bikinin Chemical Structure
  35. GC14233 BIO-acetoxime

    GSK-3α/β inhibitor

     BIO-acetoxime Chemical Structure
  36. GC38892 BIP-135 BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP-135 Chemical Structure
  37. GC42944 BIX01294 (hydrochloride hydrate) The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. BIX01294 (hydrochloride hydrate) Chemical Structure
  38. GC52376 BMP2-derived Peptide (trifluoroacetate salt) A synthetic peptide BMP2-derived Peptide (trifluoroacetate salt) Chemical Structure
  39. GC13673 BMS-708163 (Avagacestat) A potent inhibitor of γ-secretase BMS-708163 (Avagacestat) Chemical Structure
  40. GC13628 BMS-833923 An orally bioavailable Smo inhibitor BMS-833923 Chemical Structure
  41. GC35535 BMS-906024 BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC50s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity. BMS-906024 Chemical Structure
  42. GC35537 BMS-983970 BMS-983970 is an oral pan-Notch inhibitor for the treatment of multiplecancers. BMS-983970 Chemical Structure
  43. GC46939 BODIPY-aminoacetaldehyde diethyl acetal A stable precursor to the fluorescent ALDH substrate BAAA BODIPY-aminoacetaldehyde diethyl acetal Chemical Structure
  44. GC46947 BRD-K4477 A small molecule promotor of hepatocyte differentiation BRD-K4477 Chemical Structure
  45. GC39181 BRD0705 BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML) research. BRD0705 Chemical Structure
  46. GC12811 BRD7116 inhibitor of leukemia stem cell activity BRD7116 Chemical Structure
  47. GC68809 Brontictuzumab

    Brontictuzumab (OMP 52M51) is a monoclonal antibody (MAb) that can inhibit the Notch1 signal. Brontictuzumab selectively binds to the negative regulatory region of Notch1. Brontictuzumab can inhibit tumor cell proliferation and is used in research for leukemia and lymphoma.

     Brontictuzumab Chemical Structure
  48. GC35559 Bruceine D Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D Chemical Structure
  49. GC11275 C34 C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis. C34 Chemical Structure
  50. GC65165 Carboxylesterase-IN-2 Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease. Carboxylesterase-IN-2 Chemical Structure
  51. GC65167 Carboxylesterase-IN-3 Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease. Carboxylesterase-IN-3 Chemical Structure
  52. GC17840 Cardiogenol C hydrochloride Induces differentiation of mouse embryonic stem cells (ESCs) into cardiomyocytes Cardiogenol C hydrochloride Chemical Structure
  53. GC17782 Cardionogen 1 Wnt signaling modulator Cardionogen 1 Chemical Structure
  54. GC35612 Carvacrol Carvacrol is a monoterpenoid phenol isolated from Thymus mongolicus Ronn. Carvacrol Chemical Structure
  55. GC66033 Casein kinase 1δ-IN-1 Casein kinase 1δ-IN-1 (compound 822) is an inhibitor of casein kinase 1 delta (CK1δ), exhibits inhibition of greater than 5%. Casein kinase 1δ-IN-1 can be used for neurodegenerative disorders such as Alzheimer's disease research. Casein kinase 1δ-IN-1 Chemical Structure
  56. GC67775 Casein kinase 1δ-IN-3 Casein kinase 1δ-IN-3 Chemical Structure
  57. GC30276 Casein Kinase II Inhibitor IV

    Casein Kinase II Inhibitor IV is a potent, ATP-competitive of casein kinase II inhibitor with an IC50 of 9 nM.

     Casein Kinase II Inhibitor IV Chemical Structure
  58. GC34356 Casein Kinase II Inhibitor IV Hydrochloride Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocytedifferentiation. Casein Kinase II Inhibitor IV Hydrochloride Chemical Structure
  59. GC38745 CB-103 CB-103 is a first-in-class, orally active protein-protein interaction (PPI) inhibitor of the NOTCH transcriptional activation complex. CB-103 has anti-tumor activity. CB-103 Chemical Structure
  60. GC10253 CCT 031374 hydrobromide inhibits TCF-dependent transcription, blocks BIO-induced β-catenin stabilization CCT 031374 hydrobromide Chemical Structure
  61. GC17606 CCT251545 Orally bioavailable and potent WNT signaling inhibitor CCT251545 Chemical Structure
  62. GC48992 CGP 77675 (hydrate) An inhibitor of Src family kinases CGP 77675 (hydrate) Chemical Structure
  63. GC15642 CHIR 99021 trihydrochloride Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR 99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR 99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR 99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR 99021 trihydrochloride induces autophagy. CHIR 99021 trihydrochloride Chemical Structure
  64. GC12176 CHIR-98014 GSK-3β inhibitor,selective and ATP-competitive CHIR-98014 Chemical Structure
  65. GC16702 CHIR-99021 (CT99021)

