(S)-SCH-23390 hydrochloride is the S-enantiomer of SCH-23390. SCH-23390 is a dopamine D1-like receptor antagonist (with K i values of 0.2 nM and 0.3 nM for the D1 and D5 receptor subtypes, respectively) [1].
In Vivo, (S)-SCH-23390 (0.05-15.5 mg/kg, i.p., single dose) hydrochloride results in no significant reduction of the cerebrospinal fluid (CSF) in rats[1].
References:
[1]. Boyson SJ, et al. Net production of cerebrospinal fluid is decreased by SCH-23390. Ann Neurol. 1990 Jun;27(6):631-5.
In Vivo, (S)-SCH-23390 (0.05-15.5 mg/kg, i.p., single dose) hydrochloride results in no significant reduction of the cerebrospinal fluid (CSF) in rats[1].
References:
[1]. Boyson SJ, et al. Net production of cerebrospinal fluid is decreased by SCH-23390. Ann Neurol. 1990 Jun;27(6):631-5.