Stem Cell
- CK1(5)
- EZH2(10)
- GSK-3(48)
- HSC(6)
- iPSC(6)
- Hedgehog(38)
- Notch(31)
- Smoothened(34)
- Wnt/β-catenin(111)
- Hippo Signaling(4)
- Cancer stem cell(23)
- MST1/2(1)
- ESC(1)
- Casein Kinase(24)
- Oct3/4(5)
- Porcupine(6)
- YAP(17)
- Cat.No. Product Name Information
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GN10797
Tangeretin
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GN10017
Wogonin
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GC14037
Triptonide
A diterpenoid with diverse biological activities
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GC18107
Salinomycin sodium salt
A selective cancer stem cell inhibitor
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GC14882
Salinomycin
A selective cancer stem cell inhibitor
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GC10556
PF-670462
An inhibitor of the CK1 isoforms CK1ε and CK1δ
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GC14169
LDE225 Diphosphate
A Smo antagonist
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GC16454
IWP-2
An inhibitor of Wnt production
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GC12951
HhAntag
A hedgehog pathway inhibitor
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GC17534
GSK343
A selective, cell-permeable EZH2 inhibitor
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GC15783
GSK126
A selective EZH2 inhibitor
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GC16789
GANT 58
An inhibitor of Gli transcription
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GC12134
FH535
An inhibitor of β-catenin signaling
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GC13202
D4476
Inhibitor of CK1 and ALK5
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GC13628
BMS-833923
An orally bioavailable Smo inhibitor
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GC17107
PluriSIn #1 (NSC 14613)
A selective inhibitor of stearoyl-CoA desaturase
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GC12653
LY3039478
A Notch inhibitor
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GC15794
Valproic acid sodium salt (Sodium valproate)
A class I HDAC inhibitor
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GC13878
EPZ005687
A potent, selective inhibitor of EZH2
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GC13673
BMS-708163 (Avagacestat)
A potent inhibitor of γ-secretase
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GC12191
LY-411575
A γ-secretase inhibitor
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GC17671
YO-01027 (Dibenzazepine, DBZ)
An inhibitor of γ-secretase
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GC16197
RO4929097
An inhibitor of γ-secretase
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GC10493
GDC-0449 (Vismodegib)
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GC16702
CHIR-99021 (CT99021)
A selective GSK3 inhibitor
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GC12096
Semagacestat (LY450139)
A pan γ-secretase inhibitor
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GC17907
3-Deazaneplanocin A (DZNep) hydrochloride
An inhibitor of the lysine methyltransferase EZH2
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GC13145
3-Deazaneplanocin,DZNep
An inhibitor of lysine methyltransferase EZH2
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GC26088
YAP-TEAD Inhibitor 1 (Peptide 17)
YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.
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GC26049
WAY-119064
WAY-119064 is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 value of 80.5 nM.
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GC25838
RBPJ Inhibitor-1 (RIN1)
RBPJ Inhibitor-1 (RIN1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ.
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GC25603
M2912
M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity.
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GC68028
Wnt/β-catenin agonist 4
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GC67775
Casein kinase 1δ-IN-3
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GC67737
NLS-StAx-h TFA
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GC52376
BMP2-derived Peptide (trifluoroacetate salt)
A synthetic peptide
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GC66390
3-epi-Vitamin D3
3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC50 of 39.2 μM measured in U87MG cells.
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GC66371
(E)-Ferulic acid-d3
(E)-Ferulic acid-d3 ((E)-Coniferic acid-d3) is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.
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GC66039
Wnt/β-catenin agonist 3
Wnt/β-catenin agonist 3 (compound 98) is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis.
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GC66035
GSK3-IN-1
GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes.
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GC66033
Casein kinase 1δ-IN-1
Casein kinase 1δ-IN-1 (compound 822) is an inhibitor of casein kinase 1 delta (CK1δ), exhibits inhibition of greater than 5%. Casein kinase 1δ-IN-1 can be used for neurodegenerative disorders such as Alzheimer's disease research.
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GC66032
GSK-3β inhibitor 11
GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research.
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GC65993
MSC-4106
MSC-4106 is an orally active and potent inhibitor of YAP/TAZ-TEAD. MSC-4106 inhibits TEAD1 or TEAD3 auto-palmitoylation and shows inhibitory effect on NCI-H226 tumor xenograft model.
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GC65919
NRX-252114
NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation.
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GC65916
NRX-103095
NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM.
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GC65889
TDI-011536
TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration.
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GC65375
Phospho-Glycogen Synthase Peptide-2(substrate) TFA
Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases.
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GC65356
KY-02327 acetate
KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor.