    A selective GSK3 inhibitor

     CHIR-99021 (CT99021) Chemical Structure
  66. GC17153 CHIR-99021 (CT99021) HCl Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 (CT99021) HCl shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 (CT99021) HCl is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 (CT99021) HCl enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 (CT99021) HCl induces autophagy. CHIR-99021 (CT99021) HCl Chemical Structure
  67. GC32942 CHIR-99021 monohydrochloride (CT99021 monohydrochloride) CHIR-99021 monohydrochloride (CT99021 monohydrochloride) Chemical Structure
  68. GC11476 Ciliobrevin A

    Hh pathway antagonist

     Ciliobrevin A Chemical Structure
  69. GC39359 Ciliobrevin D Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro. Ciliobrevin D Chemical Structure
  70. GC41587 cis-Vaccenic Acid An ω-7 fatty acid cis-Vaccenic Acid Chemical Structure
  71. GC34536 CK1-IN-1 CK1-IN-1 is a casein kinase 1 (CK1) inhibitor extracted from patent WO2015119579A1, compound 1c, has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively. CK1-IN-1 Chemical Structure
  72. GC16325 CKI 7 dihydrochloride Casein kinase 1 (CK1) inhibitor CKI 7 dihydrochloride Chemical Structure
  73. GC38755 CKI-7 CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases. CKI-7 Chemical Structure
  74. GC64816 Coronaridine Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression. Coronaridine Chemical Structure
  75. GC13176 CP21R7 GSK3β inhibitor CP21R7 Chemical Structure
  76. GC16599 CPI-169 EZH2 inhibitor CPI-169 Chemical Structure
  77. GC12146 CPI-169 R-enantiomer EZH2 inhibitor CPI-169 R-enantiomer Chemical Structure
  78. GC11484 CPI-169 S-enantiomer EZH2 inhibitor CPI-169 S-enantiomer Chemical Structure
  79. GC17690 Cromolyn sodium Mast cell membrane stabilizer Cromolyn sodium Chemical Structure
  80. GC11217 CUR 61414 potent inhibitor of hedgehog-induced cellular activity CUR 61414 Chemical Structure
  81. GC13037 CX-4945 (Silmitasertib) CX-4945 (Silmitasertib) (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. CX-4945 (Silmitasertib) Chemical Structure
  82. GC11325 CX-4945 sodium salt CX-4945 sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. CX-4945 sodium salt Chemical Structure
  83. GC13441 Cyclopamine Hedgehog (Hh) signaling Inhibitor Cyclopamine Chemical Structure
  84. GC43346 Cyclopamine-KAAD Cyclopamine-KAAD, a hedgehog signaling inhibitor, is a smoothened antagonist. Cyclopamine-KAAD Chemical Structure
  85. GC13202 D4476 Inhibitor of CK1 and ALK5 D4476 Chemical Structure
  86. GC43462 Dihydrolipoic Acid Dihydrolipoic acid (DHLA) is a dithiol-containing carboxylic acid that is the reduced form of α-lipoic acid. Dihydrolipoic Acid Chemical Structure
  87. GC35873 DK419 DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK. DK419 Chemical Structure
  88. GC50685 Dynapyrazole A Dynapyrazole A Chemical Structure
  89. GC50486 Dynarrestin Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein Dynarrestin Chemical Structure
  90. GC38330 EHT 5372 EHT 5372 Chemical Structure
  91. GC14756 EI1 EZH2 inhibitor EI1 Chemical Structure
  92. GC15548 Ellagic acid Casein kinase 2 (CK2) inhibitor Ellagic acid Chemical Structure
  93. GC48434 Elsinochrome A A fungal metabolite Elsinochrome A Chemical Structure
  94. GC32914 EMT inhibitor-1 EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities. EMT inhibitor-1 Chemical Structure
  95. GC48980 EPZ004777 (formate) A potent inhibitor of DOT1L EPZ004777 (formate) Chemical Structure
  96. GC13878 EPZ005687 A potent, selective inhibitor of EZH2 EPZ005687 Chemical Structure
  97. GC19144 ETC-159 ETC-159 is a potent, orally available PORCN inhibitor. ETC-159 Chemical Structure
  98. GC14299 exo-IWR 1 Negative control for endo-IWR 1 (Wnt signaling inhibitor) exo-IWR 1 Chemical Structure
  99. GC12134 FH535 An inhibitor of β-catenin signaling FH535 Chemical Structure
  100. GC62214 FIDAS-3 FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. FIDAS-3 Chemical Structure
  101. GC10211 FLI-06 A novel inhibitor of Notch signaling FLI-06 Chemical Structure

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