GLPBio

TRP Channel

TRP (transient receptor potential) channels are a family of cation channels that sense various external and celluar signals such as mechanical stress, temperature, cellular messengers and exogenous chemicals. It is implicated in vascular tone , neurological disorders, kidney diseases, hypomagnesemia and hypocalcemia etc.

Products Related to TRP Channel(184)

  • GC13218 structure
    GC13218TRPC6 inhibitor
    CAS: 1333207-63-8
    Purity: >99.50%

    TRPC6 inhibitor is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.

  • GC15947 structure
    GC15947HC-030031
    CAS: 349085-38-7
    Purity: >98.00%

    HC-030031 is a selective inhibitor of transient receptor potential ankyrin subfamily member 1 (TRPA1). HC-030031 blocks calcium influx in cells, with IC 50 values of 4.9±0.1 and 7.5±0.2μM for calcium influx induced by cinnamaldehyde and allyl isothiocyanate (AITC), respectively.

  • GC16882 structure
    GC16882Icilin
    CAS: 36945-98-9
    Purity: >98%

    TRPM8/ hENaCδ agonist

  • GC38465 structure
    GC38465GsMTx4
    CAS: 1209500-46-8
    Purity: >98.00%

    GsMTx4 is a 34 amino acid spider venom peptide and belongs to the huwentoxin-1 family.

  • GC10188 structure
    GC101886'-Iodoresiniferatoxin
    CAS: 335151-55-8
    Purity: >98%

    TRPV1 (VR1) vanilloid receptor partial agonist

  • GC10221 structure
    GC102219-Phenanthrol
    CAS: 484-17-3
    Purity: >97.00%

    TRPM4 blocker

  • GC10873 structure
    GC10873α-Spinasterol
    CAS: 481-18-5
    Purity: >99.00%

    TRPV1 antagonist

  • GC11185 structure
    GC11185TCS 5861528
    CAS: 332117-28-9
    Purity: >99.00%

    TCS 5861528 (TCS 5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively.

  • GC11293 structure
    GC11293PPAHV
    CAS: 175796-50-6
    Purity: >98%

    vanilloid TRPV1 (VR1) receptor agonist

  • GC11318 structure
    GC11318Rosiglitazone maleate
    CAS: 155141-29-0
    Purity: >99.50%

    A PPARγ agonist

  • GC11613 structure
    GC11613L-R4W2
    CAS: 206350-79-0
    Purity: >99.00%

    Vanilloid TRPV1 (VR1) receptor antagonist peptide

  • GC11701 structure
    GC11701A 967079
    CAS: 1170613-55-4
    Purity: >99.00%

    Selective TRPA1 channel blocker

  • GC11906 structure
    GC11906Ononetin
    CAS: 487-49-0
    Purity: >95.00%

    TRPM3 channel blocker

  • GC11926 structure
    GC11926AMG 9810
    CAS: 545395-94-6
    Purity: >98.00%

    AMG 9810 is a highly selective and competitive TRPV1 antagonist (human: IC 50 = 24.5nM; mouse: IC 50 = 85.6nM).

  • GC12260 structure
    GC12260HC 067047
    CAS: 883031-03-6
    Purity: >98.00%

    HC 067047 is a selective antagonist of the TRPV4 channel. HC 067047 exhibits IC50 values of 48±6nM, 133±25nM and 17±3nM against human, rat, and mouse TRPV4 channels, respectively.

  • GC12520 structure
    GC12520Diphenyleneiodonium chloride
    CAS: 4673-26-1
    Purity: >99.50%

    Diphenyleneiodonium chloride (DPI), as a NADH/NADPH oxidase inhibitor, has possessing potent antimicrobial activity against Mycobacterium tuberculosis and Staphylococcus aureus.

  • GC12580 structure
    GC12580Polygodial
    CAS: 6754-20-7
    Purity: >98.00%

    Polygodial is a sesquiterpene dialdehyde compound with bactericidal rather than bacteriostatic properties.

  • GC12597 structure
    GC12597Optovin
    CAS: 348575-88-2
    Purity: >99.00%

    photoactivator of TRPA1

  • GC12783 structure
    GC12783Resiniferatoxin
    CAS: 57444-62-9
    Purity: >98.00%

    Resiniferatoxin (RTX), an ultrapotent capsaicin analog, is a vanilloid agonist that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1).

  • GC13003 structure
    GC13003AMG-517
    CAS: 659730-32-2
    Purity: >99.50%

    TRPV1 antagonist,potent and highly selective

  • GC13457 structure
    GC13457ML 204
    CAS: 5465-86-1
    Purity: >98.00%

    TRPC4 channels blocker

  • GC13679 structure
    GC136796-Iodonordihydrocapsaicin
    CAS: 859171-97-4
    Purity: >98%

    Vanilloid receptor antagonist

  • GC13930 structure
    GC13930N-(p-amylcinnamoyl) Anthranilic Acid
    CAS: 110683-10-8
    Purity: >98%

    phospholipase A2 (PLA2) inhibitor and TRP channel blocker

  • GC13994 structure
    GC13994Phenamil
    CAS: 1161-94-0
    Purity: >98.00%

    Phenamil is a selective inhibitor of transient receptor potentials (TRPs) and acid-sensing ion channels (ASICs).