RO5461111
Catalog No.: GC69824Purity:>98.00%
RO5461111 is a highly specific and orally effective Cathepsin S inhibitor (IC50: 0.4 nM, human Cathepsin S; 0.5 nM, murine Cathepsin S). It can effectively inhibit antigen-specific T cell and B cell activation. RO5461111 has an improvement effect on pulmonary inflammation and lupus nephritis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1252637-46-9
5mgQuote
Contact for Price
10mgQuote
Contact for Price
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 5mg | Contact Us | Quote | -- | |
| 10mg | Contact Us | Quote | -- |
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com
Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Product Documents
Purity:>98.00%Appearance:A solid
Chemical Properties
CAS No.
1252637-46-9
Molecular Formula
C27H24F6N4O4S
Molecular Weight
614.56
Solubility
DMSO : 100 mg/mL (162.72 mM; Need ultrasonic)
Storage
4°C, away from moisture and light
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
Reviews
Review for RO5461111
Rating: 5
- 5 Star100%
- 4 Star0%
- 3 Star0%
- 2 Star0%
- 1 Star0%