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GC65336
NRX-252262
NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM.
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GC65185
TEAD-IN-2
TEAD-IN-2 is a novel, orally active inhibitor of transcriptional enhancer associate domain (TEAD) and modulates TEAD by ubiquitination and/or degradation by compounds. TEAD-IN-2 can be used for the research of a variety of diseases, disorders or conditions associated with TEAD.
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GC65167
Carboxylesterase-IN-3
Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease.
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GC65165
Carboxylesterase-IN-2
Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease.
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GC65131
YAP/TAZ inhibitor-2
YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity.
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GC65116
GA-017
GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids.
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GC65066
Prodigiosin hydrochloride
Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite.
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GC64922
Rovalpituzumab
Rovalpituzumab is a humanized monoclonal antibody against delta-like protein 3 (DLL3). Rovalpituzumab can be used in the synthesis of antibody-drug conjugate (ADC), Rovalpituzumab Tesirine. Rovalpituzumab has activity against small cell lung cancer (SCLC).
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GC64837
Nefopam D3 hydrochloride
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GC64832
NRX-2663
NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 ?M and a Kd of 54.8 nM.
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GC64816
Coronaridine
Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression.
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GC64638
ALV1
ALV1 is a potent Ikaros and Helios degrader.
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GC64536
Notch 1 TFA
Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins.
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GC64419
MRT-14
MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling.
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GC64382
SGC-CK2-1
SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC50s of 36 and 16 nM for CK2α and CK2α′respectively in the nanoBRET assay.
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GC49827
5-Androstenetriol
An active metabolite of DHEA
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GC64378
Valproic acid-d6
Valproic acid-d6 (VPA-d6) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
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GC64134
Hh-Ag1.5
Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM.
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GC64131
TMX-4116
TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma.
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GC64005
FPFT-2216
FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α).
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GC63863
MRT-83 hydrochloride
MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease.
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GC49687
Goralatide (acetate)
A tetrapeptide regulator of hematopoiesis
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GC49667
PD 168568 (hydrochloride)
A dopamine D4 receptor antagonist
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GC49651
19-alkyne Cholesterol
An alkyne derivative of cholesterol for click chemistry
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GC63695
Wnt/β-catenin agonist 2
Wnt/β-catenin agonist 2 is a potent Wnt agonist.
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GC63560
ZW4864
ZW4864 is an orally active and selective β catenin/B-Cell lymphoma 9 protein?protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM.
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GC63559
ZW4864 free base
ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein?protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 (free base) inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM.
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GC63465
KY-02327
KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor.
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GC63336
MRT-81
MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer.
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GC63303
YB-0158
YB-0158 is known as Wnt pathway inhibitor 2.
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GC63257
VT103
VT103, an analog of VT101, is an orally active and selective TEAD1 protein palmitoylation inhibitor. VT103 inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation, and disrupts interaction between YAP/TAZ and TEAD. VT103 can be used for the research of cancer.
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GC63100
N-Desmethylnefopam D5 hydrochloride
N-Desmethylnefopam D5 hydrochloride is a deuterium labeled N-Desmethylnefopam hydrochloride.
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GC63088
MYF-01-37
MYF-01-37 is a covalent TEAD inhibitor targeting Cys380. MYF-01-37 has a reversible inhibition on YAP/TEAD interaction.
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GC49241
Methyl Diethyldithiocarbamate
An active metabolite of disulfiram
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GC49110
AICA Ribonucleotide
An AMPK activator
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GC49027
Hexamethylene bisacetamide
Hexamethylene bisacetamide is a tumor cell-differentiating agent.
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GC48992
CGP 77675 (hydrate)
An inhibitor of Src family kinases
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GC48980
EPZ004777 (formate)
A potent inhibitor of DOT1L
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GC62524
VT107
VT-107, as an analogous to VT104, is an orally active and potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer.
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GC62432
β-catenin-IN-2
β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer.
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GC62424
PY-60
PY-60 is a robust and specific activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a Kd of 1.4 ?M.
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GC62394
Teplinovivint
Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor.
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GC62258
SAG-d3
SAG-d3 is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM).
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GC62214
FIDAS-3
FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities.
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GC62132
K-975
K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma.
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GC61861
Oct3/4-inducer-1
Oct3/4-inducer-1 (compound 2) is a potent Oct3/4 inducer.
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GC61781
Super-TDU
Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model.
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GC61527
Lats-IN-1
Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases.
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GC61410
I3MT-3
I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM).
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GC48434
Elsinochrome A
A fungal metabolite
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GC50703
Yhhu 3792
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GC50685
Dynapyrazole A