Other Signal Transduction

GATA4-NKX2-5-IN-1 (3i-1000) is a small-molecule compound inhibiting GATA4 and NKX2-5 transcriptional synergy with IC50 of 3 uM

Panx-1 mimetic inhibitory peptide, blocks pannexin-1 gap junctions

Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. It disturbs endoplasmic reticulum (ER) homeostasis and has anticancer activities resembling that of Bortezomib. Eeyarestatin I inhibits Sec61 translocon.

10Panx is a potent Panx1 channel inhibitor that targets the W74 to Y83 segment of the ECL1 of Panx1 protein.

Antiepileptic drug

BLU-782 is an orally active inhibitor for Activin receptor-like kinase 2 (ALK2) with IC 50 values of 0.2nM, 0.6nM, 3nM, 24nM, 45nM, 65nM, and 155nM for ALK2 R206H , ALK2, ALK1, ALK6, ALK3, ALK4, and ALK5, respectively.

M2N12

LP-935509 is an orally active, potent, selective, ATP-competitive and brain-penetrant inhibitor of adaptor protein-2 associated kinase 1 (AAK1) with an IC50 of 3.3 nM and a Ki of 0.9 nM, respectively.

Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.

Compound 43 TAO kinase inhibitor is an ATP-competitive inhibitor of the thousand-and-one amino acid kinases TAOK1 and TAOK2 (IC50s = 11 and 15 nM, respectively).

Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.

D-myo-inositol-1,2,3,5,6-pentaphosphate (Ins(1,2,3,5,6)-P5) (sodium salt) is produced from Ins(1,2,3,4,5,6)P6 via a minor enzymatic phytate degradation pathway by K.

D-myo-Inositol-1,2,3,5-tetraphosphate (Ins(1,2,3,5)P4) is one of the many inositol phosphate isomers that could act as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1,2,4,5,6-pentaphosphate (sodium salt) (Ins(1,2,4,5,6)P5 (sodium salt)) is one of several different inositol oligophosphate isomers implicated in signal transduction.

Ins(1,2,4,5)P4 is one of the many inositol phosphate (InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals..

D-myo-Inositol-1,2,6-phosphate (Ins(1,2,6)-P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals.

The phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway plays critical roles in cell growth and proliferation making it an attractive target for anticancer agents.

The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals.

D-myo-Inositol-1,3,5-phosphate (Ins(1,3,5)P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals.

D-myo-Inositol-1,4-phosphate (Ins(1,4)P2) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1,5-phosphate (Ins(1,5)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate molecular family of second messengers that play critical roles in intracellular signaling.

D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate (InsP) molecular family of second messengers that play a critical role in the transmission of cellular signals.

D-myo-inositol-2,3,5,6-tetraphosphate (sodium salt) (Ins(2,3,5,6)-P4 (sodium salt)) is produced from Ins(1,2,3,5,6)P5 via a minor enzymatic phytate degradation pathway by K.