GLPBio

SMPT

Catalog No.: GC39441Purity:>98%
SMPT is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Products are for research use only. Not for human use. We do not sell to patients.


SMPT
Cas No.: 112241-19-7
25mgIn Stock
$89.00
1
50mgIn Stock
$142.00
1
100mgIn Stock
$228.00
1
250mgIn Stock
$362.00
1

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

SMPT is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical Properties

CAS No.
112241-19-7
SMILES
O=C(ON1C(CCC1=O)=O)C2=CC=C(C(SSC3=NC=CC=C3)C)C=C2
Molecular Formula
C18H16N2O4S2
Molecular Weight
388.46
Solubility
Soluble in DMSO
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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