D-myo-Inositol-1,3,4-triphosphate (sodium salt) (Synonyms: Ins(1,3,4)P3 (sodium salt), 1,3,4IP3 (sodium salt)) |
| Catalog No.GC43518 |
The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals. D-myo-Inositol-1,3,4-triphosphate (Ins(1,3,4)-P3) is one of several different inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P3 acts through the inhibition of Ins(3,4,5,6)-P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-P4 and thus inhibit calcium-activated chloride channels. The levels of Ins(1,3,4)-P3 are in turn regulated by the levels of cytosolic free calcium. The receptor-mediated activation of phospholipase C (PLC) can be seen as the initiating event in this cascade, since PLC generates Ins(1,4,5)-P3 which releases calcium from intracellular storage reservoirs, leading to a dramatic but transient increase in the cytosolic concentration of free calcium.
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