4-Chloro-N-methylpicolinamide -d 3 is the deuterated-labeled 4-Chloro-N-methylpicolinamide. 4-Chloro-N-methylpicolinamide (Compound 3) is a BAZ2A bromodomain inhibitor with a K d of >500 μM. 4-Chloro-N-methylpicolinamide forms a weak hydrogen bond with the carbonyl oxygen of Pro1817. 4-Chloro-N-methylpicolinamide can be used in the research of invasive prostate cancer [1].
In Vitro, Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
References:
[1]. Spiliotopoulos D, et al. Discovery of BAZ2A bromodomain ligands. Eur J Med Chem. 2017 Oct 20;139:564-572.
In Vitro, Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
References:
[1]. Spiliotopoulos D, et al. Discovery of BAZ2A bromodomain ligands. Eur J Med Chem. 2017 Oct 20;139:564-572.