YAP
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The transcriptional coactivator Yes-associated protein (YAP) is a major regulator of organ size and proliferation in vertebrates. As such, YAP can act as an oncogene in several tissue types if its activity is increased aberrantly. YAP enhances multiple processes known to be important for tumor progression and metastasis, including cellular proliferation, transformation, migration, and invasion.
Products Related to YAP(37)
- GC73349YAP-TEAD-IN-2CAS: 2714432-83-2Purity: >98.00%
YAP-TEAD-IN-2 (compound 6) is a potent YAP-TEAD PPI (protein-protein interaction) inhibitor with IC50 is 2.7 nM.
- GC74115YAP/TAZ inhibitor-3CAS: 2506273-81-8Purity: >99.00%
YAP/TAZ inhibitor-3 (Compound 24) is a YAP/TAZ inhibitor.
- GC81347YAP/TEAD-IN-2CAS: 2957895-40-6Purity: >95.00%
YAP/TEAD-IN-2 (Compound T-1) is a YAP/TEAD inhibitor.
- GC81349(R,S)-YAP-TEAD-IN-2Purity: >98.00%
(R,S)-YAP-TEAD-IN-2 is the racemic mixture of YAP-TEAD-IN-2.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC73127 | GNE-7883 | 2648450-42-2 | >98.00% | |
GNE-7883 is a pan-TEAD inhibitor that blocks the association of YAP/TAZ with TEAD. | ||||
| GC73298 | YTP-17 | - | >99.00% | |
YTP-17 is an orally active YAP-TEAD protein-protein interaction inhibitor with an IC50 of 4 nM. | ||||
| GC73349 | YAP-TEAD-IN-2 | 2714432-83-2 | >98.00% | |
YAP-TEAD-IN-2 (compound 6) is a potent YAP-TEAD PPI (protein-protein interaction) inhibitor with IC50 is 2.7 nM. | ||||
| GC73457 | IK-930 | 2563892-44-2 | >99.00% | |
IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC50 value of <0.1 µM. | ||||
| GC73562 | LM-41 | 2996821-30-6 | >99.00% | |
LM-41 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2. | ||||
| GC73564 | SWTX-143 | 2766575-48-6 | >99.00% | |
SWTX-143 is an orally active YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. | ||||
| GC73569 | MY-1076 | 3008262-76-5 | >99.00% | |
MY-1076 is an inhibitor of YAP. | ||||
| GC73954 | BAY-593 | 2413020-56-9 | >99.00% | |
BAY-593 is an orally active GGTase-I inhibitor. | ||||
| GC73955 | (7S)-BAY-593 | 2413068-25-2 | >99.00% | |
(7S)-BAY-593 is the S-enantiomer of BAY-593. | ||||
| GC74115 | YAP/TAZ inhibitor-3 | 2506273-81-8 | >99.00% | |
YAP/TAZ inhibitor-3 (Compound 24) is a YAP/TAZ inhibitor. | ||||
| GC81347 | YAP/TEAD-IN-2 | 2957895-40-6 | >95.00% | |
YAP/TEAD-IN-2 (Compound T-1) is a YAP/TEAD inhibitor. | ||||
| GC81349 | (R,S)-YAP-TEAD-IN-2 | - | >98.00% | |
(R,S)-YAP-TEAD-IN-2 is the racemic mixture of YAP-TEAD-IN-2. | ||||
| GC81778 | LATS-IN-2 | 2248728-49-4 | >99.00% | |
LATS-IN-2 is an efficiently acting LATS ( large tumor suppressor kinase) inhibitor. | ||||