GLPBio

RN-1665

Catalog No.: GC73917Purity:>99.00%
COASDSData Sheet
RN-1665 is an orally active TRPV4 antagonist that exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3 and TRPM8.

Products are for research use only. Not for human use. We do not sell to patients.

RN-1665
Cas No.: 1803003-65-7
1 mgIn Stock
$146.00
1
5 mgIn Stock
$293.00
1
10 mgIn Stock
$408.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    31, 1291–1307 (2021)

Description

RN-1665 is an orally active TRPV4 antagonist that exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3 and TRPM8. RN-1665 is a TRPV4 probe for focus screens, with IC50s of 0.26 μM and 0.39 μM for hTRPV4 and rTRPV4 from human and rat, respectively.

Pharmacokinetic Analysis in Wistar rats[1]

References:
[1]. Wei ZL, et al. Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4011-5.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1803003-65-7
Molecular Formula
C20H24F5N3O3S2
Molecular Weight
513.54
Solubility
DMSO : 100 mg/mL (194.73 mM; Need ultrasonic)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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